Tobacco Documents Online

Jack P. Strong, M.D. Professor and Head Departrent of Patholo~r Lotiisiana State University Medical Center 151+2 T.i? ar.e Avenue r1ew Orleans, Louisiana 70112 Dear Doctor Strong: ~ I have been planning to write to you ever since our visit last January, about the several items in my notes. Your letter now pr_ ,rides the stim,zlus to tuke ection. Acetonitr-, ic 2r.ost of what has been done on tRi s' is no'it yet publisi:e3 and ve thina that corsiderably more chemical: croa•: is sti?l n:.•eded to validate the L:ethoe?olo,>y and espe•ciuhy~ to solve the probler^:.~ ol" kirC.'f:~ '7.cs in' £tbsJrp''vion and excretion. S'G4diL.s ' :.iT the subject w:.3'e i.nit-iac'cd at the Suuth:.7est Research Insti tute in San Antonio un de:c government contrect-s and then continued under a ~sant fro-i this Council. Before the vor1: iiay completed, the mn *;ino ;-;ns r':,o::t corce.-nea v*ith it L'"x^.dC a move. We have just received a "I'].n°.l" r epor t btit this 1.e-.-': as many lo7:,e ends. Under sE.rm-rate cover, ty:' are sending -%'%-.,u c:)pies o2' the brief notes that Y•,ave been pticlishra and excarpt, fmm t}ze repor'L.s we 'hk^.tTe. Vnese are to be considcre:i confid4ntia:1l and, as ycai wil?' see, do not addd tip to a validated method ready for r:.}atil:e aj al icztion. Tf you sris,z to (,;Pt into thi.s subject, it m:.3..]l reduiie so_.e constriicti•ze thin':.- ing and further re:,earch. The mterial iw ir,t; n~;3 to s<ve time and as; ist in research into applicahility rather than as a da:cription of a teyf:e•d r:e th:.eIo7.oZy. Inhalation St-ndiew I thin?; you have received a copy of our Arlnu^1 Y.epo,.t for 7.955-l5~~. On pa„es 11-13 yau fri_ll ftir.d a report of our conference on tecilnini:es for exaosure of anjr:;ls to ci;3rE:ttc s,no'.ic illial- ation, incli:clir., a statcr.ent of the conditions that we feel r:ust be net to 1=::'.-:L ..^;Llch ralaLy Li.^•f'fZ,L1: in dE.'.`.'cribing dose-response Until there is so:-_c satisfactoi f I_etho:l for controlli:~~ and es>r~:,ttir~ the aCtu.~~ ]_t'.i - sL1I'f c ce e2.`?37211~ C3 to {;h~ ?32rticllL'Ite ai, dgas plu: vapor p:1.;lses 1Jf smol-.e, attellpts to relut` specific h1s l oil,'~n,tlloLogicz1 cl_an;;es to do::W;;e will reL:ain im"ther vaZ~Lely q!aali tative. t1e are concentrutir.i-3 on, these probl.mr_s at present and have r:~cte pr~o,-;ress ir.sofar as si!al1 €tniLials are cor,cerne•d. .~,`zmn].l r.;dents, however, have r.ot been use•d very 1:'i'.Ich for studies of the carili o:rC4.JcLlJ__ir. S,r.i tCM , Lilal, so far as I know, there is little bacnZic-:r,d on the proce'-ses of Ertez•iW sclerosis in such zni;::aLs.

. lines. They will surel,y preyent a more difficult problcm because of We are just now undertalcing an inl:a].ation stuJy with dogs to vorI: out better method.oloa.r. Wo rlve not tacklicd primiteU along these their ffarni•a7l de.Yterity. to physio7.o~ice,1, p atholo-ica,h orUbioch ::aicall ones. . For tslese rc:Nso:Is, I am sure our Board mc,bers feel that spon- ttlneous s~olcin~ by baboons cat present, contribute in a ~;eaninGf7z1 n:anner rather to stud;,• of pSyd'~l_of-ieal and r:':otivations.~l p`aenoz~~er.a than pila'.s or by injection) at uev~?2c-A levels for oC.wcrvation oi any di2fe?rt:ncvs induced by the a]%m].oi'd. The pocsibility of using prir,atec, especially s~ller onpN, as a Lodel for atherosclerosis studies see.aG r<o.:a prc•misin~ for tiie i~Ii~leai~at eate future. If conditions can be established for i,rof?ucin- lesions closely rese,mblinn the Ir;~:an ones, in a c3.r ~ ~~.~~_ s ii t~•nt aazd renrocl~~cibtn "^i.,~•, it ~ , nig_zt be pousible to' suPorir•:posc chronic .ic~%c I~:~ s:;er, food, cr~Zn~~.r-~; heter3~;er.eous aerosol. thi,^a scCr:LS not y,~"C- to be at hand. L`.';:1 f1'Jre in'1:c-2'E'..Stin~--n,, perii':75, would be supe=•i^~p:,sEd in.hc:l.ation of tac Gas p:L:se of s?~ohe or of cc1;;_~zIc cor.- stituen4s, eSp<:ci:.'..?:y car'con' zloT.oni'de (see ilsurizp). The last ::i;o-irld. be far eZtier e:~erimentclJ:y since it would not inwolve t'sie h--r.d,'!in~ of a rapidly _It 4rould actua.ll . be much Ltore interesting to s:tp-a•rir:n;,ue uhole sraohe inh??ntin:a upon the at-hero~;e.zic rc.;;i,:_c:I, but t.Yie r~eth,3oloa for To riake any such studier practical, we would nced a basic a4i:ox- o~4nic regu.n giving rathc?• unifo3.-a ca°fectn sa tha.t we Ffo',u.d i;ot have to ;tlye >andiL?y large nur.?bers of anii:.al.s. ~ • utJfia;'l s ~~?u..~y At2ong wl'L the subjects t;e discussed, it seen-3 Loat a_r.r:,nos to provide for continuation off youz p,esent autopsy si,uc!.y until a tatall of 1500 cases has bi Cil acctLT:'1'.LZ1tGd, a2'sd to Colltinuc9 ana~.]ysiN of d•'-l,t,.~'. ArtCricl of ••o;; L"T I::^I1 2'Ace rehltior. ,. ...... -~....-..~ . ~..,~_..._...J_ Thi:: lcihd of t'clir.~ ur.:~oubtc;c'>f ou~ht to be donc• but I n~I tun ceT•t,in as to h:=u directly reZev,:r.L to our purpoCec; shch stuciies c:iL be co ~.ic'crel by our i?.card. Lur•~ lz11 i_c?s Since seveval. studies orI tiie effects of e:uonic inflt.ences on lung st:rfactant arc r_c,;r under way unc?er our sponsol:iri:p c)r trnt of the A.~:I.A.---'. car:::ot ca:'+i1J' JLI::~~? Slhet2'i-r oilz' .^U3a1'd :7'il1_ fCe.l tl?<^t L"J~1"e is n~'.'.L.C:.~i ..L.C:.~i. It r1~;ht depend on 01lct?Ier >7oi~e pra;s~isin- r.I^ttiocis or bci;ter c ntel desij~I;s can-bc cu.`zestcd.

Jack P. Strong, M.D. «e are enclosing a copy of the recent paper by Torii3orn Lundmn It presents very co3ent evidence of the Senetic influence in coronary ;. heart disease as cor:ipared to enviror^ientwl ones. Yeanwhile proaress is being mde in the study of ho,•r other habits and practises tend to °cluster"' t::ith ci,3rette smokinS. Mr. Kurt Ehs3.ein who is aaplyinS rmltivaria.te analysis to large bodies of descriptive data fron. epi«emiolo~i cal studies erpres; es this by sayin~ that "s::o:;inS and drinking appear to be stu?-:arizin-g other and p_rh aps un M4asured variables". In termr of such variabi.es, he is attermptin- to "describe" the smoker es compared to the non-smoker. We hope that the co.riJin`1t7.on of data from such tiore sopnisticated epidt-mio]:o~;,ical studies and expcrit-iental one;; will produce some defir.ite ans1'ieis ln~ time. With kind regards, Sincerely yours, Robert C. Yo.^::?i:t, Tit.D. Associate Scientific Director P.S. We enclose three sets of our revised apul.i catiot, for;:1. ilte• next logical tai•Get date wi]1 be the Se,Aedber r:.cet~.nS of our Scicntific Advisozy raard. The dcad].ine is AuC-;ust first but c_ v1_er receipt is an advu.nta ;e since it spreads out the Boe.rd''s wor k load.