Philip Morris
Attachment I Graphs of Data From NCI / Ntp 83 Daminozide
Fields
- Type
- CHAR, CHART, GRAPH, TABLE, MAPS
- Area
- LOGUE,MAYADA/OFFICE
- Site
- N426
- Characteristic
- EXTR, EXTRA
- Document File
- 2025545619/2025546382/Harvard University Office of
- Continuing Education Short Course Program Harvard School
- of Public Health
- Continuing Education Short Course Program Harvard School
- Master ID
- 2025545673/6381
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- Litigation
- Stmn/Produced
- Named Person
- Fisher
- Request
- Stmn/R1-072
- Named Organization
- NCI, Natl Cancer Inst
- Ntp
- Date Loaded
- 24 May 1999
- UCSF Legacy ID
- slp02a00
Document Images
Attachment I
GRAPHS OF DATA
from
NCI/NTP 83
DAMINOZIDE
1.0
0.8
Z#Z
1.4
C:4
E-~ 0
6
O
E-
~ .
~
~
O
~
0
4
~ .
E-+
~
E-~
~
~
~ 0.2
0.0
2
DAMINOZIDE
4 6
DOSE (1000 PPM)
Female rats - Uterus
-3-
10
1.0
0.8
~
N
0-"
~
~ 0.2
0:0
0
4 6
DOSE (1000 PPM)
Male mice - Lung
8
-5-
10
1.0
Ei
x
F
0-4
0.8
0.0
D A N I N 0 Z I D E ( N C I/ N T P N 0 3 3)
(calculated by MSTAGE)
, I, II I, I, 1
0 2 4 6 8 10
DOSE (1000 PPM)
MALE RATS - INTERSTITIAL CELL TUMORS
TMe "error bars" are the statisticaleirr:or.s (standard deviation) given
by V Npq : N = No. of animals; p = probability of tumor; q= l- p.
A line is a good fit if it goes through 2/3 of the error bars.
-9-
1.0
0.8
0.0..L i i i ( J;'m ' t 1
0 2 4 6 8 1 0
DOSt (1000 PPM)
FEMALE RATS - LUNG
Z*z
1.0
0.8
0.6
0.4
0.2
0.0
DOSE (1000 PPM)
MALE MICE - LIVER
-7-
MALE RATS - INTERSTITIAL CELL TUMORS
Summary of input data
----Dose---- -----Number----- Fisher exact
# value w. tumor tested comparison (Compared with control-zero dose)
-----------------------------------------------
1 0.000E+00 13 20
2 5.000E+00 46 50 9.491E-03
3 1.000E+01 47 50 4.241E-03
Parameter Approximate Gradient of
number Status Value p value logliklihood
--------------------------------------------------------------------------
0 optimised '1.150E+00 5.986E-03 -2.975E-14
1 optimiaed 2.036E-01 4.257E-02 -2.132E-13
2 set to zero 0 1.000E+00 -4.863E+01
95.0% one-sided confidence limits ( 90.0* confidence interval) on stage 1
are: 1.281E-02 to 3.222E-01 (Optimum value: 2.036E-01)
DATA FROM NCI/NTP 83
~~~~sszc~z
MALE MICE - LUNG
Summary of input data
---- Dose---- -----Number----- Fisher exact
# value w. tumor tested comparison
-----------------------------------------------
1 0.000E+00 4 14
2 5.000E+00 17 50 4.846E-01
3 1.000E+01 20 50 3.247E-01
Parameter Approximate Gradient of
number Status Value p value logliklihood
-----------------°---------------------------------------------------------
0 optimised 3.365E-01 3.390E-01 2.716E-13
1 optimised 1.418E-02 4.160E-01 -4.814E-12
2 optimised 3.253E-04 4.775E-01 =5.005E-11
95.0% one-sided confidence limits ( 90.0% confidence interval) on stage 1
are: 0.000E+00 to 4.820E-02 (Optimu.m value: 1.418E-02)
OGT9VSszoz
EEMALE RAT - UTERUS
Summary of input data
---- Dose---- -----Number----- Fisher exact
(# value w. tumor tested comparison
-----------------------------------------------
1 0.000E+00 0 19
2 5.000E+00 7 50 9.258E-02
3 1.000E+01 8 50 6.421E-02
Parameter Approximate Gradient of
number Status Value p value logliklihood
-------------------------------------
0 set to zero 0 5.012E-02 -9.984E+00
1 optimised 2.172E-02 5.255E-02 0.000E+00
2 set to zero 0 1.000E+00 -4.508E+02
95.0% one-sided confidence limits ( 90.0% confidence interval) on stage 1
are: 0.000E+00 to 3.231E-02 (Optimum value: 2.172E-02)
~
~~~rs~sszoz
H'EMALE RAT - LUNG
Suttmary of input data
----Dose---- -----Number----- Fisher exact
# value w. tumor tested comparison
-~--------------®-------------------------------
1 0.000E+00 1 20
2 5.000E+00 3 50 6.787E-01
3 1.000E+01 4 48 5.376E-01
Parameter Approximate Gradient of
number Status Value p value logliklihood
-------------------------------------
0 optimised 5.129E-02 4.237E-01 4.441E-16
1 optimised 6.610E-04 4.877E-01 4.441E-15
2 optimised 2.911E-04 4.412E-01 2.220E-14
95.0% one-sided confidence limits ( 90.0% confidence interval) on stage 1
are: 0.000E+00 to 1.352E-02 (Optimum value: 6.610E-04)
tG19tsS7oz
19
MALE MICE - LIVER
Summary of input data
---- Dose---- -----Number----- Fisher exact
# value w. tumor tested comparison
-----------------------
1 0.000E+00 1 14
2 5.000E+00 9 50 2.994E-01
3 1.000E+01 16 46 4.037E-02
Parameter Approximate Gradient of
number Status Value p value logliklihood
-------------------------®m----------
0 optimised 6.080E-02 6.349E-03 -8.882E-16
1 optimised 3.350E-02 6.349E-03 -8.882E-15
2 fixed 0 n.a. 1.476E+02
95.0% one-sided confidence limits ( 90.0$ confidence- interval) on stage 1
are: 1.276E-02 to 5.149E-02 (Optimum value: 3.350E-02)
ZGT9tsSzOz
