Philip Morris
Passive Smoking and Cardiorespiratory Health in Scotland
Fields
- Author
- Chopra, C.
- Gillis, C.R.
- Hawthorne, V.M.
- Hole, D.J.
- Gillis, C.R.
- Document File
- 2023511660/2023512308/Ets: Heart Disease 930900
- Area
- SCIENTIFIC AFFAIRS/BLACK LATERAL OLD S&T
- Type
- PSCI, PUBLICATION SCIENTIFIC
- BIBL, BIBLIOGRAPHY
- Master ID
- 2023511661/2307
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- Characteristic
- EXTR, EXTRA
- MARG, MARGINALIA
- Named Person
- Hole, D.J.
- Lee, P.N.
- Litigation
- Okag/Privilege Withdrawn
- Okag/Produced
- Author (Organization)
- Bmj
- Ruchill Hospital Glasgow
- Univ of Mi
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Document Images
5' council of the Royal Collbge of General Proc-
uuoners and the General Medical Services
Committee (Wales).
Ih overall terms our deputation feared'that the
general principles of tbereferral isystem wereeom-
promised, access to specialist psychiatric services
was ill defined, and the declared'role of the meotal
health team in primary tsre could Ithd only to
fragmentation and confusion,, Furthermore, the
contractualiobligations of the general practitioner
were totallyy bypastedl
The deputation'received a sympathetic hearing,
and it was with,great d'tsappouttment that we read
the final paper, Menral Hral1A' Sersiaa, a Saarejy
for Wakr, issued in June 1989: Littk has changed
from that set out in the cottsultation document,
and we are conviitced'that if the recommendations
of this paper are implemented the task of treating'
psychiatric disorder in Waits is likely' to be
muddled and expensive.
C,ekna. u.
PowysNPS1AP
Ud.e<.iry ora,le. cme~.fMi;cloe,
cadarGF44XN
R C HUMPHREYS
N C H STOTT
I Shephsrd M'. Prwrry oR uf pntents.ith meotddoatd8r m tk'e
communuty: BrMdJ 1919;299:666-9. (9Septmber.)
Rape and subsequent
seroconversion to' HIV
SIR,-The paper by Dr S Murphy and colleagues
highlights the potential risks and worries for
women who have been sexually assaulted during
the current phase of the HIV epidemic.' If we
assume that such assailanu are hettsosexual men
the overall risk of transmission is likely to be small
in view of the present low carriage rate for the virus
atttottg:this group in Britain,! In addition, vaginal
~ intercoursse is possibly a less likely mode of trans-
mission than anal intercourse.! The situation for
male victims of sexual assault may, however, be
different.
Male "rape 'a5 altgal term dUGSs not.ellst in the
United Kingdom, as rape specifies forcible vaginal
peaetration: Furthermore, taale sexual'assattlt is
nor recogni szi as s distinct entity within the 1976
:? z+ It Offeny: _~ ('.lmendment) Act.' Thismay well'
itavrwnsequences for thenumber of cases reported
and for public awareness of such events.' Docu-
mented cases of sexual assault of men by women
have been reported,' but it is generally thought
that men att more commonly assaulted by other
men.
In the United States it has been estimated that
only J 0+20°/d of all sexual assaults are ever reported.'
In addition, there is some evidence to suggest that
male victims are more reluctant to come forward
than'their female counterparts, possibly related to
the fear of being labelled as bomosexual' or to
society's concept that a'"real man" c,nnot be
npeA.'
Pat t! y Ls a.:ont<q ttence of its legal non-ezistence
there a, v ao reliable figures of the frequentv'and
natura of male sexual assault in Britain. The onlyy
orgaw irinn providing care for victims of male
sexull ?vanlbiu Btitainanpresentis'"Survivors; a
servic>, no by ^luntc?rs to which various govern-
ment vnd +:iiariitblr agencies refer their clients..
The service piovides a telephone belb line
(currently ans-wering just over 100 inquiries a
month),t ,gether :vith counselling and support. No
studies tu date have assessed'the risk of sexually
acquirni'.infection in malt victims ofassault; but
of 5 12 v ic t Gns known to Survivors in 1'988, 24 of 73'
who sought medical advice were diagnosed as
naving a sexually transmitted: disease presumed'
be consequent on their assault, Data on HIV
seroconversion are not available, but 148 of the 512'
victims reported skin or mucosal bleeding, and 278:
expressed concern about the possibiliry of'ttans-
mission of HIV. In 92 of the cases the assailann
deliberately threatened the victim with the possi;
billrv ofcontracting HIV infection as a consequence
of the assault L
It has been suggested that between 50%" and
82%' of assailants of male victims are either
homosexual or biscxual. The assailants are there-
fore in relatively higher risk groups for HIV
infection than heterosexual assailants of women.
Futhermoreanal penetration, blood'v non-genitall
violence, , and mulUple: assailants are more likely when the victim is male.'
Rape treatment centres have been set up pri-
marily for female victims and'amy lack the skills to
deal with men, We believe that an increased level
of awareness of male sexual assault is needed
among the general'public and especially by health
care professionals to encourage victims to come
forward. Only when tbis happens can the scale of
the problem be fully grasped and appropriate
treatment provided.
RICHARDHILLMANt>rtViD TAYLOR-ROBINSON
Dtmm o(SccuaBy Tummltred Dt.o.n,.
Glinia4 Rewrch Cmuc,
H,.eo.,
Mddlesc
sunw,,.
to.doo WCI
NIGF1 O'AMRA
I MwmbyS, Kncbm V,.Hartu JRC", Fonur SM.. Rape lod
wbietiucni lavconvenqo toH1V: BrMd J1949199:718:.
(16 Sepmm6er.)
2 PHLSCammuntobk Due.e SurreiWoce Ceaue. Huwoutmuoode6cxocTy..vus (HIV-1) anobodj..,teporu: United',
Fnedom; :.ak's a4U5-89[39. Gwm+o.nrui4Orunv R pmo.
1989;40:3.
3. P.dii.n NS. Hetero.e.ual trm.nuuton of.tcquired immuno
de6LK0[}', f)RIQtCme: Nif(IYtlotlil, PCRPCCUVC{ltlld ;
ytqpV
peoronans. Res.1 nlmDu. 1987;9;94 i40.
4 M~ 'G'RutaM. Thceffecesof.esuuLUSaWt on tnen.: a
uurq.of 22'vtct+nu. PMrhuf Med 19a9;19:205-9.
5M-y G, Kivts M. Male vxtum of saual awWt. Me! Sn Lem 1987;27:122-4..
6Scbiff AF. Fsam¢nt,uoo .nd ttntmeut ~of'tbe mJk upe vwtlm.
Sa.th'M.dJ 1980773:1498'.502 7Gene FR. SesuaOy rshted tnuma. E-rr Md Cla. NwU Aw.
196a:6:439b6..
t Raufman ~ A, . Div.no P, Jacksaa R, Voorbees. D, Ctinsty. J:
Mak r.pe ncums: nooinsutuawoali}ed auWt.
A. J PryrAury 1980;t37:221-3.
9Glircr JB, Hammenchla8 MR, Mcfarmack WM. Epidemw
lop: of'.exuallytrwsmmeddnrsus m upe v+cums. RmlJat Du 19a9;1 t:246-54.
I0GraA AN,.Bursess AW:.M.k npe:.onenders andv,ctimt.
Aw. j Prydnany 1980i137:806-10.
F
E
r
t
c
V
t
t
a
f
t
I
. ,
relative risk for active smokers compared with
Passive smoking and lifelong non-smokers is 5,85. This would be
3
incompatible with rrtes of'denial greater than 5%.
cardiorespiratory lhealth, in
Therefore, the largest relative risk to be expected
Scotland among p.ssive smokers due to this form of biu
"
"
avhen the
true
risk is unity is 1 F20. A relative risk
StR,-Mr Peter N Lee' implies that our obser- of 241 was foundin our study: ,
~
vation of increased risk for four respiratory Again, the same approach applied to iachaemic
symptoms and two cardiovascular symptoms, heart disease assttming a"rrtte" relative risk of 3 for
mortality ftom lung cancer,, mortality from acuve smokers and 1 for passive smokers and a raee
i
(
ischaemic beart disease, all causes of death related of denial of smoking of 5% produces an obaerved
to smoking, and mortality from all causes in reiative risk of 105 for passive smokers and 242
passive smokers compared witli controls' can be for active smokers. Thus if the relative risk for
explained by bias-that of smokers declaring active smokers is considerably Jess than 20, as in all i
themselves to be lifelong non-smokers. He cites the conditions we considered other than lung
(presumably) lung cancer, for which ifs as he C3nCer, the effecrofmicnlo«ifv.nuan is to produce
supposes, no increased risk is usociated' with only'small biases in the relative risk for passive
exposure to environmental tobacco smoke and the strookers. Our risks for each of the respitatay
"true" risk is increased 20 times in active smokers, sympooms, urdiovascttlar, symptnms, and orr
v
r
L-.
TASCS l-Differeniial msrzl6ssificasan canted by 2'A.of rndex'rabjectr denvmg swto4ing rejardleu of
cnAabuee'r swrokiwg
Aab'its
~ c
Eepo.u+c Obxrved "True" Flfeets of Pmt.enuar who
ara+p' distntiution} dlsvibuum denultuvcsmoked' V.1 t
F
~
Canvola 9'~17. a81 t36~ 3-9' li" r
Pzu,.e>moken
1538 1461 .77 5-0 ~ lA
~
Su>sle unoken t751. 1797 -36
. rTi
r
Doubk .moken 3791 3868 -77 W
'
h
As dt6zted by Hole n d.' tDau fromn ubl! I of Hote a n!.' L
li-
1
2%' of smokers denying smoking would'result in
observed relative risks of 1 74 for passive smokers
and 690 ifor active smokers. This is illustrated in
his table, using the distribution of subjects in the
smoking groups defined in our study. But why
does he use only men and ignore women when our
analysis and results were based on both sexes
and' women comprised 84 2% of our passive
smokers?, If' he had included women 5-0% of
passive smokers and 3:996 of'controls would have
smoked''(table I)'-quitediffetent from the figures
of 15-6% and''68% respectively presented in his
tablt. Our figures in turn produce an observed
relative risk of 1'12 for passive smoking (sub-
stantiall'y less than the ]f74'be quotes by sdecting
only men) and considerably less' than our study
finding of 2-41 for lung cancer among passive
smokers. Ckeariy; misclas.ifinrion owing to the
2% rate of denial of smadcing he suggests does not
aplain our finding.
in addH]Onl higher r7te.s of dlnial of smoking do
aot produce sufficient bias to crpl*in our risk for
htng cancer. Table II presents the effect on the
basis of a'"true" relative risk of 20 for active
smoking and I for passive smoking and of rates of
denial varying from J% to 1,0%. Two facts emerge:
firstly, the bias in the relative risk for passive
smokers does not increase linearly' as the rate of
denial increases, it flattens considenbly; secondly;
the observed relative risk for active smokers
diminis}ies lapidlV as the rate of denial increases.
TABLE tt-Relattrae risks forpatsine aad art'roe tmoking
fortwrying rates of rmokirtg
Obrerrcd rdluvc risk
Rate.of denW
(%). Pasv.e smoken . Acuw smokers
1 107 13-95~
2~ 1.12 10-67.
3. 1.15 B61
4 1IB 717
5. 119 6- 14
6~ 1-2Q~ 535~
7~ 1.21 473
a 142 443
9~. 123'. 382~
10~. 123. 347.
This is important, as by comparing the observed
relative risk for active smokers from abe table with
the relative risk found in the study'an upper bound
nn: be defined for the rate of denial
The study
1100 BMJ VOLUME 299' 28'oc-rosER 1989 1

It in
,kers
:din
Ithe
why
I our '
cies
;5]v. ,,
ures
his
-ved
sub-
tin8
udy
sive
the
not
do
for
the
uve
s of
rge:
sive
= of
1Jy,
:crs
ses.
Sories of mortality quoted are well in excas of that
produced by the form of biu suggested. Also, as
oontr+ol subjects expertena some level of ta.iron-
mental tobacco smoke" otu esumates of risk could
be caatervativo.
Mr Lee misunderstands our use of urinary
cotinine concentrations in passive smokers. We
were using published data to establish whether our~
study had sufhcient statistical power to detect the
size of risk that might be expected among passive
smokers. If Mr Lee is correct and urinary rotinine
concentntions are equivalent i to a lower, dose than
assumed then our decision not to rely solely on
statistical sigaificancc as evidence of a genuine
effect was definitely coetxt, Ours was a cohort
study of a general population and was not subjecti
to the biases associated with a case-control design: ,
In addition, subjects reported their own smoking
histories, and' environmental exposure was based I
on record linkage of cobabitees, thereby avoiding,
the need to rely on self reporting of passive
exposure.
Our observations on lung cancer may be based
on only nine deaths but arr consistent with the
aeatlit of a metaynatyas' combining 13 sep.nte
soldies, which concluded that breathing other
peoplc's tobaeoo ®oke auses lung cancer. The
smporunce of our study lles in the estimates of tisk
for ischaemic heart disease (based on 84 deaths), all
causes of death related to smoking (175 deaths),
mortaliry from all causes (263 deaths), respiratory,
symptoms (292 ases), and cardiovascular
.symptoms (117 oses): The consistent increae in
riaks for such a wide variety of health otttoomes
trom an unbiased prospective cohort study together
with a dose-reesponse relauon in passive smokers
atrongly, ssuggests that there is now a cse to be
answered agttinst pssive smoking that estends
beyond the causation of liing cancer.
DAViDfHOLE
QiARLFS R GILLIS
Wen of ScoUMd C.ecv. Sm.eill.e¢ Unir,
RWChiB Hospral,
G Waw G2a 9NB'
CA1tOL CHOPRA
VICTOR M HAw7HORNE
~ed
ith
nd
idy
tth
be
96.
ed'
ias.
Isk
Rg'
Deprtuu:au d Epdemwloay;
UL-ry dMra4pm,
Mrch,aan,
Umred Sous
I I.x PN. Pasove mokint. .od ordiansyuuory lellh,
m.
Sttoelurod.. Br Med.J 1919;299:742: (16 SepemEer, ).
2Hols DJ. GiBrsCR, mopn C, Hhtlaw vM~ Pauac®akma.
and ordqrespra,ory Aala6 u.aeonl popul+owo m tAe
of smtl.m. Be Mrd Ja 9t9;299:Q3-7. (12 Autuw:) .
3w.1d NJ, N4u:haWK, TDomp- SCG,.Cuckk.HS. Don
bruNima aNer people'r.oCrco moMe ouu luna oocv?Br.
M1dJ 1996;793:1217-22:.
Referrals from general practice
to hospitaD outpatient
departments
SIR,-One aspect highlighted in the report by Drs
John Emmanuel and Nigel !Walker' is treatment of
skin disorders in general practice. Proposals in the
white paper are likely to encourage more minor
surgery to be undertaken by general practitioners.
This may be more cost effective (although our own
experience indicates that this tmy not necessarily
be so), but skin surgery should be undertaken in
general'pnctiee only if the diagnosis is certain-
otherwise referrals may be innvsed rather than
decreased as intended. We report two problems
that resulted from inappropriate skin surgery in
general practice.
A 49 year old woman had a pigmented lesion
removed by curettage and cautery from her lower
leg by her general practitioner. Histology, showed
ttnlignant melanoma, but~ it was iafpossible to
ascertain the depth of the tunwur on the basis of,
the inadequately thin cunettage specimen. The
patient then had a wide excision and graft, but!it is
possible that she would not have required an
extensive operation because narrow excision
margins can sometimes be adequate for very thin i
melanomas.
In another patient, a 46 year old woman, a
slightl}, raised nodule on the leg was treated by
curettage and'autery by her general'practiuoner.
Histology showed invasive squamous cell ar-
cinoma and the patient was referred for further
advice. Because it was diffieult to know the ade-
quacy of the initial i treatment the patient was
committed to prolonged follow up to exclude
recurrence of'tlie lesion.
Dep.rtmrni of tleemnoioay,
Bnuvqo, Hocp, W ':..
Lnar,n IA1,2JF
Dep~i of P.ceolotl,
lanarrtt Mnor }io:prud,
Luas,a lAl 3RJ i
PHILIP HARRISON
ROBERT BLEB°ITT
1 t.mm.nuel'~. J, waher N. Refanlf from amer.l P..ctier m
tmsfxud oucp.um. dep.otmepn:. stntet\-lor ®peo.®ent..
BrMrd,j 19t9;299:722y(. (16September.)
Provision of services
SIR,-It seems to be the custom that when a
specialist advisory committee pronounces on how
senices should be provided this is accepted; but
there arc occasions when someone needs to stand
up and say "You are wrong."
The North West Thames eu, nose, and throat
regional advisorv subcommittee says that inpatiem
ear, noseand throat services should be provided
only in subregional specialisrcentres and nat,in
the smaller district gcnernl'hospitalt. I have been
the anaesthetist for three to four nr, nose, and
throat lists per week fonover 20'years and knoww
that most of these operations are everyday bread
and butter surgery, and that over half are on
children. Indeed the commonest pudiatric open.
uons are ear, nose, and throat-tonsils, glue ean
etc. These services have ahvavs been available at
the local hospital and to say they should all go to
subregional eentres is tantamount to saying all
hernias and ingrowing toenails should go to
specialised units. Not only does this deprive
patients of what I would call a core service but it
has , profound knock on, effects on most other
services in the district general hospital through the
possible loss of recognition of anaesthetic jobs.
Before someone brings out the old chestnut of
"Make rotations"'I will!answer "Just you try to,"
We are facing this situation in North'i West
Hertfordshire Districtwhere the loss of inpauentt
ear, nose, and'throat services will disadvantage our
patients and could cause havoc with the hospital
servtces9s a wliole Iiam afiaid'that this may be
only the beginning of specialist groups building
their own little empires without regard to the
patients and hospitals from whom they withdraw
their services.
Sr AItuns OtpHonp-l,
5r At6.ns AL3 9XX
MARGARET E PICKERING-PICK
Psychiatric illness among the
homeless
StR,-Dr Max Marshall describes a high pro-
poruon of residents of Oxford hostels for the
homeless as being long term psychiatric patients"
and implies that. they are deinstitutionalised long
stay patients.' Our findings, however, suggest that
hostel l residents with psychiatnc disabilities may
have had numerous yet relatively brief hospitall
admissions and'inciude those sometimes referred
to as "revolving door" patients.
We are currently evaluating a psychiatric liiison
service to residents of a direct access hostel for
homeless women in central London. Of 33 women
seen to date26 are known to have had at least one
previous psychtatric admission, but only four have
spent periods of more than one year continuously
as inpauents: We believe the current emphasis on
deinstituuonalised'dong stay patients is mispiaced:
it is the needs of those with ~ chronic, severe
psychiatric disabilities in the communin and'
the revolving door patients that are not bemgg
addressed. Deferring the closure of psychiatric
hospitals~ will have little impact on this large group
of people. The Department of Hbalth has stated
that the forthcroming white paper on cotnmunin
are will contain plans to prevent the unplanned
discharge of long staypanents into the communin.
Thesc safeguards will be of no value to mosl
severeh disabled psyehiatnc patients in the
commurlirv:
Dr Marshall's findings and our own data both
sliow,high levels of unmet need and are in keeping
with most surveys of people witli psychiatnc
disorders in the commtlniry. These findings
clearly indicate inadequate provision of cars, but
they should not be used as evidence of the
inef7ectiveness of deinstituuonalisation pro-
grammes or properly planned'and funded cont-
mututy services. The few controlled studies: of
selected patients discharged within arefullyv
planned community programmes' sliou that
long term psychiatric patients (whether or not
they have had long stay psychiatric admissions)
can be maintained outside hospital without the
deterioration in symptoms, poor psychosocial
functioning, and readiltissions that are al1 too
commonly found in the surveys. Perhaps more
importantly, the controlled studies in whicti
patients : wishes and satisfaction have been recorded
clearli, show that they prefer to be trnted'in the
community.
KRLETI¢J.tC R PUGH
Depnmrn, dPryduwl , ,
Mrddksa Ho.pW,
Laodoo W I N~~ tAA'
I. Marsli.B M, . Golknd;.nd netkcud: - Odordbuqeb for
Uu 6ourku 511mt up~p ab dnfbkd pycEutnr poema? B. Mkd J.19r9;299! 7D6A: (16Sep®bcr. ),
2welYec BGA,.C'6[ke MP9, Coker EMahome.d S. C-a au
CUnstmu 19a6. Lakrr 14E7 u:553-~:.
3Bnun P: Kocb.nsky" G, Shapvu R, nof. O-: demsuru-
uauirarwo of I ps.chmrK p.urn,s... mcual. mr- doutco®r audin: Aw ) Pryrfmrry19a I:138:736-"
.
Safety of Picolax in
inflammatory bowel disease
StR,-In view of the suggestion of Dr A J G
McDonagh and colleagues that further evaluation
of Picolax is merited' we would like to report
our own experience with this preparation in a
large cohort of' ehildien undergoing fibreoptic
colonoscopy at St Bartholomew's Hospital.
Between 1982 and'1988 we performed 534 colono-
scopies on 412 children attending this hospital and,
with few exceptions, Picolax was used routinely
to prepare the colon before endoscopy. This in-
cluded the 287 procedures performed on children
with chronic inflammatory bowel disease (163 with
Crohn's disease, 101 with ulcerstlve colitis, 23
with indeterminate colitis) that was either known
to preKxist or suspected and confirmed'at the time
of endoscopy: We found the preparation to be
successful forcleansing the bowel and free of major
complications.
Based on our experience we have developed the
following regimen for preparing the colon before
endoscopy, in children. The child is given only
8uids for 24 hours before the procedure and is
given two doses of Picolax, one about 15 hours
before endoscopy and the other three hours before.
The dose is age dependent: children oven6 years
:9 BMJ voLUME 299 28 OCTOBER 1989 1101
