Tobacco Documents Online

Brownson, R.C., Reif, J.S., Keefe, T.J., Ferguson, S.W. and Pritzl, J.A., "Risk Factors for Adenocarcinoma of the Lung," American Journal of Epidemioloqy 125(1): 25- 34, 1987. Microscopically confirmed~pulmonary adenocarcinoma cases and controls (group-matched for age and sex) were examined in this Denver, CO case-control study. A total of 102 cases and 131 controls were included; 50 cases and 65 controls were ma1e, 52 cases and 66 controls were female. Cases were located through~the Colorado Central Cancer Registry; controls were individuals with cancer at other sites. Proxy interviews were conducted for 68.6% of cases and 38.9% of controls. The study's focus was the evaluation of the roles of smoking, "'passive smoking," occupation, air pollution and socioeconomic status in the etiology of adenocarcinoma. Exposure estimates were spousal smoking status and number of hours per day spent in the presence of a smoker. For the former, RRs of 1.40 (95% CI 0.66-2.14) for males and 1.54 (95% CI 0.72- 2.35) for females were reported; for the latter, reported RRs were 1.01 (9b% CI 0.42-2.41) for males and 2.42 (95% CI 0.94-6.22) for females. The authors claimed that their data suggested a statistically significant trend for the number of hours/day "passive smoke exposure"' in females; the lowest exposure category was 0-3 hours/day. Potential confounding factors of income and! occupation were included in a multiple logistic regression analysis.