Tobacco Documents Online

-2- 11. Depressor activity from nicotine metabolites. Edward R. Bowman, H. B. Kennedy, Jr., Einosuke Wada, and Herbert McKennis, Jr. - Abstracts of Communications, XXI. International Congress of Physiological Sciences., 41, Buenos Aires, August 9-15, 1959. The isolation andistructure of a ketoamide formed in the metabolism of nicotine. Herbert McKennis, Jr., Edward R. Bowman, and Lennox B. Turnbull. Journal of the American Chemical Society, 82, 3974 (1960). 13. Methylation-in the.metabolism of (-)-nicotine. •Lennox B. Turnbull, Edward R. Bowman, and Herber•t'McKennis, Jr. Federation Proceedings, 19, 268 (1960). 14. The excretion and metabolism of nicotine. Herbert MeKennis, Jr. Annals of the New York Academy of Sciences, 90, 36 (1960). 15. Norcotinine (desmethylcotinine) as a urinary metabolite of nornicotine. Einosuke Wada, Edward R. Bowman, Lennox B. Turnbull, and Herbert McKennis, Jr. Journal of Medicinal and:Pharmaceutical Chemistry, 4, 21 (1961). 16. Depressor effects arising from (-)-cotinine. Joseph F. Borzelleca, Edward R. Bowman, and Herbert McKennis, Jr. The Pharmacologist, 2, 72 (1960). 17. Oxidation of nicotine-C-14 and nicotine-methyl-C-14 in vivo. Lennox B. Turnbull, Einosuke Wada, Edward R. Bowman, and Herbert McKennis, Jr. Federation Proceedings, 20, 172 (1961). 18. Metabolism,of nicotine in the human. Edward!R. Bowman, Lennox B. Turnbull, and-Herbert McKennis, Jr. Virginia Journal of Science, 9, 438 (1948). 19. Degradation of (-)-cotinine in the human. Herbert McKennis, Jr., and Edward R. Bowman. Abstracts of Communications, V. International Congress of Biochemistry, Moscow, August 10-16, 1961, p. 393. 20. The mammalian degradation of (-)-nicotine to 3-pyridylacetic acid and other compounds. Herbert McKennis, Jr., Edward R. Bowman, and Lennox B. Turnbull. Proceedings of the Society for Experimental Biology and Medicine, 107, 145 (1961). 21. Metabolism of (-)-cotinine in the rat. Is Sorell L. Schwartz, Edward R. Bowman, and Herbert McKennis, Jr. Virginia Journal of Science, 12, 196 (1961).

-3- 22. Demethylation in the metabolism of (-)-nicotine. Herbert McKennis, Jr., Lennox B. Turnbull., Sorell L. Schwartz, Einosuke Tamaki. and Edward R. Bowman. The Journal of Biological Chemistry, 237, 541 (1962). .23. Metabolism of (-)-cotinine to a keto acid. . Sorell L. Schwartz, and Herbert McKennis, Jr. -Federation Proceedings, 21, 183 (1962). 24. .Studies on the respiratory and cardiovascular effects of (-)-cotinine. Joseph F. Borzelleca, Edward R. Bowman., and Herbert McKennis, Jr. The Journal of Pharmacology and Experimental Therapeutics, 137, 313 (1962). 25. Studies on the metabolism of (-)-cotinine in the human. Edward R. Bowman, and Herbert McKennis, Jr. The Journal of Pharmacology and Experimental Therapeutics, 135, 306 (1962). _ 26. Routes in the mammalian metabolism of (-)-nicotine to 3-pyridylacetic acid. Sorell L. Schwartz, Edward R. Bowman, and,Herbert McKennis, Jr. Abstracts of Papers, 16th Tobacco Chemists' Research Conference, Richmond, Virginia, Sept. 26-28, 1962, p. 7. 27. Studies on the metabolic fate of 3-acetylpyridine. Lennox B. Turnbull, Edward R'. Bowman, and Herbert McKennis, Jr. Abstracts of Papers, 16th Tobacco Chemists' Research Conference, Richmond, Virginia, Sept. 26-28, 1962, p. 6. 28. The corrected structure of a ketoamide arising from the metabolism of (-)-nicotine. Herbert McKennis, Jr., Lennox B. Turnbull, Edward R. Bowman, and Sorell L. Schwartz. Journal of the American Chemical Society, 84, 4598 (1962). 29. N-Methylation of nicotine and cotinine in vivo.' Herbert McKennis, Jr.,•Lennox B. Turnbull, and Edward R. Bowman. The Journal of Biological Chemistry, 238, 719 (1963). 30. Studies on-the degradation of the pyrrolidine ring of (-)-nicotine in vivo. Formation of Y-(3-pyri,dyl)-Y,-oxobutyric acid. Sorell L. Schwartz, and Herbert A•fcf:ennis, Jr. The Journal of Biological Chemistry, 238, 1807 (1963). 31. The synthesis of hydroxycotinine and studies on its structure. Herbert McKennis, Jr., Lennox B. Turnbull, Edward R. Bowman, and Einosuke Tamaki. Journal of Organic Chemistry, 28, 383 (1963). 32. (-)-Cotinine. Edward R. Bowman, and Herbert McKennis, Jr. Biochemical Preparations, 10, 36 (1963).

33. Conjugate formation in the metabolisni of 3-acetylpyridine..' Lennox B. Turnbull, Edward R. Bowman, and Herbert McKennis, Jr. Abstracts of Papers, 17th-Tobacco Chemists' Research Conference, Montreal, Quebec, Canada, Sept. 22-25, 1963, p. 11. A comparative study of the metabolic release of methyl groups from a series of N-methylpyridinium compounds. Herbert McKennis, Jr., Edward'R. Bowman, Antonio Horvath, and John P. Bederka, Jr. ~ Nature, 202, 699 (1964). i • 35. Mammalian degradation of (-)-demethylcotinine. Sorell L. Schwartz, and Herbert McKennis, Jr. Nature, 202, 594 (1964). 36. Disposition and fate of (-)-cotinine-H3 in the mouse. Edward R: Bowman, Eskil Hansson, Lennox B. Turnbull, Herbert McKennis, Jr., and Carl G_ Schmiterlt5w. The Journal of Pharmacology and!Experimental Therapeutics, 143, 301 (1964). 40. Alternate routes in the metabolic degradation of the pyrrolidine ring of nicotine. Herbert McKennis, Jr., Sorell L. Schwartz, and-Edward R. Bowman. The Journal of Biological Chemistry,, 239, 3990 (1964). Herbert MeF:ennis, Jr., Sorell L. Schwartz, Lennox B. Turnbull, Einosuke Tamaki, and Edward R. Bowman. The Journal of Biological Chemistry, 239, 3981 (1964). 37. Additional routes in the metabolism:of 3-acetylpyridine. Herbert McKennis, Jr., Lennox B. Turnbull, and Edward R. Bowman. The Journal of Biological Chemistry, 239, 121S (1964). 38. Effect of cotinine and other nicotine metabolites in-yitro on duod'enum-and;ileum segments. K. S. Kim, Joseph F. Borzelleca, Edward R. Bowman, and Herbert McKennis, Jr. Federation Proceedings, 23, 330. (1964). 39. The metabolic formation of y-(3-pyridyl)-y-hydroxybutyric acid and its possible intermediary role in the mammalian metabolism of nicotine. 41. Metabolism of 3-acetylpyridine to an analog of mandelic acid. Lennox B. Turnbull, C. N1. Lukhard,, and Herbert McKennis, Jr. Toxicology and Applied Pharmacology, 6, 362 (1964). 42. Disposition and fate of nicotine in animals. Herbert McKennis, Jr. Tobacco Alkaloids and Related Compounds, U. S. Von Euler, editor, Pergamon Press, Oxford, 1965, p. 53.

43. Urinary excretion of conjugate forms.of 1-(3-pyridyl)ethanol aftei administration of 3-acetylpyridine. Herbert McKennis, Jr., Lennox B. Turnbull, Edward R. Bowman., and C. Norman Lukhard. The Journal of Biological Chemistry, 241, 1878 (1966). 44. The structure of dibromoticonine, a bromination product of nicotine. • New York, N. Y., Sept. 12-16, 1966. Abstracts of Papers, 152nd Meeting, American Chemical Society, Herbert McKennis, Jr., Edward R. Bowman, L. D. Quin, and R. C. Denney: 45. Studies on the synthesis and metabolism*of 4-(3-pyridyl)-4- methylaminobutyric acid-4-14C. Paolo L. Morselli, Edward R. Bowman, Helen H. 0ng, and! Herbert McKennis, Jr. Virginia Journal of Science, 17, 345 (1966). 46. The fate and distribution of 1-(3-pyridyl)ethanol methiodide in relation to the toxicity.of 1-(3-pyridyl)ethanol and 3-acetylpyridine. John P. Bederka, Jr., Eskil Hansson, Edward R. Bowman, and Herbert McKennis, Jr. Biochemical Pharmacology, 16, 1 (1967). 47. Studies on the separation of acidic metabolites of nicotine by gas chromatography. Herbert McKennis, Jr., Edward R. Bowman, and Mohammad Saeed Dar. Virginia Journal of Science, 18, 13 (1967). 48. Pharmacological action and intermediary role of 5-(3- -pyridyl)tetrahydrofuranone-2. Edward R. Bowman, Pavol lirdina and; Herbert McKennis, Jr. Federation Proceedings, 26, 616 (1967). 49. Metabolism of (')-Cotinine-2-Z 4C in the rat. Paolo L. Morselli, Helen H. Ong, Edward R. Bowman, and Herbert McKennis, Jr. Journal of Medicinal Chemistry, in press. 50. 1`1ethylamine metabolism in normal and, mao-inhibitor-treated Paolo L. biorselli, Edward R. Bowman,, and Herbert McKennis, The Pllarmacologist, in press. rats. Jr.

-6- 51. On•the congeners of whiskey. Herbert McKennis, Jr.,:-and;Harvey B. Haag. Journal of the American Geriatrics Society, 7, 848 (1959). 52. ,Depressor effects arising from (-)-cotinine. Joseph F. Borzelleca, Edwar.d R. Bowman, and Herbert McKennis, Jr. •The Pharmacologist, 2, 72 (1960). 53. The excretion and metabolism of nicotine. Herbert McKennis, Jr. Annals of the New York Academy of Sciences, 90, 36 (1960). 54. The isolation and structure of a ketoamide formed in the metabolism of nicotine. Herbert McKennis, Jr., Edward R. Bowman, and: Lennox B. Turnbull. . Journal of the American Chemical Society, 82, 3974 (1960). 5S. Methylation in the metabolism of (-)-nicotine. Lennox B. Turnbull, Edward R. Bowman, and Herbert McKennis, Jr. Federation Proceedings, 19, 268' (1960). 56. L-y-Glutamylhydrazine and the metabolism of hydrazine. Herbert McKennis, Jr., Allan S. Yard, Elizabeth J. Adair, and J. H. Weatherby. The Journal of Pharmacology and Experimental Therapeutics, 131, 152 (1961). ` 57. Demethylation in the metabolism,of (-)-nicotine in vivo. Herbert McKennis, Jr., Einosuke Wada, Edward R. Bowman, and Lennox B. Turnbull. Nature, 190, 910 (1961). 58. Norcotinine (Desmethylcotinine) as a urinary metabolite of nornicotine. Einosuke R'ada, Edward R. Bowman, Lennox B. Turnbull, and Herbert McKennis, Jr. Journal of Medicinal and Pharmaceutical Chemistry, 4, 21 (1961). 59. The isolation of 3-pyridylacetic acidi, a urinary metabolite of (-)-cotinine. Edward R. Bowman,, Lennox B. Turnbull, and Herbert McKennis, Jr. Abstracts of Papers, 14th Tobacco Chemists'- Research Conference, Oct. 13-14, 1960, Winston-Salem, North-Carolina. 60. Oxidation,of nicotine-C14 and nicotine-methyl-C14 in viyo. Lennox B. Turnbull, Einosuke iiada-, Edward R. Bowman, and Herbert McKennis, Jr. " Federation Proceedings, 20, 172 (1961). 61. Inhibition by thyroxine of y-aminobutyrate-a-ketoglutarate transaminasc. Antonio Horva:th, Fernando Orrego, and Herbert McKennis, Jr. Federation Proceedings, 20, S (1961).

62. Factors controlling the metabolism of Y-aminobutyric acid. Antonio Horvath, Fernando Orrego, and Herbert McKennis, Jr. The Journal of Pharmacologyy and Experimental Therapeutics, 134, ,222 (1961). 63. Mammalian degradation of (-)-nicotine to 3-pyridylacetic acid and other compounds. . Herbert McKennis, Jr., Edward R. Bowman, and Lennox B: Turnbull. Proceedings of the Society for Experimental Biology and Medicine, 107, 145 (1961). 64. Selective toxicity. (Book review). Herbert McKennis, Jr. Revista Medica de Chile, 88, 864 (1960). 65. Los oxoesteroides, el uso de-hidrazidos fen6licos para su- detecci6n, caracterizaci6n y medici6n,. (Book review). Herbert McKennis, Jr. Revista Medica de Chile, 88, 626 (1960). 66. Metabolism of nicotine in the human. Edward R. Bowman, Lennox B. Turnbull, and Herbert McKennis, Jr. Virginia Journal of Science, 9, 438 (1958). 67. Metabolism of (-)-cotinine in the rat. Sorell L. Schwartz, Edward:R. Bowman, andiHerbert McKennis, Jr. Virginia Journal of Science, 12, 196 (1961). 68. Degradation of (-)!-cotinine in the human.. Herbert McKennis, Jr., and Edward,R. Bowman. Abstracts of Communications, V. International Congress of Biochemistry, Moscow, August 10-16, 1961, p. 393. 69. Aspects of the metabolism of isoniazid and acetylisoniazid in the human and the dog. Allan S. Yard, and Herbert McKennis, Jr. Journal of Medicinal and Pharmaceutical Chemistry, 5, 196 (1962). 70. Demethylation in the metabolism of (-)-nicotine. , Herbert McKennis, Jr., Lennox B. Turnbull, Sorell L. Schwartz, Einosuke Tamaki, and Edward R. Bowman.. The Journal of Biol~ogical Chemistry, 237, 541 (1962). Inhibition of the catabolism of aspartic-4-C14 acid by thyroxine in vivo. Antonio Horvath, and•Herbert McKennis, Jr. Enzymologia 24 91 (1962) N 0 , , . Studies on-the metabolism of (-)-cotinine in the human. G.? C11 .~ Edward R. Bowman, and Herbert McKennis, Jr. ~ The Journal of Pharmacology and Experimental Therapeutics, ~ 135, 306 (1962). ~

73. Metabolism.of (-)-cotinine to a keto acid. Sorell L. Schwartz, and Herbert McKennis, Jr. Federation Proceedings, 21, 183 (1962). 74. The_excretion and metabolism of triethylene glycol. Herbert McKennis, Jr., Robert A. Turner, Lennox B: Trunbull, .and Edward R. Bowman. W. W. Muelder, M. P. Neidhardt, and"Carl L. Hake. - Richard Henderson, Herbert G. Nadaeu, and Samuel Spencer. Toxicology and Applied Pharmacology, 4, 411 (1962)1. 75. Studies on the respiratory and cardiovascular effects of (-)-cotinine. Joseph F. Borzelleca, Edward R. Bowman, and Herbert McKennis, Jr. The Journal of Pharmacology and-Experimental Therapeutics, 137, 313 (1962). 76. Routes in the mammalian metabolism of (-)-nicotine to 3-pyridylacetic acid. Sorell L. Schwartz, Edward R. Bowman, and Herbert hlcKennis, Jr. Abstracts of Papers, 16th. Tobacco Chemists' Research Conference, Sept. 26-28, 1962, Richmond, Virginia, p. 7. 77. Studies on the metabolic fate of 3-acetylpyridine. Lennox B. Turnbull, Edward R. Bowman, and Herbert McKennis, Jr. Abstracts of Papers, 16th Tobacco Chemists' Research Conference, Sept. 26-28, 1962, Richmond, Virginia, p. 6. 78. Acetylhydrazine as an intermediate in•the metabolism of aroylhydrazines. Lennox B. Turnbull, Allan S. Yard, and Herbert McKennis, Jr. Journal of Medicinal and Pharmaceutical Chemistry, 5, 1327 (1962). 79. N-Methylation of nicotine and cotinine in vivo. Herbert McKennis, Jr., Lennox B. Turnbull~, aE-d Edward R. Bowman. The Journal of Biological Chemistry, 238, 719.(1963). > 80. The synthesis of hydroxycotinine and:studies on its structure. Herbert McKennis, Jr., Lennox B. Turnbull, Edward R. Bowman, and Einosuke Tamaki. Journal of Organic Chemistry, 28, 383 (1963). 81. The corrected structure of a ketoamide arising from the metabolism of (-)-nicotine. Herbert McKennis, Jr., Lennox B. Turnbull, Edward R. Bowman, 82. and Sorell L. Schwartz. Journal of the American Chemical Society, 84~, 4598 (1962). (-)-Cotinine. Edward R. Bowman, and Herbert McKennis, Jr. Biochemical Preparations, 10., 36 (1963). ti

83.. Studies on the degradation of the pyrrolidine ring of (-)-nicotine in vivo. Formationm of.7-(3-pyri•dyl)-Y-oxobutyric acid. Sorell L., Schwartz, and Hkerbert McKennis, Jr. The Journal of Biological Chemistry, 238, 1807 (1963). 84. Conjugate formation in the metabolism of 3-acetylpyridine. Lennox R. Turnbull, Edward R. Bowman, and Herbert McKennis, Jr. Abstracts of Papers, 17th Tobacco Chemists', Research Conference, Sept. 22-25, 1963, Montreal, Quebec, p. 11. 85. Metabolic release of methyl groups from a series of N-methylpyridinium compounds. Herbert McKennis, Jr., Edward R. Bowman, Antonio Horvath, and John P. Bederka, Jr. Nature, 202, 699 (1964). 86. Mammalian degradation•bf (-)-demethylcotinine. Sorell L. Schwartz, and Herbert McKennis,, Jr. Nature, 202, 594 (1964). 87. Disposition and fate of (-)-cotinine-H3'in the mouse. Edward R. Bowman, Eskil Hansson, Lennox B. Turnbull, Herbert McKennis, Jr.; and Carl G. Schmiterlbw. The Journal of Pharmacology and:Experimental Therapeutics, 143, 301 (1964). 88. Additional routes in the metabolism of 3-acetylpyridine. Herbert McKennis, Jr., Lennox B. Turnbull, and Edtaard R. Bowman. The Journal of Biological Chemistry, 239, 1215 (1964). 89. The metabolic formation of Y-(3-pyridyl)-y-hydroxybutyric acid and its possible intermediary role in the mammalian metabolism of nicotine. Herbert McKennis, Jr., Sorell L. Schwartz, Lennox B. Turnbull, Einosuke Tamaki, and Edward R. Bowman. The Journal of Biological Chemistry, 239, 3981 (1964). 90. Alternate routes in the metabolic degradation of the pyrrolidine ring of nicotine. Herbert McKennis, Jr., Sorell L. Schwartz, and Edward R. Bowman. The Journal of Biological Chemistry, 239, 3990 (1964). 91. Effect of cotinine and other nicotine nmetabolites in vitro on duodenum and ileum segments. K. S. Kim, Joseph F. Borzelleca, Edward R. Bowman, and Herbert McKennis, Jr. Federation Proceedings, 23, 330 (1964). 92. Metabolism of 3-acetylpyridine to an, analog of mandelic acid. Lennox B. Turnbull, C. N_ Lukhard, and Herbert McKennis, Jr. Toxicology and Applied°Pharmacology, 6, 362 (1964). ..~,.~._.;~::....,..d.~~...~.».-.: ~~w...

.-10- + 93. Disposition and fate of nicotine irn animals. Herbert McKennis, Jr. ' Tobacco Alkaloids and Related Compounds, U. S. Von Euler, editor, Perganon Press, Oxford, 1965, p.'53. 94. Viewpoints of the study of drug toxicity. (Book review). Herbert McKennis, Jr. American Journal of Pharmaceutical Education, 28,469 (1964). 95. Urinary excretion of conjugate forms of 1-(3-pyridyl)ethanol after administration of 3-acetylpyrid2ne. Herbert McKennis, Jr., Lennox B. Turnbull, Edward R. Bowman, and C. Norman Lukhard. The Journal of Biological Chemistry, 241,.1878 (1966). 96. The structure of dibromoticonine, a bromination product of nicotine. Herbert McKennis, Jr., Edward R. Bowman, L. D. Quin, and R. C. Denney.

Papers Published During the Period of This Report i 1. Urinary excretion of conjugate forms of 1•-(3-pyridyl)ethanol after administration of 3-acetylpyridine. Herbert McKennis, Jr., Lennox B. Turnbull, Edward R. Bowman,, and C. Norman Lukhard. The Journal of Biological Chemistry, 241, 1878 (1966). 2. The structure of dibromoticonine, a bromination.product of nicotine. Herbert McKennis, Jr., Edward R. Bowman, L. D. Quin, and R. C. Denney. Abstracts of Papers, 152nd Meeting, American Chemical Society, New York, N. Y., Sept. 12-16, 1966. 3. Studies on the synthesis and metabolism of 4-(3-pyridy.l)-4- methylam%nobutyric acid-4~I`'C. Paolo L. Morselli, Edward R. Bowman, Helen H. Ong, and Herbert McKennis, Jr. , Virginia Journal of Science, 17, 345 (1966). 4. The fate and distribution, of I-(3-pyridyl)ethanol methiodide im relation to the toxicity of 1-(3-pyridyl)ethanol and 3-acetylpyridine. John P. Bederka, Jr., Eskil Hansson, Edward R. Bowman, and Herbert McKennis, Jr. Biochemical Pharmacology, 16, 1 (1967). 5. Studies on the separation of acidic metabolites of nicotine by gas chromatography. ` Herbert bicKemtis, Jr., Edward R. Bowman, and Mohammad Saeed Dar. Virginia Journal of Science., 18, 13 (1967). 6. Pharmacological action and intermediary role of 5-(3- pyrid'y1)tetrahydrofuranone-2. - Edward R. Bowman, Pavol lirdina and Herbert McKennis, Jr. Federation Proceedings, 26, 616 (1967). 7. b1etabolism• of (=)-cotinine-2-14C in the rat. Paolo L. Morselli, Helen H. Ong, Edward R. Bowman, and Herbert McKennis, Jr. Journal of Medicinal Chemistry, in press. 8. Methylamine metabolism in normal and mao-inhibitor-treated rats. F.1 Paolo L. Morselli, Edi,rard~ R. Bowman, and Herbert McKennis, Jr. O The Pharmacologist, in press. CO CA 4 0? M ~ ~ . . o~