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f T S OSDFNE APR 1 3 M7 UNIVERSITY OF GOTHENBURG Departmentof Environmental Hygiene April 3, 1987 Dr Thomas S. Osdene, Ph.D. Director of Science and Technology Philip Morris USA Operation Center P 0 Box 26603 Richmond, Virginia 23261, USA Dear Tom: Thank you for your comments and suggestions concerning the Japanese researcher inlGeneva, I' quite agree with your view points and we wilil try to solve her engagement problemlat the university - not necessarilly at our unit - throughlthe means of a private Swi.ss foundation. Let me in this context express how valuable I think it is that we can openly d'ilscuss possibilities for chang,es or expansions of our joint program like this. Even if the question of money is always embarrassing,, I very much appreciate the tradition that we have established to discuss any'new projects openly even if the end-result is negative. Regarding our joint work in general, I have a few comments for your consideration. Work at INBIFO is going very well and the exchange of input between INBIFO, our unit at Geneva and the department in Gothenburg is very useful for all parties i:nvollvedi. We have recentLy terminated a study on the interstitial lung cells after tobacco smoke exposure and I intend to present the data at INBIFO when the final results are availablie. The exchange with Patrick Holt is a further interesting collaboration and one of his technicians wilil spend'a few months at IiNBIFO for exchange of experimental techniques. Postal adtlre',55 StreEt~~ddtlles5 Te~.lephOne Telex~ F-k h1ed~c~naregatan 031-8'~.2^15,611 21 390:M.EDENV'S'. S-400 ~33: G tl TE 80 R G 33 ~. 41 0¢'~GO 031•85 36 00 - >-.at-, 3n-

UNIVERSITY OF'GOTHENBURG Department of Environmental Hygiene Regarding our own work in Gothenburg, the efforts have been concentrated upon long term exposures with secondary cell reactions influenced by cigarette smoke. The last study demonstrates that in spite of what i~s said in the literature, the macrophage capacity to secrete chemotactic factors after cigarette smoke exposure seems to impaired whereas a:slower response from the neutrophils may be the reason why there is less accumulation of neutrophils in the lung after an inflammatory stimulance. This work has taken a considerable time as it involves five to seven weeks exposures withia fairly tedious evaluation of interstitial lung cells. I hope, however, to have a manuscript describing those data avai~lablie within the near future. In this context, a few comments about the budget. Thiss has now been at the same level for seveniyears. Initially the increasing costs were compensated by the stronger exchange position of the d'ollar. As you know, this has changed during the last years and we have now been forced to;cut back expenditures as we are hit both by the exchange rate decline and the increase in prices. With a more limited program it is, however, feasible to keep within the budget until you consider it possiblie to,expand it toicompensate for increasing, costs at some future date.. The only actual cost which, will be increasing slightly is that for travel although percentage wise it wi11! not be very dramatic. As you may recall, I organized a small symposium on inhalation toxicity last year in France where two persons from INBIFO (Walk and~Kind), as well as Patrick Holt and'ipersons from our Geneva unit participated. This type of very informali exchange of information was very fruitful and we were planning to repeat it again this year. The subject will be "Cell dynamics in pulmonary inflammation" and the meeting is planned to take place July 11 to 3, 1987. In addition to Patrick Holt, I intended to invite Clive Page from London, who has done extensive work on platelets and with whom we have been collaborating over the years. The total W N ON.=

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UNIVERSITY OF GOTHENBURG Department of Environmental Hygiene budget for this meeting,is estimatedito about 3 800 dollars. Is this a sum that you could helip out with wholly or partially from an addition to the budget or shall I try to meet it within the framework of the present bud'get? Regarding the ETS question, this i~s now in a temporary hold. I am still pressing on Linda Koo:to pushifor the publication of her tea data in its originali form. A short summary of the findings will appear in the manuscript on tea mutagenicity, which will be forwarded to you for approval shortly. Follow-up contacts have indicated that the on-going national toxicology program study on quercetine has yiel&negative result when rats are fed with the substance andithe presence of tumors is investigated. I intend to di~scuss this further with INBIFO at my next visit to establish plans for the continuation in this very interesting area. We have also requested a planning grant for an epidemiological study in Swed'en with one of the aims to try to reproduce Linda Koo's data from her Chinese population. So far, I have heard nothing regarding the possible ETS meeting in Japan and I gather that I will not be included in the program. Linda Koo is apparently going, to participate and I may be able to di~scuss this with Don Hoel as we are planning to meet during one of his forthcoming,visits to Europe. I hope that the above reviews and comments have been useful to you and I am looking forward to your comments on anyone of them. With my kindest regards Yours sincerely Ragnar Rylander Encl RR/YP