Tobacco Documents Online

BIOASSAY, CARCINOGENESIS and TISSUE CULTURE TII~ COUNCIL FOR TOBACCO RESEARCIi - U.S.A. tObIlITTEE Dr. Reimann, Chm. Dr. Jacobson Dr. Loosli Dr. Sommers 633 Z7:IHD AVF.'VUE ATEAY~ YaRI{. N. Y~.~ 10017~ Application For Renewal of Research Grant First IN Second D I ,.. ;.~.i+.",. r ;. -- No. 566-Ri '' Activated: 10 1,66 Cf. #276 Activated: 6/1/60 Renewed annually as of June l, 1961- 1965 inclusive. Supplement: 6/1/66 1. Name of Investigator(s): (include title and' degrees) Kenneth M. Lynch, M.D., Eneritus Professor of Pathology or e. McIver, M.D., Associate Professor of Pathology 2. Institution & Address: Medical College of South Carolina 80 Barre Street Charlest on, South Carolina 29401 3. Short Title of Project: Environmental Factors and Pulmonary Carcinogenicity 1. Asbestos Dust II. Asbestos and Co-carcinogens, Viral and Chemical 4. Proposed Renewal Starting Date: (Anniversary or other) 1 October 1967 5. Discuss any Important Changes or Additions to Objectives or Specific Aims: No significant changes or additions to objectives or specific aims. ' 6. Give a Brief Statement of your Working Hypothesis if altered or modified: No alteration in working hypothesis. .:._. ., _:.. __ ,... ~. :.::... .<,.,.__ . ._._. .. . . . : . . . .. . . _._ . _.. _ ._. _ _ ._ ~-.u:~ ~ ~.- ' . . .~:. , . ,..__.

7. Changes or Additions to Experimental Design and' Procedures: (Attach Separate Pages) No major changes in experimental design,.but this feature is restated and brought up to date in the Progress Report. 8. Additional Requirements: Except for the continued advice and assistance of the Staff of the Oak Ridge National Laboratories, no additional requirements are anticipated. The desire to report portions of this work at the Second International Conference on the Biological Effects of .,Asbestos in Dresden, Germany in April 1968 is reflected in the . budget request. O G7 U't EA 0? ~ . ~ 9. Changes in Personnel with Biographical Sketches of new Personnel (append) No changes in professional personnel. Mr. Grimsley, who served as Project Assistant last year, has entered graduate school and Mr. Cummings has taken over both posi- tions. Heyward Wesley has replaced Ben Simmons as Animal Caretaker. Paul Gillette and James Powers, medical students, have been employed to take care of animals and supervise the project on week-ends and holidays. 10. Publications or Papers in Press resulting from the Project or closely related work •Manuscript on exposure of dogs to asbestos dust in preparation for presentation at Second International Conference on the Biological Effects of Asbestos. Manuscript (thesis) on Asbestos as a Possible Co-carcinogen completed by Martha R. McGee (see attached copy). i , _ .. . _ ...,. _~ __.. _. . . . ._.~.:._:.~:.r,...,r.b::- . .,.- , ' ~ - ,. ~:.~ :'. .~ ~;. .:. -.. . . . . ,. . . .:,.. . , . . .. . _. a,~- , ... . . ~ ........_. .. >. .a~...._.,...

~ ~ : . t! M1 ~.. }':?rt ',1 t. Budget (for coming year) .r Technical > A. Salaries (Personnel by names or category) Professional Kenneth M Lynch, M.D. ,:.Forde A. McIver, M.D. (See attached page 1) B. Consumable Supplies (list bycategories) C. Other Expenses Ctemize) D. Permanent Equipment (itemize) None E. Overhead (15% of A+ B-HC) See attached page 1) (See attached page 2) C Sub-Total Sub-Total' Sub-Total % time Amount 0.00 0.00 14,340.00 1,395.00 4,248.00 Total 32,570.00 i C• h is undentood that the applicant and institutional officers in applying for a grant have read and found acceptable the Council's "Statement of Policy Containing Conditions Ond Terms Under Which Project Grants Are Made." 0,00 Signature~_ ' tea Fo7rde A. Pf1¢fve-k;'_v , 723-9411 Telephone Signatui 4~lC . ~~ !us neu O licer of the Institution 723=94'11 John E, Wise, T 'e bone Vice President for Business A~f~'irs ~ `_

1 Attached Page 1 11. Budget (for coming year) ,Mrs. Patricia Dumas 100 Michael Cummings 100 Heyward Wesley 100 Ben Martin 2 Paul Gillette* 10 James Powers* 10 4,800.00 3,600.00 3,300.00 ' 240.00 1,200.00 1,200.00 $14,340.00 *Paid at high rate per hour for week-end~and~holiday supervision and care of animals. Animal Care Committee maintenance charge for mice without caretaker @ 0.01 per animal/day Animal Care Committee maintenance charge for 20 dogs without caretaker @ 0.15 per animal/day Animal Care Committee maintenance charge for 70 guinea pigs with animal caretaker @ $0.08 per animal/day Laboratory supplies for light and electron microscopy Photographic supplies Asbestos and dusting supplies 7,020.00 1,026.00 2,016.00 1,350.00 375.00 O 0 450 00 w . 91 ~ 350.00 ~ ~ $12,587.00 ~ *Please note that new Medical College policy has resulted~in a sharp increase in the cost of animal care. Nevertheless, these charges are 25% to 40% below those of neighboring medical colleges. . Animal care supplies - gloves, shoe covers, coveralls, disinfectants, etc. C. Other Expenses (itemize) Travel to report on previous studies at the Second International Conference on the Biological Effects of Asbestos and for advice and consultations at Oak Ridge National Laboratories 875.00 ~~9'~

Attached Page 2 Services by Surgery Department for broncho- Sub-total $1,395.00 Permanent equipment (itemize) None Sub-total 0.00 4,248.00 T otal $32,570.00

Current list financial support for research from all sources, including own institution, for this and/or related research projects. Title of Project No other funded research at this time. .i,: Pending No other research applications pending. ZS49VSEOOZ