Tobacco Documents Online

Jack P. Stronr, M.D. ProfecEor of P`itholoM.y School of 1'edicine Iaui:siana State University 1542 rimlane Avenue P.1ew Orleans, Louisiana 70112 Dear Doctor Stror:g: - === Mr. Hoyt has turned over to rce the abstract you prepared for the sic?erah7~r influence tr.e fut±rre di.rection anl cr:p':.ir~la in our reccarcn pro4Jrer~, long-te~1:, study rat:.ar irupatientl.y in the c::ia~^cta~;ion that they would con- , rcad F.ith F;reat interest. Indeed we have t,ee;~ ati~ aiti~rS the resul'~s of this r~ m,ericaii Ifedrt Associt:tion r^: etin3 in Vesr York on Cct:,ber 20th. It has been, '; . T'his prasises to be the czse. c,evi:.e some e_•:perim-Vntal aphrocchery to this p.ro'bl::r3, in the expectation that ""Mt t~Lri fhtui'e ir.tcrest in cardiovascular diccase vould J•ie in this area. fai)y to occru: waclc .,uc.h _r•~,,1ox~J are ~ery F~uvz?ncc~~. r~n cil~rt ~aas M.;~a~ to frE~,uently occur: ~1 hwre there iw r`l,.tiit~aly Iittl:e at:_eLosL3.zro:~i a:ia and aftei, + .. ~ . ather:,.^,cl erosiz tends in Ceneral to prosi.sPone to int'arct:lon, yet the 1...~tt;c~r infox-L-al conference on thi:, latter subjc:ct S:;?3 h?2d in our ofi'ice83 on Jture 10, " ' ~cilit "' h.~, atterued by about a dozen :; e a a y. lhey t:ec:.,ed' to a;;~~ea that t:~oa~;n tion in : ub;;ects vho have dcvcd opcd a prc.+dic,posi_r: ; do~;rer of se'! ea•oai::. An ania:^s that precipitate acute clinical events sacli as thr--:a'cosi:. arcl/os, ir_x^r-c-~ ~ i:e could then have focussed our attention chiefZy upon the a;i.11-::~ascurc mech :'4 eleroti.c precaaceU and could virtually have vritten t:+_is off a^ a po::azbili'ty, w„ of any other ci&arette cuo::e inSre'ient sy ;;i2if i c.~:ili;i_y~ tl?y? f:tf:2r'3:j- mi;;1it have been warranted. We cculd have asst;r:e3, rather dc.?i ~zitr•1;~, that neither chronic nicotine absorption at cusico7i:-ix*y levels, nor the absorption s:?O~Sii'1n and the der%e..^ hc^.rJ scler osi. so~ r~:~t} i:r G.ef yni vi3 c7i:^~.'•1;. J;72'9 `~ ~ ~~ n ~f at _^, .~' a .. , tA If you had found a definite lack of correlr.ti o:r bet,,.een ci,;:ar.ette tion. 'L'he rensoz;n for this exaactation were Pa fello .+s : We h,a rather e::pccted that you would fir•d sucP+_ a lack of co: rcla- 1. Gur own cni*-3l gtu:dics involving t:.uperpaditaon of chroni c nic- otii:c dosaSt; up:,n an athero;;enic dii;t sao::cd no consiytent difi"ercr.ces bctweLn the ni:ii;.zlr, receivi.n; tl:c aLha~].oid ard t21n.;e on the die t aloizc. S 2. The sivila2• pasii- ortcm p':tliolo;:,y ctudies of ;f3let:s i1n;l Pl;_.ir and of Spwin, which F-t:ocatia little r,:;coci ation. 3. Tiie Fr. ry3n~;'ae~ :~.11? Zr,y n ti.~lice sho,: i:n~ that anZii;a pectoris no oft:c»er or carlicr thar: no>>-ai~."j.-.:a;:cra. 1003546880

The fact that cigar and pipe s:.:okcrs e:,pcricnce little greater:' 7 mortality frou•I iucli4raic heart diseascs than no:I-cml<,ers althoujj~ they probably absorb as much nicotine as ciryarettry sz.zo'iera. = (This rer:•:.~ins to be de:~onstratetl definitely). ~ 1•~r re2aoning throu;hout the eourse of your atuety has been that the ' deronstration of a non-corre2ation would pclmjt definite scientil'ic concZus- ion3. On the other hand, the findin.Z of a positive correlation would leave us, froT:1 the standpoint of lo-ic, very nearly where we were beforc. That is, the o^cibility that ni cot ine (or soms other sI~ohe inyr_edient) ray contribute to the Ati.era3c'lerotic process would reiairj open, but the exiotcnce of a cor- relation would IIo-t be sufficiel,t to d:.monstr.ate t:°_xt nicoti.I.e or othcr in,;,rcd- ient actual.l,y d;res so. ihe -Y'canon, of course, is tliat cne subjects a:ere not ranctv.~Iized before the irp:sitioli oi nicotil,L do30-e (or :,moxing) s4. would be the case in or sni"ml cai:cri:+._ont, but were we17 -avlc'c4cd. If sm•~''a.rg is a respora;e to constitutio.nal ia.ct'oru of oersana.ity, ability to copL with stres3 and alL,ieLy etc. ai.d ic t.z-3,refore c.caoci..,tod 1"'it'ri a v}.o?.e ~•stylr of ].ii°e "°e" Cunt is different fro,i i;'_at of eVLl0 r.cea sces to in3icc.te, then thc;~c ft.ctoz•~: or liic: h:b_i.ts (e,:crcize, sl.ce_), use oif aQplri.n, coffee drilir-inZ, alcohol coI.::t1:ip'U*_;,n, diet etc.) ::Z_,;Zt be tiae cau:,cs otf thIe dii'.icz•Cnc-_s in dC~i'::c of arcerinl only be rez 1_.ectc~d in the s~lo:,ing pr~icLis°.,. Your fin(ZiI?£;F3 !'ill;,gefit tvlat we f2?~v.3 t::) U:hie i`t li:e i~t= 1.1 Si1! 2' contro]_lc;l £I13L:1l e_q:ericanis, hopc;,1,tlly u:.an2y~ beU:r mdlals Fc::a dc:t the previouy one:s, to i.ro]ai;c a:A evaluate [illy speci.ii.c n ic'~Lit.e ei 'ei:t t:::at mly exist. They E.'ZfJJ €Liv"~~ Cil: that.ve I:'.uy I;~i.'.:;:Z to l?J`:tenGi "1:u:r thl":1' our S3'uvt:iJ:c7Li of perZor.a2ity an3: "styi.e of life" it7 smo-:::r:, as cc+~~~:zr:~d' to non-Uz=~:.er,. Sti.l), furthcr, they su;;ost tlint we r:ust ,:o,rtihun, a&a intai:aiz'y ouu-.- effovts to prri"ect bioche:aica1 I-:etl:ods of caaparir.~, the aci+T•A n:.cocire abcor•.p;a.an by p1.pe, ci, ar. and ci.Laz'e tte s-n?.ol:e)'s under their il?'bi;tu.al co.;r?i 4io r,N of tobacco us4. I an afraid that uhen tliis paper is pre::cni;cfl publicl.y, 1-re rzgy he called upon for theu ,ii w•e t;entral.a:y di.;J:i~r:e to do :;o in the pu.oZic pres:.. If co_:.~c?s.c;i to do oo, the i:i.iz:Is o' cJ;-ncat~ ~ra would be inci:inc;d to Ls~I:e are i~'p3.'Lect in thc,e ot~.t?incd above. It wot+?d be quitL un i~ri~i.r:at~c, I thin::, if t'hL.r.^ ttpp;.ar.2d to be any d'iv-parity bnt.;een Yaui• vic.:;; ans :air.: on the intcrpreiation or ic:nli.c::tions of tlr;;:,e re~ulc::, ",,'!-mvt th•are :hc,te?.,1 be ^,.^ sriu c any actual das,`y to I~e ~-cry un1:.::ely, but re,,ortAr.:_,ortAr.: li-, to el~~cc^.te the Ay)_)cai.•a2:ce oi a contrJversy. 11'}2i$ could prc~bably be c.vclcled if you sce the i<sn2icclticns as ;,•;; s.^:: tner.i nI:j di:a?~:j the pres:: by inc1u '1ir.~; in your prc, cr.i;, tion a caution A-si_nat ovcrin'ccrorei;ution. Ti-,.n, if we wa•re forced to ce:_:_ent, we cculd sirply E~p:~2oi~e our a~;ree.a~lt with you. ~ 1003546881

i If you fe41 that thia mitter needs discuNsion I can probably arrange to atoh ofof in I'cw Or).eana on wy fort-hcomin- trip to Teaa:y. Robert C. Hoc':r:tt, Pi.D. ,,.:;~, ~ Associat•c Scientific Director yjY , . ~. < P.S. If f1-,11 co~iev of the varici:i- p,t)crs you are - k4scr:~,at~~ at t?le Cccti rg could b: r.cdc Z-vcilaule to tzs in advarce, it trvuld be very hclpf xLL.