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To: Frmm: P'FN!I L IP M©RR I S U. S. A. ` RICHMOND, VIRGINIA , t ~~~~~~ ~~ J ~'.. Memo for ' Record Date: T. S. Osdene C'4G Subject: . Adhoc ProgramiAdvisory Group - Paissive Smoking Meeting -~ ~ National Cancer Institute, Washington, D.C., September 30', j~ rA - 1981 I attended the meeting on September 30, 1981, in my capacity as a private citizen. A brief'summary of what occurred is outlined below. We met at 9:0i0a.m. and after a brief welcome by Dr. Adamson, Dr. Wynder opened the meeting. Hie felt,the subject of sidestream smoke was of' scientific and societal significance. In addition, he stated that smoking,itself was thie cause of lung cancer, but whether sidestream smoke was carcinogenic to man was not clear. He pointed out that to measure thiee effect of'sidestream smoke on non-smokers would be quite difficult, and would require large numbers of people for e~iidemiologicail studies. Dr. Hoffmann followed with a discussion on sources andi analyses of polluted indoor environment and pointed to the increase of nitrosamines in sidestream smoke. He mentioned that the problem of'sidestreamismoke toxicity could largely be attributed to the volatile nitrosamines. Since sidestream is really rather diluted, he did not feel the activity would be too intense. This was followed by a review of the Epidemiology of Passive Smoking in a paper by Dr. Garfinkel of' the American Cancer Society and he briefly mentioned the White and Froeb paper as well as the Trichopoulos and Hirayama papers. He said, his own conclusionis were contrary to the findings of Trichopoulos and Hirayama. He recalled that in an earlier study which he conducted withiDr. Auerbach, that Auerbach could predict smokers. "b7lindi'"' from lung biopsies in which cellular "atypism" was shown. N He never found atypism, in the non-smoker, and thus it would be ~, very surprising, if the non-smokers were to be exposed to a sufficiently large enough dose of smoke which couldicreate this ~ "atypism." Hie felt„ the problem itself was not of high import- ~, ance and mentioned that the American Cancer Society is still debating,the issue. He erso aTl: feels that the bannin of GJ. smokin g in public places, on on the basis o iscom ort or irritation, is perfect y acce~pta le. I wou thus say that he Re..... ... . . . .. '1. ud, o1d / i9k / Hugh Cuuiman ,. ---- October 21, 198'1 5 '

Memo for Record' -2- October 21, 1, 1981 should not be considered a great friend of'ttie industry. Following a brief recess there were additional discussions by all participants (list of participants is attached) and'the summary of the meeting was a request that all participants send one or two specific ideas on what to do in the future to Dr. Tom Owen. Both Dr. Spears and I, as well as Dr. Garfinkel, felt that there were matters of greater priority for th~e NCI than to open up this subjiect. A decision on whether this will lead to additional work has not yet been made. I might point out that Dr. Joanne Luoto (Acting Head of the Office of Smoking and Health and'most likely to be involved in additives nego- tiations) made several comments on transplaicental carcinogen- esis. She felt, that on the s:ubjiect of sidestream. smoking, wee owe the.public an answer. Her priorities, which may change in a formal submission,were: 1. Examing the existing studies 2. Not to be sanguine about levels ini rooms but define and evaluate levels of gas phase components 3. Study air flowpatterns of passive smoker 4. Undertake animal testing to see if one can demonstrate any injury She then again brought up the subject of transplacental carcinogenesis which seems to tie heavy on her mind~. Overall, my feeling is that relatively little will come of this subJect at the present time due to funding shortages. However, comments from participants submitted to Dr. Owen, will be studied for priority evaluation and will th~en be submitted to the divisional advisory board for possible funding. / iw cc: Mr. H. Cullman Mr. Mr. Dr. Dr. Dr. Mr. Mr. W. A. R. M. R. R. J. McDowell Holtzman Seligman Hausermann Fagan Carpenter Charles Enclosure.