Tobacco Documents Online

22~ Jun.~ "9111:117~ lung carcinogen, responsibie for approximately 3,11(DO lung, nonsmokers'. Assessment (U.S. EPA, 198I6a). EPA's m~pr conellision was: studies were analysed according to the U.S. EPA's Guid "Respirstory Health Effects of'Pcssive Smolring'. In tliis report (EPA/gOQ/tS-90Mo6F; December 199 MHFH BIIOPIETR'IE: TEL 4951115324295 Comments of'an Expert Group of'Stati'sticians and on the Concepts of Risk Assessment in the U: S. Kespiratory Health t?ffiects of Passive Sm Lung Canoer, and Other Disorders In Daoember, 1'992 United States Environmental Pzotection Validity of ine s assessing ex posure (3'.3 W (indoor e surc ~u • b 'b and ~~ mcas ~ conccnt~artions the compou ~) ~ concerning the validity of the data and methodblogical concepti< comments of an expert group of cpidemiologists and stati are subject of' diverging opinions and! heterograidous disaussii The validity of the databa9e and methodological' concepts on w The following problems and questions should be commented: li. Estimation of environmental toliacuo smoke expasnrr. (ch m Validity of questioiiaires for assessing LTS' exposure (3. (Prof. Atteslhnder„ Augsburg PRG) 2. ~3ozard Identification (chapt. 4 and 5 of EPA recxt) ~~~ ~~T~~a~2`t' ( ~~~uv Validity of statiairal infen~ce (S.2 and 5.3) (Pref_ Flew, Z.ItK) Validity of'long.-term animal'bioassays and lung,cancer risk assessment of ETS (chapt. 4) (Dt.A.J.Valleron~ Paris) Validity of relative risk estimates from spousal BT'S'~ by (Dr. A.JL Vnileron, Paris) HIF g4ncy published a report: e results of epidemiologiic es for Carcinogfnic Risk. In adults: ETS is a human cer deaths annally in U.S. ch this conclusion is bascd s. 1t is' intended to gSther ans on scLxticd questions no applied in the EPA ncport. ~t. ;1 of t? PA report) 3.2) n rs; hralgti-it~-t of diC Validity and limitations of epidemiologic studies to quan very small excess risks; impact of political goals and consequences to lifestyle o populations) ~~ (tests of effects and trend tests: problem of muld(Die te B FRG) (Prof6w'geJ', 1 Hamburt;, 1 1 2

22', J u n. ' 93 11:10 M1FW B t mh1ETR 2 E TEL 495115324295 , p Riak astirnates with continuous ecposure; Validity of cx t, , _,~. (Prof Feld '~""' ~l,j,i= 3. 'nu Interpretation of'the results of the epidemiologic stul The validity of the "weight-of-evidence anatyRis" and a rtlurt (L:hapt. l and 5.6). (Prof.Dr.P.Urbach, LondoniUlC) H b menn, bm~orglSanr,, PR!C) n,,m - fn a r,ct4e OC Bi 3 ure modcls in EPA reWrt. ~°O' -t' i NYnxuti+-GY+c 1' /A;7A-~. ~ tG ~ Su t~ ~nc~ 0 VV:ticZ+tc ( sment of cau sality in EPA Conclusions from the rosults'. of the epidemiologic studi o (Are the aonciusions drawn by EPA fromi thc'results of the epidemiotogic studies ju 'fied ?) (Gary L Huber, MD, ~ston, TX, US+A) I 0 4. Popuiotlon rick of lung rnncer from passive smoking (ch 'I1e concept of attributable tisk' and the estimation epidenuioiogic studias (isthe concept of attributable ris report to utimate population risk ~ 7). (I'rofi Schneider, I$annover, FRO) S. Passiwe i smok,ing and respiratory disorders otLcr, then i ca Validity of studies and conclusions fmr impact of'E1'S to drawn in EPA report 0 (Ciary L. Huber, MD, Hston, TX, USA')) t. 6 of'EPA report) of population, risk from, applied correctly in EPA (chapt! 9 and 8 ) isorders other than, cancer, {t.,fZl } V'A; c 4z-rz,,3 N -F- kE-1n-M lna,t ~