Tobacco Documents Online

Summary of Report by Dr. E. L W}nider to the NCI-Tobacco Workung Croup , Persons known to be present include the followinz `~ , ~ ~ . . ; ~ax.:~, fi.. fK. n •6 ,51,'t„T+.`•: a i r"~a'-~~ fe'; J'f ..~g&`tx~ .'3 ~" -.; --- ... : ~: t ' - " ` ~ Research" on or about October 22 and 23, 1970 In New York City on the first meeting of his International Study Group on Tobacco and Health rs. Oscar Auerbach Umberto Saffiotti W. Dontenwill D. Hoffmann ' F . G. Bock •T. C. Tso B. L. Van Duuren E. L. Wynder J. D. J. Bross and Murfee The purpose of the meeting was stated to be to discuss research on smoking and health and to develop new proarams on s:noking problems. Ernphasis was placed on the development of a less harmful ctgaret. Dr. Wynder stated that tobacco industry people were no tnvi e o t is meeting because two days. they are "not free to report their own research results." The meeting lasted The group was divided into four subcommittees for purposes of specialized discussion. Chemistry: Dr. Dietrich Hoffman, Chairman cholesteiol, blood coagu;ation, platelet aciilesion as complicating factors in identifying the effects of cigarct smoke. They were concerned about carbon be controlled. The cardiologists discussed the complications of blo,Ur' pressure, 10 years;bccause of complicatinb factors, the alcohol intake of subiects must and that the tests must be able to show that this ratio can be reduced. It was felt that test:: of this nature would require subjects to smoke the cigaret~ for t eic is a morta ity ratio of at least 3 to 1 between smokers and non-smokers, Medical Association. It was agreed that these tests wiI not bc possib e un ess logists discussed monitorinb systems for testing tlic 'Tess harmful" cigaret in man. Possibilities were tests based on studies published by Bross and Gibson and by Wynder, et al., most recently in the Journal of the American tests with each other. Emphasis was placed on in vitro tests. The epidemio- ficance of the tests, how to standardize them, and how to correlate the different what are the most useful bioassay systems to test safety of cigarets, signi- indicators might used to predict biological activity. The biologists discussed 41 Biology: Dr. Umberto Saffiotti, Chairi„an Epidemiology: Dr. Bross (Roswell Park Memorial Institute), Chairman Cardiovascular: Dr. Murfee, Chairman. - The chemists discussed one of Dr. Wynder's pet subjects -- what chemical monotide and nicotine effects, and deplored the lack of work in this area. . They talked about the cffect of smoking on the acute episode. It was hypothcsized that cardiac arrhythmias may be caused by smo?:ing. The group talked about the development of new cooperative programs for the identity of less hazard- ous cigarets. They felt that positive mouse skin results should be confirnied -by tests in other systems such as animal inhalation. me

Dr. Wyzider concluded by saying that the meetings permitted people to have other similar meetings on an annual basis in various places. discuss freely their work on smoking problems; that they eap-cted to summaries being prepared by the subbroup chairmen will be made avail- - In response to an inquiry from Dr. Carl Baker, Dr. W}mder stated that able to members of the Tobacco Wor. king Group.