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1?/0a '94 19:0d a'4d 33323001 BURSONYARSTFLLER Q6osiolo 'Ge1:39-2-862163 ib Giu 94 L1:17 No.009 P.02 Burson-Marsieller ExECVrtvS sve9VuAY 1be sample Aim of the Pro~'cct was gattteriag the optnion of inAuen~tinl leadcra in the bealthcare field about the setting up oE an fiuropean Sdentists Netwodc, based on the idea ahat all public policies should be referred on good eabdng sdonce, not on_asyths, unproven hypotheses or distorted scienea For t~s reason we bave snter+rlawed tive spec,alfsta wor3dng In Man.. The positive optnions lnt general the i'ive intesviewees tbink tlntt this Projeet could be pou"tiva especially regardiag two oatcomes: its influence oa political'avthorit~Ies and the scientific problcros evalaation, provided that these subjects arc nott lz,rgely debated yet, or are not correctly divulgated by mas media and sdentifc publications. 'The panel should taice in account topics not yet wett- developed• for instance nowadays onvironmental problems are catmnY a large debate, but ' Alt tha inte:vicwed. experts haw stated that this Project is too ambitious hecwse It should include too many d3scipHnes aadd tbe sciantists' different ideological positions as well. Jt's iruponant_ to guarantee a scicnii8c super-pa.ees psusra, which should m~vcrcome the snternzl conflicu. Moreaver iYs difficult for the panel to inAaencapo liticinas as the heahhcare political decisions are not based on scientific backg<ounds, but oa other yet ; says prot Ottolenghi. TLe negati.e opinbns unfortunately we dpn't have an objeawa ludgemeat in the sdenttt ic field N I 1

17/06 '94 17:07 1245 33323001 Ile 1'=J~$-e-aocsvo aURSONX&RS'TELt.ER . - - 0010/O10 Burson•Marsteller interests. For this reason the inteiviewees suppose that politicisns wouldn't be interested in a sinisla r Projem rtew propos:2s As the Yroject presents some wesk points, the fivc phrs{danx haye suggested some indications whieL cauld modify this idea. 'M .external foundation should guarantee the panel's activity : sa3d prof. Mocareui, and prnL Paoletti added. 7t would be better if the notw.ork wero maft up of two strnctures: a panel with Nobel prizes (represeating i 11igber authority) and seversl tec'hnicsl eommittees taking in acoount mora spedffic $rguibtcnts". Another pn:posal regards the impravement of the relations between each country's Scientitic Societies and its srientiHc publications, if they don't exist. Conclusion Four out of five interviewees are wiUing to otEer their support, but they would MoC to look throvgh a statetnent itiustraft all the contents and the form of this network in advance.'I7ta lsist one wouldprefer to be excluded because of the private cotnpauias sponsoring the Projeet and with pacticular reference to Phiiip Morris. FurtFiarmore, sometimes tthey haven't given satisfying anmwess, either because g~~L no elemcats to s~r stuaetbi, ~g ,, or berruse the questions were too 2 ,

17/06 ' D4 17: 08 $45 33323001 $ZJRSpDpURSTELIER ~001/OOS Te1:39-2-862163. 16 Giu 94 11:18 No.[1O9 P.04 Burson-Marsteller SO'UND SCIENCE PROJECT QUESTIONNAIRE We have strucwred the questionnaire in 10 qaeiies and interviewed five outs~anding physLcians: prof Qianni Bonadonna, pro£~ Carlo La Vecchia, pto£ Paolo Mocarclli, pro£ Sergio Otta~lenghi, prof. Rodolfo Paolesui. Hem srE the questions: 1. What do you think about the Sound Science Project? Would you ldce to taka part to a simi'lar 8uropean network? 2. Within the Project,. which spedfic issues are the scientists particularly interested in? 3. Doyo u agzee we need to establish or def'iua clear and univocal criterii evaTuating burnan risks~ e.g. standards an good epideniialogy? 4. Wbich should be these standwds, according to your opinion? 5. How sboutd such a network be organised (also as fu as lagal struaum is concerned)? 6. Should this network be made up of scientists alone, or also of political decision Aaakers and journalists? 7_ Wo~y~ like to work in a network sponsored by a coalition of privace ~ 8 According to you, what would be the possible perception of policy- makers regardmg such a network? 9. Are you interested in pariicipattng to an Europeansymp~ um to discuss these issues, probably sc~eduied next September 1994? 10. Do~yon know if there are iulian publications about this topiG, In Italy? Wl~ch are they? i 11 No 3

17/06 '94 17:08 $`45 33323001 g1MWNXARSTELx" Te 1:39-2-862163, 16 G i u 94 11~ =18 No _ 00 ~ p OS S BLiriJOII•MSY'Steu@t' SOUND SCIENCE QUESTIONNAIRE RfiSPONDENTS NA1vlE: GLSNNI BONLADONNA TI77.E: DIRECTOR DIVISION OF 1KEDIGL ONCOLOGY SP=IAZdTY: ONCOLOGY NAME OF TtIE HOSPITiUWATIONAL CANCER INSTITUIE, MILAN Prof. Bonadonna gives a positive op'mion about ihe Project, even thoush ho ooti,ccs, as the other iatetviewees, tTtat it's veryy ambitious and $ttl) too gelneral 4n it's contents and structure. He thinks that an European networtc could be useful pardculariy to make tbe~ poliid.tt'cal authorities aware of the communication problcros in thh e scientific fic Answers L 'polftfcians are unaware of scientific matters. So it would be inurestinz to set up a panel aiming at infor[aing them ibout several probleras . Accordiag to AroL Gianni Bonadonna this problem reguds also atass mcdia and their responsibility towards the public opinion". 2 it is important to inforcepo1iticiars regarding slxcif;c issues. Every member of tbe panel thould help dhrough his own experience. 3-4 "Tbe fundamental univocal eriteria are good and precise indicationx'. S. The panel should have a pysamid struewre: it should bo made up of a responsibk, a committee oomposed of few peoptc. an Advisory, board and some consultants pjving inforasation about specific sub,jacts. "i'he members will work in tbair eonntryparticipating to only two or three meetings In a year and will send tbeir specific contribute to the ocntral seat", says proL Boaadonna.'T could beeome part of theAdvisory board and surely give a support as consultant concerning my brancb, that Is oncologil'. - 6. "Of course the panel should Include journalists and politicians because they need to be informed"_ 7. Prof. Bonadonna would accept the job even though the Project Is sponsored by private aompanies, particularly Philip WOrris. & "I think political authosi/ies.vould agrea" 9. " September seems to him too eArly for a rymposfum, but be is willing to corr-ider It. 10. He doesa't know a particular bibZiograpby. 0 4

17/.na '9s 17:09 'ata 33323001 BURSOIIIYARCTRT.rfiD RDooa/oos TeI,:39-2-862163 16 Glu 94 • il'19 No.009 P.06 Burson•Marsteller RESPONDENTS rUS1ViE: CARLO lA VECCHtA TTTLE: >;IBAD OF LA1iORA'tnRY OF EPtDEMIOLOGY SPECIALITY: EPIDFMIOLOGY ,M OF THE IATSTI?iT!'L FOR PH~iRMACOLOGICAi. RFSEARCHs '1~! LA.LRIO NEGRI' ProL La Vecehia is sceptical about the Pro~' tand ha doesn't think this network could have a s~~u ficant role to play in Europe. Anyway it would be itnpprtant to imgrove inTormatinri ia the scientific field. To this purpose the netwwk should be better structured. Aeswars 1. "It dotsn't e:etst a~speufic verification eQneerrang scientifie information,. In which way would ttus panel work ia order to be efficieirt'?". 2. Pro£ La veaahia bas not answered preaisdy to this gaestIoa bc t+eerely said that the problem of a. correct secentifie information is very eraciaL 3-4L "Good and precise eritetia are well strucaued in the acientific field saad they are -respected by the scientific publications„ but it doesn't happen that way for other sectors. The press Is not always the only responsible for an tmcorrect information but sometimesprivate compan3es protect their intere:ta so that they give only pariial information to it'. 5. Proi: La VeccJua estimates that the network should be made up of an external Advisory Baird and should receive a report of the annual activities by its consultants. 6. Sournalists would be an important,~,,re in the network as they are responsible for the publio opinfoa ~aUarmatfon whereas politicians are less suitable for this job as they seek an immediate consensus ratber than providing sdentiflcally proved data. 7. ProtA La Vecehia is not aga4nst the participation of the private aantpani~ but his consensus depends on coiapanies' ideatury_ i~ie wwidn't cooperate with a company such as Philip Moais beawse Iu ttri.nks tberawovid be eonfticts of interest. & Politieal authorities woutdn't hava any particular reaction to the setting vp of such a paneL 9 He -has already stated his position about the sponsors of the Project (see animer 7) so that he considers bfimself the lcss suitable person to partialpate to this networit F0. He has no parcicutar indications about bibtiograpby. 4W 5

17/06 '94 17:00 Te1:39-2-862163 16 6iu 94 11:20 No.009 R.07 'a`4S 33323001 $tR{$ONJURsTELiF1t Bnrson•Marsteller R£SPONDENT'S NAME: PAOLO MOC,ARELLI TM"1l.E: PROFESSOSt EXPEItTMENTAL AND CLIIMCAL PATHOLOGY SPEC1ALriY: PATHOLOGY NAME OF'CHS [NSTM`U'I'Es UNIVI+',.RSITY OF THE STUDIES, MSGAN Prog Mocarelti is willing to particigatc to the Pro3ect, ii it takes on a precise idaaEeity. For this purpose it should be important to know whirb inxtrumer~ts are available to rzalise tbis Pro,jea. Theunetwork should ba.re the task of monitoring the scienaSHc pttblications andIxcviewing the articles because often spccialized press is not a guarantee of scaentific ethies. Answr.rs 1. w3e Project is ambitious. Whst kind o#paww would it wield over political authorities and mass media? Could this Project really mead misleadiag ucws? We have to consider all the Vuacts we have at disposal in order to pve a correct scientific infolmation. Unamwerad quesVons are also an uncorrect infonnadon". 2. "According to otu deeision makeis we are uauseitit because politirdl decisions are not taken ioltowln~ scientific aiterin. Nowadays science acts according to a systemm which is not interested in giving a correct ieformation ir order to achteve this goal we have to hit this system". 3-4. Of eoursc good and dev criteria In scientific field are necessary: results must be certaiA and have a statistic relevance. S. The panel should read the scientific articles and define their validity. Not aA the specialiud publications arc reliable so they slwukl be verified. 1t should be necessary to set up a sort of foundation which guarantees tbe impartiglity of the network. 6. In particular some journalistt would be necessary. In this .way they woutd bave the opporto ' to acquire further scientif'ic know]edge and to write articles be:ng real awaro off the probleas 7_ "In gencral the panicipation of private companics to the ProjCct is not an obstade, but it could become a problem if their aim is protecting their private irtterests. The network should btcva its indipcndenae and shoul7 take its decisions in agreemeat". !1; "I think formally political authorities would accept the, network buil,dictg." 9_ lIe is interested in participuing to the Symposium. 20. Hc has no particular ideas about b:'bliiagraphy. 0004/005 OR 6

17/06 'Da 17:10 a4a 33323001 gURSpNVAgcTct.rcn Te1:39-2-862163 16 Giu 94 Bwr$on•Marsteller Q~oosioos 11:20 No.009 P.08 RESPONDENTS NwMB: SERGIO OITOLENGHi TlUM PROFF.SSOR OF MOLEOOLAR GENETICS SPrCIALCt'Y: GEPIETICS AND BIOLOGY OF MICRORGANtSM NAME OF THE INSTIT[TI'Lt: vNIVRRSITY OF THB b"1't1DIE8, MILAN 1Le= network should take in account perdcular problems requiria~ an impjtadgement by consultants so that public opinion wouldn t be ir:fl ,•uie~ncod by emotional upccts. But the solution i's not necessary the settc'ng up of a network: if scientific societies acted as go-between for spedazca publicatioac, a more correct information would be assured. Answers 1. "Tbs Pro,ler' tis too ambitious, too tt:any disciplines are involved. If you want to ~uild correct seientific iusformztion, you shall try to put in contact the Editorial Board of sctentific pablications and the newspapers, ournalixts and scientiQe societies (for oncology, genetics,...) be~onging to each country' : 2. The network s}wuld be a super`partrs body ooneeraft mattcrs already known by -eommon people (stich as the environmental subject) whictt at present are not really known in a eorrect, scientific way. 'Different ideological tendencies requiro an impards+i review. 3-4 `In scientific field the method is always the samc, it's eager to verifications and denials. When we consider other fields, such as the political or ideolog ieal ones, we cannot refer to good and clear criteria. I think that the difference between the two levels is too broad to be filled by such a notwork'. S. He hasn't answered. 6. He thinks that politidgtzs and journalists should not participate to the network beenuse it would cause a scientific debate witbin the body and moreover they woulda't have any competence. 7. He batn't Eiven anx precise answer. He wanted to know whicb privatc companies arc behind the Project and added thai the nwn important thine is that people will discuss it without ideological preclusiorss. 8. "Att the committees have political influenee.lbe indipendence of the network depends on its members and on the contents which they would like to diffuse". 9 He would like to look through a document before Eivjn= his consensus. 1Q He has given no indications. 7

17/06 ' D4 17:11 'Q4S 33323001 gtJRSpIJYAgSTEI1,FR - Q001/005 Te1:39-2-862163 16 6iu 94 11:21, Mo.009 P.09 Burson•Marsteller RBSPONDEN]"S NAME: RODOIFO PAOl.EI'TT TIT,E.E: AF.,AD OF PHARMACEUTlCAL DF•PAR11VWWT SPECIALiTY: PFUR1tilACOLOGY NAME OF THE 1NSTl?Lft'E: UNIVERS3IY OF THE ST[7DTSS, MILAN Praf. Pao2ettf thinks that the Prof eet it st7t too general and he cannot give his consensus with the few indiratioss we gave him about it. The nfost itnportant sLt~gestion Is dtviditag thc netwaork into two gro~ips, a pg nel made up of Nobol prizes and other tcchnical committees aivtng their support on specific subjectS. Answers 1. It is a too lar;c program. A paael of Nobel prfzes should be supported by soffie speciaNze.d coiamittecs which, for example,, could correct some texts of their competence. 2. "The network should ask a financial support to the European Government and to alt the other bodies for us research and its work We must keep in mind that in Europe a smaller sum of money Ls aDocated to the research compared to AmcriW. 3-4 There sre no univoeal criteria in bealtbesre field. For instance some M g~ (sucb ~ casdiovasc+olsr .nes) need to be compl harmkss le for others (as in oncological therapies) this is not stri y required. S. See answer 1. 6. The network should include also politicians and ;ournalists, grovided that tbey are professionaliy bigh level. In Italy schools aimed at educating medical journatistt do exist. So it would be interestiag to eet in touch with them and ask their opinion. 7. "Yes, bccausc in that way there would be private funds to support reesearCb% 8. "I think that political author?tics would be indifferent tawanls the network". 9. Ho would li}:e to receive moro and deta7od information about the setting up of this network. 10. k's difficult to find a specific bibliography. 9

R: REDACTED MATERIAL 17/0k94 27:12 a`tS 33323001 BURSpNX4ASTELLER W002/005 Te1=39-2-862163 16 G1u 94 11=21 No.009 P.10. BursOn•Marsteller OPINION LEADERS' CQRRICULA Prot.iFerdlaando Aiutt Directos of tbe 3rd Cliaic at tho Polidiaico in Rome. Director of the Speciality School in Allergoloqy and ImmunWo ' Clinic. Espert in immunotoytrai dcfiaerwr connected to sevent puhological conditians, iuch as tutnot~rs, malmun on, AIDS. Vice-oresident of the National Asseciadon AWa:t AIDS- eProG Gionni Bonadonna . X- Director Dhrltiion of Medical Oncolow. National Cancer Institute.. REDACTED ProL Claudio Bordignon ¢ c _ . Itesponsble for the Mat~taw Traasulaflt Prc¢ram snd Geriic?heravv. x, Cespoasi-lbIe for the Biotechnology and Bioinstirum~ntation Projert of the R~es7Rponstbte for the Genetic Engineering Project of the CNR (National Resiarch Center). Prot Giuseppe Delta Porta Scientific Director of tha It.tiaa Association for Cancer Research. Researcb Coordinator at the European OneoJov Inctitute. Mfian. REDACTED . 9

R: REDACTED MATERIAL 1T/da '94 17:12 'a45 33123001 BURSONIIARSTEILER TeI:39-2-852163 16 G•lu 94, Bursiu,n•Marsteller ProLiArtnro Falascbt REDACTED =Prot Carlo La vecchia Q 003/OOS 11:22 No.009 P.11 r- IHegd of'~ tdemiology Laboratory'Muio Negn'. AssocIat professor of Fpidem[o4)gy University of Milan. Me*tber of the editorial board o~ the following blications: ArnericaR 7ou,arul of EpidwniologK Cancer Carrsts wrd CartrorErero Jorsrnal of Cancer Preve~tio~+, Revue d'Epull~mtologie et de SantE Pubf~ Sozial und P.aer+entivnudizipt- sProL Paolo Mocu+elli p- Director of the vepartmens of PatSo'logy of the Hospital of Desio. Pzmfessctr of Iixperonentt PQtkology and Clinical Pathology at the Faculty of Mcc}icIne, UniverSlty of M~an. Coordinator of the WHO MONICA (MONitos3ng lschet»ic Cardiac Attack) nian for the Italian North West ReAions REDACTED SFroL•5ergto Ottolongbi 'Q- Ptofessor of MoTetular C3eneua, peparanent or c,ieneucs and tiotogy or Microrganisms. University of Milan. RGScarchcr, specialist In thc biachemistry of 'TMalauemia and leukemic colls, and member. of the European Molecular Biology Organi,sation. Sw 0 u ~ ~ ~ ~ 10 Q) ~ ------ -- ----- - ----~

R: REDACTED MATERIAL 17/06 '94 17:13 $'4S 33323001 gURSpNx4RSTELIER Te 2• :39-2-862163 16 6 i u: 94 11 :22 No. 009~ P.s12 S Burson-Marstelier •ProG AodoUb Paolstti REDACTED Director of the Institute of Pharmaeological Scieaces, University of M'ilan. Coor'diaa,tor of research doctorate in To)dcoloV of the envlronment and food Dirtct~ofnth-e Ceatra for Studv and RaseBrrh on Nenroflharmaeolaqv REDACTED Prot.. Ceeare Strwr! Professor of Cinkat Pharmacology. University of Mflsn h~~ aGrossi Paoletti Centre for the stndy of inetabolic deseases and REDACTED Prot Marcello Tkrs REDACTED Di'rcctor of the Nutrifional Documentation and Information Umit, NaBonat Nutritional Institute, Rome. Ywt Ginseppe Vicarn virector of the National Health Institute, Italy.: QlualifSr of Univasitv Teachhm REDACTED : REDACTED -~ We have interviewed the five Profusors fedicated whh -, 11 0 ,