Philip Morris
Application for Renewal of Research Grant the Effect of Cigarette Smoking on the Ultramicroscopic Structure the Bronchial Mucosa
Fields
- Author
- Brinkman, G.L.
- Area
- JOHN-WARE,JUDY/SHB FILE ROOM
- Type
- FORM, FORM
- BUDG, BUDGET/BUDGET REVIEW
- PHOT, PHOTOGRAPH
- SREP, SCIENTIFIC RESEARCH PROPOSAL
- BUDG, BUDGET/BUDGET REVIEW
- Site
- R22
- Request
- Stmn/R1-037
- Named Organization
- American Cancer Society
- Childrens Hospital of Michigan
- Detroit Tb + Health Society
- Rand Foundation
- Wayne State Univ
- Childrens Hospital of Michigan
- Named Person
- Bing
- Brinkman, G.L.
- Perczak, M.A.
- Reimann
- Sommers
- Brinkman, G.L.
- Document File
- 1003546610/1003547082/Meeting Scientific Advisory Board 670923 670924 Book 1 of 1
- Litigation
- Stmn/Produced
- Author (Organization)
- Ctr, Council for Tobacco Research
- Master ID
- 1003546610/7082
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- Characteristic
- EXTR, EXTRA
- ILLE, ILLEGIBLE
- MISS, MISSING PAGES
- ILLE, ILLEGIBLE
- Date Loaded
- 24 May 1999
- UCSF Legacy ID
- yfw02a00
Document Images
FIGLTRE 7. Shows two cells adjacent to the bronchial lumen. The one on the rijht
is a normal ciliated cell with~~~~eil-formed cilia and pellicular material containin~
laroe numbers of mitochondria which extend up close to the basal body of the cilia.
The cell on the left has a nude appearance due to the loss of the luminal structures.
The mitochondria in this cell are much sparser, giving the cell an empty appearance.
This cell is probably in~a state of exhaustion and about to be shed into the lumen.
FIGURE 8. Shows tracheal mucosal cells which were obtained adjacent to a squamous cell carcinoma
of the tracliea. This figure shows well-developed desmosomes, while in the cells themselves there
are numerous tonofibrils which may indicate that this cell is reverting to a more primitive state.
sM9VSEOOZ
FICURF 9. The next four photomicrographs were obtained from grossly normal bronchial mucosa in a
paticnt witli squamous cell carcinoma. This figure shows a large cell containing numerous vacuoles
with varyin~; types o' substructure within. As well, large cisternae are noted. The cell on the
right of this figure shows well-developed tonofibrils.
FIGURI: 10. Shows the granules seen in the previous figure
two and three-layered membranes are forming, some of which
of the virus-like bodies seen in Figures 1 and 2.
in greater detaii. Within these granules
are concentric and begin to have
the appearance
FIGURE 11. Shows these granules at greater magnification with these unusual scroll-like
forming within the granules.
zV4stscooi
substructures
FIGURF 12. Further demonstration of these scroll-like substructures, some of which bear close re-
semhlance to the virus-like bodies. The possibility that this cell is the site of either
multiplication
or destruction of viruses must be entertained.
EV49VSEOOZ
