Tobacco Documents Online

1 w Jack P. Stror,;, bS.D. Iiead Professor and Departmen"t of Fatholoa Iou.i.siz~na State University .'•s`edicaa. Cez;ter 1Y42 T\c._,:e Avcltue 2yew ©rleen,, Iouisi sna 70112 Decemb2r 5, 1566 Derr hoctor St_orz: 1 In acco,: ~ance yrnth your rel~1L''3 Y, ne sent you a}~plicat: o t for•~s o:~ Octo3er 2'st, a..dassk~,c that t:e s~oo1d : c rect~ivy~ a for Fsz a;~r~zl S{il?~ jj on i:eff ~,C "~ J~' .^i ~lo~C1IIr ?_1~ Y'_"! CC v7 i2c: = c JG?? :: ..".Cl^._`'O.^, :S . 1 :i:2oiLlCi ~ .aa:~ J. a :1Cyt ::~}, ~1 ?.e:.1 t: E'.r:'iio:1T•i poila out ~ :.ir :: .:~~ sze ravisj.nG oas• fo~ ~Zn J E.r .d ;~ y ' be E'~i^:?~..~~)._ i, _i in ^ fL;i Wc^.c''.~iS ..~iS. i:v^ iT'~11 :.'.'.Cl' ~'.7L:. C0y)1.c3 of ±~.'sC3C~ 2I1~ ' '~i_ri:'.y I7.°.y reach J ou in t_j1,.e for use in outlinir. ; y:.:]r pl a",~Jc: e3 i~t r_si~~a4~ c_z. ~ :'1,n.e haIl. •"ie::1Z Li'3.vc.'•'lc.`~.e r"l?ferC:1CC'j' to 4:: 1C _~~ t. '_lr ;lJL' ai.'it''' been J~3 O. by ' ia C'Jl'.A. J c u1 `JiZ S l l'l :~~'a3 :~Olt .i.f:.~.s i+ ~~"1 T:23'1. t.U dClI { ~ b!'..~.^,.ooa."i. 'I'Z?l3 pt7.2'1pClC.' of us1n`i b£:Loo::S i.1 cTr.'cd~n'I?.scul.ox c^,.S Y L.i1 C. ~i:?11~. '' ~ ~F~M:^ siJr".ZJ 'th:V ~ ~• ..a•' ClO:c^7,)~' i~2~^~.:i-^:1 s.:i-^:1s to ~ii~:^ hv?1G1•? 5~.~ is J '~'Y.Z~1L J"~i~ 1.°..:.° ~ F211I.. )(,L':\ ~O ~ 1G .. ,v ' • J\ J. disease. l;lso, since it is : c' •~ :~u .': ; cn.t' c~: ,~d ;_L^os~ any kil,,± of ea^c_. .a~n~a1 die;, ti•.ct .~cf Ue of iii{;^rat in to c_;ii;o- ~. ~..,.~1..... ,.. vt?.vCa'LIL.' Ci1.°C::~C. On th^ o~'1.1a°r h?_`•.id:, Yl.',.•a c'~:J~`i of i~„ a.:......,.~_.1'IZ3 bCbooi3:S rCLi?Cr 1'.i'ic;ii.Z?IiS I:C 's:?.^.?l I ti:•i?£\t T:Ltst be i?]vOhi::Ci. l:c°9.2' nol::al JL.CfC sr,~t.n JJ w..\~..JJ.I. t'n c1~L'it.. 1~~7•1-JJU.S2~l ` •: ~•J 4:L'~C..t lC~.'j, lss ol ii0:.a1.la.l~ bt~ + uC. ~.t J - - alveCasaly. l+.Yl.^JS.'h..n.' reason for vZ33 .".Cltscti v-1 of tJeJCo:1S, Cw~'CO.'lL.lll~~j. b0 :Jo.'i+C that they cc~ be t._t;,.1~ ~,:*t J to c~ •ro~'-.,. ci~~-arctt.cs ,arcttcs as ~no:~ ~~e t•i>^,,.:..~ reports, is t.]o iit ~ls . `i'his fac'c, if it is true, su<;Gcstc t:Za.t t'c,,eir r.::c in' tc'swvic.:cl .tLr'.±'es i.light be Si?-t~S "~ On tl '.c o'° Yr.~r .~_ e' ~ta ^1, o- e C~<~.,~ p: ..o~le.1, eV~n ~.Il h....s:1 sti_?i?-t~ •~_ qua:Y_ of s3to~~:r;, is -it?e dii'ficuJ.-cs of relctir_-; zctuc_L c]~.o: x desage to euny biolo-ical or h;,+-~Yoi;hctical consequence of s::,o):i;1<;. L•?e ha-re been conluctir,-, sro?:^ inh•:1ntton e::p°ri.-:c]Its with sne11. IJ eaZ~iT:~sls fo.^ ::.h^,_:';: ten y~rrs. T?,^ origi*ta1 *_c°et'~ods ti~e_~e pret~y ccude bttt, little O ~ ~. ,~L,___;, l:~ve bc ..i so that .o r ~.e fcel that ti,L i2to1~ O by ~..~ ~tle, ,. „ c,~ q es ?_ p o: ed ~ Motr to crsrf~ o~.t ~rto':^ inhal~:tio~i exi~:Jsure ssures t;r: cr coiidi{~;rci:, clo:.:~~ : es;.=~~lin~ '~ ~"ti`~'~.. ' enrQ~`3i'CC~` r~Cl in ii!C' .n'.n tT~.th o~Js- "ci.iV3 of ac~.ui!1 L'.aQo.^~U.Y'b' to ~'i^..th ~` v_A., 1'ih2 P%'.i t1cU-1__t3 %111 ea sp'2a:cs of {:h,-smoliC r W,°?C p ~.c^:.\'I' to C:1'l.E'.:".:1 th^,se svU^1e.. J.n ~ an effort to ~c ~~o~~3 dczc resi o:ac r:c~ ,~rc' ei?ia in tc~: ts of pal.^i~onaxnf Qp m : ~ In thirJ f_tell -L•l:~-re a_c great aclrranJGar-es iIi the usc of 1=iec silace 00 I ~cll-St<~~ ~.~Y'c?L~^4 ii::-leC ~leC~ 3J.rui:1,5 are rCliy~liCli ntti)er3 Oi eni'm rls cc;i' Ue u.sed s'or li`_'etil:-n e, c~^:~L :o~n;a . Th _ pro5]~e~:^p o" n swa tze ~: c~ela:^.iI .f1 -, • t dif.i c~:1 4. I~Iice I.~~ c~el for Lt~;ies of , -'.,a.xs " ~o be s' ;:~la r ~tl' ,:rosclc;•osi.s y ~7~ _a _ Y

•Jack P. Strong, M.D. . t b i ' ~ no L verf sat sfactory for such ~ror r.. We sponso:ed a few studies several years aZo in w.ach -rabbits and hens, fed high cholesterol die ts, 'Wer^ used as. the nodel. This techrdqi.e vas not eltogcther satisfactory ti:e, thought, culd WL batie Yioped that a better raodel miGht now be available for a reixsti tion of this kind of work. W.e have been told for several yea.rr that a coloq* of 'Mall primates was to be set up in Boston in connection with the Hasvard School of Public Hea].th.'s ~ r _.. Depart.ent ox Ilutz•itzoi. This ha,s now boen done and sev~:rald varieties of small primates are being bred in captivity and stanei.<ti-diced strains developed. Since dietary factors az•e regarded as havin ; a relatioln to atherosclerosis, this colony has se::m_d to us to be a possibly prosising locale for 'atheroge7esis studies i•Ahere sta_nda±-dized diets could be caazain=d wi;:h eitner chz°oaLc nicotine dos4se or actual sno'r_e e}rosure. We have not yet enctered into any actuall neUotiatio.ris with that group, az:d would certainly like to ka:o1;* r..ore abov.t the bwckgrous_d work and pilot studies tih-st- have been carr ied out by you and your associates. I think it Slouldd be a very good thing if we couiLd' get toge tner in the very near futw•c for a leisurely discuss.z on of tlti^ whole p2c~ale;~ and the vaxious trar^s in tinUch it znight be anproa.chvd.. A.rour.d th;; ttLrr_ of the yL,a,r I F;:, pla-ra.iir.; to rse0ke a trip to Houston and proba.bl,}r Sun ts.Lonio oa other r1a.LtA:.Ts. Ferh:~:as vre could a1so have a conference in t.ic course of that triP, and if there is wok k on athLrosc1Grozis in San Lntonio that I shol`.~,.d sEe I niCtl'i~ I'~...aj.4 orGe vi sit sex re' sevc;ral p112'p: J;;e s . I = enclosing copies of t,:o publications Ll~at I haiJr,a,~c:d to ruwa iTito . recently a-al which nay be of srs:n.,, interest to you. With kind re;;r~~ds, RCH: ek SincFrc7y, Robert C. Hoc::;.•tit, 1-"n.D. Associate Scien;;ir.ic Director encl.a. 1. A. S. Milton. The effect of nicotine on blood glucose levels and plasma non-esterified fatty acid levels in the intact and adrenalectomized ca.t. Brit. J. Pharmacol., 26/1:256-263 (1966). 2. Robert E. CGrrol].. The relationship of cadmiura in the air to cardiovascular disease death rates. JI.A.M.A., 198/3:267-269, Oct. 17, i;b6. 40