Tobacco Documents Online

I F I i . . . . r CJ~1'i\C~I!i ~ SG.,1 C71' ct ~f=l'~'S S~I~~~iC ~[~ f0 -4 Ct;& 219 EAST 42nd STREET (IEIS' YoRY,, N. Y. 10017 (212) t1G7-3700 . efI'1E EFFECTS OF CIGI~i E'CTE StiOhING U?n.y DOGS" I I i I- information and interpretation of the reports by Dr. E. Cuyler Hammond, Vice President, EpidernnioloZy and; Statistical Reseurch, timerican Cancer Society, and Dr. Oscar Auerbach, Senior iiedic23_ - ,Y.n~~estigator, Veterans A~mznistration i'Iospital, ;ast Orange, T,J., and Professor of Pathology, New, York L'lleda.cal! College, at a special scientific meeting held in con,junctio-n with the meeting of. the Americ~n Cancer Society Board of Directois, February 5, 1970; Waldorf Astoria Hotel, New York City. to the same research pi oGram: "Effcdt s at Ca_UUrette S:rrokina Upon Dogs." Dr. HarLmond presented data on the design of the study, mortality and findinus in lung tissue. Dr. Aunrbachpresented findings and d-*--scussed 1,: nc-- tumors and carc:inio:niq s The work was supported by the American Cancer Society and. the Veter«ns Administration. The e-xperirnnnt was carried out at the 1jA I11jospitat in East Crance 5 N. J. Scien.tific Si.,,lif.J_cance of the Study_ 10050916'79 . . . (1) For thc *first time, scieni:ists }.latre produced 1unQ c~--'v.,~..~°t.+"v- ~-•"t.,.-"•+- "~~--`~~.........~,.---•-~..~..--.~-~- . . , . ., ; cancer iri a si~nif~_c~=nt`.ly 1argc e;cperlir.ental animal as a resu of heavy cif;arette 'siinoMng. _'.The. lung cancez' was - -~- . ~~ ~..o.~;y~^'i.rRar~~-.«f~~'~"'.''C~5'. ~•ti'?'.- -s. •- ~ a~ r

, group of pure bred beagJ.•, dogs by haviiig them . . :t cigarettes through tracheostomS_c.s. The r_csult- smoked.the cigarettes, inhaling the smoke and taking the srnol:e into their lungs xn vich the ..humans do when they smoke. (2) ' It demonstrates. for the first* time that cigarettes with . _ , fiIte-r. tips capable of reduci_ng the inhaled tar and nicotine content of the smoke by at least 49% of the tar, and by at least 37% of the nicotine are less harniful t:) smokc (in dogs) than nn- filter cigarettes. - (3) The research demonstrated dramatic differences in the incidence of malignant tumors in the filter s;r~okir:g; and non-- €ilter smoicing dogs, The fiTtcr.s used w e r e cantly reducing levels of tar and nicotine, to reduce other elements, such as gas. smolec non-filter was that the d'ogs "puffa.ng," thereby same way that effeciive in signifi- but were not de sidned higher than am:)no, the control do~s (do ;s wh-5_ch did not. smoke). However, the death rate of those dogs srnoj:ing filter cigarett.es was lo~aer- than those which smoleed the same number of non-f3l_ter cigarettes. l~~lthough Jogs fiJ_ter ci&arctE:es cxper:'1:enced less extensive dam.abe to lung tissue -- in the form of,ernphysenia,

were still a-l.i,ve and smolting filt-er ci~arettcs to the end of the study ;demonst7atcd signif:icant lung damage at auto4psy. According to Dr. 1Iammond, who reported the findings in 1ung tissues, "since the, degx•ee of such dam;xgc progr_esses with- dur2tion of smoking, thL~ euidencc indicates that lung parenchymal (tissue) damage advances less r4pidly with the smohi_n; of filter-ta.p .: . '~~. I I ~ cigarettes than with the smoking of non-filter cigarettes." He referred to this pheromenon as a"d3se-respon~se relationship Production of ',,una Cancer in Dogs 'Turnors classified as 11non•-invasiUes' were fo=d in the filter smoking do~s .. No "invas ive"' tu~~aors were found in ttiese dogs. "Invasive" twnors (cancer.) were fo111id in 12 of the heavy ,.~..~.,.~.........~-~F.,.~~-•-~..~,...~....~:~,.,..4~.-,........,~,..,a~.....-.~.~~ -~,.~~-.~..,~:~,~~.~-...~~,.,a.x..~~.~._.~ s, snnokirg non-f7_I.ter ci<,-;axette:s.-Dr. Eiuerbach stated ' smoj:er-doe in his : report that in two of the non- filter smolcincg, dogs early invasive sq,uamous cell. carcino,-,a was found in the bronchial tubes. In ca.r~!ful pathological_ e};arni:nation they were histolocicall]:y indistinoui_.shable. from that same, quite cosmon form of 1_uizd czincer in huma ns . 1005091681= L Poci_tion or tlle A:rerican Cancer Sociery (1) The ~nerican Cr-:ncer Society recogn2,Zcs the si(;nific~ nt ~;,,,.,-.._...,•,_ -~.-~..,..,.~,.....~._.~.-•-~_.._.....e.~,..-...~_....~-..,....-x.......-.....- --- .ea... nchievement of Drs. Atierbach and, Ylammond: in producing lung ,~,...~.~......,~,._. .~ .~ cancer in ~do~s sriolcin;; cigaretLesand the'i uT:pori:ant role o more - 4

the Veter ans'Administration in this joint project. Tlea_r findings should have a significant impact on the ~.a.....,._~.~...a.....~..,...._..,m..a,.~..m..~.~..~,....- smoking of cigarettes in this count-ry," and will probably lead ,.... ..~._,.,~ .~y..d.~~.....~~.. . - to a reassessmi,nt of adver_tising clairs and policies of the (2) The reports by Ih s. Haa-nnond and Auerbach demonstrate =that smoking fil:ter" cigarettes, with certain degrees of filtration, ::educed the . in-Adence of actual lung cancer within a relative:.y short ti.nie (the dogs smoked for approxir;atcly 22 years. This approximately 18 years of hum~sn life).-However, initial examinati_on of lung tissue of filter arnnkinc> rina.q w11n smnkPd fnr 27S dflvs shnwed lung tlssue damagc: 'very sa..milar to that found at an earlier stage in lungs,of dogs . smol~ing non-filter cigarettes. The latter were in the same' groups in which lung cancers later developed. Therefore, the filter cigarette cannot obJective]_y be ea:IlIed `safe" cigarette. Ho;le°~-er, cigarettes with effect.ive filte~.s are demonstrated to be less harmful than non--filters. OO CJI . O (3) The repor ts by Drs, Harr-mor:ci and Aucrb :ch are zn~ full accord with the conc.Zuive epidec11i_o7.o.2;ical and pathol.oUica1 studies in humans which led to the det' ermznution of a causal ~ .. y re3.ation^hip bet~~~e.en cigaret:te sino?:.iizg and lu:~g cancer x

.5 (L~) The findings of Drs. Aue~~l~ach and HU:~nraond eff.ect.i~>el}T ,a.,_,,.,....~.~---~- ~...•.....~...~-~-~°""°",,,,e,_•,,,,,,o----..,.~.,,.,o.~, reflite contentions by cj~~_garette manufacturing interests that ~ - . i 1' I~ and zn claims to the con' .gal ette--canec:r ~n - .,......~~...~ .~.,.~•~...o..~,~,.~.. -.~ r t (5) Filter--tip cigarette smokers should', not be Iulled into - . a feeling of false secuxity by the report of the fil.ter-tip t . - . that filter-tip ci.g"arettes s, if they ef :;ectivc.ly re-duce tar and smol:ing Portioiis of these two stu.dies. They should realize nicotine in the mainstream smoke, are, at hest, only less trary were only IIst~.tistical." ,.,o......,~...._..o...,~.~,.~....~... .~.<.._~ damaging to lung tissue than, non-filte:: cigarettes, As such, ho;~7ever, they are better than the non-filter tyPes. _

----- - '~__--_......_._ -_ ... _ _ . _ •'- - New York Times _i+cl>ruary D Ci1Gtn, p L U'; 2~ CGm=• . ~ l ~ . ~ 3 ) fff In G ro~~,z~ c! C .~~r:..P;; h L 4 c~ By LA~':ItL-\CI: K. ALT:Ii~u\T Twelve of SG bca ;t_ts that were e7hc dc •led to smoke:dcrtlop^,dlun,^, o esscs nee , two seicntists reported knol in b tH 5•' :d i }• r . T e} sa s stcrd t was ir st trmt rh b nr.nt umcrs had en pao:uced tn,lar anir,tats cxp; sii:g the aaimals to e :;arette smokc- The xientist; arc Drr E. Cuy lr r2zead, an cnid miologist' -.,o_rated with the American ~ce: Socie:}, and Dr. Oscar G,- zrbach: a patholc-ist at the erans Administration Hospi- nt Fzst Orange, N. Ji They 'r'i. ~scloscd their findings at a ~c•:s cadcrcr,cc following a reatific session of thc Amc.- n C2Wcer Society at the 473t3crfl~stort..lto3el ~ The cicty said the f r-'r;gs r 1cti c•} rc uto co.n.,.n.corsl cl„a,ctt_ manufzciur:r,g in tctrsts that ti:crc v:=s no c:gar- the tr . o tom orn, t•res con r I to 1 u rettc hold- Cri 'It:c dors ~+c;c lraillcdl to t grad;:, Ilpsmc, c,i to a ma~:i- mmnof nine ci~^rcttcs a day. All were the same brand of Frce of iirn rrrm't;;e; ci rttc, 1R ch ile res.zrchc:s rtf duration efl u linrd to tI-1 . ~t I ut t ic evid nc~ ln•~ Tnc}t' c ltl;cir tt:!c and hin I:ates t':at lun p ran h nlaij Au 5.,'r.l for s a c, arctte, "D:, (ticscc) ral ta e ac.tar,ces 1es- lr'ssu J dvna 'cav;:n [s ) c,~l The rescR c' crs rcmo, fi!tr. .~ cr~arutts ih:n .:U7:,', t1 l y do2s f o nd-a (;rousof 97< the smoking of non-fill : cig- II defo c thecs c. in%Lo;al tf iOl 1thc f arcltes." 94 rc.,l..:n 1 .:-: t tti erc Tlie srnof m r:; n_nti clcecl, as co .i: o!c 'iat is, with he 21~s t a m n;l ,ou„1 ,,ey had tr,:ch~nstor;ies„ May, 1967 at t c:ans, t::c:v dia not sa:;ke. The minis 1 tr tion Ho ^:tal in I-ast' t ro' c s'n cd in ca,cs in ~'Jrarv nd' is s~,l con i ui ^I hc c, ci r s v:herc theS6 accordm to DA+.erS c 7 Of, o , do st ved. the 91 braglcs i no:ced mhc; ~ 7 dos r^.d' con 'ctCrably cxicriment: all r~E a c-... r , 1tic.;,~a: The 33 ire. icst t;etc ~~rouq of c:g t ucre ta ,r.t to nct in oa.o gr?u,~ "t:•ith the in• 15-r:okc throuon an incaroa intent:cn cL} staok• ihci o ts. in t-lt' il c ually dicd;' In Pr ~~io,:s ~so b ot .cr }h c st J. e~:nenr rs c'c .s diod lt-I f c c: atnrlt <a s:nol;ing~ [cr 1 in b cn c res i to a c'0 v c d v d ra ao nly rc; o o: ls Ci2sz c pen ~ ti o h p: s T eh'e r_n 1 c c u:~s s. le cd G,1~3 f cr tip !rls-:[ as to v::^ .rcr li.:[-• c..cc., r. _._t~'•;,.1 t.._ C7oe__xsoi !had' bec-n in du:e.i by the . c..,,:.-i r^ lt ':i•e 36 o:ccr -n-car ccrlint-: and -:t o;aimsl } lct - . y t'ce con ary nzrc oaty I D 7 i 'no d? a T~r. 1[ hr:r e !> nn; nt )zidi _ isiict ' : I u,u auu n;ecal 11M1:O Pt.PJ..S Ode[r m nr: - „v a , sr^o I Z 7epy, the T[UUaL2v rnstt• 3 an o.a nL:.Btionspon o:ed the tobacco indts.ry, said tl•.tt it was inte:ested in the r r,fed relts of ih~ c>••p cri- m~t. hut ta~uat it t':as pos- si to ".Jta:: a m niogfuf I :par-let bet s en humz•r smok- ;in~dog.s Sicctcd to ihese m t stresfnl iaharatory coridi- liazs The stud) by Dr. Iiar.trnond (h~ Dr. Anerbadr also; foand ti follo vu : g . ._ IC-CiZarettes vrth faer tipsi ti rc::urc Lie rrhalcd tar con-' tc o`'the srt~ e by at lcastt 4 _r ccnt and th_ mhaluf nicr~..[re content by. t]cast 37 r•s ccnt are less L•trmful ti~ r t;e [11 da s] tha-[ non fl c c'cs rr rr z c..matl:. d;ffcr- cr.c tn tbe rnc,d ncc ofrn~h- - filter sntol: ;a :cnd non-fittcr smoking i~tc , • I SDcath rilcs for t'lc c.o;s l); a; snlc;c3 ssere "si ;.^.ifirnt- ly~;:;crl"ti:an ar.:o..;..iec enn- r. that [Cr..5:nei:_•.. t; , a lng nxtl tr,r_ter ci; rc "sj s ac ' , l c c a. eP; c ofv:'ltl[ on ctGcl i fi!tcr is 1 5 f Cr lt:p It harmful: tr:csc 3g [•, re cl s,ticd as li~ht than 5TO) 7:i' pI , are, es but sc ti~ lt t i= fi s."'.okers; they s.ao;:e 3,103' ci- znd "to as;cts::r n,.•_,.^.c.i Ezrottcs in the samo pcriod. s:noking ciearetles for t%co They 2; o;her dos s:'nokcd p•ear or 0 1 r%[ ll produoc G-129 no:[ fi!ter•tip c bi c!tes. lun~c.n erndo in an ta.i?: vr Dr. Auer : D1 '; the S75 dat s, "thc bach recall_1 that pitot s 1 s' dc `l rates were in 11' nmcnt done rt.l ,: m d 117aU'sc`to ,cdi itiitn oosar of lcr ard tueot'rte .1r rc!_ti[e to bodl' Ilt"' ihc C.oC tica••Ies dcv°toped Ju, diseae ucit as ec p 1}c ,~ lrescarchers c iJ ~b of the t:ad pu!m ary tib o s, as ncl!~i,c^ltrok[tied dl trisr riud as ch1n . tct t :•h^1 c~ u lt 2S of the SG c;or ilf, dog; amire I cndM a mcicscn r Ildiccf of thcse discas_s that secnbl d esrly cri cn Fn 11. . Y Ull co s thc_: sZid. Pema involves destr.c.ion ofj The lim^ d s s~s, ptdmonary air, s:1cs. Pt.lnlonar[ ubro •s,in•!~crlph3se na and fibrosis, and colirs t!m c!:vc!o?c:cr.C of fi-"t!:cirresuitnnt str,.in on tl:c brousL suc in th lu^5. . 4honrt, r..!led cor p•Imona!r. findin ' ti e re- 17•~ccr tl:e rrincipal c: u_cs of <carch r rc;)or'od At• s l~".catli tliat b a(•I6 do sv c s t > . t' d-i)• fi, iho rcvci rchcrs for ~rc p.irFa, t h..c ~7 , 1 zn p lthri to dhi h the riacd t i cot' 1`+2 1-en t! i. aops 11. I froL:,I; c• o pt fh^ for a c irf, n' r z,t!Y o !I;c t~ c~',a li ,Ics sinul.tir 4o ob i- c IUn^, tnr,u cfic t.onfiltu iir rctt r. 1 Ac: ~ c:~'t !y, the tasc. icl isj Auto lcirs uc:e p^ifon;uit bouy I t 97 yd cd m; 1 l ,,an all tl:c r'c d doi• Slidts p,les frorn tireccre svr [ ?t t rurc of t!lc lui crclio,lsicerc 1\et•r YorL nnd o. c.cn'cd tl,~.rtcn!: cl fhrn t} _Y v.Lrc resd by for' :.ca•c::.! r:cc•r., in :,lurrhlrh l:hn lrld no Ornn;:c. \V::en tt:cY b'e;.ln ;i:c-- .---_-_-. shrcl)., th'cy rn~d c a c:: nii i~ir, thrun; Ii t':u ffo:lt of cjahi do;~'s mock into LIS lrlc,:e.l, a n[innr Jlr;medurc l:no•.~n as a ir. chcoslun:y. ~ A l:cl!i,;v inhe, Mcdto 1.(4) i knowledge of c_ct[ do;'s idclitil%% IIcni z^.r,d r^a'i uu ~lo s were fcu .d in tf lua< rf o` lltesr do g. 1 0 of t' ar cS. in the control group h t cn . n. tttmots. t: e m i~n:.nt t lc.,, or cancers, were found r n 12 or the heavy smol::rs of mo:ar!tc: cig rottc . Thc t ^.;ority of mai~onant tumcrs fc'_nd ia the dogs were of a type F ov n as bronrhic-alvcot r which c s the bro-tchi and the lu 's .:, sacs I! Th sl.dcs that D: A rbach intcrprc. cd : s r7sl.~aa cc: in•r e rc ,:e'i t r Or, T` -r~-d CYcs er a,,~t o b r~ra 't \'et- erans A !ni'1 5 :1ion r:~paalin West Y-asen, Conn. I'r s,!d he „rcod with the -n ations. Tri_ msearcl:ors ss.d ...cc ; %:'ould stud' otir iiss::c;sa,c`7~as rtcn s i a-y j 4; •~ ~'~a s to c' c rn in t t r l...l 09 : s r'L lt h t rM-•t iau u_e,:n_.e -11 Lt_ sCllef-::1 ting dc ic-s. tt :fel ! the A -cln~fi Car er Socety ti[ rr.ed t-: tip a, re, ^~ s^l,:ers r_ t h~~ "1u !Jcd into a feciing of falsc; securu; by the report c:` ttr_i fiitc tio s-no:ono p,art3or:s.'o these ud c Fil er a er a f cs. if ther ctfc ti Jj rc u. tar ina n:ca•~'' (Inc in t e n [i.carn - e, ;are t b t o ly hcss utn t gi It t.::.,.u .,.an nu !t :i c:5-rc Its ' t:ic socicty so::d.

r-- r r-- r- r~~• ~. ~..~ ~.,., r r r~~ r r r~r v!vrLS!v 1 HE IdE v/ YOP.K TIi/ES, FRIAAY, FEBRUARY 6, 19i0 . - ----- -. ., y - -------- -/-•~ --~, - ---~-~--{-- ------ --ry - __- ~~'- ' ~ 1C~~~~ ~~ ofS~ V ~a ' l k~ ~JVL &l.JU LI. Y.L`lJ1l1A..j VV I'D 611l ~v: . - . . . .. . C%; 43a:tizc,i:ion ancl PlesuiEs e(- E>:;,erimonL • ' C01CNT PER . .17 Ct'A!1_'•TES "~.~eTr: • .. . . ~. ~SMOI<FD~ ~ Onr..;llh;'d:rs) OtiOI:P$ NO.OFD0G5. PcRCOG 'F.:r (vico:fnC D£ATH$ pCf'O,t " CAY S73 GROC/PC-GONT6OL5 - ' - ~- - --- 0 0 0 O . • (NC,Nsnllo is .rs) ~ - ~ ~ G. iCUP F -- ~ --- T--- ---~ ~ (S.yOKE] FILTER CIGARETTFS) 12 E,143 17.3 1.17 2 ' G r Ur'L ( Ir ~r-cr c, •0•<CRo ' OF 12 3,133 3.4.13 1.85 2~ . • _ Ou ( (F VI R~•0~(En5 CF 2,q G,729 • ( 3-3 8 1.L'5 rc IuEr,s) . PER CEO,:7 C' ,'.:JTOFSY SECTIO'S WITH .`,c`dCRE FIBF0515 G,?OUP C: GONTROLS PER CEUT OF 41-1T°^SY S?CTIOtiS WITH SSV.-Rc EuPHYScMA PEfi CENTOF 83cf ti":iiii ('i,;,Z (.1n~u~ ~ A1C E\! N Tli': ~_93 \\\\ \\ \\\~ , ,. . _ "cS^;tYOrkTi.r.r.: SoCI:'a;!crI cd ?71. ^ c~ t:r::o*o•:> tr ^ tisc¢c at scs51on. S89T60S00T _. crtaJ ic n tcaoa on crfcc: of cr- r, ,_ sr.:^f c.i c:^ -....: c:cclactc: ' c:~^^ oa ~ . [, ,~tms:: ..crc r a ncrro^s.r !. T.,.y : e 1, ^ c . ...c ,

NEW .Y D. 595;50$ - S. 1,446„507 HE%y'YOgr, CITY N.ETCOYOLtTAK /VU% Smoltin~'ari~ Cance~ To the ~;ditor: I am writ'ing, in refcrenc the Feb:,8 The e to NVcch i t lteti ietiv zrticle by 1Valt er Sulli van en- titled he L 13 ea~le Sznoked t;te ca~l e 'T Got Lunn E, Cancen. Z~'C are toltf th at 97 d o~s were used in ihe caf1eriment, iheseancI 3<et evidence on 41 ot is noi given. «'h1? pI are also to1di that the ~ heavicst do~S v;erefe e`t pu on th h~~ Slna1'l'~ scie Inlett, ntifically cedt: unso;;nd hroy :e: the ori;inal sh 97 c+ dn< ouiti }:a~~e 1:Ictn divil;, d ia n, dorn'; arno n~ the nunsmoker and tltree snlol:cr ;roU Ds b ,e- eave, the Pa,sibilexists that 1 dass are more ~ror.e t,o tutnors, irrespecfi~e of t=;ltcther they sn:al;e or not . Sincc th^ c~pe;i;;3cnt fails to rule out this nassibiiitl~ the conc•l~lsa~ns as lr c L -.6 1s not on attcmllt to eiri:;ic, ic the tob:zrao indu<t31 (I on;, no, stocl, tlicrcin), n'or docs it r.t: tenlnt' to justiR, mv a•,~: rt hahi`s sen,~cd arn not bc tzlcen sc I rlouslg, t;l;othcr criticis;lr of the c,,,;., . ..~ , aua.iU1°. Cqr~it'Clli.•r')l':', t' too small to iic usedi,r a.ta;;;tical test . cce;ltah)c Fuith.arnlare tl efo cri~;~tists. that int~licl`;on the fi, ; ~ter-tip tr;,ahcrs a higiler incitlc:nce of tunr.~ns than thclion- no};ers i; pletely co. mu;,su'i;tanti ;ted. nq) rcanal}sis of thcsc 6r pt¢ritaaicalbclic;s. (!i(1o,:rot' smolcc lr-'cause I should r;'thcr Spend my moncy on other ac- tivities.) What docs bother lne I;tho misuse of so-callcd scicntitic results by one group 1:;th vestc~t! intrrests to attacl: Prl. othcr. All this e:•:Pcrimcr,t proves i'st ~','hethcr or rot smokin" causcs JUn~; caficer in bea„Ics is as inconciusie•c now, =• ..rs it was before the cxhcri- mcnt was carried out. J.INCOr.N I'JEi:SO*1 Di;oR'ER Professor of Biolo, Amherst 'Collc~e Amherst, b4ass., Feb. 9, 1970 . .

PHILII' MOR-RIS IM.CU.lfOAAffU 100 FnRK AVEInUr_. NCV; Yo ,`K. N.Y. 10017 .Tos)i1't) 11~.('iC~r"L?LA\.aR1D CHAIRMAR 6FTH[ I30ARD Mr. WilI'ianb B. Lewis,,Chairman of the Board American Cancer Society 219 East 42nd Strect - New York, New York 10017 ~ Dear Mr. Lewis: February 27, 1970 On Fcbruary 5, Drs. Oscar Aucrbacll and E. Cuylcr Hamniond prescntedto the press at a special mcetin,; held in conjunction with the mccoing of the Anlcricar. Cancer Society Board of Dj ectors the finc:in`s of their stuciyr on "The Effects of Cjcarette Snicking Ul.on Do-s." The Society t that time issued a"Liac;;groundcr" press release intcrprctir,.; the results of the expcrilnent as a si; njfic.:nt achicvt ment :"epresenting the. first time that scientists have produced lling cancer in a)arge espcrilnctttal animal as a result of heavy smol:ing: TL-c Socjc.ty's release furthcr clainlell that thcse findings should have a si.- ,nj'ficant iurtpact on'the sniol;ja -of cig:;rettes and wili probably lead to a re; ssessl;iela of advcrti:ine claims and po;icies of the ci~arctte i'ndustry/. The report and these interprctivccolirntents have be lat ijven wide publicity. As you may l:now, there have b.:en ~rt*~~iocls st~u~'es ~1~itli cigarette snol:e in wlliclt tlie:. initial report ~ has clainleij that Itln`, Ci ncer-resenlbiln2 W11l' Ca111'Cr in hbnn,,ns-Was inC!U.r.Cil Jll CXi I11I1C:11i;1i ;1I11tn iIS. These!\'el'e PrOVt'd eltn:r\11C?_?.~~ 0, (^~ ti cjr'llrlr+ Il?lce -Iftzr t!1C recrv~C 11"f'C.' SWI ICCted,t0`lrqlit:Ol;r SClel J C C] ' l !i. U4iTC,. CeVC1op;111illtS 1i11 Cl)'lil.:etlol W1:^ Si130}i1nP.:;nU 11Caai1 nClVe soir!e1111a'S u4::;1 A.nnotlla'0j L Ililer)liihrc'.ssll'i:' IluspiCes-Sucl,l as a major universlty°-;ind,af tt'I evaluation, I1:iJe been found l0 dis;til1 olnt tilElr s1)o,IsOrs. • Since the American Cancer Soci; ty asserts that the pre.sent studh is of considcrahie import to smo}:crs, I heljcvc thatthe inllklstry is entilled to have a full undirstanding of the nature and signifirancc of the findings as duiclJy as possib,e. In U!a: intere.st of accol;lplisliin.g this ailn, I r: olt est th"ttllc Socic.t\r11rt rl thorour}l e+ tl; ntion of time e." ~I,crilnCnt cn~ it< reslllt,, hv < P;lne +.e 1 c{ nt ! of ...._.e.,. _ _- .. -. ..•. „a,_-~_ ,..,..~.......~.,,.,.«.~.-:~.~~ ~.o sCICITl15ts 1-,It1l 1t'j(lC t.\l`ir;cllci in :?9"C:1S rCI.-C•3'lt to tile (l;it;l. 1 stlr~Cst thc.foilo"-inn procellurc: 1\ hen 11ic Amenjcr,n Canr;~r Society notifics me th-lt they and! i"le invcsti;;ators have agreed to ipcrmit access to the reltvrlnt niaterials and data, ]\N-il1 nonain , r1. ,Is revi. v.rssr?yc1•:I_~ti ~ Il l l,r,h scjentistt 111o111y <tu r(i,~rl ln th•^Gcldc of ex~;erimow ! I\i1 }:,tr l:o~r pat3tolo_y and IualJdj,._ases. I b:liL;e thes; selentjs,s \;lll be recor nlzecd by the So..l,t}' : nd bytileir co).lcagues as rnen of outstandjn ; com;ntence and intcLrity. If the Socict'y should, for pod reason, rcject any of the men whosc namcs I o;ter, Iwould'appoint a substiture. The tobc?cco inr{ustrv \vjll, of coarst: bc;lr alCcosts in conncc tion with this rc\,ic\%r. J looh forwai~.d to ancilrlyfavoraLle ll~c:sponse front }',ott so that this work may Cotnmcltcc ati til, earlicst possible d'L1tC. Yours very truly, + ~! t ~~:7 tir" ~~`' 1 "•' ,.\ Vvle' E/.N ~wr JoSCpll 1. Ctlllman, 3rd Chair;nan of the Executive Comtnitlcc The Tobacco Instltutc, Ltc - • y ~ 'sa'~#,* ~+`.~ -y~~;~*~e. *~;; _.,. . . r..;~~_;..:

~~~~~r, C A N C A r~TC 1-743 Pll~ S 01 c~~~T Ys I r~TCo 219 EAST 42ND STREET • NEW YOR:, N.Y. 10017 •.(212) 867-3700 R E f:37 A kL C I-1 EF3LJCR.TIOIN SERVLCE Mr. Joseph F. Cullman, 31d = Chair nan of the E-xecu'ive Committee The 7 abacco lnstitute, Inc. Philif, Morris, Inc. 100 Park Avenue New York, New York 10017 Dear Mr. Culhnan: WILLIAM R. LEWIS CPIAIRMAN, BOARD OF qIRI'CTO7:S This Nvill ackno;~ ledge receipt of your lett&r expressing interest in the research work of Doctors Aucrbacli andHaun:nond asreported'at a spccial nrcetili~~of the ~ln,erica:~ Cancer Society lioard'~ (~n 1"e?brn3r~. C 19 'JfY Your appraisal and su, ~cstions are based a summary ~~•llichi~ti~as l~repared for the edi;';catyi~n of science «'rlterS. It is C\peetrJd that tl;c t P ) l pej?CIrt \ i ! ! l t1 n[11)]!si _~"1 li2 the ~'Cr~~T;t':,le' f! il rrC~ ~l~h;s \':Ill ~ ..-. ._ -,. _ .L~-.~ . . -_.r . _ ~. ,. $110~~` the ldlet!C!1101IS \t'Ofl3 t l~ti \ti'Clit 111tC1 t~ 1S,1: tiSt c;,~:ni ili, CXp.111]]ialt \'.'hlch we t4<;hC ve U7CCtS the hibhcst traditions and protocol of scientific invcsti/atio::. Over the years and in this latest experinient these scientists have contributed sih,,if cantly to the l:nowledCe rcfatin« to the eftects of ci«tirette snrol:M3 on do`s and humans. We suggest a study, of their fonnal papers will satisfy any scientific or other questions rcL,zrding their find'on~q witlhout = further inv.csli~!ition. ., o.. ®..,,, ~, ,.,...,. ~.~....., ~ Sincerel}; l :LLB. Williana B. Lewis