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DR.OSWALD R.JONES 71 EAST SEVENTY-FIRST STREET NEW'YORK.21, N.lt August 2, 1967 ..I}r. Robert C. Hockett Council for Tobacco Research 633 3rd Avenue New York City Dear Doctor Hockett: I am enclosing my application for research grant from the Council. I hope it is properly filled out. If not let me know. As you may remember, we are starting on the second part of a two year grant of $10,000. per annum. As the study has continually grown in size and scope so have the expenses. Would it be poqsible for the Council to consider starting this fall the research grant for which this anplication has been submitted? ::in most of these was the virus, type not determined. During the past year our study has completedthe bulmonary tests on thirty-one children ranging in ages seven to fourteen. '!`vnanty of these were controls, healthy children. The remaining eleven were children who had had a period of pulmonary infection previously, which took the form -.-of'bronchitis, bronchiolitis, pneumonia or asthma. The etiological factor findings and shall continue this study. This coming,year, due to the establishment of a diagnostic viral laboratory at St. Luke's HosDital, we l will be able to identify the type of virus or other organism~which has caused the lung damage. paper, a copy of which will be sent to you. We are most encouraged in our :` The results • of this study are now being put together for our preliminary . The controls shovred'normal pulmonary tests, including diffusion studies, while the others all showed definite signs of lung damage. I am enclosing three copies of a rebort which show canine distemper virus in the respiratory tract of infected dogs. We think it is an amazing piece of work from our Ithaca study on the e=fects of canine distemper on the resnira.tor,y tract. As distemaer in the dog is practically the same as measles in the child, we can safely conclude that the resbirator:)T tract of children probably is injured by measles and similar o~.her viruses. Our original thouRhts held that pulmonary emohysema probably vras caused by childhoo dviral infections, such as measles, chicken pox and resniratory syncytial viruses. Our animal and human studies are beginning to show a definite trend in that direction.

DR.OSWALD R.JONES 71 EAST SEVENTY-FIRST STREET NEW YORK 21, N:.Y. I do hope that the Council will affirm this request for a research grant which will make it possible to continue our present well oriented studies and to augment them through virological studies. Oswald R. Jones, M.D.