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®s l}4ViF2QYAL C~~~%Jl ®t UNIROYAL CHEMICAL COMPANY, INC. 74 Amity Road Bethany, Connecticut 06525 (243) 393-2163 THE REIATIVE RISK OF DAMINOZIDE (ALAR~/KYIAR®) IISE Dr. Bruce 7x~es, inventor of the widely used Ames Mutagenicity Assay and Professor of Biochemistry at the Dniversity of California, Berkeley, has recently p-6-w-Iished a study xhich describes the relative risks of a variety of natural and man-made carcinogens.l/ In this article, Dr: Ames states that rodent cancer tests can't be naed to predict absolute huatian risks. gowever, they can be used to indicate that s=e chemicals might be of greater concern than others. He ranks these,carcinogenic hazards to humans by an index which relates h-man exposure to carcinogenic potency. This index is called a FERP MEX (g=an Exposure/Rodent Potency). Dr. Ames stresses the need to identify i=pordant causes of cancer anong the vast rntmber of minimal risks. This ree_uires knowledge of both the amounts of a substance to which h=a.*%s are exposed and its carcinogenic potency. A graphical representation of the relative carcinogenic risk or MERP IhDEX for several substances which appear in Dr. Ames' article is attached. The relative carcinogenic risk of these substances which include beer, mushroomr, diet cola, peanut butter, bacon and chlorinated tap water will surprise you. More surprisingly, when a BSRP I2IDFx is calculated for daaiinozide and its by-product UMM, usinq worst case resulta from ssouse studies conducted by B. Toth, the relative risk is tenfold lower than tap water. e 1/ B..N. Ames et al., Rarilcing Possib2e Carcinovenic Hazards, Science, Vol. 236; pp. 271-280 (1987). - -- ... a n.. oo_'T /G /AR

:JUL E: ' E:$ I I: 0Z F FpM UN I P.U',AL BE THAIaY 0 TO OX-AGrHEM FAGE.00 1)r. Anmes cautions that the HERP INAEX should not be used as a direct estima•Le of human hazard, ssnce huaan zusceptibility at lower dose rates ![Nost likely differ from the high dosage rates that rodents are exposed to. nlerefore, the actual hazard or risk at low dose rates might be 'much less than the fiERP values aould suqgest. HQ eoncludes that ... current levels of pesticide residues... are likely to ba of stinimal concern relative to the background levels of natural subctances..."

\ 100-a 90-I 80-~ 70 -~ RELRTIVE CRRCIPd®aENIC RISK k~OOl.tS 100 DIET COU 60 PEANUT BUTTER 30 30-1 20-r 10-~ ALAR BAC®N TAP PLUS ' tlfA"tfR LlOtA-i .--~ 1 0.1