Monthly Report Highlights 910600

Philip Morris

Monthly Report Highlights 910600

Date: 29 Jun 1991
Length: 15 pages
2021599204-2021599218
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Author: Gaisch, H.W.
Author (Organization): Ftr, Fabriques De Tabac Reunies S.A.
Document File: 2021599091/2021599400/910000
Type: MEMO, MEMORANDUM; REPT, REPORT, OTHER; ROUT, ROUTING SLIP
Area: CENTRAL FILES/PRE-DB WAREHOUSE
Litigation: Stmn/Produced
Site: R107
Characteristic: MARG, MARGINALIA
Copied: Pages, R.A.; Purcell, C.; Robinson, J.B.; Schardt, J.; Thoma, W.; Andrade, A.; Bible, G.C.; Bourlas, M.C.; Brass, H.; Brooks, B.B.; Buzzi, A.G.; Carlson, S.; Dulles, F.H.; Gembler, A.; Horst, M.D.; Lively, R.; Milby, D.; Osdene, T.S.
Request: Stmn/R1-004; Stmn/R1-005; Stmn/R2-038
Named Organization: Asfc, Assn Swisse Des Fabricants De Cigerettes; Ashrae, American Society of Heating, Refrigerating + Air-Conditioninv; Bat, British American Tobacco; Bovard; Burrus; C+B; Chiba Cancer Center; Common Working Group; Coresta Board; Coresta, Coresta; Danish Patent Office; English Language Seminar; Epa, Environmental Protection Agency; Ets Task Force; Eurobarometer; European Patent Office; Federal Office of Public Health; Fish Neave; Fresenius; Ftr, Fabriques De Tabac Reunies S.A.; German Patent Office; Hood College; Illustra; Imperial College; Inbifo, Institut Fur Biologische Forschung; Intl News Video; Iscsh; Iso; Japan Tobacco; Japanese Tobacco; London Times; Ministry of Research; Molecular Basis Human Cancer Conference; Neuchatel Office Occup Medicine Ind Hygi; Norwegian Patent Office; of People + Numbers Video; Reddie Grose; RJR, R.J.Reynolds; Ryo; Scientific Comm of the; Scientific Commission; Scientific Commission Vettorazzi Report; Scr Associati; Shb, Shook,Hardy & Bacon; Smoke Group; Social Affairs Unit; Tc; Technical Comm; Tno; Tobacco Products Research Trust; Trondheim Univ; Uk Ministry of Agriculture Food + Fish; Univ of Newcastle; Univ of Zurich; US Patent + Trademark Office; Who, World Health Org; Working Group on Ingredients; World Intellectual Property Org; Ftf; PM-Eec, PM-Eec; PM-Eema, PM-Eema; Aria
Named Person: Weetman; Westlin, A.; Wild, J.; Daylor, F.; Pages, R.A.; Altmann, H.; Anderson, D.; Andrade, A.; Atteslander, P.; Badstuber, A.; Besques, J.; Bieva, C.; Bilat, D.; Bonneric, F.; Brana, F.J.; Campbelljohnson, A.; Carchman, R.; Carugno, N.; Cerda, Lmc; Ceschini, P.; Clancy, R.; Crettaz, U.; Crommelin, R.; Dempsey, R.; Falconi, M.; Fukuma; Gaisch, H.W.; Gardiner; Gorrod; Gregg, E.; Gutzwiller; Hawkes, N.; Hoel, D.K.; Ingerman, J.; Jacono, L.; Kassman, A.; Kimura, H.; Kusumoto, Y.; Lee; Leger, J.F.; Leslie, G.; Lister, C.; Lord Mountbatten; Maillard, J.M.; Malmfors, T.; Mandiratta, J.C.; Marcovitch, I.; Martin, P.; May, R.; Montebelli, M.R.; Neurath; Newsom, J.; Nilsen; Ohkawa, Y.; Palin, B.; Peck, E.; Perry; Perry, R.; Polak, M.; Redfern, P.; Reif, H.; Romanens, Y.; Roord, Gcj; Rylander, R.; Schlatter, J.; Schneider; Schwartz; Seigo; Sterling, E.; Stuhl, O.; Thornton, R.; Tremp, E.; Vettorazzi, G.; Voss, T.; Wahren
Recipient: Logue, M.; Mcalpin, L.; Pages, R.A.; Parrish, S.; Peters, N.
Recipient (Organization): Ftr, Fabriques De Tabac Reunies S.A.
Date Loaded: 05 Jun 1998
Brand: Viceroy
UCSF Legacy ID: hrx58e00

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ROUTING LIST !voc- M. McM-p i n, --L . Peters, N. Return to Dr. Pages x Return to N. Peters - DISCARD ~

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Jt!!, 3 4991 R. A, PAGES FTR SCIENCE AND TECHNOLOGY P.O. Box CH-2003 Neuchatei / Switzerland INTER-OFFICE CORRESPONDENCE To : Mr. S. PARRISH Date : 29th June, 1991 From : H.W. GAISCH Subject : MONTHLY REPORT H I G H' L I G H T S J U N E 1 9 9 1 COPIES TO : Mr. G.C. BIBLE Mr. J. SCHARDT Mr. W. THOMA Mr. A. GEMBLER Mr. M.D. HORST Mr. F.R . DULLES Mr. H. BRASS Dr. T.S . OSDENE Mr. R. LIVELY Mr. B.B . BROOKS Mr. J.B. ROBINSON Mr. A.G . BUZZI Dr. M.C. BOURLAS Mr. D. MILBY Mr. S. CARLSON' Dr. R. PAGES Ms. C. PURCELL Mr. A. ANDRADE Abbreviations : ANB = A. BADSTUBER MPO = M. POLAK HER' = H. RE I F' PEM- P. MARTI N HGA = H.W. GAISCH PIC = P. CESCHINI, IAM1= I!. MARCOVITCH RDE = R. DEMPSEY' MJA = J.C. MANDIRATTA For further information, please contact S&T Neuchatel TEL : 41 38 31 81 71 FAX : 41 38 31 24 76

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IN-REP June, 1991 - 2 Visits/Contacts made by S&T'staff : Austria, England, France, Germany, Spain, The Netherlands, and the United States. (I)-SCIENTIFIC BRIEFINGS, MEDIA WORK - Briefings were given to (a) Mr. NIGEL HAWKES, science editor of The Times, (b) scientists of the Japanese Tobacco Company and one of their scientific advisors, (c) an Italian scientist who is a consultant to SCR Associati, Milam, and (id) Corporate Affairs staff from PM Spain. A meeting took place with Mr. ALAN CAMPBELL-JOHNSON in view of expanding!the network of contacts in the political world. The video "International News" was re-cut and reviewed. (2)-EXTRAMURAL PROJECTS,. PRIMARILY IAO EXPERIMENTAL WORK - PRESENT STATUS : - TNO CORRELATION OF RSP MEASUREMENT METHODS - OBJECTIVE : TO ESTABLISH A CORRELATION BETWEEN THE RESULTS OF THE FILTER PAD AND LIGHT SCATTERING METHODS. STATUS : The final report has been received. The report shows that light scattering methods can only be used under well defined situations. Measurements in normal situations show extremely high variations. The authors are now working on an abridged version of the report for publication. - TNO - AIR FLOW PATTERNS IN AIRCRAFT CABINS - OBJECTIVE : TO IMPROVE THE AIR QUALITY IN' PASSENGER CABINS OF NARROW-BODY AIRCRAFT. STATUS . A report is beingg prepared on mathematical models which can be derived from the experimentali data obtained from the mock-up model. Possible publications and future research, directions are now being considered. - IMPERIAL COLLEGE, LONDON - IAQ IN UK OFFICES - OBJECTIVE : TO SUPPLEMENT THE BASIC RESULTS OF THE "PERRY STUDY" WITH SOME MORE DETAILED AND REFINED INVESTIGATIONS (e.g. THE TIMEWISE CHANGE IN IAQ). STATUS : A novel type of laser-based RSP counter was finally rejected because of

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M-REP June, 1991 - 3 large long-term fluctuations and lack of correlation with gravimetric methods. - FRESENIUS - METHODS FOR IAQ MEASUREMENT - OBJECTIVE~: TO DEVELOP EQUIPMENT' (NON-OBTRUSIVE AND LABORATORY TYPE), AND METHODS TO MEASURE A WIDE VARIETY OF IAQ PARAMETERS. STATUS : No new developments. - NEURATH - VENTILATION REGIMES - OBJECTIVE : TO STUDY HOW IAQ IS INFLUENCED BY DIFFERENT TYPES OF VENTILATION, AND THEIR CONCOMITANT EFFICACIES. STATUS : Experiments of the flow characteristics of the chamber with simulated smokers are ongoing. It may be necessary to install a cooling device for the incoming air so as to stabilise the air layers in the displacement ventilation mode. - INBIFO - HUMAN CONTRIBUTIONS TO STALE AIR - OBJECTIVE : TO RELATE STALENESS OF AIR TO HUMAN METABOLIC COMPOUNDS. STATUS : Work continues on using a mass spectrometer (MS) to identify the "peak of interest", but it has been complicated by the large number of peaks and the change in retention times when the MS is connected to the GC. By isolating sections of the human body it seems that the material originates from the skin and not from breath. Measurements have shown it disappears from a room within a couple of hours, but this will be repeated with carbon dioxide measurements to d'etermine the role of ventilation. - NILSEN, TRONDHEIM UNIVERSITY - NICOTINE' CONTENT OF HUMAN HAIR AS A POSSIBLE MONITOR FOR ETS EXPOSURE - OBJECTIVE : TO ESTABLISH WHETHER OR NOT THE NICOTINE DEPOSITS FOUND IN HAIR COULD GIVE A QUANTITATIVE INDICATION OF ETS EXPOSURE. STATUS : No new developments reported'.this month. - GORROD/SCHWARTZ/WAHREN - NICOTINE METABOLISM STUDIES - OBJECTIVE: TO DESCRIBE AND MEASURE METABOLIC PATHWAYS OF NICOTINE. STATUS . Invitations have been sent to 17 persons asking, them to contribute specific chapters towards a book on nicotine and its metabolisms. The computer model

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M-REP June, 1991 - 4 - is being improved to combine pharmacodynamics (response changes according to treatment history) with the physiological phamacokinetic. - SCHNEIDER - COMPARING RISK FACTORS IN THE MODERN ENVIRONMENT - OBJECTIVE . TO INVESTIGATE AND ANALYSE MATHEMATICAL MODELS FOR RISK ASSESSMENT UNDER COMPETING RISK FACTORS AND CONFOUNDING CONDITIONS. STATUS . Testing of the computer programme has continued in order to identify and eliminate problems, and to improve its capabilities. - FRESENIUS - NICOTINE AND RELATED ALKALOIDS IN FOOD - OBJECTIVE: TO CHECK A VARIETY OF WIDELY USED FOOD AND SPICES FOR THE PRESENCE OF NICOTINE, NORNICOTINE, ANABASINE AND COTININE, AND TO DETERMINE THE AMOUNTS QUANTITATIVELY. STATUS : Due to technical difficulties there will be a delay for the results on teas, vegetables, and other foodstuffs. - LEE / GARD][NER - AVIAN CONTACTS AND RELATED DISEASES - OBJECTIVE . TO DEVELOP QUESTIONNAIRES AND CARRY OUT INTERVIEWS TO OBTAIN INFORMATION ON THE INFLUENCE OF CONTACTS WITH PET' BIRDS IN THE DEVELOPMENT OF LUNG DISEASES. STATUS : Results from 86 cases and 114 controls have been put on the computer, compared with an ultimate target of 200 cases and 400 controls. There will be no statistical evaluation before the data set is complete. - WEETMAN - REVIEW OF ASSUMPTIONS MADE BY TECHNICAL COMMITTEES WHEN DECIDING ON 'SAFE' EXPOSURE LEVELS - OBJECTIVE : TO IDENTIFY THE' SETS OF ASSUMPTIONS USED BY VARIOUS TECHNICAL COMMITTEES IN' SETTING 'SAFE' LEVELS OF EXPOSURE TO PUTATIVE INDUSTRIAL HAZARDS. STATUS : No new developments. - FRESENIUS - IAQ IN AUTOMOBILES - OBJECTIVE : TO MEASURE THE EXPOSURE OF CAR DRIVERS TO AIR POLLUTION CAUSED BY THE

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M-REP June, 1991 - 5 SURROUNDING TRAFFIC. STATUS . No new developments. A delay of the project is likely because of a shortage in trained staff at Fresenius. - FRESENIUS - LOWER ANALYTICAL THRESHOLD FOR GRAVIMETRIC MEASUREMENT OF RESPIRABLE PARTICLES - OBJECTIVE . TO ESTABLISH LOWER THRESHOLD LIMITS FOR GRAVIMETRIC RSP DETERMINATION. STATUS : No new developments. The ultra- sensitive balance is still not working. - TNO - ODOUR TRAPPING BY MEMBRANE FILTRATION - OBJECTIVE : TO REMOVE GASEOUS TOBACCO SMOKE COMPONENTS EFFECTIVELY FROM~ A SMOKE-LADEN ROOM. STATUS : Work is ongoing to define the optimal parameters for filtering hydrophilic gaseous compounds. (3)-PATENTS : D-ALANINE TREATMENT OF TOBACCO. European Patent Application No. 8719392 - FTR0081. A reply to the European Patent Office (EPO) examiner's Action has been prepared and submitted in the EPO-with a request to let this application proceed for grant. TUBE-IN-TOW HOLLOW FILTER. Norwegian Patent Application No. 882621 - FTR0072. The draft of a reply to the Norwegian Patent Office Action has been reviewed by us. Our Norwegian associates have been instructed to file this with the patent office. EXTRA SLIM CIGARETTE. British American Tobacco Co., Denmark. The Danish Patent' Examiner has issued an Official Action on this application. The examiner believes that the application contains a patentable invention, however, he requires certain amendments to be made before he grants the patent. we are keeping a watch on Danish Patent Office files. Swiss Patent 664876. For the pending court proceedings in Geneva, agreement has been finally reached between BAT and ourselves on the appointment of three

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M-REP June, 1991 - 6 common experts before the court. The team of experts is Ms. JEAN FRANCINE LEGER, Patent Attorney, Geneva, Professor NICOLA CARUGNO and Mr. FRANCIS BONNERIC. GIFT PACKET - FTR112, NEW SHOULDER PACKET - FTR113, FLAT CARTON I & II - FTR114. Formalities have been completed and these applications have now been filed in the United States Patent and Trademark Office (USPTO) before the deadlines. SKEW CUT FILTER. European Patent Application No. 87305840 - FTR0068. To meet the requirements of the EPO, the Swedish, Dutch and Italian translations have been submitted and the issue fee paid. NOVEL HINGED LID CIGARETTE PACKET - FTR123. New Patent Application. Details of this pack have been~ received from the Packaging Department in Lausanne. State-of-art searches were conducted and the information given to Reddie & Grose (R&G) with a request that we receive a copy of the draft application for approval. MIRROR PACKET. United States Design Patent Application No. 415539 - FTR0086. In response to the USPTO examiner's final~ rejection, our EEC operations management has decided not to file an appeal or continuation in this case. Fish & Neave (F&N) has been instructed accordingly. AUTOMATIC LOADER FOR FILTER TESTING MACHINE. European Patent Application No. 86810181 - FTR0065. To meet the requirements of EPO we have filed the Italian and English translations of this application in the respective patent offices. CIGARETTE WITH RECONSTITUTED TOBACCO WRAPPER. European Patent Application No. 90,312761 - FTRO092. The requested EPO Search has been received. All eight documents cited by the examiner are of technological background. We will wait for the examiner's comments before we amend the application.

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M-REP June, 1991 - 7 - PROCESS, AND MACHINE TO MANUFACTURE A CONTINUAL TOBACCO ROD. United States Patent Application No. 07/525702 - FTRO095. A reply to the USPTO Office Action has been prepared with Mr. Jeff INGERMAN of F&N who visited Neuchatel between 3rd and 6th June, 1991. DISPLAY RACK. New International Design Registration - FTR124. Instructions have been given to R&G to filie this design case in the World Intellectual Property Organisation (WIPO) designating all countries. HINGEDiRACK CIGARETTE PACKET WITH OVAL BASE SURFACE. United States Design Patent Application No. 269008 - FTROO85. We have approved~ the draft of our appeal against the USPTO examiner's final rejection and instructions have been:given to F&N to file the appeal. BACTERIAL CONTROL OF CIGARETTE BEETLES. Turkish Patent Application No. 99/91 - FTRO100. Instructions have been given to R&G to file this search before the deadline. PNEUMATIC TRANSPORT OF TOBACCO. European Patent Application No. 88810749 - FTR0074. The EPO examiner has suggested proceeding to an oral hearing to bring this application to the grant stage. We have agreed to this and have requested Bovard to attend the hearing in the EPO. PROCESS AND HOLDING DEVICE FOR THE DISTRIBUTION OF CIGARETTES. European Patent Application 91810052 - FTR102, GLUE APPLICATOR. European Patent Application No. 91810017 - FTR0096. We have received the results of European search reports which cite the same references as the International search reports. The chances that these applications will mature into patents are good and~ we have instructed our associates to wait for the examiner's comments before making any amendments. MACHINE FOR CONTROLLING THE FLOW OF TOBACCO BEFORE TRIMMING. New Applications - FTR108. Based on the Swiss

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M-REP June, 1991 - 8 - priority, a European application designating Belgium, Switzerland, Germany, France, Great Britain, Italy and the Netherlands has been filed. This case has also been filed in~ the USPTO. PROCESS AND APPARATUS FOR OPENING BOBBINS. European Patent Application No. 89810128 - FTR0082. In response to the EPO's Office Action~, we have submitted this application with new claims and an amended'specification. MACHINE FOR JOINING TWO TRAILING ENDS OF CIGARETTE FILTER PAPER. Swiss Patent Application No. 2750-90 - FTR105. The result of the international search report has been received. Four documents cited by the searching examiner are of technological nature. Bovard has beem instructed to file this case in the EPO designating Switzerland, Germany and Italy, and a national application in the United States. MACHINE FOR RECLAIMING TOBACCO FROM FAULTY CIGARETTES. West German Patent Application 4029263 - FTR107. The German Patent Office has issued an Office Action and rejected~ claims 16, 19 and 20. The examiner has also mad'e some minor specification changes. We have instructed our Germam associate to accept these changes, and also to file this case im, the EPO, designating all countries, and in the USPTO in collaboration with F&N. INVENTOR'S CERTIFICATES . During a brief handing-over ceremony on 5th June, 19911, ten inventors were honoured with certificates for their achievements by R&D and' FTR management. PATENT SEMINAR : A one day English language seminar was held in Neuchatel on 6th June, 11991. Participants included members of staff from S&T/R&D, from the legal departments of EEC and EEMA, and from,PM Munich.

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M-REP June, 1991 - 9 - (4)-WEEKLY HIGHLIGHTS : Monday 3rd : HGA/ANB - Presented our approach to the "Smoking and Health" topic to Messrs. SE:IGO FUKUMA, Emeritus Director of Chiba Cancer Center, Chiba, Japan and Corporate Adviser of Japan Tobacco Inc. (JTI), Tokyo, YOSHIHIKO OHKAWA, General Manager Scientific Information Department JTI, Tokyo, HIROSHI KIMURA, Deputy General Manager, JTI, London and YOSHIKI KUSUMOTO, Manager JTI, London. The possibility of cooperating with JTI in the political area was also explored; i.e. to join forces wherever JTI has better access or better contacts than we have. PEM/HER/RDE - Visit by Prof. GORROD to discuss the progress on the nicotine metabolism publication, the associated conference and the proposed work on glucuronides. Tuesday 4th : HGA/HER/PEM/RDE/ANB - Introductory visit to -?tteL-- GDwP Neuchatel of Messrs. ANTHONY ANDRADE, EVAN GREGG and EUGENE Y.,vvsc-~ o the Shook, Hardy & Bacon office in London. HGA ~ Meeting with Messrs. R. MAY, U. CRETTAZ and J. BESQUE on -rmzE.wA Lws.., othe coordination of ongoing work. It was decided that S&T ~P should devote more direct attention to the World Health Organisation imGeneva. IAM will increase his efforts to meet with delegates in an effort both to obtain and to convey information. To facilitate this he will liaise directly with RODIGER MAY and JEAN BESQUES, Corporate Affairs EEC and EEMA, and with TONY ANDRADE, LegaL Department PME, Lausanne. These contacts will help ensure communication along the management lines of the Company. HER/PEM - Discussion with Messrs. ANDRADE, GREGG and PECK about the planned pesticide and additive database. Wednesday 5th : IAM - Attended the presentations by the INBIFO scientists of their research projects to Drs. R. CARCHMAN (R&D Richmond) and A. KASSMAN (R&D Neuchatel). Friday 7th : HGA - Meeting in Vienna with Messrs. C. LISTER (C&B), G. LESLIE, R. PERRY and H. ALTMANN to prepare for N C N 06 ~ ~ ~ ~ W

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