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LAW OFFICES SHOOK, HARDY & BACON MO TELECOPIER (816) 421-5547 ONE KANSAS CITY PLACE KS TELECOPIER (913) 451-8879 1200 MAIN STREET W.U.T. TELEX 426291 SH® KSCA KANSAS CITY, MISSOURI 64105 A PARTNERSHIP INCLUDING (816) 4744550 PROFESSIONAL CORPORATIONS December 6, 1988 Alexander Holtzman, Esquire Wayne W. Juchatz, Esquire Josiah S. Murray, III, Esquire Ernest Pepples, Esquire Paul A. Randover, Esquire Arthur J. Stevens, Esquire KANSAS OFFiCE 9401 INDIAN CREEK PARKWAY OVERLAND PARK, KANSAS 66210 (913) 451-M Re: Dr. Bennett Jenson's CTR Special Project Gentlemen: Dr. Bennett Jenson of Georgetown University is currently receiving support for his investigation into the presence of papil- lomavirus DNA in malignant squamous cell lesions of the upper and lower respiratory tracts on a CTR Special Project. The fresh lung tissue for this investigation was supplied by Dr. Pat Dean of the Baptist Memorial Hospital in Memphis. Dr. Dean was compensated in the amount of $3,500 every six months from project funds. Unfor- tunately, Dr. Dean has suffered a stroke and will be unable to continue his involvement in the project. In light of this development, Dr. Jenson has suggested that the project be modified to take advantage of a new and sub- stantially more sensitive test for the detection of papillomavirus DNA in paraffin-embedded tissue sections. Consequently, he has requested that the funds designated for Dr. Dean, but not expended ($14,000), and a supplementary grant of $16,000 be used to purchase laboratory equipment to continue the project. The equipment involved is a polymerase chain reaction machine ($10,000) and a DNA synthesizer ($20,000). All the reagents and technical support would be covered by current funding. We believe that this supplementary request for $16,000 is appropriate, given the change in circumstances. Moreover, it would provide the opportunity for Dr. Jenson to study archival material from his own department via the newest pathologic techniques. 2015006800

SHOOK.HARTJY&BACON December 6, 1988 Page 2 Unless I hear to the contrary by December 27, I will inform CTR that you have approved this supplementary funding. Sincerely, Bernard V. O'Neill, Jr. BVO/tks cc: Miss Janet C. Brown Francis K. Decker, Jr., Esq. Michael A. Nims, Esq. 10021036 2015006801