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n , 1 3KHM06p3J0aS, nO,lt `rCHHhte HaMBdaH9blC Ha Ti3TU'1tf0 GV.1bwF)NM' 11peaCTaBHTe.lbli0YM3Te- t.1C IOKa3d83K)T CBH3b IHTIH4HOr0 I11/r.7HMR C ).111non.poreMHv3Ntt 11.133Mbi KpOBH B pea.1b11rdXtOBKR,•B nOn}`.1RI1HH. OOha3aTCabHO. 4M B pe- ,.JbrJTe Hawero HCC.lC1OBEHHH KaH60aro Bblpa, tiCWIaM .iaB.(CHMOCTb a110 B H A'l OTNe'13eTCR 01 H:/rUOBOrO hoMnOHeHT~.a pd11HOHJ H OT, rlOh3JaTC1eN NaCCW Ttl.Ta! rlB.lA'4eHHaR HH4)rDpMal1HY1 MWIirT 6btTb Il0.le3HU{I' .1.1H BSIpa60Tf:H 060CHOBdHHbtX ZHeTH4CC.I.HX. 1fOa- xojLoB npo4)laTaf;TUtKH .tTCporcHHb+x C1BHroB B CHC- TCMe' anD:lHnunpOTe.H110B Raa3MW KpOBH BnORV.:rR- LLNH. .1111TEPaT!J'?:1 I. K:+uroe A H. /,<Dnc.lvrnnnponrH.tcunu n H1tleVMNefKa11 (SOAe]hb cep.suv/llo1pea. E II. 4asoaa. A. 1t. Kaurn- ea - M., 1980. - C. 1 1-25. 2. Rrpoea H. B:. lllep-iu,:,.eu 11, A.. tlerr.ibctcus B. .t.. Kyp7aKo6 X. A'..[/ CTlHKa CuCy1°! a aTePO' H TpuM6ure• Hele. - M.. 1983: - C. 94-I0i. 31 Xa:rrone H. r.. 11rKr+uc 6. //'Kap3ao.ionta. - 1976, - Yi 9- C. 1 13-1 18. 4. .ivo?aro P., Biftolo Bon C.. Cuzzuluro C et al.,/' Lan- cer. - 1979' - Vol. 1. - P. 901-903:. 5. Avogaro P., Biflolo Bon C.. Btfhssi F. ct al ;' Interna- tionat Meeting on Atherosclerosis. ath. Prncceding: - Boston. 1982. - P. 41!-46. 6. Biackburn H. 1/ Nutrition. Lipids and Coronary Be3rt Dise°se / Fd. R. Levy et al. - New York. 1979. - P 309-349. 7. Blaton V. De Buyzere M., Declerp B. et al. //Athero• sclerosis. - 1984. - Vol. 53. - P. 9-20. 8. Burs/em, S.. Sch'on/,rld C., Homald M., et, al.//Metabo- tism. - 1978. - Vol., 27. ='P. 711-7 19: 9. Camargo C. A.. Williams P. T.. Vranizan K. M, // J. A. M. A. - 1985. - Vol. 253. - P. 2854-2857: 10. L.or,s,n . .4 . bilrrrlrr, / L ., .. . . ~ ,. .. - ,`.'rl - I n l .19 - P '-':'(i. I I. Cirru N /J . iiouru:'rr P' 1.., ....j Chem -- 1976 - V'oI1 2^'-? .Si'` 12 !)t'dbndtnl)c1 mrrn:un (.' . 1 -. .: Il~, ... p".. E. cr al /.lthero5clf-,,,.,, - ly.•u P J59-S6ti 13'. Dtrrrrngton P' .1', Br,lion C H:. Hurfur .tt c! Ibld - 1977 - Vol 17 - P 465-475 la frrrJtrrud 1t° T. l.r.'y R. 1. fcrdrukson [J. S Chem - 1972. - Vol. I tl. - P. 49d-502: Go)ds:nul l, Brj,an Al: // Metabolism. - I°" /. - % ul. _16 -- P 1257-1275. l:1 16. Gurdrm T. Custdll W. P. Hiurlland A1. C ef al. // .Imer. J. t1ed. - 1977: - Vol. 61. - P' 707-714. 17, Gordr,m T. Kagan r1 . Carria-Palhurr A9. ct al. /,' Cir- ruiatwn. --• 1981'. - Vol. 63' - P. 500-5t5. Kunnr/ tl"' R. // amer. J. Cardiot. - 1976. - Vol: 37. - P 264 Krys A. ,'/ Atherosclerosis - 1975:- Vol ': '- P 149- 1!92 IK ty. 20. Kiudetzky R. C.. Assrnann C., IDa/gerrbaNt S. et al. fl artery: - 1980. - Vol. 7. - P. 191-205. 21. Luurnll, C 8, /!'Scand. J. On. Lab., Invest. - 197.. - Vol. 9 - P. 2l. 22: Lock D. R.. Vorho! A.,, Grimes S. et al // Metabolisrn - 1983. - Vol. 22. - P. 1142-1145., 23: Miller N. E. ,"'Lipids: - 1978 - Vol! t3. - P 914. 24. Schmandt P., lanelschek P.. tC'eisazilrr P. // Athero<cle- rosia.,- 1982. - Vol. 44. - P. 9-17: 25. Shepherd l:, Packard C.1'_ Potsh, 1: R. et al. // Ji c1in. Inctst. - 1978. - Vol. 61. - P. 1582-1!592. 26: Shepherd 1.. Packard C.1.. Crundy S. M: J/J. Lipid Res. - 1980: - P. 91-99. 27: Slamler 1.// Circulatlon. - 1979. - Vol 60 - P. 1575- 1587.. 28. mriimriler P., Dros+ur M., Sontlschek P, et al. !/ At'he- rosclerosis. - 1983. - Vol. 49. - P. 325-332:, 29. Williams P. T., Krauss R. M':. Wood P. D. et al. // Me-• tabollim: - 1985. - Vol. 34. - P. 524-530. Rorrynr.ia al 04 a6 YJl[ 41G.t4-006.4lIR:ata.ail 3: Ll'J. Xa,tdirx, B: A. lCnoKrzoe BJIHAHHE af1ACCHBHOrOa KYPEHHSI HA TOJIEPAHTHOCTb K mH3H'qELKOR HAI'PY3KE Y BOJ1bHb1X HWEMH4ECKOi1 bOJ1E3Hb)O CEP11I1A CaparoecxRO OAlataA (1txp. - npo4). 3. ltl. )CampeN) :1ennnrpancKOro HHN' KapawonornH MKKSApaea PC+aCP B HaCTORwee BpeMR He nbi3blBaeT COMHEHHR, RT0 KVpe.HHe c:nor-.o6creyeT pa3BHTHn) HiAeMBiteCKOR 60-JIe3HHl C:pAtla (HbC) 11, 2, 4, 5). PHCK pS3BHTH'R 1"IEiC yBe.1H4HBaCTCR B 2-3 pa3a SdR; AHtl. B6iKV,- pHnaloulttx 6o:nce G', na4KH ctrrapeT B aeHb [3. 101. Cl'acTOTa pa3BItTHR HH4)apKT2 MHOKapRa HBHe-3anM0A cMCPTHH npRMo~ CBRaaHaC KVpCHHCM 15,. 7). & TO »ce BpeMR npeKpauteHHe KypetntR CHH>tcarr pHCx pac+BHT/tR nonropHOro~ nr0apKTa MuOKapaa 11 Btte3anttuit eMepTH Ha 20-50 % [11, 12J. lilpM r1pOBe'1eHHH BC7o3prOMCTpM4eCl(OIS npo.6d Bb1P.BJleHd OTpN11aTe.1bHaR Koppe7R'llHA, MCktAy. Ky- pCKHCM CHrapCT 11 TO.TepaHTHOCTb10 K4)H3NPeCK0A HGrpy3Ke 1I.). 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BCe Ky,pR211He B Te4exHe 2 4 ao nposeaeHHR Be- .1OjprOMerpH4ectioA npo6d' BOaaep)KHaBJiHCb oT Kyl peHHR. 3E CyrxH ao HCeJIeaOBaHHR aceM bonbHdM OTMeHRJIH aHTHBHrHHa.9bHble CpeaCTBB, 38 HCKJIK)- 4eH11eM Ta6AeTOK HHTporl1H11epHHa. Beno3proMerpH4eCKylo npo6y npoBOaHAH 8 nono- iKeHHH CH1CR H8 seno9proMerpe .CHMeHC•3aeMas c perHCTpauHeA 3KI' a 3 orseaeHHAX no He6y' HS crpyAHOM nonHrpa4)e tMHHrorpa4)•823-. Hcnonbao• Ba11H CryneH4aT0 B03pdCT81011lyl0 HenpepdBHyb sa• rpy3Ky anHTeJibHOCTbK) 3 MHH C nOC1CIlO8aTe11bHdM npHpaweHHexll MOwHOCTN H8 25 BT. npH4NH0A'i npe- KpawCHxR seao3proMerpH4ecKOAl npo6d cnyktxnK ,l[1cTH)KeHHe Cy6MaxeHMa:1lbHOA 4aCTOTd nynbca, cMeweHHe cerMeHTa ST ropH30HT8I1bHOr0 H' KACo- HHCXOJIRwero THna HH?#cC' H301[NHHH HS 1 NM H 6o- JICC„ BO3HHKHOBeHIIe THnH4HOr0 npHCryna QTeHO- ,tap.iHH'. 1;ynHpy:owerocR npHeMOM HHrpornHUepH- Ha. 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B Ha- liVpeIlnnNl' nUMCWCIIItdI cro asaVFiad (~B KOHUe Ka)K- a0rU4;1CJ) il(?flHl'TpIIBS.111 B TC4CHHe' 10MI. I 4l'pC3'q)pJ:V\'ry 11.1U113a4'O U!J M'. LAS1 TOro 4T06W VCT3HOBHTb.-He B.1H'ACT 'IH npU~ BCaeHHe npCaBapHT0.1bHUi1 Be.109prOMeTpH4eCKOa ~ npo6d H.a. ee nOKa3aTC.T11 npll' 11OBTOpHOM npOBtae• HHH npo4 4Cp13 2-1; y 10 60.1bHdX CTtHOKapaHeH HanpRM:eHNR 11-IV 4)VHKI1HOHaJIbHorO KJIBCCa (cpeaHHA B03paCT 48'1er) T0+1CPaHTHOCTH K, Ha- rpy3xe KCCilea08a:1fP, aBaH{!ld' C HHTepBalloM 2 4: nOCAe npe6dB3HHR B OnHCBHNnM B61We nU• MeLIleHHH, a KOTOpOM He KvpH.1ll. OKa3a, AOCb„ 4T0 HCXOaHBR To.'IepaHTHOtTb l+ Harpy3hC B rpynne cocTaBHna B cpeaHrM 62.5:t1„4 Br, a npH nOBTOpHOM HCC.IeaObaHHH 4epe3 2' tI - 70t2,0! Br (y 3 6o.nbHdx creHOKep;nHek HanpR:+:cHHA npH noBTOpHOM npOBeaeHHH npo6bl orMe4eHO no8dwe- HHC T0.1epaHTHOCTH H8 I CTyneHb - 25 BT)'. npOBeaeHHde HCC11ea08aHHR' noaTBCp)KaaK)T npD- soMepHOCrb HcnOJlb30B8HHR nBpHdX BeJ109proMtT• pH4eCKHx H'arpy30K, 0 4em CBHACTeAbCrayeT H WHh pOKHAIOldT HX HCn0Ab30BBHHR V'H8C B C7paHt H 38 py6emoM npH noa6ope 6o11bHWM aHTHeHrHHanb- Hdx npenaparoe. rlpoBeIleHHde HccAeJlosaHHR nOKa3anH, 4?01 B rpynne npaKTH4ecxH 3llOpOBdx n!'tu TonepaH'rHOCTb K Harpy3Ke a0 npe6bl'sBHHR B HaxypeHHOM nOMe- WeHNH B CpeaHeM COCTBBHd3 192_5,5 Br, IICI - 246±7,2 yw. ea., a noKa :arenb ,iIII/BT - 1,3'=t $0,04., ROCJie tnaCCHBHO'Os KypeHHA, TOlIepBHT• HOCrb K Narpy3Ke 6 9TOH rpynne eocraBHna 1,97= :±:5,7 Br, 1II1 - 238:i-7,1 yca. ea. H ZIIT/Br - 1',2:i-0,©3. 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