Tobacco Documents Online

TEL No. -------------- Nov. 8,90 17:17 P.03 ------------------- ENVIRONMENTAL PROTECTION AflENCY ~ SCIENCE ADVISORY BOARD INDOOR AIR GUA, ITY AND TOTAL HUMAN EXPOSURE COMMITTEE OPEN MEETING Decembar 4•5, 1900 Under the proAct, Public Law 92•4i of tha Seience Adv1a Exposure Committee, tog0 beqinning st gt on December, 5. T CrystilCity Hote1, Virgin7a 22202. The lstona of the Federal Advisory Conmittee 3, notlce t• hareby 91ven of a publio metting ry 8oard's Indoor Air Quality and Total Human thts msattng wiil be hetd on December 4-5, 10 a.m, on December 1 and ending at 5100 p.m. e meeting will be hsld at the Days Inn I2000 Jefferson Davis Highway, Arllnyton, phohs number at tht hotvl is IT08) g20-D600, The purpose of the meeting ts to r.view two EPA prepared 'documents eoneerninp nvironmantAl tobacco amoke. These Are: (i) Health Effectv of Pa sive SmokSng: Asgessment of Lung Cancerin Adults and Respiratory Dlsorders In Children fEPA/600l6-a00oeA1 ('Rtsk Assessment'), ;nd (2) Environmental Tobaceo Smoke: A Gutde to Workplace Smaking P 3icies IEPAJ400/E.90J0041 (•Po)!Cy Guide'p. To obtain single oopi a of the Rtsk Aasessment, please Contact the U.S. pPA, Office of A search and Development Publiostione Office, CERI-PAN, U.S. £nvtronfiental Protection Agency, 26 West Martin Luther King Drive, Cin~innstl, 014 45268, (513! 588-7882 or FYS 684• 7a62. Please provtde our name nnd malling atldress and request,tha Risk Assesament by title and EPA number- Ths Po71cy Guide ts available from the U. EPA, Office of Air and Radiation, Indoor Air Division tANR-445401 N Street, SW, Washington, DC 20450, (T03) 308•8470. These'pocumenta are NOT available from the Science Advisory Board. The Aqency seeks the advice of the SAB on the accuracy end completeneas of the Ri k Assessment and on the question o! whether its conclusions on the wetght of evidenee of ETS caused cancer and other respiratory dlaea e are well oonsidered based on ths tlats and accepted scientifio pr ctices, Sn Addition, the Agency hAs asked the SAB to adtlress the followinq specific issues: A, n nc i ul : i, Has EPA met the requirements stated in tts carcino en 9uidetines for char.cterizing E7S in Category A, i.e. !s the evidence suffiofent to oonclude the ETS is esusatiy aosocfated wi h lung oancer7 2. Is spousal smokin0 a proper messure of €TS e;posure to asaess lung cancer riak? 3. Are the differences in relative risk observed between studies in the U.S. snd those averseaalof eoncern, and If so, to what degree? 4. Is Meta-Analysie an appr priatt tool to use In the doCument and haa it basn applied correct~y4 Have the eptdcmiologicsl studies been properly evaEuated and ombined using this teChniqueY b, Have the most important eonfound~rs bean properly addressedT Has the issue of mtictassification (cs,ansifyinq current and former amokers as gDO ~pj 8 AQN 1JS Yd3 89 L ZUZQ 99;ST 08i8oiit - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

TEL No. .2. Nov. 8,90 17:18 P.04 never smokorel bsen dequateiy sddressed and the Proper adiustments made7 Are there o her confounders which could be addressed in greater detsil? 6, Does the document charaeterize the uncertaintiet, both in the Weiyht•of•evidence and the number of attributable deaths, appropr(ate7y? )'. Haa the quantitative risk af lung cancer beenroperly assees+d4 Would tt be more properly assesseq by a dos• esponse sasesament using either cotfnihe or respirab3e su+pendad particufates as surroqate measures of ekposure (Appendix C)? Wout modellnfl approaches IAppendix 0)? Should a dose-response model ~e developed for STS•radon interaotion effects? 6. Should the Draft, Report attempt to distinguish between the effects of home vs, orkp)aee exposure to ETS? B, s 1 rd r 1. Flps the weight of evidenoe !or €TS re ated respiratory disorders in children been properiy ehar.ateriz d? A draft report with a detailed desoription and anatysis of 26 recent atudiss haa recently been prepared. Should It be inotude in a revised report ats Appendix €? 2. Have eonfounders in the ep demiotoDie studies been adequately addressed? 3. Should a meta sn iysis approach be attempted as In the lung eencer anily9(s? The review of tje Pot toy Guide wi 11 be .) imited to how the scientific issues rsiaed in the Risk Assessment ere charaeteriZed (primarity paCes 6•20, Inclusive ot the Po3icy Ouide). The meeting is 6pen to the pubtic and sestinp is on a first Come basis. tlembersl of the public wishing to provide oral •or Written statements iit Ithe meeting must contact Mr. A. Robert FIaaK, Desipnated Federiti Olficia) for this Committee, at the address given below no later than November 26, 1910 in order to reserve space on the agenda. ach speaker wi11 be limited to a maximum of 6 minutes. At least 0 copies of any written stitements must be submitted to Mr. Fiaa no tater than the time of the meeting. The 8AE expects that ora statements will supp)ement, rather tnan repeat wriLlen etatem~nts. If a 7arfle number of tndividua3s or groups ask to providc corrments the amount of time each may speak may be reduced, the "ting may be extended into the evening to aCCodrnodate addltiohal'apeakers, or we may ask that oral atatemants be limited and that aItiona3 conments be provlded in writinq. For further infor stion concerning the meeting or to request time on the i9enda to speaK, please contact Mr. A. Robert Ftaek, Asetstant Direetor, 9c ence Advisory Board, U.S. EPA, (A.t01F), 401 N Street, SW, Wash(npt~in, DC 20460. Telephone; (202) 382•2552; FTS 362•2552; FAX; (;Q2) 475-9693. For copies of the Aqenda and the Coemfttee Roster, ~lease contact 1NS. Carolyn Osborne, Senior Staff Secrstary, At the address and numbers listed above. The Risk Asseasment and Aolioy~Guide are not available from the Science Adv/9ory @o,trd. I6©~ ~~ Ug AaY 15S Vi33 E696 SLb ZiTZa L9; 5T 06i80iII,