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°rV .= ,.r ...-• Q)u\c;Ii. F(lP' TOBACCO TF.SEARCIT U.S.A. _ _ . -. ..,<._.. _. .. • . _ ~ ; :;. CONFIDEIGTIAL REPORT . „. _ _,.s.. SCIENTIl1IC ADVISORY BOARD MEETING New York, New York - May 20-21, 1967 A y Dr. Kenneth M. Lynch,`Chairman Dr. C. C. Little ~ Dr. Richard J. Bing Dr. McKeen Cattell Dr. Leon 0. Jacobson Dr. Clayton G. Loosli" Dr. Stanley P'. Reimann f Dr. Sheldon C. Sommers / ~ ~ Dr. John W. Fertig (5/20/67) Columbia University =xs' Mr. W. T. Hoyt Executive Director, CTR Dr. Robert C. Hockett Associate Scientific Director, C'i~t Dr. J. Morrison Brady Associate Scientific Director, CTR Dr. John H. ISreisher Associate Scientific Director, CTR F;- Dr. Vincent F. Lisanti Scientific Associate, CTR The report of actions taken at the December meeting was approved by the Board. •s Administrative Actions #390R2 -Peter H. Knapp, Ph.D. A balance of $252.36 from the completed project ..1 , . . , - .. .. .. . . ,' . Yit' was received and deposited. •#408R1 _ Benjamin Burrows, M.D. A balance of $1, 500.00 from the completed project was received and deposited. ~66R1 E. C. Hoff, Ph.D., M.D. The grantee was authorized to use the une~Tended'balance of approximately $4,000.00 for the needs of the project after the termination date of May 31, 1967 w. Cr : #510R1 Donald J. Massaro, Mi.D. This grant will be transferred to Duke University Medical Center following receipt of financial report and refund from Georgetown University. #592 Donald J. Massaro, Mi.D. $7,820.00 Transferred to Duke University Medical Center. 1003546613 #528R1 Sue Buckingham, M.D. After staff negotiation, the final sl:.m approved for this year's grant is $15,155.00 with the understanding-that the money still remaining from her previous grants be used also to defray the costs of this project to a total of $31,624.00, plus $2,000.00 4 - from carryover for contingencies. _..~...... .~ Scientific Director, CTR ~i.,..._ _ y .• _~___,.~.~~..~.::~..;y~..

#543R1 - Ulrich 3chaeppi,"M. D. $17, 260.00 Ulrich Schaeppi, M.D. $10,175.00 from the personnel category to travel ($450) and sup-plies & contract or grant should be clarified and decided before the was aAproved in order to summarize work status and to allow transfer of such information to Mr. Kurt Enslein for evaluation. These monies are to provide for salaries to keep Dr. Thomas' group together and are not for the purpose of continuing the project indefinitely. The Board agreed that Mr. Enslein should be remunerated for this service in accord with past procedures. John R. Rowlands, Ph.D. The committee recommended placing this application on the agenda for the September meeting, 3• Supplements _ The request of a transfer of both grants from The Worcester - Foundation for Exrperimental Biology to Ma,son Research Institute also of Worcester, Massachusetts, approved. The question of a letter of approval is sent. r, .y ..A •;~,~~-• ~ ^r• ..ati~ ~.: Z;,er `.i~i #572 T. Timothy Crocker, M.D. Permissi= was granted to transfer $1,000 : project funds to travel expenses. #607 Samuel Bellet, M.D. Permission was granted to transfer $800 of the , agreed upon, pending Dr. Larson s discussions with publishers. #591 Paul S. Larson, Ph.D. The final amount for this grant has not been grants is to be returned~to The Council. Approved. The balance of $13,879.67 remaining from previous r~'r585 George W. Smetters, M.D. (Thomas C. Laipply, M.D.) $11,963.00 an w an s ere e gran will proceed. _ t I been d' d th services ($550)• #579 Naiter M. Chopra, Ph.D. -$23,955.00 Abproved. All questions have #610 Caroline Bedell Thomas, M.D. $29,865.00 A terminal one-year grant - for activation as of July 1, 1967. University has been received and the grant has been authorized g609 Donald B. Louria, M.D. Proper official approval from Cornell #516R1S Donald M. Pace, Ph.D. $2,003.60 Approved~. #5585 G. H. Friedell, M.D. $5,403.00~ Approved. #566s Kenneth M. Lynch, M.D. and Forde A. McIver, M.D. $1,200.00 Anrroved.

. . _ .., ,:_ 00 Approved for the terminal-year Bertram Lichel D D S $29 594 ' . , . . , . ~~• ~+ ~~ of a three-year program at the previous rate of $17,950.00. It: Rose Marie Pangborn, M.S. $22,433.00 Approved. Thomas C. Westfall, Ph.D. $11, 500~.00 Approved for the terminal "~R~ ~ ~~ ~ •~ ~ ' ~ ~~ '<< year of a three-year program. Z ~ 1 ~tr Nf ' ' ' ~ ~ ~ > _ ~ . . -~ - ~. - . ~ ~ • ._. .. , . .c . . , . • ....evb tSf ear of James S roved for the first P Toman Ph D $15 225 00 A . , . . pp y . , . a three-year program. Marcus N. Carroll Jr., Ph.D. $19,620X0 Approved for one year at .the requested amount contingent upon assurance from the institution that his salary will be secure for the entire period of the grant. of a three-year program. -:Stephen M. Ayres, M.D. $22,890.00 Approved for the terminal year Walter M. Booker, Ph.D. $19,568.00 Approved for the terminal year of a three-year project at the previous rate of $17,705.00. Hyman Engelberg, M.D. $24,966.00 Approved for the terminal year of ~ a two-year program. Dr. Loosli will request that Dr. Samuel Rappaport review this research program before the next meeting. Cesare Biancifiori, M.D.' $10,100.00 Approved for the second year of a program originally submitted as a three-year plan. It was suggested that urethane be used as a control to produce carcinoma of the lung. The staff will review this program for the next meeting and a visit by a Board member is contemplated'. ~ , .. Roger K. Larson, M.D. $17,424.00 Approved for the terminal year of, a two-year program. #534R1 ~ Paul Goldhaber, D.D.S. $23,396•75 Approved for the second year of a -three-year program -with the understanding that any residual funds remaining from the previous year be applied against this grant total. Ines Mandl, Ph.D. $25,969.00 Approved for the second year of a three- year plan. ; Gustave A. Laurenzi, M.D. $12,229.00 Approved. A future conference . should be developed around this program. S. N. Pradhan, M.D., Ph.D. $9,928.00 Approved for the second year of a three-year plan. Broda 0. Barnes, Ph.D., M.D. $,23,000.00 Denied. Dr. Loosli will contact WHO, NCI; etc., to see if an overall effort for an ongoing survey is possible. . 1003546615 p h Gene M. Smith, X.D. $14,184.00 Approved as a terminal grant. Sheldon C. Sommers, M.D. $14,536.00 Approved for the second year o a three-year plan.

~~:in the grant applicati= forms to the effect that the investigators should abide by Jay D. Coffman, M.D. $5,192.00 Approved. Ernest Clark, Ph.D. $23,328.80 Denied. Maurice S. Segal, M.D. $85,650.00 Approved in the amount of 430,000.00 plus overhead. Final arrangements are to be made by staff. A. Weinstock, Ph.D. $40,036.00 Approved as a one-year program with review by the staff at the end of nine months. concerning research carried out on humans, and possibly incorporate a statement New Applications # 578M .-Harry S. Bernton, X.D. $21,460.00 Denied. Tr`o15 Charles E. Tobin, Ph.D. $7,634.85 Denied. .withinthe scope of The Council's program. Board thought this was an excellent research proposal but not i619 H. A. I. Newman, Ph.D. $17,675.00 Denied without prejudice. The year of a two-year program. #618 Edmond Antony Murphy, M.D., Sc.D. $8,430.00 Approved for the first #616 . Robert A., Kuhn, M.D. $30,072.50 Denied. T1617 Luben G. Angeloff $12,805.00 Denied. #621 Ole A. Holtermann, M.D. $12,978.00 Denied. The staff was requested to look into the forms used by other granting agencies :Zne Helsinki Declaration. -7. The staff will send to Dr. Ratzenhofer a copy of the Scientific Director's 11 emphasize the non-prejudicial attitude toward foreign applications for Report and a letter of explanation of the mission of The Council. This letter research grantW. U. The next meeting of the Scientific Advisory Board will be held in New York City on September 23-24, 1967.