Tobacco Documents Online

R1CNMOND, VIRGINIA SASO PROJECT TRIP REL'ORT (MARCH 7- 27 ) Accomplished: Developed draft of testing procedures to be used by SASO (i.e., 'water/nicotine by GC, statistical evaluation). l,sampling, monitors, conditioning, smoking, determination of Met and participated in the PHILIP MORRIS U. S. A. INTER-GFFiCE CGRRESPGNDENCE .M. Nassir Assiri M. Mutlag Tayyari training of two SASO chemists. 3 Nassir has a degree in Food Science. Mutlag has a degree in 'Organic Chemistry. Both of them plan to get advanced degrees in previously observed the Ministry of Health's smoking operation for .however, Mutlag understands English fairly well. Both chemists had pesticides. Both have very limited skills in speaking English, the USA or UK. Mutlag has used a GC before in analyzing rwo aays. Also met PM's lawyer in the Middle East. M. Mohammed El-Zubeir Mohammed is very active in public relations work for PM in Saudi Arabia and served as the interpreter for the two SASO chemists. a possible date. (As I mentioned in an earlier memo, Mrs. Marafi, a chemist from Kuwait is also interested in a visit.) I explained on several occasions to the lawyer and chemists PM-USA's role in making and delivering the product to Saudi Arabia. Invited the two chemists and lawyer to Richmond. These three individuals are very interested in visiting Richmond's QA facility' and observing our ISO lab in the future. We discussed September as 0 .4= Discussed with PM's lawyer the organization of SASO. (See attached ~ sheet for organization chart.) SASO is a public corporation. It ~ f h i h ' ' f es s mon rom t e Ministry o as it s own budget, but receives it ~ Finance (Saudi government). All SASO employees are government ~ paid.

w 5. -Factory tour - cigarette construction -Sample receiving -Sample preparation (marking butt length) -Conditioning -Filtrona 350 smoking machine -ISO norms for cigarette testing -Operation of GC -Preparation of reagents and standards .-Calculation of ISO tar and statistical data evaluation -- During their third week of training, they will review and practice The training with the SASO chemists for the first two weeks '-covered the following: the methods and discuss "Channel-specific ventilated cigarettes" with H. Gaisch. The concept of the monitor was introduced throughout the training to the SASO chemists. PM offered to supply the monitor cigarettes to them. The following statistical evaluations weTe recommended to the chemists. a. run. ,March 30_- April 3. ~~ Jacque Zuber, Jean Marc Renaud, and-Joe HornerTwill,go to Riyadh the r'aeek of April 6 to check on progress of air conditioning and lab construction.. Jean Marc Renaud and Jacque Zuber will go back to Riyadh approximately one week later to install equipment and --begin one month process of making lab functional. Use Dixon Statistical Test for outliers on 16 port sample data. Use monitor cigarette "specifications" to provide the basis for control charts to accept or reject each smoking 8. The" completion'-of'the-SASO training'program includes: - SASO chemists will continue to train in Neuchatel during yet. If we do, PM-USA will either have to (a) have Engineering modify two of our Phipps & Bird smoking machine to take clearing puff or (b) build in a correction factor into testing. Product Development will have to be informed of impact on tar/nicotine has yet to be performed on the SM350 (the model given to SASO). It ~. has not been decided if PkI will recommend the clearing puff to SASO ~ 0 Preliminary testing at FTR has shown that taking a clearing puff Gt (as recommended by ISO) increases ISO tar by 0.2 mg/cigt. an C average and nicotine by 0.02 mg/cigt. on the Filtrona 300. Testing N delivery.

'~It is still unclear whether FTR will pursue using gas CC: C. C. Bright standardize on the testing methodology. on all their testing. They currently feel it is more convenient and efficient to stay with the Karl Fischer and Autoanalyzer. I emphasized to them the potential benefits to PM if we totally -chr.omatographic procedure (GC) for water or nicotine determination that we should both use the HP5880 in the collaborative study. How will:,.co.l],ab.or,ati..ve studies between two labs be conducted in the future? FTR currently plans to continue using their old method (Karl Fischer/Still) until HP5880 is operational. I recommended ffand approved by PM-USA, PME, and TTG. The SASO (ISO) testing methodology document needs to be finalized propose a revision to the procedure. We are currently gathering data that illustrates that injecting . duplicate aliquots does not analytically improve testing.' FTR is in agreement that we should submit data to ISO on this topic and isopropanol and methanol as an extraction solution for nicotine and water. FTR still needs to perform a study of the differences between C. E. Horner F. A. Lowman F. Pierce ~ A. Roberts -~ ;• . .. . .