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p P% I F i'X A`L No, 455R1 Activated: 1• 5 THE COUNCIL FOR TOBACCo RESEARCH - U.S.A. " . . . ess TIIII2D SvENLrs . ) STATISTICS (Methodolo - r7EPIDEMLOIOtiY a:~ Addresss a ; 2 Institution & 43 E:'F~ry,.c:°s °` t = ``~`• Director and Assistant Director respectively of Normative Aging Study. Date•. August 25, 1967 - 1. Name of Investigator(s): QncludeTitle and Degrees) :_~Co-principal Investigators: Benjamim Bell, N.D. and Charles L. Rose, A.M~.: Veterans Administration Outpatient Clinic . gy - ~ Dr. Little Application For Research Grant ~ ... _ .. . •Dr. Cattell `_ Dr. Sommers, Chm. ~ COMMITTEE: N$w Yoas. N. z 1ooiT i - 17 Court Street, Boston, Massachusetts 0210B; r.....~.;..,,..:}.~„~~ .~.:...: . . 9. Shorf Title of Projed: ~~ -;15 lt Aite to the Normative Aging andLongevity Study ::emenasssanc-. ',..~>_ uPP =Y ~ ; /. Proposed Starting Data October 1, 1967 : S. Anticipated Duration oF,lhis Specific 51udy: -Twelve months Q@rsef Descripton of Objectives or Specific Aimsa Lti~dinal Study of Healthy Aging!',, and reprints are attached. Briefly, this is a s g erans m n e e t e: er the t nserted into the literature un ;:;..The objectives and specific aims of the Normative Aging Study have alreadybeen tration Lon i- V Ad i i i Th t d l " ~~,,large scale longitudinal aging study sponsored by the Veterans Administration with , ",j°.formative stages, and is expected to grow and enlarge particularly over the next five "a budget in excess of $154,000 pe'r year. The supplementary assistance we are re- questing is primarily for "seed money" purposes. The Study is still in its beginning ,": Fdti ihhllilhtt t th Std Th Retina ounaonn optamoogca researc a negligible cosoeuy.e buted by A. He are also stretching our research dollar through our policy of cross- which modest funds from funding. source A (e.g. The Council for Tobacco Research) are added to the larger funds already appropriated by funding source B (e.g. The Veterans Administration) so that the net result is many times the augmentation factor contri- as an ongoing orogram also makes possible the "piggy backing" principle, through y ng Stu ::possi~ble subsequent budgetary develoonent many times over, the Normative Ag i~velopment. In addition to the "seeding" concept through. which:small grants make d i :;years. "Seed maiey" at this early stage will assist us in making possible this de- :•linking with, otherstudies. We utilize the sophisticated resources of the Retina A Foundation benefits by having our study nonulation made available to them including administrative services of scheduling and record keeping as well as other data which: bave been collected on.our Subjects. The same sort of arrangement has been worked out with the Psychiatric Department of the Mass. General Hospital in,the field of Information Processing of the Central Nervous System. Most recently we have linked up with the.LongirGudinal Studies of the Gerontology Branch, of NICHD in Baltimore through the,establishment of a Joint Scientific Committee so.that these two major studies mi~ght coordinate their procedures and- produce findings on combined data. For the rationale and, accomn3ishments of the Normative Aging Study, the reader is aQ i f~rrn o h a ta '+e3 reorint: "The Veterans Administration Longitudinal . 7. Givca ne So ement o ny$qr~ _Cm~ yp y, stt:,, Study e~ Hea~t~iv Aging ~~ddionaL material on the development and accomplishments of the Study are contained in the official reports of the last threeyears, and copies i C

of these are also attached A l p g a stica l tools for multivarzate an .alysis, and devel'opment of the .. 4.. ..i.,.a _. . ~ speeia aspect of the lFormative Aging Study is the prob- =~•~C ~t lem of deve l in st ti ~ o •=.--"y unknown area or multivariate treatment of time series (longxtudinall data. The solutions to these problems will be apnlicable to all complex aging and other biomed" 1 d' ica stu ies whether- they take place at one point in time or stuitiple points in time. 8. Details of Experimental Design and Procedures: (AttacTi Se arat B ) p e ages _.Funds requested to carry out the,proposed procedures are described in attachement sheet. The emnhasis of r df t eques e unding is in thf f .e exploration oeasibility and development of inethodology. 9: Physical Fadlties Available (Where Other thon Administering Organization Indicate Geographical tocation); The physical facilities of the Boston VA Outpatient Clinic and those of collaborating ipvestigators in nearby hospitals and universities•are available. 10. Additiona(Requirementse C The continuing relationship of the Council for Tobacco Research with. Kurt Enslein, an. internationally known specialist in biomedical anolicatioris of computers, is indis- pensable to the development of our data acquisition and comoutational program. The ' statistical, programming, and comouter resources offered by Mr. Enslein is at the top -of the•"State of the Art" in computer technology. For examole, Mr. Ensleints data link with the computer of the Smithsonian- Astrophysical Laboratory. in Cambridge pro- vides the best computational services of its kind available anywhere. -- C 11. 6ioflraphiiol sketches of all principal andproiessional personnel (append) Biographical sketches of the princinal co-investigat.ors are apnended, 12. lisloof publications: (Five most recent as pertinen.)'.(npgend). .. List of five most recent relevant oub).ications. is appended., on attachment sheet.

C. Other. Expenses (Itemize) 0. Permanent Equipment (Itemize) E. Overhead (15% of A-F B-I- C) Esf'unated Future Requirements: Total Salaries Consumable Suppf. Other•Expenses Pormanant Equip. Yeor 2 Year 3 It is understood that the applicant and institutional'officen In applj•ing for a grant have read and found acceptable the Covncil's "Statement of Poliey Containing Conditions and Terms Under Which Project Grants Are Made " i Sub•Total Sub-Totall Overhead ' Total ~ - ~ Signature'i~/•., /.n Li.7-}3;_J :4r ~ Sianafure .! I / -- - • r4L x• - --T TelepHone 'Ca los7neir ofRcs of 1h. tr.dim4.n Telephone C, ~011 ~ W~J

. S69gPSE:00Z ' Ust ffnanelal support for rs.arch from all rourc.., Inctudlnp own Initltotion, for thfs and/orralaNd ra.orah prol.eN.

ATTACHMENT SHEET' charge from the brain evoked by a stimulus. he processing o e involves a special purpose computer which carries out on line calculations ra c study consists o e e ro-encep a oIo ; • T f th data ' ~ phic recording of electri,cal dis- t h 1 a f 1 which have never been carried out longitudinally. The evoked potential "` Hospital. The Study involves evoked potential and'EEG investigations `.~ by available equipment and investigators at the Massachusetts General .total costs of the Study. The remainder of the costs would. be absorbed at the h4assachusetts General Hospital which would amount to 100 of the : (1) The funding off a part time technician for neuroohysiologic studies' so that directions and amplitudes of the stimulus might be varied. r,ama:inAAr_ Tha RPtina -Foundation is world famous for its develonment of less than 10oof the total cost with the Retina Foundatiom picking up the fied image of the nerioheral retina and choroid. The fundin.g would invoive k (2) The funding of develonment of instrummentation to ohotoaraoh a magni- ).~~~ :~,~:~ well equinped laboratories and w.orkshons. The obj:ective of this proposal instrumentation and has available sophisticatedd biomedical engineers and peripheral retinal vasculature and choriocapillar•ies. •~-<<s"~r~ is to develov means for objective renresentation and measurement of the , V (4) Funding of services bv Dart time yhvsicians to accomplish unforseen jobs that come up in research development, such as reading EKG's, inter- preting medical records to generate coded quantifiedidata, and X-ray read- ing. . . able at the Surgical-Vascular Laboratory of the Peter Bent Brigham Hospital. The sophisticated apparatus to carry out this procedure is already avail- sion,. The nroblem here is to fund the services of a part time physician. calculation of systolic slope, as a predictor of peripheral vascular occlu-.,{,; ,; . (3) The fundinff of a snecial mPthod of pulse reaistration with automated (5) Funding of technical asnects of manuscrint preoaration such as photo- 2'RI®R ~ graphs, drac•rings, graphs, slides, bibliographic materials, etc. Also, fund- ing-costs of obtaining official documents such as birth and death certi- 0 r ficates and hospital records. CJ , ~... (6) FundinF of trave]: for professional meetings and local travel for searching hospital or other official records. ~ ~ ~ Item 12: Publications ~ (1) B. Bell, C.L. Rose and A. Damon "The VA Longitudinal Study of Healthy Aging.." Gerontologist 6:179-184, Dec• 1966. ~ (2) C.L. Rose, R. Nuttall and K. Enslein "ttethodolog•ic Problems irr Predic- tion of Lonaevity" Proc 7th Znt. Congress of Gerontology 7:255-258 Vienna, 1966. 1 Item 8: PROPOSEDPPROCEIDURES

Item 12: Publications_ (Continued) Item in Lonc_itudinal Studies of Agin¢" J.Amer. Geriat. Soc. .(3) r-.L. Rose and B. Bell "Selection of Geographically Stable Subjects " 4.:~ . 12:143-151, 1965 • (4) C.L. Rose "Representativeness of Volunteer Subjects in a Longitudinal Study of Aging'lHum,.Dev. 8:152-156, 1965. . . _..,~.__ . W. use as described in item. 8, it would be difficult a:priori to specify each item in.the budget, so that a general budget is offered instead: In view of the need for flexibility and the principles of supplementary fund, A total of $18,500, is. requested broken down as follows: A, Personnel - - - - - - - - - - - - - - - - - - 20 0 B. Consu.mable Suoplies - - - - - - - - - - - - - 30 % C. Other expenses (Services, travel, etc.) - - - 50% D. Equioment - - - - - - - - - - - - - - - - - - 0 0 E. Overhead - - - - - - - - - - - - - - - - - - 0% • .

R: REDACTED MATERIAL Biograpttical Sketch ~ BELL,.Benjs%in DATES 1924 to 1928 1936 to 1932 1938 to da te 1939 to 1940 1940 to 1942 154•2 to 1946 1946 to 1947 1946 to date 1960 to date 1960 to 1962 1962 to date. Ze.r12 to elcte 1963 tc uaie PLACE Boston Latin Sc`nool. Harvard Co3Zege Jefferson Medical Co11ege Philadelphia Jefferson Medical Colie~e E?osni'tal, Philadelphia . !4BSSdChusettS lVedicc21. Society; Norfolk District itgdical Societq; American Med ica.l Assoc i a-tion.. ?3essUchusztts Ge::eral E:osnital, Boston Boston. Disnensary, Eos-ton RhinoDlasty course (Fornan)< Mi].itar•y Hospitals, Arr^y of United States Boston City 'r"osui-~a;. Ai:ra1 Servi.ce Veterans AdmInis°tration Ourpati.eni Clinic, Boston Veterans Administration Qutr.atiert Clinic, Boston Clinical Associate in Otolarvn'oiogy, Boston Gnisre^sity School of 'Sediyine BOStoZ• U':i Yersi*y'Scihoo3, of ?iedicine Fv,,tion Grnit ansity School of H•_dicir.c Veterzins -",d:a:r ictrz:ic<i Cutoatien; CLi.nic, 5ostcn PCSITiON OR DEGREE A.B,, cum laude, in Biochemical Scfences lf.D. House D~H icer, (Surp,,ical)' :`iP_Sn}Je2' Graduate Assistant Gr adtate Assi srant ( Lt;2 ) ChIeE of EE;iT, Basic Science Course Chier, EEc?T Service S_a=f Chief of ,: '. ~w:~x Assr:. C1i.nicah °:•of~~ssar ol` 0i.o1ar ;.':7z~-)1'o?Y LC.^.iar C» on .r.+E3h gt;-i.U7.(71or y Chief, t:orr^ativ-a r?S•i.o-a S t l•..; y 100354669$ J

PUBLTCATIOt?S' ' Siu,~ha Co.mposition De La Caseinef• Le Lait, 113':181--1,72• (?larch) 1932, Pertyoff, V,A.; and Bell, $,,: UP Histeriut;e Des Prenlzres Re.^,herches r • Bell, D,,: Office OnhthalTColoay - 11ornal. Fundi, ?tass,. G. Practice t1ews, Ee11, B.: Office Onh•thalr,o2o?y - Abr.or:~al Fcandi, Mass. G„ Practice tdeits, IV, 4:3-5 (July) 19S6e ..h Bell, B,: Hill, G,E,; anl . Wyeth, J.H,: tiabilization of Staoes Ooerati:on for Deafness due to Clinical Otosclerosis, Medical Research in the Veterar-s Administration, 2:73b-737 ('.ay) 11959. Bell, B.: and-Coc ell, -L.L.: Effect of Svstenic Cort:costeroid Tharar.y on.Ir.traocular Pressure, Medical Research in the Veterans Aciminis- :, trztio•o, 2:736 (May) 1959. Bell, B.,; Harrison, R,; Trotter, aJR,; and tiolft, E.: f+quecur Dynamics in• 107 Spunisn-A^ii!ri can "War Veterans, presented at, National Veterans Administration Research Conterence in Cincinnati December 1961; Abstract, Journal of Gerontology, October 1962„ Ophthalmology 57 :235-2L0, 1954, 2.arr•ison, Ho1f, E,,, and I:L11r B,,: Ocular s'tudies with• snecial reference to glaucoma in: a Drout+ of 107 eld~er1y males, Aaia J. Rose, C,h,y, ea-:d Bell, B,: Seie4tion cT GeognaT)hical'!V Stable Subjects in the LoiigiL`1?diiidl Study of tging,. J-. of the Ani. Geriatric Society, February 1S05 a PR^PESSIG'dAL CC:'~•s:3?tiTY RELATIONS 0 Ynvited Lcctau'er to Clinical Asser,b].>es (1935, 1960 £ 1961) of American Acader.ly of General Practice (IiasJn Cbapter), tifass:. Speech ar.d tiearinr; Society (1950), Rehabilitation Sci~inar at Boston College (19'S1), F`ed'zcal TV (Ycu and Your fiealth, 195c)., nnd; RaZio I'^o;;raMs (Ask the Doc`coi•, and Medical Foram of the Air, 1953: to 19E1), Task Force on AginE of iiass:, 23ental Health Planning Pro;.ecs:, 19o3•-1584s ~-

R: REDACTED MATERIAL C~ ~r,~t,Zss v~ ~~: ~ ~~•. . . _. r1_re t e;~~lc~ L. 8oc= A. tiv, L~rtSve.aitl ©~ tiac^~~o, 1~~:5, G'ac:aate Sc~aol.o~ SvcT~i :ervicc s::a'y,uiat_a_tr~a Pagt Pcofesslonal Ex~rriar.c::: SccL`n' ~ , ` 1 s~ .. ,~'zSr-^::^.'.S a. t'L'D~'.iG' iiiiYare, ' ; nn (S;.r.cc I'ove--,?er 1960) InaYructca, ;;ort',r_natern Ilnive_•s?~Lys uafver; ity Co? 1 ,;;a, zoatctn, Hza.^,aeLwsctta (Since 1962) Edsca; ion: _ A. Do , I.crvard, 1937- - P=yc ;clc~,.: Eaiy::a!tqr :I:~d:crds 2la~ucchLa~tta (Sic:cc April i:~_40) ReseBZch S3cia1 ;'o?•iti2r, YA. C1ztpctier.t Clinic, 17 Co-r?: Et,, Bczeoa, 2•If:ar.ac.asz;etcu -_C-zrreat Poaitio•a: Ee.aarCh jocfS)i.ie3: a:l it Ye9ZjaaSE~=~ :.Mt::4e9 of flr- ~ iaat iicr Sup~^rted si,~ "- ~'. "'CZ6 S , ~t~~7-2952 x 4a.. ~~Y 19i;5-194?; SuFervic0"s 'i~ ~ V~a iit9.i•a1 ` , C:z_c~ ~3, 29s~~1;.,~2; Cafc~.-:ca Ca~ s eelcr I1liaciU St^`C~ - r ~' r ' ir.a~ni.co ,,c ' zafl't lcr Lo"~a _ f Z9~2a1~~:5; Scciai tici':ar, i7s~' Ilos~ital - liaZiQP.^,1 i•:avCCifZ?vA Cf a~.0Cic"il i+0:.LCsr$ ;;, E„ Socicf~y Fe~: F'n:ecx c`; in PFy chintr.i Boston Soziety fci Gero>ztClagic pa,•chicLry }.'~'~TZ;:. I ril'1 10: i a lo "Czrracttve :3ya{c~l ,esL:r,bi?j.taticn ~ t.n Ezfcctiye AnpYa:chfl 1 i K ? Sy-j ~~ • 33 : 3 2;~I 35, 19hS I* Ci IYC^>~ 7:rE? Gb:1E'-%rci1ce in r.e~ahi 1 itat•ia~'r : 3e rr~ ~'j,n ZiT. ai:~c L'Z~^~ Ae ;~_z-3: ..l•L%aliV, i'jl !n Et:l Cti?6i7 of rln_?:.,'A,BiG^S tJ E Y: ztal 1:v^p-!taVr o rL'.;yt2;aG 1952 35. Gc~,t u a;Itu to th..ti- C.-- fs ~ .,.~~.v>?± y ls7XCb 1J,53 '

._.Ctzazles, L. Rose: (^ontiruod ku6lira4ioa3) 60 `~"Groip P.Eam-arch by Stu:'ent So•'wial 1:Ork-:;a", 1~ Fo ,c.•.iav l~Sqc~ t:'k,. 3;:nuaxy 1954 n "SOCiL11 .'a:Zvi.CC Fir;67 Cit?rr9ctivC il]°Ld19w" Ry,~hr.bo, 9:uS°,138, 1955 , "Ftelatives' AttitusJes End 2~:entaZ Nospitalizaticn", ~!,r.tZl f1M, April 1958 90 "Attituv-loa of RolAti-7c~ of ,:nr-tal. Pu^ti2cta", read at Mnos~ Coafe.re :cL of Sacial t'crti, zoocon, ?,3-'ss„ , IinW_''Gt3,er 5, 1959 •-10. nlntcrcorstiation of r adicaZ, Anr ;repr.•"^a:rtc s:d aocial? Indicc3 in OcCvBC.~a; ~±a",. raad at i)'ier:•2aiirn:3l CLIi,-'rE'SB of Catontolobye Cope.raagen, Au;-tat 1963 11., ; rl~Lcr of Soas' t<'ani~;. IZln,~3~ o,: Olc2z _T'~: ~~ t rfbad SC GZrV:,ColC*;ici:'}, Society A:Z:'3u+1 'sZ.azCisZ$,: Ro :tca, F;asa, , t•Iovezbwr 19-53 12. nS0,:i:21 rAC€oVa I:1 1,01%i.11OVity'r, Ti.o 4:27-1?, 1964 • 13. ".oL`i82. Co.::al':1tiL'•s of M1IvVj.ty";~ Ctle 5 l.rc n ,,,,y ~ ~y •+ h0 N~.4`~~~1'+L:~..z~' (GU) t Spti:%(?2', Uo Z'o , 11.1)C4 14. uS; lrcticzt of G=rSrrak .ically SyaSle Subj::cts in the Iot'; it}3d2.:3sI ,°,+:G;dy of n, _..:...;.._.,~..,.. _. ~-.,.. ~ ....,, ~., .s