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REPORT RELATES CANCER AND SMOKING and E. -Cuyler Iiam.~nond, Sc. D. at a 3ytnposium on -Dis•eases of the was made todiy (June 24) in joint paper by Oscar Auerbach, M. D., Chest at the 119th Annual American Medical Association Convention., For P.M. (CDT) Release June 24, 1970 rusrArn_e4 rPlationshi_n between 1>.1ne cancer an& cicarettes n the first of the two papers, Dr. Harmmond demonstrated that lung cancer developed in dogs v~ho smoked proportionally as many cigarettes as a habitual human smoker. ~ his:paper, Dr. Auerbach showed that filter tip cigarettes I ~, 1; r, ~ ' ~~ ~~ ` ~ f ur [TE-Q E_ AVCE R6 ~CAN itoin fJ~ k=[~CC /°;,L A s S 0 C C~ A ~ T E~ 0 !rd' 535 North nearborn Strcet,. Chicag.o,. ilUnois GOF,tO .. Rren Code 312 I L do not damage the lungs as rapidly as t.on-fi.lter cigarettes. Dr. Auer'L,-ich stated, "In dogs whi:h smoked the same number ° of cigarettes per' day, the death rate was lo,:er amonE those that slnoked: filter-tip cigarettes than amonB those which smoked non-filiter 527-1500 AUERBhC11•-lil,&UfOND - -~ --- Smoking Beagles

6 I ( i I I cigarettes." - He described the five types of tissue change which occur in the lungs of dogs exposed' to cigareL-te smoke: fibrosis; emphysema; pad-like attachments Dr. Auerba.ch concluded, "Cigarette smoking is accompanied by to.alveolar septa; thickening of arteriolar walls; and thickening of the pleura. -these histopathologic changes; the changes become progressively more advanced so long as smoking is continued; and they progress more - - _ _- - ~ ,rapidly in hea,;y smokers than in lighter smokers." In the experiment 94 pedigreed male beagles were_divided into five groups. Group C (control) smoked no cigarettes; group F (filter) smoked filter-tips; group L(light-) smoked non-filters, but only half as much as the other Qroups; Qroup H(heavy) smoked non-filters. A Teflon tube was inserted into the windpipe of each dog, and the animals were taught to inhale cigarette smoke voluntarily. Groups H and h smoked seven cigarettes a day, equal'to 42 for a 150 lb, man; group L smoked 3.5, equa7. to 21 for a 150 Lb. man. The test - per iod ttita s 875 days. 1005091740 - , I- ._ The filtered cigarettes used' Ln the experiment contained an average of 17.8 mg. of total tar, and 1..1-7' m;. of nicotine. With the filter removed, the smoke contuined: an average of 34.8 mg. of tar and 1.85 cr~;. of nicotine. The filt.er reduced the tar by 49%, nicotine by 37%. 4

c I ..3 .. 616 2(1,6. 7%) ; gr-oup L, 2 (16. 7%; group II', 12 (50'%)'; group h, 12 (5U%) . ~ '_'The death rates of the five groups of dogs," Dr. Hammond~ notes, in alignment with:the dosage of tar and nicotine relative to their mean body weight at start of the experiment." that, n the second section of the-paper Dr. Liuerbach demonstrates "Inhalation of cigarette smoke will pr_od'uce lung cancer in , °:'dogs." He'reports his findings in respect to the occurrence of non-invasive and invasive.bronchiolo-a1veolar tumors and early inVasive bronch'_al carcinoma in the same group of dogs.