Philip Morris
Ultrasonic Generation of An Aqueous Nicotine Aerosol for Subjective Testing
Fields
- Author
- Lipowicz, P.J.
- Type
- SPCH, SPEECH, PRESENTATION
- CHAR, CHART, GRAPH, TABLE, MAPS
- DRAW, DRAWING
- CHAR, CHART, GRAPH, TABLE, MAPS
- Named Person
- Gullotta, F.
- Litigation
- Stmn/Produced
- Request
- Stmn/R4-005
- Site
- R481
- Document File
- 2020126756/2020126882/Inter-Departmental Mail
- Area
- LOSEE,BRUCE/OFFICE
- Date Loaded
- 05 Jun 1998
- UCSF Legacy ID
- jtj88e00
Document Images
COlVIP ' !SON OF PHYSICAL CHARACTERISTICS
OF ULTRASONIC AEROSOL AND CIGARETTE SMOKE
Particle size
Deposition in the respiratory tract
Stability
SIZE D~ISTRIBUTION OF UL'I'RAS'ONIC AEROSOL FROM
DEVILBISS ULTRA-NEB 99
lob
2020126848
Figure 13.12 Water droplet lifetimes as function of droplet size for 0, 50, and 100%
relative humidity at 20° C.
GOALS OF PRELIMINARY TFSTING'
Adjust nicotine solution concentration
Specify certain pH levels
Adjust pressure drop in sampling tube
CURRENT PROCEDURE
Make 200 ml of 0.01 M nicotine(0.17%)! in~ water
Adjust pH of solution to range of 6 to 9' with phosphoric acid
Filter sterilize solution
Sterilize ultrasonic nebulizer in autoclave
Generate aerosol at highest power setting ( 4.5 g/min )
Confirm nicotine level in aerosol ( 30 ug per puff }.
Subject samples every 30 sec for next 4 - 6 min
CITRRENT STATUS
Aerosol generator is set up~ in Frank Gullotta'slaboratory
(T426)
We are testing different procedures for measuring nicotine
concentration in the aerosol
Preliminary subjective testing has not begun
CONCLUSIONS
We have developed an aerosol generation system for subjective
testing of an aqueous nicotine aerosol
We have resolved the major issues concerning, the test protocol
Once in place, this protocol can serve as the basis for
protocols to test other substances
