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ASSESSMENT OF TME ASSOCIATION sETWEEN PASSIVE SMOKING AND LUNG CANCER 1/ARELAv LUIS R. DEGREE DATE: 1987 ~

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SJO r ~V CUM ordn Namber •6O1ee3 Assersment of the aisoclatfon between passfve smoking and lung cancer Vatela, Luii R, Ph.D. Yale Usi..nity, 19f'1 U-M-I }W N. Zecb RC Aan AMMr. Ati aq 106

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8flMET,7-110% ..- % r,v.,,,. ASSES9MENi OF 'Dff AS.90QATIQJ 8E3WFE7: PAS52VE 94O!QPC AFO 1:94 O1tCR A Dissertation Presented to the Fbcvlty of tt., Craduate Sd+oo1 of Yale utivetsity in Csndidacy Cor the Mqree of Doctor of Philosophy [uis R. Varela Pay 1987

A2.'~?91T LSF53~E^. oP ThT .1S'0C'~1TIVI H=tN PASSNE RNt)IM .iND ;:1MG .^.J•=R i.uis R. Varela Yale University 1987 A :K;Cv..d asrcrntrol study was carried out to evaluate the associaunn Eetx+m OxpOSre to e+wttvrnc+tal tehaec5 saolce (Fess:w sadcusa) ary lLmy caneer risk. 'ihe study populatix was ompr!sed of 439 ases of lunq esnoer d-arnOsOd asQ+9 ncn-s^o~'1s. Ml of these cases .ero clinically ard histoloqi.illy oonfizeed. The oorzr_spo.ci~9 cor:trols were d_a+n fras the Nev Yark State Ueper*ment of hbtor Vehicles ard were :nii%nduslly .wtcnad to the cases on aqe, seu, county of residence ard previous 3Mcing history. A facr.-to-iace interviev ufty rl{+'_ied to obcain infocsrtim an es{+xun to emiramntal tobacco snnks. W inaease in risk was fourd associatel vith e)posias to three neesurments of spane sneklnqr or with eVosure to oo-.erkers' srohiriq.. wrverssly, e3posure to the sadu of othars in the hoaxhold was fc.ud ,.o affect th- risk of lu:q crr.caer. Fbr an exposure to 15C persanlyears ,)f ssnkirw the odds ratio was fourd to be 1.86. '11us effect aewas to be :arqer for epiosscvid ard snnll call tumars (GR-2.a]1 taan for a6--=arciriams ard other tuac" (OR-1.42). A+cza.suq mmoaa_-e to ;assive sm" in social sltustlAru was fourL' to W ir.sersely ass!clatsd with the risk of lunq nnoer. E~e iaFlicqtion of t.".is fL-duq -- at oAis with ~rer_xn results - is discisxci. 9-4 VOr' C,.C7LEf~O% AOQOW1EDC'~!~ I am qrent!y iJdebt.ed to Dr. pvSoht T. Janerich for providinq rte with the opfnrcunity to oarticipate in the pro7ec, frcve .hach the setervl for this dissertation was derived. rbrkuig vith him was not ornly intellectually atisularnq, but also a acairoe of qratifyiaq professisal arrd prrsona: interaRion. lb the M.K. Kelloq Floutiiation I am qrateful for ptovidinq a+e r+ith the filarrial assistance to cmduct my doctoral studies. Tb friends evid swbe=s of the Faculty of the Depaitmmt of 15idmdoloqy I am ;Jrrrcful for their .x.rti~unas help and supfort. tl

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