Tobacco Documents Online

18/03 '93 17:55 $72 2 2878089 P.1GC.S BRUSSELS international Center for a Scientific Ecology Q 004/012 GtideUmes fnr the sPm4ma¢-on lioear trelatiomship fos•riskasesmment ozlow rloces otr'alrinogcsu 'Phe morning of the seminar will be devoted to cummunications on the following topics: - methodology of predictivs studies based on the 1inaar relationship concept applied to low-level exposure to carcinogens; studies of specific casea; esYwatoe (ProL J. (arbett MaaDonald); • areaaic (Prof. Gerhard Sttlhrer); • vinyl chloride monomar (VCM) (Dr. Waraer Freieslebex); • DDT (...), • saccharin (Prof. Samuel Cohenr • passive smoldng (PivC P. N. Lee). These ease studies are intended to show whether there ara any significant correlations betweon forecasts based on the linear relationship principle and the tiu.-ts or data available (elinical and statistical aspeata) which caa be observed today. These six substances have been selected on the basis of the following c'riteriu: their diversity of aetion- swffieient follow-up Nm: to permit In-sltu observation; the dti$eulty of evaluating the effects of low-level exposure using conventional epidemiologlcal methods. With this in mind, we think it would be a good idea if all our speakers could include the following points: • dose levels below which convent,ional epidemiology ceases to be applicable (cohort size, oost, time required); • mortal[ty prediction based on linear maUwmatical extrapolation; • clinical observations in keeping with the forecasts derived from mathematical axtrapolations• " • evaluation of tlaa deviations; • a description, if appropriate, of'the regulatory response to these forecasts, their mats in tenusor public health and.of the economic and a0cial costs; • rialcaThemeflt consideratiune; - the spaaker'ss personal comol.•sion. In ordar to allow a••Md•-• time for discussion with the scientific panel, we propose the following two-phase schedule: 1• Submission of a written report (10/1b pages, including the bibliography). This ptpat whic6 should be in english, will becircuwlated to all panel memb.rs- '(.9oailtg date for submitting texta 5 April 10, 1993. 2• A t6n-minutn oral communication given on May 10, 1993. An abstract focussing on ttu3conelusions of your written paper. Jf theze is anything which is not el.ar to you. please to not hesitate to ask us about it: byx: (881) 418900 60 ltlJMi1Vlml8/9NM iNenwfionat CYadr 1or a SaEnt11o EoowgY 10- avanua efe NlesShe. )5008 PW k. France TW :33145622D06. Fcx: 33 142 8907 59