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i Alejandro Zaffaroni, Ph.D. 8/23/91 Biography Dr. Alejandro Zaffaroni, Founder and Co-Chairman of the Board of Directors of ALZA Corporation, Founder and member of the Policy Board of DNAX Research Institute of Molecular and Cellular Biology, Inc., and Founder and Managing Director of Affymax, N.V. is noted for his major contributions to, the field of steroid biochemistry and for his pioneering accomplishments in the field of controlled drug delivery systems. A native of Montevideo, Uruguay, Dr. Zaffaroni in 1941 was awarded his B.S. degree from the University of Rochester under the auspices of a scholarship granted by the Institute of International Education. He remained with the University of Rochester, New York until 1951 as a National Institutes of Health Research Fellow. In 1951, Dr. Zaffaroni joined Syntex Corporation as Associate Director of Biological Research and subsequently held positions as Director of Research, Executive Vice President of the Corporation, and a member of the Board of Directors; eventually, he became President of Syntex Laboratories and President of Syntex Research. He resigned from Syntex in mid-1968 to establish ALZA Corporation and to begin a new scientific endeavor-pursuit of the therapeutic application of humoral and hormonal factors. On of his aims was to develop more physiological approaches to therapy, involving drug delivery systems that would maintain temporal patterns of pharmacologically active substances according to the individual needs of patients. To bring to life such research goals, new and precise physical, chemical, and biological systems had to be developed that could not only deliver drugs, but also guide and monitor their administration. In 1980, Dr. Zaffaroni founded and became Chairman of the Board of Directors of DNAX Ltd. The new company was formed to develop macromolecular products for medicine by combining the technologies of genetic engineering and irnmunobiology. In mid-1982, DNAX Research Institute of Molecular and Cellular and Biology, Inc. was acquired by Schering-Plough. Dr. Zaffaroni serves as a member of the Policy Board. In 1988, Dr. Zaffaroni founded Affymax, N_V., and assumed the position of Managing Director. Affymax is a new therapeutic drug discovery company that will dramatically reduce the cost and time required to identify promising compounds for treating important diseases. He successfully recruited numerous world renowned scientists who now work with Affymax in the development of a novel affinity matrix drug discovery system. This technology combines synthetic chemistry with advanced techniques pioneered by the semiconductor industry, notably photolithography, minaturization and parallel processing.

R: REDACTED MATERIAL Alejandro Zaffaroni, Ph.D. Page 2 Personal Data Birthdate and Place: Status: Education REDACTED 1941 Bachelor of Science, University of Montevideo, Montevideo, Uruguay 1941-1944 Attended the Faculty of Medicine, University of Montevideo, Montevideo, Uruguay 1945-1949 Attended the University of Rochester, Rochester, New York an obtained a Ph.D. in Biochemistry. 1949-1951 Postdoctoral Fellow of the National Institutes of Health, Utuversity of Rochester, Rochester, New York. Employment History 1951-1954 Director of Biochemical Research, Syntex S.A. Mexico, D.F., Mexico 1954-1956 Vice President and Director of Research, Syntex, S.A., Mexico, D.F., Mexico 1956-1968 Executive Vice President and Director of Syntex, Corp. 1962-1968 President of Syntex Laboratories, Inc., and President of Syntex Research, Palo Alto, California 1968- Founder, and Co-Chairman of the Board, ALZA Corporation, Palo Alto, California 1980- Founder, DNAX Research Institute of Molecular and Cellular Biology, Inc., Palo Alto, California 1988- Founder and Managing Director, Affymax N.V. The Netherlands

14 Alejandro Zaffaroni Honors Page 3 1945-1949 Fellow of the Institute of International Education, University of Rochester, Rochester, New York 1957 Honorary Professor of Biochemistry, National University of Mexico, Mexico, D.F., Mexico 1959 Honorary Professor, Faculty of Medicine, University of Montevideo, Montevideo, Uruguay 1972 Honorary Doctor of Science Degree, University of Rochester, Rochester, New York 1973 Elected Fellow of the American Academy of Arts and Sciences, Boston, Massachusetts 1973 Elected Fellow of the American Pharmaceutical Association, Academy of Pharmaceutical Research and Science, Washington, D.C. ".0 1973 _ Honorary Member of the National Academy of Medicine, Mexico, D.F., Mexico 1974 1974 Recipient of the Barren Medal Award from the Barren Foundation, Chicago, Illinois, for contributions in the field of reproductive physiology_ 1977 Member of the Institute of Medicine of the National ` Academy of Sciences, Washington, D.C. 1978 Consulting Professor of Pharmacology, Stanford University Medical School, Stanford, California 1978 President's Award, Weizmann Institute of Science Rehovot, Israel, in recognition for service on the Board of Governors. N O ~rJ 1979 Chemical Pioneer Award The American Institute of ~ , Chemists, Inc., Washington, D.C. ~ N 1983 Honorary Doctorate Degree, University of the Republic, ~ Faculty of Medicine, Montevideo, Uruguay ~

R: REDACTED MATERIAL - - I Alejandro Zaffaroni Page 4 Professional Affiliations REDACTED Directorships and other Associations Chairman of the Board, Psoriasis Research Institute, Palo Alto, California (May 1978 to present) Founding Life Member, M.I.T. Sustaining Fellows, Massachusetts Institute of Technology, Cambridge, Massachusetts (October 1979 to present) Honorary Trustee of the Board of Trustees, University of Rochester, New York (May 1976 to present) Incorporator of the Neurosciences Research Foundation at the Massachusetts Institute of Technology, Brookline, Massachusetts (August 1972 to present) Institute of Medicine, Section 12, (Administration of Health, Science, Education and Research), National Academy of Sciences, Washington, D.C. (January 1981 to present) Member of the Board of Governors, The Weizmann Institute of Science, Rehovot, Israel (November 1973 to present)

Alejandro Zaffaroni Page 5 Member of the Council of the Institute of Medicine, National Academy of Sciences, Washington, D.C. (October 1977 to present) Member of the Pharmaceutical Panel of the. Committee on Technology and International Economic and Trade Issues of the National Academy of Engineering's Office of the Foreign Secretary and the Assembly of Engineering, Washington, D.C. (June 1980 to present)