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1, C ` PHILIP MORRIS INTERNATIONAL INC. INTER-OFFICE CORRESPONDENCE 120 PARK AVENUE, NEW YORK, N.Y. 10017 STRICTLY CONFIDENTIAL R. W. Murray August 8, 1989 TO: DATE: A. Whist FROM: SUBJECT: ETS Symposium This memorandum summarizes our earlier conversation concerning the ETS symposium at McGill University. What we have been~planning over the past several days is a major international symposium which would be both closed and private until the release, shortly after the symposium, of a monograph summarizing the proceedings. Our goal, of course, is to produce an impressive document that would have the potential of neutralizing two reports that are scheduled to be released near the end of this year -- an ETS risk assessment that is being prepared'by EPA and a detailed 'assessment of ETS health effects under preparation, at Rockefeller University, supervised by Professor Spitzer (an avowed anti-smoker). The EPA and Spitzer reports would cause substantial damage unless they are somehow countered. McGill University has tentatively agreed to host our symposium and Professor Donald Ecobichon of McGill, who has been consulting,with us, has agreed to serve as one of the symposium~'s organizers. Dr. Uberla of West Germany will be approached as a possible co-organizer. Our current thinking is to utilize a presentation/panel discussion format for the symposium. Specifically, we plan to select a keynote presenter for each of the major ETS health effects issues. The keynote presentations would open by describing, what is known and not known about ETS and various health effects -- for example, nonsmoker lung cancer. They would offer recommendations concerning research that should be undertaken to answer the as-yet unanswered questions. Such presentations should serve two related~ purposes: first, underscore the extent to which claims currently being made about ETS are unwarranted and, second, make a positive contribution to those who are prepared to approach the ETS issue objectively, by charting the course of future research. We propose to follow each of the keynote presentations with a panel discussion, drawing upon a number of our consultants with the appropriate expertise. We will transcribe and edit the panel discussions for inclusion~ in the monograph~ which will be published immediately following the symposium. Our experience in attending international scientific meetings is that some of the

more valuable and~ pointed comments often are made, not in formal presentations, but in the informal discussions that follow. We would like to take advantage of that experience in the proposed symposium. You will find attached a draft agenda, as well as a list of possible participants. A couple of comments about the attachment may be appropriate. You will note that we have listed as possible participants approximately 70 individual consulting scientists. We have not yet begun to make contacts with the scientists whose names appear on the list so that we cannot yet confirm their availability or willingness to participate. As you know, we are planning to hold the symposium in late October or very early November of this year -- a schedule that is dictated, of course, by the tentative release dates of the EPA and Spitzer reports. We expect that very tight schedule to present some problems, but we are hopeful that we will be able to overcome them. We have not yet developed firm budget figures for the symposium. If we are able ultimately to get 60 or 65 scientists to participate, the cost (not including publishing costs) should be in the neighborhood of $450,000 to $500,000 -- a projection that would be substantially below the cost of both the EPA and~ Spitzer projects. Having made that point, we certainly are aware that the cost we have projected is hardly insignificant and we therefore would recommend that RJR, and perhaps the TI in the United States, be asked to bear a portion of the symposium's cost. Specifically, we would sugg,est that PM, RJR and the TI each be asked to shoulder one-third! of the symposium's cost. For obvious reasons, we believe that RJR and the TI would be prepared to accept the cost-sharing that we are proposing for a number of reasons. We would be comfortable working with RJR and TI personnel on the proj ect and' are reasonably conf ident that neither the RJ~R nor TI project representatives would be other than helpful and fully supportive. Given the magnitude of this project, and the short lead time that confronts us, a great deal of work will be required on our part beginning almost immediately. Chuck Lister of Covington & Burling, London,, is ready to supervise the efforts of the scientists who agree to participate from our EEC/EEMA consulting groups, with assistance being provided by Keith Teel and Brad Smith in their London office. John Rupp will take responsibility for participating consultants from United~ States, Canada and Asia, working, with Clausen Ely, Melinda Sidak and David' Billings of Covington and Burling's Washington office. Dr. Phil Witorsch, our

United States consultant, will provide whatever technical assistance we might require. We have not attempted in this memo to set forth in a comprehensive manner all the items that we have under discussion concerning the meeting, or all of the issues that need to be resolved~to ensure its success. Thus, we need to make sure that the publisher we select is prepared to guarantee an almost unprecedented quick turnaround on the symposium monograph. I intend to talk to Leon Hertz about this once I get the green light from you. We also need~ to think further about the best way of distributing the monograph, making sure that we reach the appropriate audiences in just the right way before the EPA and Spitzer reports are released. These are not mere details, but of fundamental importance to the entire enterprise. The long and the short of it is that I think we can succeed. I'd prefer not to be mired in bureaucracy - j ust g,et on with it with my l ittle team (security is vital) and do the job as best we can. AW/rs Attachment cc: G. C. Bible W. H. Webb N. Beane

]. INTRODUCTORY REi+ARxS : Dr. Ecob i Chon ( Canada ), Dr. Uberla (West Germany) 2. ETS CHARACTERIZATIaN 'OpenincLPreserctation: To be selected. Discussants: Dr. Reasor (U.S.), Dr. Perry (U.K.), Dr. Neurath (West Germany), Dr. Schultz (West Germany), Dr. Kirk (U.K.), Dr. Reynolds Dr. Halliwell (U.K.),-Dr. Roh (South Korea), Dr. Scherer (West Germany) 3. EXPOSURE Ovenina Presentation: To be selected. 4. Discussants: Dr. Liao (&ong Kong), Oak Ridge representative (U.S.), Dr. Dinardi (U.S.), Dr. Idle (U.K.), Dr. Rim (South KQrea), Dr. Goodfellow (Canada), -I,T representative (U.S.), Dr. Gorrod (U.K.), Dr. Moscandreas (U.S.), Dr. Boiteau (France) LUNG AND aTHERCANCERSOpening Presentation: To be selected. Discussants: Dr. Roe (U.K.), Dr. Lee (U.K.), Dr. Faccini (France), Dr. Kessler (U.S.), Dr. Malmfors (Sweden), Dr. Leslie (U.K.), Dr. Skrabanek (U.K.), Dr. Field (U.K.), Dr. Viala (France), Dr. Gardiner (U.K.) 5. CARDIOVASCULAR DISEASE Oaenina Presentation: To be selected. Discussants: Dr. Baettig (Switzerland), Dr. Armitage (U.K.), Dr. Cerioli (Italy), Dr. P. Witorsch (U.S.), Dr. Voss (Denmarlc), Dr. Kismeyer (Denmark), Dr. WeQtman (U.K.), Dr. Reverente (Philippines) 6. RESPIRATORY EFFECTS IN.'ADQLTS Qpenino Presentation: To be selected. Discussants: Dr. Somera (Philippines), Dr. Kentner (West Germany), Dr. Feuer (Canada), Dr. von Essche (West Ger:nany}, Dr. Mikkaelson (Sweden), Dr. N1c::ol,. ; ;('U.K. }, Dr. Levy (U.K.?, Dr. Lo .Iacono (2talyy

7. RESPIRATORY EFFECTS IN CHILDREN Opening Presentation: To be selected. Discussants: Dr. Brown (U.K.), Dr. Go (Philippines), Dr. R. Witorsch (t1.S. ) $. RISK ASSESSMENT OpeninQ Presentation: To be selected. Discussants: Dr. Schneider (West Germany), Dr. Layard (U.S.), Dr. Atteslander (West Germany), Dr. Ginevan (,U.S.), Dr. Werko (Swed~en), Dr. Kilpatrick (U.S.), Dr. Beckleke (Canada), Dr. Bacon-Shone (Hong Kong) 9. REPRODUCTIVE EFFECTS Opening Presentation: To be selected. Discussants: Dr. Husting (U,.S.), Dr. Sullivan (U.K.), 10. Dr. Butler (U.S.) SUMMARY AND CONCLIIDING OBSERVATIONS: Dr. Ecobichon (Canada),, Dr. U erla (,West Germany)