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J Coam~ents on Article by J. J. 7rentin, Y. Yabe and G. ~ylor entitled, ~ 1"The Quest for Hwmn Cancer Qiruses," published in Science, Yol. 137, V 3~ ,pages 835-8~•l, September l4, 1962 r.~ , .. bl This article is an important one and a follow-up of information yt .. ~r~ f , F "~~„ 4 r l. " - . •a ~ . . ... ~ . - ?'~'"Y~~~`~ supplied earlier in connection with the scientific meetings in Atlantic City and the reports from newspapers in April 1962. This is one of the ~ ~ ~c••"a., ~..- . . . .~ ,. a . ._..,.,....e _. f7f ~ more important papers pertaining to production of cancer by hunan viruses. gdenoviruses are comnon in a large percentage of children ... . _ . ... .. . .. . ._ ~-. ,. _.~...., . .,_. although the significance of the type 12 virus is obscure. A copy of the article is appended with two marlfled areas on page 835, one on page `'article. It should be noted from ~,ble 2 that a high percentage of i ~ ~K.... . .' . .~. . _'_... ~ . . ... .. :.. . . . ': .. ' . . .... ~ .. . .. . . . . . . . .~ . : ~ .. . ., . . ~ ... . . ,. . . ~ ., . . . . .. .... . .. : .. .with the st~ry represent the most pertinent and quotable parts of the •~ `~;..~ ,~,~"~r 839, three on page 8~+0 and one on page 8~+1. These marked areas together ~~~ected into hamsters that were less than 24 hours old. The injections tuoors was obtained with the h~i type 12 adenovirus, which was in- were made into the lung and all the tumors arose in the thoiax with some had a short induction period of only one to three months. Mention is in childhood would be important. It should be noted that the t~ors viruses. According to the theories advanced here, exposure to viruses at least being in the lung. Young animals are more susceptible to made on page 839 that simian virus produces twnors after injection into newborn hamsters. The authors present reasonably good proof that the tumors which they observed were not caused by some other viruses. Although in my opinion this does not prove that many h~sn cancers are.

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