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) l ) 1 ? RE: XAROLINSKA INSP. TQ,EIP), G~ )Q,EIlJ, .E 'd.H.O. COVER LEGEND Cover Legend. Cancer Rea., U (10), Oct., 1975. The Karolinska Institutet was established in 1'$10 by King Charles uf S. cden to increase the numb.r of doctors for the army, and it be- :ame a regular medical school some 50 years latcr. Its outstanding professor of chemistry. Bcrzelius. was instrumental in raising it from wh.t the universities considered as a "school of raw buben and fcldschers° to what is now Scandinavia i largest medical school. With neart% too departments. it educatcs the largest number of medical students in Sweden. awards both Rt.D. and Ph.D. degrees, and also has a faculty of dentistry. According to the will of Alfred Nobel. the Institutet is entrusted with the annual awards of the Nobel prize in ph) siolagy and medicine. The Department of Tumor Biology. est3blished by an act of Parlianem in 1957. is one of 12 departments involved in research and postgraduate training. With a total'scientiGc suRof approt.imately 50, the department, is engaged in research on tumor immunology. .irolog.. and xomatic cYll gcnctics, with the support of grants from the SMedish Cancer Society; the Swedish state. and the National Institu.es of Health ofahe U. S. Public Health Service. George Klein, Director of this department, and his wife, Dr. Eva Kkin. Vice Director, have had long and illustrious careers in cancer immunology and are among the world's authorities in this fald: The current worldwide interest in cancer immunology is due in no small measure to their pioneering work in this area. Among their important efforts are studies that led to the identifintioo of the Epucia.Barr virus as a causative agent in the Burkitt lymphoma. They are also forerunners in the use of cell hybridization to understand the nature of feae expression in cancer. George Klein ic a co-editor of Ad.vnca In Canca Research and is a member of the Nobel Committee for Physiology and Medicine. Since t961, he has been a member of the Board of Directors of the Swedish Cancer Society and serves on the WHO Expert Advisory Counc3l on Cancer. Together with Eva Klein, his wife and collaborator. he is a recipient of a number of awards. including the Berths Goldblatt Teplitz Award. the Dunham Lectureship at Harvard University. and the Clowes Memorial Lectureship of the American Association (or Cancer Research (Cancer Res.. 28: 625-635, 1%E)• We are indebted to Dr. George Klein for the photographs aod'information. S. W. Page I of 2 RE: WHO Virus- Cancer Croaspoint. Sci. 8ews, 108 (1'9), 298- ME TEE, G. . 299, Nov. 8, 19?5, T=, P. Quim , C• cancer. thus opening tlrc possibility of '.,A~~~r~t*1. ~p. on I~+E, W. indicting the virus as a canccr.cansing :. ~p{~~ R, agent and suutstint ways of preventing CCMP• IOrA• Resea.rch, Co- rrFrur~ t!:~ infection with it. ( PeahA Bms ca. Oct. 20, 1g7r'j. Th f f e tesu ts of the study were ptesented New evidence points to virus Iar dw 7th International Symposium on antibodies as cancer-causing ~ Cattpvative Leukemia Research held re- I catalysts in certain °ostl)' in Copenhagen (SN: io/25/TS. p. tedis Bed 1lnffians ~.~ by Dr. Guy de T1tE of the Insessa-, ~ iM tional Agency for Research in Lyon. So far, the strongest link between a i .irus and human cancer has been between ' BY JOAN AREHART-TREICHEL tAe so-calkd EB (Epsttsin-Barr) virus and ~ several cancers of Iymphoid ajatss-; Although viruses have been shown to gurkitt's lymphoma and nasopharyngeal : trigger a number of animal cancers, their carcinoma. While the ED virus cannot be i link with human cancers has been less detected in human tissua, antibodies b~ certatn. Now a masaive four-year popula- f'I the v'vns eann tion stuJ'y in Africa, conducted by scien- Finding vitus antibodies in people .ttet tists from three continents, provides some they corrsc down with these Iwo kinds of of the strongest evidence yet that one kind IcancK. however, is not suAfcient proof of human cancer at least is caused by a that those viruses cause the cancers. Better l virus. The study is unprecedented in that , proof would consist of detecting virus it involved the screening of people's blood , antibodiea in people without the cancers, 6or a virus befnre they were aAlicted with i d+en watching to see whetfier those with especially high levels of antibodies come~ dowa with-tlie cancers. Conseyuentl2r that is what ds ThE and his fellow tarn mem- ben in Europe, Africa and' ehe United States attempted to do. The studY, which was done in Uganda, involved 70 scientists ftrota Uganda, Europe and the United States. Some of .. the principal investigators, besides de ThE, included: Peter Tukei of the Ugan- dan Virus Institute, Charfes Otweny of the Ugandan Cancer institute, Werner Henk of Children's Hospital in Priladetphia. Richard Morrow of the Harvard Schootl of Pubiic Health in Boston and George Klein of the Karolinska Institute in Stock- holm. The study was conducted under the auspices of the World Health Organi- zation. It cost S 1.5 million, 90 percent of (Over)