Philip Morris
the Wasteful Pursuit of Zero Risk
Fields
- Author
- Brookes, W.T.
- Type
- MAGA, MAGAZINE ARTICLE
- PHOT, PHOTOGRAPH
- Area
- BORELLI,TOM/OFFICE
- Site
- N329
- Named Organization
- Air Force
- Atlanta Environmental Symposium
- Carnegie Mellon Univ
- Cbs
- Centers for Disease Control
- Congress
- Dupont
- Epa, Environmental Protection Agency
- FDA, Food and Drug Administration
- Forbes
- Hew, Dept of Health Education and Welfare
- Lawrence Berkeley Lab
- Natl Center for Toxicological Research
- Natl Research Council
- Natural Resources Defense Council
- NCI, Natl Cancer Inst
- Office of Information + Regulatory Affai
- Office of Management + Budget
- Office of Technology Assessment
- Oxford
- Perrier
- Regulation
- Science
- Scientific Advisory Panel
- Stanford
- Uc Berkeley
- Uniroyal Chemical
- Univ of Ca
- Univ of Ca Riverside
- Univ of or
- Univ of Tx Health Science Center
- Usda, U.S. Dept of Agriculture
- Yale
- 60 Minutes
- Atlanta Environmental Symposium
- Request
- Stmn/R1-048
- Named Person
- Ames, B.
- Archibald, S.
- Bradley, E.
- Bush
- Califano, J.
- Darman, R.
- Delaney
- Doll, R.
- Epstein, S.
- Gaylor, D.
- Gelber, D.
- Hart, R.
- Hathaway, J.
- Houk, V.
- Koshland, D.
- Miller, S.
- Nero, A.
- Nobel
- Pero, R.
- Peto, R.
- Reagan
- Rueter, F.
- Sikorski, G.
- Slovic, P.
- Steger, W.
- Stolwijk, J.
- Streep, M.
- Toth, B.
- Wildavsky, A.
- Winter, C.
- Wood, S.
- Yalow, R.
- Yeutter, C.
- Archibald, S.
- Master ID
- 2023586414/6491
Related Documents:- 2023586414-6458 the Risk Assessment Guidelines and Review Procedures of the United States Environmental Protection Agency
- 2023586460-6467 Appendix: I Glossary
- 2023586477-6479 News & Comment. Counting on Science at Epa. William Reilly Is Trying to Give Science A Bigger Role in Epa Policy and Wants to Focus on the Worst Environmental Problems, Not Just the Most Visible. It May Be An Uphill Struggle
- 2023586480 Acs Plenary Focuses on Risk Assessment
- 2023586482 Uncle Sam Wants You to Join the Environmental Army Where There's Smoke There's Politics
- 2023586484-6491 How Useful Is Epa Guide? Radon Survey: Unsafe Levels in All States Tested Settlement Near in Kan. Radon / Consumer Case
- Author (Organization)
- Forbes
- Litigation
- Stmn/Produced
- Characteristic
- ILLE, ILLEGIBLE
- Date Loaded
- 05 Jun 1998
- UCSF Legacy ID
- jtn04e00
Document Images
During the Alar crisis, scared consumers
asked the Enr.lironmental Protection Agen-
cy if it was safe to pour apple juice doum
the drain-would it pollute the ground
water? In the name of environmentalism
we are making bad regulations based on
emotion and misleading statistics.
The wasteful
pursuit
of zero risk
n Rars.a :. froobss
N OT 1+M-Y lfoPit reacted as
nystaically to the baseless
Alar scare as the folks who
were afraid to pour apple luice down
their drains, but in a way the foolish-
ness of a few symboli:es our nation's
environmentalism: an emotional re-
action that's based
on misinformation,
disinformation and
the faulty use of
statistics.
Earth Day is Apr.
22, and the self-
anointed guardians
of Mother Earth are
riding high. Profes-
sional and semipro-
fessional environ-
mental activists
have learned how to
dominate media
coverage. Congess
is in a mood to in-
dulge in, the politi-
cal equivalent of not
pouring apple juice
down the kitchen
U....~ V_
paid in one way or another by con-
sumeri or taxpayers. Thu would be
on top of current pollution control
costs estimated at SS 1 billion a year.
We know of no one who would be-
grudge 2°'% of our gross national prod-
uct or even more on the environment
if the money were well spent. There is
evidence, however, that much of it
will be wasted. Al-
most in proportion
as these costs have
climbed. the poten-
tui health benefats
from additional en-
*P10jor sale
lev qnas p.+sOtr eila Atar
.wrt Aas saads tlws sdlorw
sink. Before the end of this summer
Congess may pass ameadments to
the Clean Air Art tbat wtll force the
nation to go to expensive entremes in
an effort to control smog and acid
rain. The most responsible economic
estimates of the costs of that legisla-
tion range from $23 billion to S;5
billion per year, all of which must be
Y stein, the foanid-
le environmental
health alarmist, told
a congiessional pan-
vironaeatal con
trols have declined,
as one after another
of the maior "ha-
zards" of the 1970s
turns out to have
been a false alarm or
a severe exaggera-
tion. Alar in apples
is the least of it.
In 1976 Samuel
el that 20:L of Americans were dying
in "an epidemic of cancer" and that
70°e to 90% of husun cancers were
environmentally induced. This sorn oi
testimony gamers headlines and
votes on Capitol Hill. Never mund
that his analysis was based entirely on
hypothetical "nsk models" that ex-
tzapolated large estimates of deaths
161

t
I
w- ...+w... w
from small pieces of evidence. cal carcinogens from food processing.
As those risk estimates accumulat- The problem is not that we are
ed, they began to predict !ar more making too great an effort to make the
cancer than the nation was actually environment cleaner or our lives saf-
experiencing. This prompted Con- a. Those are worsbwhile goals. For all
gress' Office of Technology Assess- its immease benefits, industrializa-
ment to commission a study by Sir tion brtngs with it ruks, which need
Richard Doll and Rtchard Peto, two attention. The trouble is that we are
world-renowned epidemiologists at maktng the wrong efforts, with re-
Oxford. In 1981 they concluded that sults a1l too often the opposite of what
pollution accounted for only 2% of is intended.
cancers, not the 70% and more that Take the banning of Alar. Paradozi-
Epstein found. By contrast, smoking, cslly, the ban may raise cancer nsk.
diet and other lifesryle choices ac- Why? Alar, a growth hotmone,
counted for 75%. (5er tobk. p. 170.) strengthens the bond between the ap-
Consumers barraged by news re- ple and the tree, making the fruit less
ports that such-and-sucb chemical or suscepnble to leaf miners. Alar's use
pollutant "is killing X thousands of obviates the need for much harsher
Americans every yeu" may find this insecticides, whose theoretical cancer
hard to believe, but whea epidemiolo- risk is much greater.
gists went looking for those "70% to Examples of environmenul regula-
90%" of cancer deaths caused by the tians leading to results opposite to
eavironmeat, at least 97% of them those intended csa be seen all over
wen nowhere to be found. the regulatory landscape. ln pursuit of
In 1986 the National Cancer lasti- the impossible goal of eliminating all
eute confirmed much of what Doll risk, the regulations ignore side ef-
and Peto reported. The t+a said the fects of the regulations themselves
best way to cut U.S. eaacer le.els in that can be more dangerous than the
half by the year 2000 was to focus percaved otigiaal nsk. The batmmg
y on smoking, diet and sexual of the fungicide abylene dibromide
vior. But it is a lot easia for a from most food processing in 1983
coagtessmaa to get on television and probably raised cancer rates: Fung
rail agaiast a chemical company than product powerful carcinogens, and re-
to preacb that Americans should live placement fungtcides cam :heu o..a,
cleaner, more abstenious ltves. not fu1Jy explored, cancer nsks.
Hcnce, we have such legislative con- This February the U.S. branch of
sequences as the Delaney clause of Perrier recalled 72 million bottles af-
the Food, Drug and Cosmetic Act, ter a North Carolina county laborato-
baaamg the slightest trace of chemi- ry found samples of Perrier wata con-
l61
taining 19 parts per billion of benxene,
a known carcinogen.
Whil.e North Carolina health offi-
cials did not think this risk sufficient
to warrant recall, they insisted on is-
suing a bealth advisory. With the re-
percussions of the 1989 Alar crisis
still reverberating through the food
industry, Perrier bad no choice but to
recall the product. In the course of
doing so, the company adm.itted the
benzene was a natural ingred;ent of N
the carbon dionde gas that bubbles up
beaeatb its springs in Vugtxe, Framce. 0
For nearly a ceatury, Perrter has fil- N
tered the gas to remove the bes`ene ~
before miuag it with the water. Ben- ~
zene levels rose because filters ba: ~
not been changed often enough.
Is unftltered Pemer dangerous' lt Q~
all depends upon your perceptions. 4.11
David Caylor, head of biometry at the -4
FOUtS. AtAtt 30, 1990

im
me
N
N
RI
N
N
r
National Center for Toxicolopcal Re-
search in Jefferson, Ark., estimates
the addinonal cancer risk of liktime
ezposure to a I-liter bottle of the con-
tnmiaated Perria every day for 70
years to be somewbae between 1 in
100,000 and I in 10 million. Thus, if
evay Ametican were to drtak a liter
of Yerna every day f:om birth to
death, we might-might-have a cou-
ple of hundred essa deaths a year if
Fasia's filters didn'tga chaaged. Of
eourse, the springs of Pema would
have long since gone dry under all
that consumption.
That we can de:ect such z=inuscule
rtsks is something quite new. lt seems
that now we are getring too skilled at
analytical ehemutry for our own
t least if we want to continue
living the Delaney clause illusion of
sero risk. "Fifteen years ago we
couldn't even detect 35 paru pa bil-
1ion," says Gaylor's boss, Ronald
Hart, the director of the totdc research
center. "Now we identify one part per
quiatillion. That's almost the equiva-
lent of fillint the entire Great Lakes
with gin and putting a single table-
spoon of vermouth in it. That I think
you would agree would be a pretry dry
martiai."
Unforrnnately, in today's emotion-
eharged media climate Perrta could
not afford to have such arcane mathe-
matics debated on rv. So $40 million
worth of harmless product was added
to landfills. Thus dhd Pe-::e: become
the perfect paracbp of the 3ypochon-
daa that now psps an affluent society
frightened by shadows oo the wall.
Says Paul Slovic, a psychologist at the
University of Oregon specializing in
risk perception, "The more the nation
speads on regulation, no matta how
many billions azr :peat, the less safe
che American public seems to feel."
Saence Editor Daniel Roshland lam-
pooned this mood last Juae when he
invented an intervtew wtth "Dr. No-
itall" whose "appearance on three
talk shows is enough to qualify me as
an e:pert." "Are there other dangers
about which the uA has fatled to ad-
vise us?" Noitall is asked. "Breath-
ing," be says. "All breathing gener-
ates outygea radicals ... the maia
sources of mutauons in aNw. leading
to cancer, birth deiects.... Breathing
has been observed three s.mut_s 4-
fore death in 100°e of all rataltues u. e
urge everyone to stop breathutg una
proper research has been carrmed out."
But :hat kind of hypochondna is no
laughing matter. Not when we will
sooa be spendmg more than $100 bil-
163

i
,,.
I I ~~
j~.
li.
I
lion a yeu in partial response u. .
The new Clean Air Act will force
the expenditure of up to S50 billion a
year on pollution control. This
amounts to 30 times as much as the
entire budget (51.7 billion) of the Na-
conal Cancer Institute. The maic-
mum health risk target identified by
sre within the Clean Air bill is 2,700
deaths a year, and that is based on
models that almost certainly ezagger-
ate. That's a cost of about S16 million
per life that might possibly be saved,
whereas we spend only about 54,500
per life that might be saved from other
nuses-alcoholism and drug abuse,
for example, which kill 380,000
Amerfcaas every year. The savin~ of
lives is worth spending money on, but
it doesn't make much sense to spend
vast amounts in the hope
of saving a relatively few
when we cannot seem to
afford to spend any thing
like mose amounts on
things that cause hun-
dreds of times more
deaths.
The problem is that
deaths from things like al-
coholism or overesting
rarely make the 6 o'clock
news, while any cancer
scare, no matter bow
pumped up, seems to do
so. It's not bud to pump
up the numbers. Dr. Ver-
non Houk is director of
environmental health at
the Centers for Disease
Control. He says: '?he ef-
fect of irA's exaggerated
risk models is very often
to force massive atpeadi-
twes of money on minus-
cule risks. I would call
that not conservative but
very radical."
posure. Of those cases,
Durnp:ng ': millio» bortla oJPe.rie>
ft s.er.u.a aereuyi .t,ft to drink sa.aao
iotrrss qf leassw.-oeattnnUa.t t..ris..
5280 per nutritionally caused death.
"Do we really want to say that the
person who dies of cancer from bad
nutritional habits is worth S1,000,
while the person who dies of air pollu-
tion is worth S30 million or maybe
even a few billion?"
Office of.Management & Budget
Director Richard Darman says: "One
of the greatest dangers of the 1990s is
our scientific capacity to discover and
define ever-dimiaishing levels of risk.
This combined with our society's ap-
parent willingness to place an infinite
value on each humaa life is bound to
lead to investing mote and more re-
sources on smaller risks with less and
less real return in actual risk reduc-
non or health smprovement."
Case in point: This year American
taxpayers will spend over S5 billion to
remove asbestos from schools and of-
If the people want sweeter-smellfag
air, so be it. But they won't necessar-
ily get longer life spans from the
Clean Air amendments. ia a recent
Rrgularion article, economists Wilbur
Steger and Frederick Rueter of Carae-
gie-Mellon University analyze the
age-adjusted cancer rates adjacent to
and downwind of the major coke ov-
eas of Allegheny County, Pa., one of
the principal targets of the "air tox-
ics" controls. Those rates came out
20% to 30% beloir those for the coua-
ty as a whole. The two professors infer
from this-and from expected cancer
rates-that the siA's already low esti-
mate of 6.9 cancer deaths per year
nauonMide ftom coke oven emtsstons
is an overestimate of those risks by at
least a multiple of 100.
Congress and the arA are pushing
166
compaaies to reduce their tbeoretical fice buildings under a 1987 federal
emission risks to I in a million. But, law; the ulumate cost, for fixing
says Houk, "When we push risk as- 733,000 buildings, could run as high
sessmeat to I in a million, we are as $100 billion. Yet scientists are now
talking scientific, not to mention eco- discovering that ripping out asbestos
nomic, nonsense. Do you know whst often raises risks more than it reduces
I in a million really is? It's the risk them, as was reported here three
you take in driving your car 40 miles; months ago (Foaats, Jan 81 and later
t;kiag a commercial jetliaer 2,500 analyzed in more detail in the pages of
miles; canoeing for six minutes." Scienu.
In the pursuit of such perfectfon, As with other cancer scares, this
says the toAc research center's Ron- one was accompanied by a risk fore-
aid Hart, "we are busy trippiag over cast: 67,000 deaths a year from atr-
dollars to pick up pennies. For exam- borne asbestos (Health, Education &
ple, we kaow ehat diet accouats for Welfare Secreury Joseph Califano,
about 35% of all cancer deaths, or 1978). The forecast proved to be wide
about 178,000 a year, and maybe a lot of the mark by a factor of 45. In the
more. Yet the federal government U.S. population, there are, per year,
now spends less than S50 million a 1,500 cases of inesotbelioma, the can-
year on nutrition research, or about cer most associated with asbestos ez-
80% are among men over
the age of 65 who were
asbestos workers years
ago, and a sigatftcant per-
centage of those workers
were also heavy smokers.
Like all other such predic-
tions, the onginal proiec-
tion was based on mathe-
matical models, not on
human experience or on
epidemiology.
Here's another risk
model prediction. A bill-
board on Route 50 near
Washington, D.C. an-
nounces: "Radouwtll ka1
20,000 Americans this
year." This radon risk is
extrapolated from studies
of the occupational expo-
sures of 375 uranium min-
ers who died of lung can-
cer--exposures that are as
much as 12.000 nmes the
level found in average
U.S. homes and 600 times the level
found even in the nation's "hottest"
01% of homes.
But this srA risk model doesn't jibe
very well with ecological evidence
from the crA itself. Last October the
agency issued a report declaring that
Iowa has the highest radon danger risk
so far found in the U.S., with 71 % of
its homes above srA's "waraing lev-
el" and an average radon exposure
sevea times the aation's. Those num-
bers suggest Iowa should be in a lung
Yet Iows's
cancer death epidemic
.
age-adjusted lung cancer death rate is ~
12% below the nation's. Could other factors besides age explain Io..a' Pe:- ~
haps, but a more :borough stattsu:al ~
analysis of 415 U.S. counties turns up ~
ao correlarion between radon levels
~
and lung cancer rates. A leading epide- __
miologist, Yale's Dr. Jan Stolwiik,
FORBES. APAb 30, 1 990

I
i
3
sums up the situation: "If radon were
such a major risk factor it would
clearly shine throuth in the ecologi-
cal data, but it doesn't. In fact all of
the epidemiological studies suggest
that without smoking, radon is an
tmimaginably small public health
>ask."
Rosalyn Yalow, 1977 Nobel Prize
winner in medicine and physiology,
poiats out that virtually all the rise in
tttng cancer death rates came after
e9garette smoking took hold. "Befose
1920, when radon was
equally prevalent, lung
cancers were so rare that a
finding was a major event
for medical researchers,"
she says. '9Evea in 1930
the a=e-adjusted lung can-
cer death rate for men and
women was less than 3
per 100,000. Today it is
~ 57." Anthony Nero, a se-
nior scientist at Lawrence
Berkeley Laboratory and
perhaps the nation's lead-
ing authority on radon,
says: "The tre has consis-
tently and purposefully
exaggerated both the ruks
aswuated with indoor ra-
don and the prevalence of
high conceatrations.'
The weaknesses in as-
bestos and radon risk
models are mirrored in
studies of other poisons,
which are generally tested
on laboratory rats. Here's
what toxicologist Hatt
says about rat esperi
ments: "Otu risk models
are based on at least 50
assumptions, none of
which have been scientifi-
cally demonstrated. For
example, we assume that
then is no difference be-
tween continuous (as in
aaims] tests) or intermit-
eent (as in human expesi-
ence) dosages. But that ig-
nores our gtowing kaowl-
edge of the way in which
aNA repafrs tbe bnman
system-"
if humans are exposed to far, fax lower
doses? Will they get cancer?
Dioxins are such powerful carcino-
gens in rodents that even though the
highest levels measured in Times
Beach soil were very low, federal
health authorities felt they hzd no
choice but to recottsmmd evacuation
of the town. The government speat
i33 million to buy up houses and re-
sertle residents.
Now, afta costly epidemiological
studies of individuals exposed to very
en rc.r...-
hi=h levels of dioxin, in-
duaing victims of a 1976
industrial accident in Ita-
ly and the Air Force fliers
who sprayed Agent Or-
Da< Pionr lab rrs at vxrgrin
-w.f..d r.f.wxs .ttywvw.~t iwsts. r.e.rrwee
rseaAo.l. Mr.IwBts>r.ae..t..rs qj..w..r.
Hart wonders wbetha rat-feediag
tests pick up cancers that have little
to do with the chemical under study.
"We feed rodents 'all-you-ean-eat'
buffets every day, yet we know that
caloric intake is the single greatest
contributing cause of eanca," be
says. "In fact, we found you can modi-
fy the eancer-eausing impact of one of
the most potent carcinogens from
90X down to less than 3 %, just by
cutting caloric intake 20X." The rats
1N
may be dying from overeating, not
from exposure to a specific carcino-
gen, but the deaths are attributed
nonetheless to the carcinogens be-
cause that is what the experiments set
out to prove. No one really knows
how well risks for those rats t:ansiate
into risks for humans. Last year Va-
non Houk of the Centers for Disease
Control told an Atlanta environmen-
tal rymposium, '7tish a:sessment
polfcy that reliea solely on screeniag
bioasay 6aimal ta4rautts from tbe
most sensitive speeia is not based on
scientific princt~ples. Nettha is it
aedible or reiiable."
Consida how extrapolations affect-
ed the government's mponse to aa
environmental crisis in 1982, the pol-
lution of Times Beach, Mo. by diox-
ins. Dtoxins, eontaaunaats of the
Agent Orange herbicide and by-prod-
ucu of many industrial processes, are
exqutsitely toxic: A diet consisting of
less than one pan per billion of diox-
ins would kill a guiaes pig. But what
ange on Vietaam, scien-
tists are finding no con-
nection between the expo-
sure and cancer rates. The
most serious health effect
was cbloracne, a skin
rash.
What happened? Two
things. One is that the
early studies of dioxin, for
both Times Beach resi-
deau and Vietaam veter-
ans, greatly overestimated
exposures. Where the arA
said Vietnam veterans
should still have high lev-
els of dioxin ia their
blood, the Centers for Dts-
ease Conaol's blood tests
an ground emops showed
those levels no higher
than the average for the
U.S. population. Houk
found that 40°.: of the per-
sons dassified as havzng
had high exposure in
Times Beach actually had
low exposure. The other
factor seems to be that
dioxin is far less carcino-
genic in humans than in
laboratory rats. "To put it
bluntly, we found that hu-
man beings were not neas-
ly as susceptible to dioxin
~~ p~~.. says
Hou
Rat studies seem sure to
doom some vital pesticides. The uw
has the power to ban farm ehemieals,
which itgcaaally does over the obiec-
tions of the U.S. Department of Api
eulture. The P.piculcure Department
estimates that 4,500 specific applica-
tions (the right to use this chemical
on that crop' wz11 be lost tn ic :
rent round oi frA xvie..s, :~
them "essenual." Might this be a Pyr-
rhic victory for the proponents of safe
ty? It was iust a year ago that the
National Research Council concluded
FGRIES, ATAM 30. 1l90

one of the very best ways to
figbt cancer and all other chron-
ic diseases was to increase our
consumption offiesb fruits and
vegetables. Not only that, the
report argued that the benefits
of such increased consumption
iafinitely outweighed the small
risks of the cbemicals used w
produce them. Do we really
want to r.ise tbe cost of fruits
and vegetables? Do we really
want to drive farmers sway
from prodttcing them?
The National, Research Coun-
cil report didn't get much atten-
tfon, though. Three nights be-
fore it came out the Natural Re-
sources Defense Council got on
css' 60 Mmures to reach 30 mil-
lion viewers with a report de-
daring thai their children were
being poisoned by apples.
Enough Alar-Uni:oyal Cbemi-
tal's trade name for daminozide-was
used oa apptes, said the envizonmen-
tal activists, to give cancer to 250 to
910 children out of a million.
Even at the low end, that risk esti-
mate was six times the Irw's. But cas
reporter Ed Bradley didn't mention
the =rw risk number. Instead, he said
that the trw bad told him that if it
attempted to ban Alar, Uniroyal
would sue. Cut to Representative
Gerry Sikorski (D-Minn.), declaring,
2et them sue ... then let them go to
s cancer ward in any children's hospi-
tal in this country. See these bald,
wastfng-away kids. And then make a
decision whether the risks bal-
ance ova the benefits."
Emotion won ova reason.
Withia hours, apples and apple
juice were being dumped out
across the nation. It was then
that some hysterical consumers
called the arw to find out if it
was safe to the groundwater to
pour apple juice down the drain.
Now let's look at the evi-
dence. The environmental
grottp's report was based on one
dueredited 1977 study by can-
ca researcher Bela Toth. Since a
similar 1966 damiaozide study
bad shown no cancers, his find-
ings were immediately suspect.
In 1978 s National Canca lnsti-
tute study on 344 laboratory
mice and rats showed no in-
creases in tumors.
In 1985 a federal Scientific
Advisory Panel reviewed the
1977 Toth data and found that
be had fed the animals far
more than the **+a:i**um toler-
ated dosage, sometbing like
266,000 times human espo-
rr... a.Y~ sm
Baardsd-+rp .ao.r in Tmrs Baicb, Mo
We seltt d.w't Jwr Velsas itladw
wrti[ Aaos asass[ a+q ..wesr.
sure. One of the panelists concluded
that the Toth study was "useless for
assessing carcinogenic risk from
Alar, and provided no basis for can-
celing its registration."
Even so, in 1966 the uw ordered
Uniroyal to conduct additional stud-
ies. Those studies failed to produce
any cancen at the 20 pazzs per million
dosage level. So, too, when the dos-
ages were doubled. At 80 parts per
million they were able to produce sig-
aifi.mant tumon in a group of 90 mice.
But that dose level was 22,000 times a
typical human exposure as calculated
by the arw, and it was high enough
that toxicity was killing 80% of
the animals prematurely.
But note that there is good
reasoo to suspect that uwexpo-
sure numbers at least for other
agricultural chemicals are over-
stated. An October 1989 study
by Sandra Archibald of Stanford
and Carl Winter of the Universi-
ty of Califotnia at Riverside
found that assumptions used by
the National Research Council
and the vw about consumer ex-
posures to insecticides are too
high: by a factor of 21,000 for
apples, 2,600 for tomatoes and
300 for lettuce. For example, in-
stead of the t+uc's estimated
cancer risk of 1,462 deaths per
million from pesticides on ap-
ples, Archibald and Winter
found only 0.07 pa million.
Sanford Miller, dean of the
Graduate School of Biomedical
Science at the Univasity of Texas
Health Science Center, sums it up:
"The risk of pesticide residues to con-
sumas is effectively zero." This com-
monsense view, however, is still con-
travened by the 32-year-old Delaney
clause, which outlaws any additive
that tests positive for cancer in
rodents.
Given the nature of aaimal tests, it
is not surprising that half of all pesti-
cides tested turn out to be carcino-
gens. More intriguing, the same tests
show nearly half of all tbe nruural
plant pesticides tested are rodent car-
.cinogens. Says University of Califor-
Wbat caasea eanar!
It's still not known i tbese are tbe midpoiats
of sometimes quite wide ranges of possible
percentages.
ca.m es.mhnw /..caoa .i t.uw sa.c.n
nsa . us
c m
to
iodv,w&A yrodu:n - =dc: i
eJs>mowp aed maa . - ' 3 - .
9nduds umuy d pepwLy rid marvnmat
lovrr AdW,%MR Do0 w1 R ha.
- fAe fsuis d Gncer
nia's Bruce Ames: "99.99% of
all pesticide carcinogens now
ingested by humaas are natu-
ral-that is, generated as de-
fense mechanisms within the
plants themselves.... When I
realized that we were already
ingesting 10,000 times as many
natural carcinogenic pesticides
as synthetic, and human health
keeps getting better, I began to
put the risk into perspcctive."
S.ys Sanford Miller: "If we ap-
plied Delaney to all food we
would never get to die of cancer.
We would all starve to death
because we'd have to ban all the
foods we now eat."
It was a biased exposure mod-
el that underlay last Decem-
ber's decision by the uw to
phase out the use of most ethyl-
ene btdithiocarbonr.es, the
most widely used ::c; :: se:::-
cides, at a cost in highe: pnca
and ]ost commodities of over S2
billion a year. But if the Food &
Drug Administration's expo-
sure data are correct, only one-
l70 FORBES. APA1130. 1990

third of one cancer risk would be so based society is doomed." "risk budgeteer." Indeed, President
avoided. That's S6 billion per cancer. The trouble is that both Congress Bush took pride in his
Reagan-era role
Worse, the ban puts consumers at and the tra have powerful political in using this agency to inject
some
even greater risk. As winter, the Cali- incentives to run away from any al- rationality into the
regulatory pro-
fornia academic, puts it, "Elimiaation leged danger. Who wants to be pot- cess. But under Darman the
agency's
of specific fungicides could decrease trayed on a network news feature as influence has withered.
Darman ad-
the safety of the food supply by allow- callously coasigning children to the mits as much. "I have
taken some
ing the production of greater levels of cancer wardt pains not to allow Ithis agencyJ to be
fuagal carcinogens." But, says AFiculture Seetetaty used as a delaying uctic. Otherwise
Yet when Agriculture Secretary Yeutter, '1t is simply ludicrous to ap- we will have it taken away
from us
Clayton Yeutter announced his pIan ply a zero tisk standard to carciaogeas le p'slatively." Darman
is like a cop
to reform the Delaney clause and be- or anything else in this wo:ld, becsuse who doesn't dare to
make arrests of
gin weighing risks against beaeffts, the good Lord did not give us a ruk- certain obvious
wrongdoers, because
environmentalists went ballistic. Na- free world, or a risk-free environment if be does the
powers-that-be will take
tional Resources Defense Couacil for anythirtg; including fruit. Biologi- his badge away.
lawyer Janet Hathaway declared, "Al- cal zero is attainable but mathemati- What really concerns
Darman is
lowing ttw to consider the continued cal zero is not." that the process of controlliagrisk has
use of a chemical whenever the beae- The 1990 Economic Report of the become so manipulative and
theoreti-
fits outweigh the risks is absolutely President argues that "regulatory cal. "I know it sounds
absurd, but you
atuthema to the eavironmentai com- goals should be set so that potential can imagiae a situation in
which we
muaity." ,~he failed to .no longer do animal ex-
mention w o elected the periments," be says. "We
"environmental com- are not far from a situa-
bnnaity" to dictate agri tion where somebody de-
cvhural policy. . - - --~- ` velops a model of hu-
Right after i+zac's at- maas, a model for aaimals
tack on Alar, Steven and models for chemicals,
Wood, aa apple grower in and tbeypu t them all to-
West Lebanon, N.H. and a . .:~s getbe: and sssemble a risk
leading advocate of low- estimate without ever
showing any cause and ef-
pesticide, integrated pest
management, invited fect evidence."
Hathaway to come see the '' "He's right," says Ver-
damage she'd done. "We ' -Jr ~~ non Houk, the ea.iron-
showed her one packing ' %r as mental health expert at
house after aaotber the Centers for Disease
jammed to the rafters Control. "It's already Inp-
with unsold fruit, and one pening to a degree. These
farmer after another computer models of risk
wiped out by the 60 ttin- S,pnoing jangrcides in Floridc have taken on a life of
stra program. She was A wak earetwyes ta iawwas;--as a eatt te their own that has little
dearly very distressed at ..etsay y ss beutoR rsr e.*wsr ssata amusa. relationship to reality."
what she saw." So here we are on the
Distressed but not per- edge of spending tens or
suaded. Wood goes on: perhaps hundreds of bil-
"Before the 60 .1lrnwes lions of dollars on pro-
show we met with Hatha- grams of doubtful benefit,
way, as well as Meryl Streep and her benefits to the society from regula- acting not on proven facts
but on hys-
Broup and the css producer, David tion outweigh the potential costs." teria aad questionable
statistical
Gelber, and told them abour Alar's That is eminently rational, but it al- models. But who is there
to see the big
eritical role in lowering pesticide use, most never.happens, simply because ~teture when a minority
of activists
and that the 1977 bioassay study on every siency involved has the incen- have rbe politicians
buffaloed and the
Alar had been completely discxedited, tive and the power to regulate as if its media largely snowed?
Aaron Wil-
Gelber told us in effect go jump in the risk were the most serious. lts budget, davsky, political
saientist from U.C.
lake." Clearly, be did not want to let after all, depends on frightening peo- Berkeley, warns, "If
we hinder prog-
the facts get in the way of a good, ple. But no sensible person these days ress on the grouads it
brings some
scary show. identifies buresucratic interests with 'bads,' we will deny ourselves even
The toxicology center's Dr. Hast the interests of society as a whole. greater'goods.' if it seems
too cruel to
watas that the eurrent methods of Thus the pursuit of zero risk, en- contemplate any barm at all,
the even
risk assessment are dangerous to our touraged by somervcrnment offi- ~tater cruelty is to abandon
net bene-
sociery, and not only to apple farmers. cials and fed by legr's al toa nervous of fit, for giving
abar up guarantees that
He says: "?here's a fundamental in- incurring the wratb of the self-styled more people will have
worse health."
com;.atib:hry between writing law "envtronmentsl community," threat- It's really verv simple: Before
we
and doing science. Blackstowan law ens the heal:h oi our economy wrstb hrbclc our ecoaorrv and our
soaea
deals in absolutes and in definitions. out doing much for the health of our with costly new laws aad
res.ilaaons
But science is an evolving beast, con- citiseas. Budget Director Richard we should ask ourselves in
each in-
stantly chaagiug as new knowledge is Darman supervises aa agency called stance whether the hoped-for
benefits
acquired. Unless you make laws com- the Office of Information d Regula justify the costs to our
economy and
patible with science, a technology- tory Affairs that is supposed to be the our health.
l72 PoAEES, APRa 30, ls9o
_
