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Volume 86, Number 4 October 1992 _on kAS y 4 C , 00 3 I i ~~~~~~~~~~a~ ~ Ci:culation Abstracts From the 65th Scientific Sessions New Orleans Convention Center New Orleans, Louisiana November 16-19, 1992 CONTENTS Named and Invited Lectures ................................................................. I-A Louis N. Katz Basic Science Research Prize for Young Investigators Abstracts ................... I-F Melvin L Marcus Young Investigator Award in Cardicvascular Integrated Physiology Abstracts .. I-G Samuel A. Levine Young Clinical Investigator Award Abstracts .................................. I-I Irvine H. Page Arteriosclerosis Research Award for Young Investigators Abstract ................ I-K The Young Investigator Prize In Thrombosis Abstracts ........................................ I-K Abstracts From the 65th Scientific Sessions ....................................................I-1 Authorlndex ............................................................................. 1-873 Subject Index .............................. ...............I-919 Note: Abstract numbers are arranged to coincide with abstract titles in the American Heart Association's 65th Scientific Sessions Program: Subject and author indexes are keyed to abstract numbers, not page numbers. However, all Named and Invited Lectures and all Young Investigator Award/Prize Abstracts are keyed to page numbers within this supplement. Indexes are located at the back of this supplement. All other supplements to this volume of Circulation will be indexed~ in~the December issue. CIRCULATION (1SSN 0009-7322) is published monthly by the American Heart Association, 7272 Greenville Avenue,. Dallas, TX 75231-4596. For rates in Japan, contact Nankodo Co., Ltd!„42-6 Hongo 3-chome, Bunkyo-ku, Tokyo113,. Japan. In the United States, individuals may,subscribe for their personalluse at the following rates: S82 for members of an Ameriean Heart Association scientific council and 5102 for nonmembers. Outside the United States, add S80 for postage. Contact AHA for single copy rates and subscription rates for medical professionals in training and for libraries, reading rooms, and other multiple-use institutions. Second class postage paid atDallas„Texas, and additional mailing offices. POSTMASTER: Send address changes to CIRCULATION, American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231-4596.

CIRCULATION 8'6(4,), 1i99'2 .SUPPLEMENT 2494 Reduced Piutna Ascorbic Acid Conccntrations in Womcn Rejuiarly F~tposed to fnviroaatcnn7 Tobacco Smokr (ETS): Diane L Tribble and Stephcn P. Fortmann. Stanford University School of Medicine, Palo Alio, CA. Ozidative peocessu have been implicited in the pathogenesis of hun disease, offering apot=ntiaJ'explsrution for the high tisk attribunble to saiolcng. Cigarece smoke oontaitu nnsaer• ous oxidann, and smokers exhibit reduced cinvlating con- aatrstions of the andoxidant vitamin ascorbic acid (AA)., primarily as a result of oxidant-mediated deplEtion although reduced dietary intake also has been noted. We measured plasma AA concentrations and dietary AA intake in non- smoking women exposed to z20 hr/wk ETS, i.e., passive smokers (PS). as compasrd with nonsmokers a•'.th 52 hrs ETS exposurcJwk (NS) and aedve smoite:a (AS), to assess whether PS also may exhibit suboprimal AA nutrimrs. Piasma AA.vas measured by 1;pLC with elcctrocliemical dctrctios. and diesary and vitarmn supplement M intakes were assuscd nsing a scmi-quandtative food ittquency questionnaire.. $esvlts- NS(n-A6) PS(n-27) AS/n-331 Clphf' 0, 0 24.325.400 ETS czposare (hrlwk) 02t0.6 35.3t12,9•'1 20.7t20.4•• Plssma AA (µM) 69.4±21.3 5 1.9:t23.3" 42:3t20.200 Dictsry AA(mg/d) 129:E279:1 I I7.4tS6.2' 129.Itt79.1 4 NS vs. PS or AS: •pcAS; ••pc0plc PS vs. AS: fp,c 001• Both PS and AS exhibited rtducrd plasau AA relative to NS. One (-2%) NS. 4(-139a) PS, and 6(-1E%) AS exhibited bypovitaminesis C(pllstaa AA<23 µ1.i): Reduced plssma AA id PS taay be partially due so reduced dietary AA. 'tbese resulss suggest thas subogtima) AA nuainae ma~ emttibute to incsesved hean duease nsk assoeiamd with EI'S exposure. ,,//}} 4 4~- ` v