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k h ...d .. . . . .. .. . . .... . . .. ..-~.i: ~ ~~Ls . . ~? > ~.~ Digest VII, No. 9, i~age 1, September 1962: . _ .:,. .. .. . , . . , . _. . _ iN _,. ~ ; .. . _ , - . . .', : . .:.~~. . : , . .. . . `xOn],y 20% of 300 cases of lung cancer were of peripheral origin .. r ~., ,1rm • ' :ai. _,, r * ...i:`. . ;.-: t '.;,~ .:~' y ,.fl.; . . -,~i of the central cases were located in the right stem bronchus or .xt ~x * its branches. The author points out that the preponderance of cancer j~~~if; 4 .:. (,. ,.. i : :'. Y ,;4t. .~ . .; _. .•. j •` _ ... . . .... ' . : .i ~~ ~' l. ~ .. ,..i ,. .. < c 5 a'•j't.l~-~~ f~ :. on the right side cannot be ascribed only to the effects of smoking and that the development of peripheral scar cancer cannot be explained by the .. . .. . ,. effect of smoking either. The author believes that peripheral lung cancer arising from infarcts results from the reduced oxygen supply . _ : . . . .~ , . ...,. . ..... ~ , ~k . . . . .,,. ~ .: . . ti. . .,.,., to the tissue. Simil.ar effect is exercised upon the neighboring bronchi .,: by the ectasia of the aorta through compression of the nutritive vessels. '., ,;.7hns in the etiology of central cancers of the lung, pressure exerted by the organs of the mediastinum and especialltiy by the aorta plays an important role. 1hese two factors were also discussed in ny inclosed review of $ie +e book by Spencer. Dr. Ba]:o can be cited as another person who feels that smoking does not adeqvatel,y explain the etiology of lung cancer. Dr. Balo's explanation of the role of pressure exerted by organs of the mediastinu- on the lung and possible etiology of lung cancer would not be generally accepted. If you think it is important enough, I can maintain a search to ultimateltiy look for a more definitive publication by Dr. Balo. Attachment: ..,. ~ ~ - . , ' . ... .. , . - .. . . . : ' ~ ~ . Comnents on article by J.'Balo entitled, "Etiology of lung cancer.". i~,. ~ ,.; :>...~., , ~;... ... ~>: ~ . . : - a' .~., . . .:,-> _ ..~. ... _ • ,. iAuthors' Abstracts, Eighth International Cancer Congress, Moscow, t ~ '_~~ .Li'F.n _ . ~.... . ';. ~.'.':~y ~ . t,^ ,. ,~~ '•. '_ ; .,. _ ~ ,,. , .•',' ' r ,`.~. .,.. ".. .. .,' ; U.S.S.R., Ju],y 22 28, 1962, page 281; quoted in Attachment to Current ,. . x :~' },~~ ~ - r • _. . . Q? Copy of abstract

•~'' y.\'.j~•,t 'y.7 ..~ S . ~ t- ~ .: ~... ! .:S ~,p ~ . ~ 'S d,~~Siw'ry'-~~t '' ~ ~ ~ - ~~ ..-.t.-'..i_~• H f'~'i ~; 5,. ~ ~'; ~..:. 2 ~ ~ ~- Nr!$3 (~.'. pl L . __"__---•-~ ,~.-- ~l - ~ Y.'~.r r ~.k Ti . . '1V' ..^r.:.Y~ •~~l.. l:. i"L4r ~la..~r'~~ FRCM: Abstracts of Papers, VIII Internation~l Cancer Congress, 1962 ~\. ~ . ...-. ~~7;?.~ ..., . ... • - . r _. , ti ~~ .~. - .d~..~`~.~,~'...~d?'.:c.. E ~N"~~rlr~~ ARCINOMA OF THE LUNG irstMeeting ETIOLOGY OF LUNG CANCER ,?. c~4 Vv.;. 7' d;~~d~•~ .i.: ~~~...:,... ~. T d~~; .~~~ ~• ~ y rF~x`• ~r ~ ,' 11.rn 7"i n~. -,`re•_. 3 N-: J B A L O f A HUNGARY, BUDAPEST _ .. • „ , '. , . . ° 7 4 y,f , l. Lately in aetiology of lung cancer apart from occupational influences the greatest Importance has been attributed to smoking. According to Hamperl human lung cancer cases may be divided into two groups, namely central and peripheral forms. Author investigated 300 cases of lung cancer and out of them there have been 20a/p of peri- pheral origin. 60% of the central cases is located in the right stem bronchus or in its branches. The difference existing in cancer occurrence in the right and left sides can- not be ascribed only to the effect of smoking. To explain the prevalence on the right side some other factors are to be taken into consideration. The development of periphe- ral scar cancer cannot be explained by the effect of smoking either. The scar cancers originate mostly from tubercular foci or scars of infarcts. The peripheral lung cancer arising from infarcts results from the hypoxydosis which is the result of the obstruc- tion of the pulmonary arteries. Similar effect is exercized upon the neighbouring bron- chi by the ectasia of the aorta through compression of the nutritive vessels. Thus in the aetiology of central cancers of the lung pressure exerted by the organs of the mediastinum and especially by the aorta plays an important role. To explain the aetiology of human lung cancer besides smoking some other factors must be counted upon. _ ~,. . . . CORRELATION OF PRIMARY PULMONARY NEOPLASTIC GROWTH CURVES WITH MORPHOLOGY, NECROSIS, SUR- VIVAL AND AETIOLOGY ~~.._..., J. S. S P R A T T, H. J. S P J U~T, M. TER-POGOSSIAN and Ch. L. ROPER USA, ST. LOUIS The purpose of this paper is to report observations on the grossly measurable dynamics of the growth of primary pulmonary carcinomas. The basic data consist of 28 primary pulmonary cancers observed radiographically at intervals varying from 10 to 1,600 days at Barnes Hospital, St. Louis, Mo., and the Ellis Fischel State Cancer Hospital, Columbia, Mo. On. these cases the following specific questions have been explored: 1) correlation of growth rate with differentiation, 2) correlation of the size and rate of growth of the neoplasm with central necrosis, fibrosis and spontaneous re= gression in size, 3) correlation of growth rate and tumour mass with duration of sur- vival and 4) estimation of the life history of the various types of neoplasms includ- ing possible implications ofaetiol'ogy. LES PNEUMOPATHIES AIGUES COMME "MASQUES" DU CANCER BRONCHO-PULMONAIRE N. GOLDENBERG, M. CASETTI, B. OSTAP, G. CORDUV ROUMANIE, IASSY Les pneumopathies aigues sont frtquentes dan's la ptiriode du d8but, de mAme qu'au cours de 1'dvolution ulterieure du neoplasme broncho-pulmonaire. Les formes atypiques du cancer broncho-pulmonaire, ayant un d8but de pneu- mopathie aigue, atteignent dans la statistique des auteurs 300/0, ce qui constitue une • s¢1=t`t 281 .~K 4,! u~.