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R: REDACTED MATERIAL 1991 President, The Scripps Research Institute, La Jolla, California SOCIETIES AND HONORS 1- Cell ste REDACTED es , l;olci ational 985) 1986) ui %..olombia (1986) %,ectl tn. and Ida M. Green Chair in Chemistry (1989) Honorary Doctorate of Medicine, Karolinska Institute (1990) Member National Academy of Science, USA (1991) Member Scientific Policy Advisory Committee, Uppsala University, Uppsala Sweden (1991) Member Scientific Advisory Board Economic Development Board, Singapore (1991) PRIZES 19'I0 NIH AID Career Development Award 1978 Parke Davis Award 1990 JJohn A. Muntz Memorial Prize, Albany Medical College, New York 1990 San Marino Prize, Republic of San Marino 1990 The Burroughs Wellcome Fund and The FASEB, Wellcome Visiting Professor Award in Basic Medical Sciences 1991 The College De France Lectureship, College De France, Paris L991 Arthur C. Cope Scholar Award in Chemistry, Washington, D.C. 1992 CIBA-Geigy/Drew Award in Chemical Science, Drew University, Madison, New Jersey 00

BIBLIOGRAPHY 1. Lerner, R.A. and F.J. Dixon. Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum. J. Exp. Med. 124:431-442, 1966. 2. Lerner, R.A. and F.J. Dixon. Induced and spontaneous glomerulonephritis in sheep. Fed. Proc. 25:660, 1966. 3. Lerner, R.A. and F.J. Dixon. Spontaneous glomerulonephritis in sheep. Lab. Invest. 15:1279-1288, L466. 4. Lerner, R.A. and F.J. Dixon. Experimental and h»man glomerulonephritis associated with antiglomerular basement membrane antibodies. Proc. Natl. Acad. Sci. USA 15:94, 1967. 5. Lerner, RA, J.J. Glassock, and F.J. Dixon. The role of antiglomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J. Exp. Med. 126:989, 1967. 6. Unanue, E.R., R.A. Lerner, and F.J. Dixon. Experimental allergic glomerulonephritis (EAG) induced by antibodies to renal basement membrane. Proc. Vth International Immunopathology Symposium, P. Grabar and P. Miescher, eds. Schwabe and Co., Basel, 1967. 7. Lerner, R.A., F.J. Dixon, F.E. Young, and R.J. Glassock. Isolation and characterization of soluble human glomerular basement membrane (HuGBM) antigens and the demonstration of pathogenic anti-glomerular antibody in man. Fed. Proc. 26:743,1967. 8. Lerner, R.A. and F.J. Dixon. The induction of acute glomerulonephritis in rabbits by injection of autologous and homologous glomerular basement membrane (GBM) antigens isolated'from normal urine. Proc. First Ann. Conf of the Am. Soc. of Nephrology, September, 1967. 9. Glassock, R.J., R.A. Lerner, and F.J. Dixon. Transfer of giomerulonephritis from man to monkey. Proc. First Ann. Conf. of the Am. Soc. of Nephrology, September, 1967. 10. Lerner, R.A. and F.J. Dixon. Renal antigens in urine. In: Proteins in normal and pathological urine. S. Karger, Basel, 1968.

46. Hampar, B., K. Rand, R_ Lerner, B. Del Villano, R. McAllister, L: Martos, J. Derge, C. Long, and R. Gilden. Formation syncytia in human lymphoblastoid cells infected with wile-type C viruses. Virology 55:453, 1973. 47. Lerner, R.A., F.J. Dixon, B.P. Croker, B.C. Del Villano, F.C. Jensen, S.J. Kennel, and P.J. McConahey. The possible role of oncornaviruses in the etiology and pathogenesis of murine lupus. Adv. in the Biosciences, Pergamon Press, pp. 356-365, 1974. 48. Kingsbury, D.T. and RA. Lerner. Encapsulation of lymphocyte DNA by vesicular stomatitis virus. Proc. Natl. Acad. Sci. USA 71:753, 1974. 49. Hall, M.R., W. Meinke, D.A_ Goldstein, and R.A. Lerner. Differential effects of metabolic inhibitors on cytoplasmic membrane associated and nuclear DNA. Biochem. Biophys. Res. Comm. 60:96, 1974. 50. Leavitt, R.W., R.B. Sparks, D.R. Helsinki, and R.A. Lerner. Immunoelectron microscopic localization of single-stranded regions in DNA. Biochemistry/Biophysics Meeting, 1974. 51. Dixon, F.J., B.P. Croker, B.C. Del Villano, F.C. Jensen, and R.A. Lerner. The possible role of oncornaviruses in murine lupus. Proc. Int. Symp. on Infection and Immunology in the Rheumatic Diseases, Blackwell Scientific, 1974. 52. Croker, B.P., B.C. Del Villano, F.C. Jensen, and R.A. Lerner. Immunapathogenicity and oncogenicity of murine leukemia viruses. I. Induction of immunologic disease and lymphoma in (BALB/c x NZ B) F1 mice by Scripps leukemia virus. J. Exp. Med. 140:1028-1047, 1974. 53. Puga, A., A.B. Jensen, J. Boaz, F. Jensen, D. Kohne, and R.A. Lerner. Molecular analysis of a murine leukemia virus produced by continuously growing thymocytes. Proc. 2nd Int. Congress of Immunology, Brighton, England, July 21-27, 1974. 54. Dixon, F.J., B.P. Croker, B.C. Del Vifflano, F.C. Jensen, and R.A Lerner. Imrnunopathologic consequences of murine oncornavirus infection. R.F. Beers, Jr. and E.G. Bassett, eds., Raven Press, New York, 1976. 55. Dixon, F.J., B.P. Croker, B.C. Del Villano, F.C. Jensen, and R.A. Lerner. Oncornavirus infection and "auto" immune complex disease of mice. Proc. 2nd lnt. Cong. of Immunology, Brighton, England, 1974. 56. Dixon, F.J., B.P. Croker, B.C. Del Villano, R.A. Lerner, and H. Marquardt. Oncornaviruses and immunologic disease. Vth Lepetiti Colloquium, Madrid, Spain, 1974.

68. Lerner, R.A., C.B. Wilson, B.C. Del Villano, P.J. McConahey, and F.J. Dixon. Endogenous oncornaviral gene expression in adult and fetal mice: Quantitative, histologic, and physiologic studies of the major viral glycoprotein, gp70. J. Exp. Med. 143:151-166, 1976. 69. Del Villano, B.C. and R.A. Lerner. Relationship between the oncornavirus gene product gp70 and a major protein secretion of the mouse genital tract. Nature 259:497-499, 1976. 70. Del Villano, B.C., S.J. Kennel, and R.A. Lerner. Biological and structural pleomorphism of the oncornavirus envelope glycoprotein, gp70. In: Contemporary topics in Immunobiology, Vol. 6, M.G. Hanna and F. Rapp, eds., Plenum Press, New York, 1976. 71. Lerner, R.A., B.C. Del Villano, and S.J. Kennel. Viral genes and cell surface differentiation proteins of the mouse. Proceedings, ICN-UCLA Winter Conference on Molecular and Cellular Biology, Keystone, Colorado. J. Supramol. Struc. 4, 1976. 72. Geltosky, J.E., C-H Siu, and R.A. Lerner. Glycoproteins of the plasma membrane of Dic wosteliuzn discoideurm during development. Cell 8:391- 396, 1976. 73. Del Villano, B.C., R.A. Lerner, S.J. Kennel, and J.H. Elder. Expression of an oncornavirus gene product in the mouse genital tract. In: Proceedings of the Third Annual NICHD Workshop on the Testis, University of Pittsburgh School of Medicine, eds., Raven Press, New York, 1976. 74. Siu, C-H, R.A. Lerner, and W.F. Loomis. Rapid accumulation and disappearance of plasma membrane proteins during development of wild- type and mutant strains of Dictyostelium discoideurn. J. Mol. Biol. 116:469- 488,1977. 75. Elder, J.H., F.C. Jensen, M.L. Bryant, and R.A. Lerner. Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: Virion associated and differentiation antigens encoded by a multi- gene family. Nature 267:23-28, 1977. 76. Geltosky, J.E., J. Ray, and R.A. Lerner. Use of common plant lectins for isolation and characterization of constitutive and developmentally regulated cell surface associated glycoproteins of Dictpostelium discoideum. In: Cell Surface Carbohydrates and Biological Recognition, V. Marchesi, V. Ginsburg, P. Robbins, C. Fox, eds., Alan R. Liss, Inc., New York, pp. 613-619. 1977.

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~_....~:..:.e..:.'~.e+...2.iL' ~ ..:................._, 98. Sutcliffe, J.G., T.M. Shinnick, R.A. Lerner, P. Johnson, and I. Verma. Nucleotide sequence of a cloned murine leukemia viral DNA. Cold Spring Harbor Symposia on Quantitative Biology, Vol. 44, 1980. 99. Shinnick, T.M. and R.A. Lerner. The cbA gene: Role of the 26,000 dalton carbohydrate binding protein in intracellular cohesion of developing Dictvostelium discoideum cells. Proc. Natl. Acad. Sci. USA 77:4788-4792, 1979. 100. Sutcliffe, J.G., T.M. Shinnick, I.M. Verma, and R.A. Lerner. Nucleotide sequence of Moloney leukemia virus: The 3' end reveals details of replication, analogy to bacterial transposons, and an unexpected gene. Proc. Natl. Acad. Sci. USA 77:3302-3306, 1980. 101. Geltosky, J.E., C.R. Birdwell, J. Weseman, and R.A. Lerner. A glycoprotein involved in aggregation of Dictyostelium discoideum is distributed on the cell surface in a non-random fashion favoring cell junctions. Cell 21:339-345, 1980. 102. Gautsch, J.W., J.H. Elder, F.C. Jensen, and R.A. Lerner. Structural diversity among retroviral gene products: A molecular approach to the study of biological function through structural variability. Adv. in Cancer Res. 34:171-209, 1980. 103. Sutcliffe, J.G., T.M. Shinnick, N. Green, F-T Liu, H.L. Niman, and R.A. Lerner. Chemical synthesis of a protein predicted from nucleotide sequence allows detection of a new retroviral gene product. Nature 287:801- 805, 1980. 104. Sutcliffe, J.G., T.M. Shinnick, and R.A. Lerner. Moloney leukemia virus is a transposon: Nucleotide sequence analysis identifies genes and replication details. Cold Spring Harbor Symp. on Quant. Biol. Vol. XLV, 1980, pp. 707-710. 105. Bakke, A. and R.A. Lerner. The cascade of membrane events during development. Subcellular Biochem. 8:75-122, 1981. 106. Lerner,-R.A., J.G. Sutcliffe, and T.M. Shinnick. Antibodies to chemically synthesized peptides predicted from DNA sequences as probes of gene expression. Mini-review, Cel123:309-310, 1981. 107. Ray, J. and R.A. Lerner. A biologically active receptor for the carbohydrate binding protein(s) of Dictvosteliuxn d,_scoideurn. Cell 28:91-98, 1982. 108. Lerner, R.A., N. Green, H. Alexander, F-T Liu, J.G. Sutcliffe, and T.M. Shinnick. Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc. Natl. Acad. Sci. USA 78:3403-3407, 1981. 4

109. Green, N., T.M. Shinnick, O. Witte, A. Ponticelli, J.G. Sutcliffe, and R.A. Lerner. Sequence-specific antibodies reveal that the maturation of Moloney leukemia virus envelope polyprotein involves the removal of a carboxy- terminal peptide. Proc. Natl. Acad. Sci. USA 78:6023-6027, 1981. 110. Ray, J., T.M. Shinnick, S. Alexander, and R.A. Lerner. Genetics and biochemistry of cell recognition molecules in pictvostelium discoideum. J. of Supramolec. Struct, Alan R. Liss, Inc. N.Y., pp. 789-793, 1981. 111. Schindler, J., J.W. Gautsch, R.A. Lerner, and N. Hopkins. Biochemical analysis of the p30s of N-, B-, and B-NB-tropic murine leukemia viruses of BALB/c origin. J. of Vi-rol. 39:703-712, 1981. 112. Shinnick, T.M., R.A. Lerner, and J.G. Sutcliffe. Nucleotide sequence of Moloney murine leukemia virus.' Nature 293:543-548, 1981. 113. Lerner, R.A., N. Green, A. Olson, T. Shinnick, and J.G. Sutcliffe. The development of synthetic vaccines. Hospital Practice 16:55-62, 1981. 114. Lerner, R.A. Antibodies to chemically synthesized peptides from DNA sequences as probes of gene expression. In: Molecular Genetic Neuroscience, F. E. Bloom and S. Bird, eds., Raven Press, New York, 1982. 115. Green, N., H. Alexander, A. Olson, S. Alexander, T.M. Shinnick, J.G. Sutcliffe, and R.A. Lerner. The immunogenic structure of the influenza virus hemagglutinin. Cell 28:477-489, 1982. 116. Bittle, J.L., R.A. Houghten, H. Alexander, T.M. Shinnick, J.G. Sutcliffe, R.A. Lerner, D.J. Rowlands, and F. Brown. Protection against foot-and- mouth disease by immunization with a chemically synthesized peptide predicted from the viral nudeotide sequence. Nature 298:30-33, 1982. 117. Gerin, J.L., H. Alexander, J.W-K Shih, R.H. Purcell, G. Dapolito, R. Engle, N. Green, J.G. Sutcliffe, T.M. Shinnick, and R.A. Lerner. Chemically synthesized peptides of hepatitis B surface antigen duplicate d/y specificities and induce subtype-specific antibodies in chimpanzees. Proc. Natl. Acad. Sci. USA 80:2365-2369, 1982, r0 118. Sutcliffe, J.G., R.J. Milner, R.E. Bloom, and R.A. Lerner. Common 82 ~ nucleotide sequence unique to brain RNA. Proc. Natl. Acad. Sci. USA ~ 79:4942-4946,1982. 0 CJ 119. Levy, D.E., R.A. Lerner, and M.C. Wilson. A genetic locus regulates the (~ expression of tissue specific mRNAs from multiple transcription units. ~ Proc. Nat1. Acad. Sci. USA 79:5823-5827, 1982. ~

164. Moriarty, A.M., H. Alexander, G.B. Thornton, and R.A. Lerner. Antibodies to peptides detect new hepatitis B antigen: Serological correlation with hepatocellular carcinoma. Science 227:429-433, 1985. 165. Lerner, R.A. and T.M. Shinnick. The structure of proteins in solution as revealed by antibodies to predetermined sites. 9th Int. Convoc. ImmunoL, ' Buffalo, New York, 1984, p. 50. 166. MacFarlan, R.I., B. Dietzschold, T.J. Wiktor, M. Kiel, R. Houghten, R.A. Lerner, J.G. Sutcliffe and H. Koprowski. T-cell responses to cleaved rabies virus• glycoprotein and to synthetic peptides. J. Immunol. 133:2745, 1984. 167. Shinnick, T.M., J.G. Sutcliffe, and R.A. Lerner. The structure and functional determinants of proteins as revealed by antibodies to predetermined sites. In: Trends in Pharmacological Sciences, 1984. 168. MacFarlan, KI., B. Dietzschold, H. Koprowski, M. Kiel, R. Houghten, R.A. Lerner and J_G. Sutcliffe. Localization of the immunodominant domains of rabies virus glycoprotein. In: Modern Approaches to Vaccines, R.M. Chanock and R.A. Lerner, eds., Cold Spring Harbor Press 1984, pp. 139-143. 169. Levy, D.E., R.A. Lerner, and M.C. Wilson. The Gv-1 locus coordinately regulates the expression of multiple endogenous murine retroviruses. Cell 43.:89, 1985. 170. Levy, D.E., R_A. Lerner, and M.C. Wilson. Normal expression of polymorphic endogenous retroviral RNA containing segments identical to MCF virus. J. Virology 56:691-700, 1985. 171. Wilson, I.A., D.H. Haft, E.D. Getzoff, J.A. Tainer, R.A. Lerner, and S. Brenner. Identical short peptide sequences in unrelated proteins can have different conformations: A testing ground for theories of iznmune recognition. Proc. Natl. Acad. Sci. 82:5255-5259, 1985. 172. Shinnick, T.M., J.G. Sutclifl'e, and R.A. Lerner. The structure nd functional determinants of proteins as revealed by antibodies to predetermined sites. In: Modern Biotechnology and Health: Perspectives for the Year 2000, ed., M. Patarroyo, Academic Press, Inc., Orlando, Florida, 1986. 173. Dillner, J., B. Kallin, G. HIein, H. Jornvall, H. Alexander, and R.A. Lerner. Antibodies against synthetic peptides react with the second Epstein-Barr virus associated nuclear antigen. The EMBO J. 4:1813-1818, 1985.

258. Janda, K.D., J.A Ashley, T.M. Jones, D.A. McLeod, D.M. Schloeder, M.I. Weinhouse, R.A. Lerner, R.A. Gibbs, P.A. Benkovic, R. Hilhorst and S.J. Benkovic. Catalytic antibodies with acyl transfer capabilities: Mechanistic and kinetic investigations. J. Am. Chem. Soc. 113:291-297, 1991. 259. Janda, K-D., S.J. Benkovic, D.A. McLeod, D.M. Schloeder and R.A Lerner. Substrate Attenuation: An approach to improve antibody catalysis. Tetrahedron 47:2503-2506, 1991. 260. Lerner, R.A., S.J. Benkovic and P.G. Schultz. At the crossroads of chemistry and immunology: Catalytic Antibodies. Science 252:659-667, 1991. 261. Dyson, H.J., E. Norrby, M. Feinstein, D.E. Parks, R.A. Lerner and P.E. Wright. Immunogenic peptides corresponding to the dominant antigenic region A1a597 to Cyss1s in the transmembranous protein of simian immunodeficiency virus have a propensity to fold in aqueous solutoin. Biochemistry Vol. 31, No. 5 pp. 1458-1463, 1992. 262. Kang, A.S.,. C.F. Barbas, K.D. Janda, S.J. Benkovic and R.A. Lerner. Linkage of recognition and replication functions by assembling combinatorial antibody fab libraries along phage surfaces. Proc. Natl. Acad. Sci. USA 88:4363-4366, 1991. 263. Wirsching, P., J.A Ashley, S.J. Benkovic, K.D. Janda and R.A. Lerner. An Uneypectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms. Science 252:680-685, 1991. 264. Ikeka, S., M.I. Weinhouse, K.D. Janda, R.A Lerner and S.J. Danishefsky. Asymmetric induction via a catalytic antibody. J. Am. Chem. Sac. 113:7763-7764, 1991. 265. Fujii, I., R.A. Lerner, and K.D. Janda. Enantiofacial protonation by catalytic antibodies. J. Am. Chem. Soc. 113:8528-8529, 1991. 266. Barbas, C., A.S. Kang, R.A. Lerner and S.J. Benkovic. Assembly of combinatorial antibody libraries on phage surfaces: The gene III site. Proc. Natl. Acad. Sci. USA, 88:7978-7982, 1991. 267. Tsang, P., M. Rance, R.A. Lerner, T.M. Fieser, J.M. Ostresh, R.A. Houghten and P.E. Wright. Conformation and Dynamics of an Fab'- bound peptide by isotope-edited NMR spectroscopy. Submitted, Biochemistry, 1991. 268. Benkovic, S.J., J. Adams, K.D. Janda and R.A. Lerner. A catalytic antibody uses a multistep kinetic sequence. Ciba Foundation Symposium 159, Wiley, Chichester, pp_ 4-12, 1991.

269. Sastry, L., M. Mubaraki, K.D. Janda, S.J. Benkovic and R.A. Lerner. Screening combinatorial antibody libraries for catalytic acyl transfer reaction. Ciba Foundation Symposium 159, Wiley, Chichester, pp. 145-155, 1991. 270. Iverson, B.L., S.A. Iverson, K.E. Cameron, G.K. Jahangiri, D.S. 271. Pasternak and R.A. Lerner. Tritylase antibodies. Ciba Foundation Symposium 159, Wiley, Chichester, pp. 227-235, 1991. Burton, D.R., C.F. Barbas III, M.A.A. Persson, S. Koenig, R.M. Chanock 72. and R.A. Lerner. A large array of human monoclonal antibodies to HN-1 from combinatorial libraries of asymptomatic seropositive individuals. Proc. Natl. Acad. Sci. USA, 88:10134-10137, 1991. Reymond, J.L., K.D. Janda and R.A. Lerner. Antibody catalysis of glycosidic bond hydrolysis. Angewandte Chemie Int, Ed. Engl. Vol. 30 No. 12 pp. 1711-1713, 1991. 273. Lerner, R.A., C.F. Barbas, III, A.S. Kang and D.R. Burton. On the use of combinatorial antibody libraries to clone the "Fossil Record" of an individual's immune response. Proc. Natl. Acad. Sci. USA, 88:9705-9706, 1991. 41411~~ 274. Gibbs, R.A., P.A. Benkovic, K.D. Janda, R.A. Lerner and S.J. Benkovic. 75. Substituent effects on an antibody-catalyzed hydrolysis of phenyl esters: Further evidence for an acyl-antibody intermediate. J. Am. Chem. Soc., In Press, 1991. Kang, A.S., D.R. Burton and R.A. Lerner. Combinatorial 276. immunoglobulin libraries in phage. Methods Vol. 2, No. 2, 111-118, (ed: Lerner and Burton) 1991. Dyson, J.H., G. Merutka, J.P. Waltho, R.A. Lerner, P.E. Wright. Folding -Qn. 77. of peptides fragments comprising the complete sequence of proteins: Models for initiation of protein folding. I. Myohemerythrin. J. Molecular Biology, Submitted, 1991. Zebedee, S.L., C.F. Barbas, III., Y.-L. Hom, R.H. Caothein, R. LaPolla, 78. D.R. Burton, RA Lerner and G.B. Thornton. Human combinatorial libraries to hepatitis B surface antigen: Expression on the phage surface> Submitted, CSH Symposium, 1991. Barbas III, C.F and Richard Lerner. Combinatorial immunoglobulin C N C.~ G libraries on the surface of phage (Phabs): Rapid selection of antigen- ~ specific Fabs. Methods Vol. 2, No. 2, 119-124, (ed: Lerner and Burton) 1991. ~ 279 Lerner Reymond Jean-Louis A Highly K D Janda and R O . . , . , . . . Enantioselective protonation catalyzed by an antibody. J. Am. Chem. Soc., In Press, 1991. N