Tobacco Documents Online

Gt7R1: I would just like to reconcile some apparent' differences between your ;Yy~# presentation and! Dr. Astrup's presentation. Is it true that' what you were referring tu before was speciticallv obtained with CO exposurr°only,. not withlci arette smokine) Would' ou care to comment on whether there is '' ~ y an implication that other smoke components may counteract the effects of _ CO7' • ;'SCHWaRT2: The data, has not yet been totally analyzed. It may be possible. with more varied' anadysis, to look at independent effects of CO levels versus other factors. I can't answer that question. Our study basically gives the results of chronic smoking exposure in nonhuman, primates on lipids- ant. various other things. whereas •Dr. Astrup's data is qµice clearly the effect of CO. I don't think these are necessarily in eontl6ct, but we obviously have a more complicated sys- tem. ~ GORt: Dr. Astrup presented!some similar data at a meeting in Berlin almost a 1' year ago. I' remember that even at that time he showed some different results at different times during the experiment and could not confirm previous experience concernin,... ASTRUP: ...direct toxicity of CO on the endotheliall lining?' GORI: Right. At that'time, we werralsospeaking of the necessity of carrying on studies with CO in different anitnals, particularly in primates. Do you - think that the results that Dr. Schwartz has reported are more pertinent'to the human, situation than what one could have obtained with rabbits or with guinea pigs? A:STRtuP: I' think they are, because he uses tobacco smoke. I think it is J' important, to distinguish between the various components in tobacco smoke for identifying the real'toxic ones. , • . . ~ SCHWARTZ: I agree with Dr. Astrup that one really needs to be able to do. _ these things, both i^ terms of the total smoking situation and tr.e manipu- lation of different types of cigarettes gi'ving,differenrtypes of response. lnn addition, in the acute studies example. ti think we should be looking, at some of the smoking components, spet:iticallyas independent %ariables: