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R: REDACTED MATERIAL ~ •. .... ::; .. ! SCIEr1TIFIC 0%rdIn,71IQNS ROACTED . PRQFESSId':TAL. CLUBS INUT~.STIG.1TOR .,ND GR'.rFTEE The International Cancer Research Foundation 1932 37. National Cancer Institute 1948. ' Frances P. Garvan Cancer Fund., Chem.ical.Foundation 1925t-31. American Cancer Society 19h9'. ' ?4edical Consultant and Gnantees Committee on Hemorrhagic Fever), tumed Epidemiology Board 1953. National Foundation for Infaintile Paralysis 1953-55. AWARDS ....~.r.. Judd Arard: Cancer Research 19541, Wein Award Cancer Cytology 19568 t • Forces ~ O O Gj Ul ~ ~ 09

SCII1=1-IC RE-3:::1?HCII 1+'Ih;:s PET,r,ttS;Ms • Gojr) G. 00a and he-wis, l-l.N.~ THE CUT;iI~IATIOI:~ 0T I:Jf~r1II `'LifOIcS Iii t~STPLO~ Garvan C.,•ncer Research. Founda-i:ioil., Cizen. I`ouudation ~"s'ic., N.Y., 1931. FF'r'w :1'S Ur, IR,~',~U?1l,lI0PI 0?4 TISSu 1 CUi,Ttlf?ES' Eas•(;esiY Conference of Radl.olozis ts 1936. GeYy Ii.K,s S'cones H.E., ancd 04ru'i,'s,, d.C.S TISSI3E C;;L`ilTi-a,;i Ule L111JiiC1L1i#L - O.11tG-_"`.1S. Amer.i.can Association of 1lnatomists, 1938. Letr.i s' If. s.~ Geyi CiJ7m2IIZrArSGI-I Ox BT~~00 Ch,iJ, aT,.-LOFui OrF irlIE, 2ItJLSE. Amer's cart Associat;ion for Caz.cer Research., 193u", t1-1ii: b`axors tT,,•i,y OFrSERVATIUId 0:I RAT WN0t: Ci jIS I'iA.Y PIO 1-ceV;:G, CRILS Iir VITFtO. hrlericam Cancer SocYety., IT.Y.j 3.945. IrIth. >~i.ror., ssT.I•I.y and SelX9 1y,0.., CYTOI:OJICAL I3ITROFIO.Z 0T J1U•i07.A~MJS IIOfu•SAh !i';7t:;Ull~'G,iAI:F CT;hL.S.* A Siud:y vri'+h pltase cor.:f;ras~ microaCO~~ ?ni:. Cancer Co .^-.sss 1 9 ~6, _ _ .. _ _ _ ... .. _ _ .,. d .. _ ,_ ~' Sh<?pr2s,, P.,, and F~anC~ F.13.~ P'0_Zi.2L 11ID IIAI~GIIAi.T CE.L~S~ (a) STi.fUI'''S h7i IALL AhD :;AhI,f.'FmYsT 13P_T CE;LS 0?~' I50i;EJIC Or.I(ixli't Pa?ase atx2 13-eetron ,:icrosconc Oi,se:cvatl.ons. Y r w r r. w N r`.r w-- r W !O .r _-N (b) OLtaJRYA`I!l:vNS 0'I Iil;a•iAid Ch,::C2.':C=:.I~T~a,, S::rai~.ns D1 Re~ A. I'i; 4n:~ ~i•r~~- 7 zj•• ~ CIi:~~T` ~ AG;.IV'ITY a . i; t(,l, i'+ fOC ~Cv t~ r•. .~l.ullas 5 Ca%~t~•.~s.~rd•~:~ HeT?l, ul~s~Sc, !'~•II~..J~Cktcv f I. ABD 3-UTOC:I-7N:JIUAh FEI;&ITIO:i9. 1L^..er:.cun Cancer Sociei.yr 19t;5 19525. Sha.pras, P.., 13m=g, F.33:j, cncl Pazcne --., h., ACTIVITY 04IF I4ITOIlIOi:DZSd AIh^3 P7u'l`:~I.A i)a^."a-tBRANE Ti•I I:4 LLilf;r, 1u:I3 ilfJ':Iii.`IAi;F CET,LS 1~'T AND .IIt1i>LAPh Eliaezd.cu.n Cance'r Socictys 1'9I;G z95Y o ._ Gey, M. K., Svotelis, M., and Linden, H'., A Motion Picture Sequence Illustrating the Production of Gianti Cells from Hypodiploid Rat Strains NSAT-14pH and -14ph. Presented at the 1Gth Annual Meeting of the Tissue Culture Association, May 31-June 3, 1965.

R: REDACTED MATERIAL CURRICULUM VITAii NA~titE: Chiun T. Ling .~.-_..____.....-. a___. i P= LANGUAGES: English, German, French, Japanese, Chinese. Tung Iti'en College, Fukien., China (Premedical), 1919--21 Nippon Medical,College, Tokyo, Japan (Premedical), 1921-22 Nippon Medical Col lege., Tokyo., Japan (Medical), 1922-26 STUDIES AND DEGREES. Degree: M.D-., 1926 Johns Hopkins University, Baltimore, Maryland, 1945=46 Degree: M.P.H;:, 1946 VOKIM Harvard•University, Boston, Massachusetts, 1946-4.7 (Research in Nutrition) - Johns Hopkins University, Baltimore, Maryland, 1948-52 Degree: Sc.D:. (Biochemistry), 1952 Internship: University Hospital, Tokyo, Japan, 1926-27- Resident in surgery: Red Cross Hospital, Tokyo, Japan, 1929,-30 ACADEMIC APPOINTMENTS: Assistant Resident: University Hospital, Tokyo, Japan, 1927-29 Research Associate in Biochemistry, Johns Hopkins U15iversity, 1952-53 Assistant Professor of Biochemistry, Jefferson Medical College, 1953-57 Assistant Professor of Biological Chemistry, University of Michigan, Medical School, 1957•-59-' -Research Associate, Simpson Memorial~ Institute, Uni~versity of Michigan, 1957-59 Instructorr in Siurgery, Johns Hopkins University, School of Medicine, 19S9~-62 Instructor in Physiological Chemistry, Johns Hopkins. University, SchooL' of Medicine, 1959-6.2 Asst. Prof. Surgery; Asst. Prof. Physiological Chemistry, Johns Hopkins University School of r4ediclne:, 1962-to date EXPERIENCE: Over 15 years of experience in biochemica•1 and nutritional research. The following outlines the nature of probliems studied and the techniques used.

Curriculwn Vitae - Dr. Chiun T. Ling Animal experimentation and in vitro studies with tissue materials, on the functions of vitamins and their effects on carbohydrate, protein, and lipid metabolism. Quantitative micro techniques for the analyses of lipids.and nucleic acids, coenzyme assays, etc. Chromatographic and electrophoxetic analyses. Radioisotope.work with Co60, Fe59, andiCl4. Isolation of leucocytes and determination of thymidine contents in normal and leukemic cells. Isolation of erythrocyte stromata and;studying their chemical composition-in normal and pathologic cells.• ~ Five.years of experience in teaching medical biochemistry, consisting o a) Formal illustrated lectures 17 - 18 hours each,year b) Supervision of group experiments by medical students, c) Supervision of laboratory work, group~conferences and students counseling d) Supervision of graduate students PREVIOU&RESEARCH ACTIVITIES: Studies on tlze formation of lipid components of blood cells in bone marrow; incorporation of labeled precursors into components of globoside, phospho- lipids, and, sterol of the cells in yitro, with bone marrow from normal, anemic and,leukemic aninals; changes in enzyme and coenzyme activities; effects of _ vitamin antagonists in these systems. t 1.. Studies on the Nutrition of hormal and Malignant Cells in,Culture. PRESENT RESEARCH ACTIVITIES: A concentrated chemicallyy characterized medium has been developed..which maintains MBIII lymphoblasts and Walker Rat Carcino-sarcoma-256- cells in continuous culture. Investigations•in progress include: a) The influence of intracellular amino. acid concentration on the forma- tion of cell proteins and its. dependence on amino acid levels in culture media.' b) Studies. on the quantitative evaluation of cell growth in vitro; inter- relationships. betweerL cell volume, cell count, cell protein and nucleic acid contents (DNA/RNA• ratio) . • c) Effect of the nature:of glass walls off culture vessels and, their chemical treatment on cell survivali, growth and behavior.

Curriculum Vitae - Dr. Chiun T. Ling 2. Lipid Metabolism of Cells in Culture 3. • l 's0.~-. an.. .. ..., Investigations,on the Metabolic Interaction between Cholesterol, Phospholipids and;Fatty. Acids. Other Research Interests Nutritional requirements of normal bone marrow cells in factors affecting cell differentiati.on,. Culture requirement of leukemic cells Immunochemical reactions between tissue cells in vitro TEACHING ACTIVITIES: culture and Teaching and condUcting experiments with,-studentis in nutritional biochemistry as part of the biochemistry course g1ven,duri,ng one quarter only to second year medical students by the Department of Physiological Chemistry. Students' work includes studies.of changes in tissue enzymic activities in nutritional deficiency. Reference - Laboratory Manual for Biochemistry, Section VIII,. Dept. of Physiological Chemistry. i

LIST OF PUBLICATI:ONS AND REPORTS.- Dr. Chiun T. Ling Ling, C. T., Hegsted, D. M., and Stare., F. J.: The Effect of -Pyridoain Defi- ~' f t` R ts h ane Trans oima ion ciency on the hiaczn~Tryptop J. Biol. Chem., 174:803, (1948). Chow, B. Arch. of Biochem,. & Biophys., 34:151, (11951),. F., Bazrows, L., and L',ing, C. T.: The Distribution of Radioactivity in the Organs of the Fetus or of the Young Rats Born of Mothers Injected with B12 containiaig Co60 Ling, C. T., and Chow., B. F.: The Effect of V•itamin,B12 on the Body Composition of Rats. J. Bioli. Chem., 198:439, (1952). • Ling, C. T., and Chow, B, F.: The Effect of Vitamin B12 on the Levels of Solu- ble Sulfhydryl Compounds in,Blood. J. Biol. Chem., 202:445, (1953). Ling, C. T., and Chow, B. F.: The Influence of Vitamin B12 on Carbohydrate and Lipidi Metabolism. J. Biol. Chem., 206:797, (1954). Ling, C. T., and Chow, B. F.: The Effect of Vitamin B1,2,on Ribose Formation by Erythrocytes. Federation Proc., 13:253, (1954)'. Ling, C. T., and Chow, B. F.: Vitamin BZi2, and Carbohydrate Metabolism in First _ European Symposium on Vitamin B'12. and Intrinsic Factor. Ferdinand Enke Verlag, Stuttgart, Germany (1956),. Ling, C. T.: Vitamin B1,q and Lipid Metabo.lism:. Abstracts of Papers, Am. Chem_ Soc. 134th National Meetings, 57C, (Ii958) . Ling, Chiun T.: Role_of Vitamin B12 in Lipid Metabolism. Federation Proc. 18 :489•, (1959). . Ling, Chiun T., Gey, G. 0., and Richters., V..: Seven Cs Solutions: Chemically " Characterized Concentrated Corodice for Continuous.Ce11 Culture. Submitted for presentation to,the 53r.d Annual Meeting of the American Association for Cancer Research, April, 1962. Ling, C. T.,- and;Gey, G. 0.: The Role and Interaction of Trace Elements in Cell Nutrition. Submitted for presentation to the 17th Annual Meeting of the Tissue Culture!Association, May 31-Jtme 3, 1966. Ling, C. T., andiGey, G. 0.: Further Studies on the Role and Interaction of Trace Elements in Cell Nutrition. Submitted for presentation to the 18th-Annual Meeting of the Tissue Culture Association, June 4-7, 1967. • Copy-of paper submitted with application. To be~ published soon,.

R: REDACTED MATERIAL Mary V. Reed (Business)i 601 N. Broadway,°Baltimore, Ma-ryland 21205 Education: Goucher College Smith,College A.B. June, 1931 A.M. June, 1933 Johns Hopkins University speca?1 School of Hygiene F:Public Health Student University of Maryland Pll,lg, Januaiy, 1954 (Medical School) Master's Thesis - The effect of certain triihenylmethane dyes on Staphylococcus aureus and Escherichia coli communior Doctoral dissertation - A comparative study of the-metabolism of a ch1_oramphenicol-sensitive strain and a chloramphenicol-resistant strain of Escherichia coli . Professional Society Memberships / AC~~ ~~TED Academic Honors - Sigma Xi - Johns Hopkins University Teaching Positions ~ Q~ . Graduate Assistant in Bacteriology, Smith College:, Northampton, Massachusetts, 1931-1933. Assistant in Bacteriology, Smith College,.1933-1934. Instructor in-Science and Mathematics, The Knox School, Cooperstown, New York, 1934-39, 1945-46. Instructor In Science, MountVprnorn Seminary >a Junior College, Washington, D.C., i 1939-45. Assistant Professor in Chemistry and• Nutrition, University of Tennessee, Knoxvillc, Tennessee, 1946-48. Dates Degree Date of Degree

Curriculum Vitae - Dr. Mary V. Reed Instructor in Physiology and Bacterioliogy, Goucher College, Baltimore, Maryland, 1949-1954, Assistant Professor, 1954-55_ • Postdoctoral Fellow., The Johns Hopkins Medical School, Baltimore, Maryland, 1955-1965. Research Associate, The Johns Hopkins Medical School, Baltimore, Maryland, 1965-to date. Publications Reed, M. V., and Genung, E. F.: The Effect of Certain Triphenylmethane dyes on Staphylococcus aureus and Escherichia coli communior. J. Bact., 27, 29, (1934). =_ Reed, M. V., and;Genung, E. F.: Titration of Dyes for the•ir Bacteriostatic Action. Stain. Tech., 9, 117-128, (1~934);. Reed, M,.V'., and Gey, G. 0.: Cultivation of Normal and Malignant Human Lung Tissue. 1. The establishment of three adenocaz•cinoma,cell: strains. Lab. Investigations, 11, 638-652, (1962),.

R: REDACTED MATERIAL CURRICULUM VITAE ROLAND ANTItIONY PATTILLO Address: . RMACTED _ . -- - PMA~'iTED (Business) 601 N. Broadway, Baltimore, Maryland Education: Blessed Sacrament High School, Beaumont, Texas. 1951 :. B.S. Xavier University, New Orleans, Louisiaha 1955, M.D. St. Louis University School of Medicine 1959. Inter.nship: Milwaukee County Ceneral Hospital Milwaukee, Wisconsin kesidency: Obstetrics $ Gynecology ~ 1959-1960i Under Dr. Richard F`. Ma~ttingly, Professor f, Chairman, and Dr. Eleanor Delfs, Professor of Obstetrics, Department of Gynecology $ Obstetrics Marquette University School of Aiedicine Inclus•ive of Exchange Resident rotations: Boston,Lying.-In Hospital, under Dr. Duncan.Reid,, Professor & Chairman, Department of Obstetrics $. Gynecology, Harvard University, Boston,, Massachusetts General Surgery & Urology, under Dr. Edwin Elllison'•s direction, Professor and Chairman:, Department of Surgery, Marquette University School of Medicine. General, Gy.necolob2c F Obstetric Pathology, under Dr. Paul Kimmelstiel, Research ProfessTz-"of Pathology, Marquette University School of Medie%ne Academic: Instructor, Department of Gynecology $.Obstetrics 1964 - Marquette University School of Medicine Research Fellow, 1`'; tional Institute of hlealtlr 1964 - Fellow in Surgery, The Johns Hopkins University 1966 - Hospital A}?pointments : _ Staff: St. Joseph's Hospital; Mt. Sinai Hospital ' St. Michael FIos.p:ital, Milwaukee, 11'isconsin, Attending Staff: Mi1•,•:a~2kee County General Hospital

R: REDACTED MATERIAL t . -2- ~ Curriculum Vitae - Dr. Roland A. Pattillo Family: Professional Associations: 0 ACTO ACTED RWAOTED Bibliography: Pattillo, R. A., Foliey, D. V., aiid Mattingly, R. F.: _Internal Pelvic Ilymphography. American Journal of Obstetrics & Gynecology, 88:110, ~2964-). Pattillo, R. A. and San Felippa, P. M.: Carcinoma of the Vulva. Marquette Medical Review, 31:121, (May., 1965). Pattillo, R-. A., Smith,.T. E., Delfs., E.,. and'Mattingly, R. F.: Cytologic and Hormonal Activity of the Trophoblast in Explant Culture: American Journal of Obs.tetrics. and Gynecology, 96:337, (1966). Patt-illo, R. A.: The Human Trophoba ast--Its Endocrine and Neoplastic Properties. Marquette-N9edical Review-, 32, No. 4, (1966). Pattiilo, R. A., Mattingly, R. F. and Messinger, P.. S,: Visicocervicorectal Fistula: A New- Gynecologic Entity. Obstetrics &• Gynecology, 27:432, (1966). ~ - Continuing Investigation,: Carcinogenic Stimulation of the Rat Placenta - Attempts are being-made to create:an animal model for choriocarcinoma. The carcincgen 7,12 dimethylbenzanthracene is d'eposited, at the gestational site in early and mid pregnancy in Hooded rats. Hormonal support in the form of estrogen:`and progesterone is supplied exogenouslyin order tp maintain:placental viab•ility: Evidence for neoplastic changes is being sought. Rea•ctions• of the Human 'Prophoblast as Ezplanrt andi Transplant- Human trophoblastic tissue obtained stenilely from ecto.pic gestations and sterile mature pLacentas:from:Cesarean sectionss are propagated inlruller tube, T-Flask and organ cultures. Studies are directed toward identifying the ce-11 of origin of cho•rionic gonadotropim and steroid hormones. Comparisons. of the:differences in behavior of hydatiform mole and chorio--• carcinoma as to functional and cytologic chaiTar-teristics are being sought. Immunologic factors in normal trophoblast and their'variants and similarities in trophoblastic ncnp.lasms arc being•evaluated by transplantation to thymectomized nconatal r?ts. .