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T` .+` -'.M1.>...._~.-4 GtuuuUVE1Sty1,Ax. rllAltt•1ACOL0i,Y analcfED1LSTRY COt1,\CiL ON A(;iEQfOSCL[ttOSIS - Ah1ERICaN SOCI[TY FOR THE S7Up'Y OF A'2'C . . Cowaittce R^turn to. ~ . . ~*"{ng"""A6SCitICAN' hEART ASSOCIATION, 44 East 23+d Strcot, Now York, Niy.r 10010 Dr ~ ttell . - .: „ .- ' ' Abstruct of paper to bc considcrod for presenlotlon ot Iho _ - 20th Annual Mcclin57r Octo6cr 19-20, 1966 Now York, Nc w York D'cADLINC for submtss;onr postmarkcd MAY 16, 1966 TY?; ALL INFO2'dATIONI DO NOT USE INK FOR CGi.+2:CiiO\SI SU>YI'61T IN DUPLICATEI #174R7 Autivated': 2 15 ,, Renewed annually on • Dfl2tltiT FtLL, Us159 - '6 Incl. Numbor A. Roc"d REL4TIONSFQP BETiv'EEN CICAREPfE 51:OYSNG' HABITS 11Im CORONARY ATHEROSCLEP.OSI'S IN ~.UTOPSIEU MkLES Eggen, Ph.D. Ner Orleans, Louisiana _ _" L-i order co toot the association of cigarette smoking with coronary' o.tbcroscloroate; w•e- coli,:ct;.d coror.:ry artorioa irom 645 autopsicd maloa, ZO-64 yeara. of azo. Tntcrvicwc.-•a o5tai;.od` estimatca of ci;,.'. cttc omo?:f ~- habits of thes© deceased porsor,a fron aurvivic:;; relativca. The intcrviowera used a~.._..:aos that had been tested for valiaitg and reliabii : pais u of livinC persona from the same houaehold. Independently, we estimatad vic::a;l•; t'c.c ca:.c:t of each type of atherosclerotic lesion and rrscastue& tho extent of ealci:icatio.: .:7.d >r e: : coronary wall thiclcneas by optical-electronic acannin3 of radioo:•aphs. For the princi;.» ~ _ - ..r:.lyzcs wo c•.:cluded patients having diseases thought to be asoociatcd with smokin5 (c=a'.•:y aoma, lun- cancor, ctc. ) or with coronary heart disease (myocardial infarctidn, diabetes, strol;e, ete. f. The rnoan percent of the coronary intimzl atiuf4ca Sz; pc.tcd by mII grant liLi Otinf and by a grant fromm the Tobacco Research Cot:ncii._ . .• _ Council on Tobacco Rcscarc'r.-::. = 49WE `= occ::picc by raiacd at..eroaclerotie leaions (fibrous plaques, complicated lesions, or calcificu lecio :~} was a;, rc._i:nntcly twice aa groat in heavy cmoheru (•> 25 cigarettes per day) and in light smokero (< 25 cii;ar cttea per day) than in noa-rsrrokerc. Calci__..~ Inaio :s .^_::4 rncan coronary wall thicknoao measured radiograp'aically --vere, oa tuc svcr; •:, SiiLI nct in heavy omolcora and loweat in iton-nmokcra. Dilforencoa amonS thccc ccto;;o_ico.vero genorally arcatost at yowgor ngoa. Cccupational physical activi:7 .;d cduc:.:ional level ncl:icvcd could not account for obaervcd difforcnccs in c:ctcnt of leL"i.:.::z. Strong, M.D. " New Orleans, Louisiana ` ~.~ `McCill, Jr.,, M.D;; ., Nhw Orleans, Louisiana Richards, M.A. New Orleans, Louisiana