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. Applications for supplements . Resubmitted application (modified . New applications from present or recent grantees e. New applications

SCIENTIFIC ADVISORY BOARD MEE'TI'NG ~.f'.f;... ... ' ..~ . ', .. .. . . . ' . Administrative actions taken since May 20, 1967 . Staff Reports on matters referred by the Board Considerationof applications a. Renewal applications b. Supplements requested . Resubmitted (modified) application d. New applications from present or recent grantees e. New applications Program planning Special session for staff reperts on recent developments in certain projects and policy discussions of methods for effective follow-up.

4 af .~~ . , ,~. y IGTIAL REPORT CONFIDE SCIENTIl'IC ADVISORY BOARD MEETING ;;,. . . New York, New York ' - . S, May 20-21, 1967 . y..~..: i ,Y( Dr. Kenneth M. Lynch,`Chairman ~' Dr. C. C. Little ~ Scientific Director, CTR ~tiz . Dr. Richard J. Bing K Dr. McKeen Cattell ~_ Dr. Leon 0. Jacobson - 4WW', ' Dr. Clayton G. Loosli'~ -Dr. Stanley P'. Reimann f Dr. Sheldon C. Sommers ~ N A Dr. John W. Fertig (5/20/67) Columbia University Mr. W. T. Hoyt Executive Director, CTR X Dr. Robert C. Hockett Associate Scientific Director, C'iR Dr. J. Morrison Brady Associate Scientific Director, CTR Dr. John H. Kreisher Associate Scientific Director, CTR Dr. Vincent F. Lisanti Scientific Associate, CTR . The report of actions taken at the December meeting was approved by the Board. Administrative Actions ~ #390R2 -Peter H. Knapp, Ph.D. A balance of $252.36 from the completed project was received and deposited. w. ~ Cr: y _: #~+08R1 Benjamin Burrows, M.D. A balance of $1,500.00 from the completed project was received and deposited. #466R1 E. C. Hoff, Ph.D., M.D. The grantee was authorized to use the une~Tended'balance of approximately $4,000.00 for the needs of the ! project after the termination date of May 31, 1967. #510R1 Donald J. Massaro, Mi.D. This grant will be transferred to Duke University Medical Center following receipt of financial report and refund from Georgetown University. #592 Donald J. Massaro, Mi.D. $7,820.00 Transferred to Duke University Medical Center. 1003546613 #528R1 Sue Buckingham, M.D. After staff negotiation, the final sl:.m approved for this year's grant is $15,155.00 with the understanding-that the money still remaining from her previous grants be used also to defray , the costs of this project to a total of $31,624.00, plus $2,000.00 4 - from carryover for contingencies. ` , Q)LJ\(ai. FOr 7'c>z;AccO PrsrAI Z crr-U.S.A. LV .'.,t.y.~sa.t.:v:~.r....i.+:...... _..iaw.i.h~::..~...t,:-.. :.c.:.uaa..raa..ss.+.i-t~.. .. . , .... - -..,..:a.a...~..y. .. _...~~...~..._.._.~.2s..~L..e.aa+...

from the personnel category to travel ($450) and supplies & ` Ulrich Schaeppi, M.D. $10,175.00 Ulrich 3chaeppi,-M.D. $17,260.00 The request of a transfer of both grants from The Worcester - Foundation for Exrperimental Biology to Ma,son Research Institute, also of Worcester, Massachusetts, approved. The question of a contract or grant should be clarified and decided before the letter of approval is sent. . , . -,.: .. - .: ,.n.~''.::.~~,.~-. . .. ~:~:. , '.., ., .... .... . _..'. .. .....,... .:.__.... . ..-. .. a1.Mww......:.1' .ff7'lie '1?. Timoth.y Crocker, M.D. 'Permissi=was granted~ to*transfer $1,000 ; services . ~.r.. been answered'and the grant will proceed. #579 Naiter M. Chopra, Ph.D. -$23,955.00 Abproved. All questions have r~r585 project funds to travel expenses. #607 Samuel Bellet, M.D. Permission was granted to transfer $800 of the agreed upon, pending Dr. Larson's discussions with publishers. grants is to be returned~to The Council. Approved. The balance of $13,879.67 remaining from previous George W. Smetters, M.D. (Thomas C. Laipply, M.D.) $11,963.00 #591 Paul S. Larson, Ph.D. The final amount for this grant has not been #610 Caroline Bedell Thomas, M.D. $29,865.00 A terminal one-year grant - for activation as of July 1, 1967. University has been received and the grant has been authorized #609 Donald B. Louria, M.D. Proper official approval from Cornell application on the agenda for the September meeting, was aAproved in order to summarize work status and to allow transfer of such information to Mr. Kurt Enslein for evaluation. These monies a.<re to provide for salaries to keep Dr. Thomas'' group together and are not for the purpose of continuing the project " indefinitely. The Board agreed that Mr. Enslein should be ; remuneraLea ror tnis service in accord with past procedures. #611 John R. Rowlands, Ph.D. The committee recommended placing this . Supplements #516R1S Donald M. Pace, Ph.D. $2,003.60 Approved. #5585 G. H. Friedell, M.D. $5,z +03'.00~ Approved. #566s Kenneth M. Lynch, M.D. and Forde A. McIver, M.D. $1,200.00 Anrroved.

#547R1 #548R1 #554R1 'Rel Apliti enwapcaons . . ... ~,~. Bertram Eichel, D.D.S. $29,594.00 Approved for the terminal yeax ~ tf" <of a three-year p"roe am at the previous rate of $17,950.00. Rose Marie Pangborn, M.S. $22,433.00 Approved. ,..:,:.;_. ._ . .. . .. Thomas C. Westfall, Ph. D. $11, 500~.00 Approved for the terminal year of a three-year program. . . ' r. ~" `lc ~ James E. P. Toman, Ph.D. $15,225.00 Approved for the first year of a three-year program. Marcus N. Carroll Jr., Ph.D. $19,620X0 Approved for one year at the requested amount contingent upon assurance from the institution :that his salary will be secure for the entire period of the grant. Stephen M. Ayres, M.D. $22,890.00 Approved for the terminal year of a three-year program. Walter M. Booker, Ph.D. $19,568.00 Approved for the terminal year of a three-year project at the previous rate of $17,705.00. Hyman Engelberg, M.D. $24,966.00 Approved for the terminal year of a two-year program. Dr. Loosli will request that Dr. Samuel Rappaport review this research program before the next meeting. Cesare Biancifiori, M.D.' $10,100.00 Approved for the second ye ar of a program originally submitted as a three-year plan. It was suggested that urethane be used as a control to produce carcinoma of the lung. The staff will review this program for the next meeting and a visit by a Board member is contemplated. q -. , . Roger K. Larson, M.D. $17,424.00 Approved for the terminal year of a two-year program. #534R1. Paul Goldhaber, D.D.S. $23,396•75 Approved for the second year of a -three-year program -with the understanding that any residual funds remaining from the previous year be applied against this grant total. Sheldon C. Sommers, M.D. $14,536.00 ;°: a three-year plan. Ines Mandl, Ph.D. $25,969.00 Approved for the second year of a three- year plan. Gustave A. Laurenzi, M.D. $12,229.00 Approved. A future conference should be developed around this program. S. N. Pradhan, M.D., Ph.D. $9,928.00 Approved for the second year of a three-year plan. Broda 0. Barnes, Ph.D., M.D. $,23,000.00 Denied. Dr. Loosli will contact WHO, NCI; etc., to see if an overall effort for an ongoing survey is possible. 100354661s Ph, Gene M. Smith, Z Q.D. $14,184.00 Approved as a terminal grant.

~Harry S. Bernton, X.D. $21,460.00 Denied. Jay D. Coffman, M:D. $5,192.00 Approved. R. Ernest Clark, Ph.D. $23,328.80 Denied. Maurice S. Segal, M.D. $85,650.00 Approved in the amount of 430,000.00 plus overhead. Final arrangements are to be made by `` staff. r ._the Helsinki Declaration. . ; . . Board thought this was an excellent research proposal but not n Lhe grant applicatz= forms to the effect that the investigators should abide by .withinthe scope of The Council's program. A. Weinstock, Ph.D. $40,036.00 Approved as a one-year program with review by the staff at the end of nine months. . . ,,.,. . . .. ,;,..:--w . i '- T#615 Charles E. Tobin, Ph.D. $7,634.85 Denied. #616 .. Robert A.,Kuhn, M.D. $30,072.50 Denied. T1617 Luben G. Angeloff $12,805.00 Denied. i619 H. A. I. hTewman, Ph.D. $17,675.00 Denied without prejudice. The year of a two-year program. #618 Edmond Antony Murphy, M.D., Sc.D. $8,430.00 Approved for the first #620 #621 Ole A. Holtermann, M.D. $12,978.00 Denied. . The staff was requested to look into the forms used by other granting agencies concerning research carried out on humans, and possibly incorporate a statement - 7. The staff will send to Dr. Ratzenhofer a copy of the Scientific Director's - ill emphasize the non-prejudicial attitude toward foreign applications for Report and a letter of exvlanation of the mission of The Council. This letter research grantW. ti. The next meeting of the Scientific Advisory Board will be held in New York City on September 23-24, 1967.

~~~.. ' ,.... i ® ~ ~. Sa `? yr ~ °° ,A AIB~NISTRATIVE' ACTIONS a ~ Reports torScientific Advisory Board .No Action Required _ _ #534R1 Paul Goldhaber, D.D.S. The final sum approved for the renewal grant is $22,938.75 which, with an unexpended balance of $458.00 from the previous grant totals $23,396•75, the amount originally requested . . , #614 Maurice S. Segal, M.D. The final sum authorized for the new grant is $34,500,00; representing,$30,000.00 plus 15% overhead in the amount of $4,500.00. °-S Refunds Received : #385R2 William F. McNary Jr., Ph6D. Refund of $3,107.27 received and deposited. #4$9 E. T. Angelakos, M.D., Ph,D. A refund of $247.84 received and deposited. #506 Roger K. Larson, M.D. A refund of $486.57 received and deposited. , ; #585 George W. Smetters, M.D. The balance of $13,879.67 (grants #363, F, ~ 450A and 450B) was returned as requested and deposited. ~ ., a.. W~. r. _.. . . . . , Fori Toa_~cco Rrsz;nlzcll U S.A: Followup , . ,._ . . , r. ~. . , a : #,477MR2 Marcus N. Carroll Jr., Ph.D. Word has been received from the institutionaL authorities that Dr. Carroll's salary has been guarant'eed until June 30, 1968. His grant has, therefore, been activated effective July 1, 1967 in the amount of $'19,620.00. ' 4 v. #510R11 Donald J. Massaro, M.D. A refund of $4,105.83:was received from ~' Georgetown University and deposited. A new check in this amount has been issued to Duke University for continuation of Dr. Massaro's grant. ~bRe.,_...;r _ .'.'. . ,..:.,........ : ~ .. ~ports to Scientific Advisory Board Action Required September23-2k, 1 . 1ts s., l PZ 7_ -Q, Time Extensions #415R1 Duane G. Wenzel, Ph.D. A time extension was authorized for one year, without additional funds, to May 31, 1968. #k48Ri John S. Waugh, Ph.D. A time extension to June 30, 1968 and use of uncommitted balance of $11,495.42 was authorized for the purposes of the project. #495 Walter Redischy M6D. Permission granted to extend the grant from June 30 to September 30, 1967, and to use the uncommitt'ed funds for the purposes of the project during that interval. A financial report was requested. 0 ~

Budget Reallocations authorized-to cover travel expenses in the amount of $229.00. --. #493N4, Barbara K. Watson, Ph.D. Reallocation of the granc budget w , as #599 Domingo M. Aviado, M.D. 'Permission was granted to realloca.te the . . . _ . _ . .. . . . ,. . . . : l . . , a. .:. , , r'~T.q{}~~ #409R2 Frederik B. .Bang, M.D. Permission requested to carry over'balance of $5,184.67 from the 1966 grant to the current year. ~,' ~ #493m1 , ,,r . Barbara K. Watson, Ph.D. Permission requested to carry over balance of $5,072.88 from previous grant. budget to provide $750.00 for traT~el expenses. „~~~~`~ 'Carryover of Grant Funds excess funds. of Nebraska requesting a financial statement and return of the: ~ personnel and equipment. A letter has been sent to the University to the University of the Pacific to be used for additional balance of $1,000+ be transferred from the University of Nebraska #516 D. M. Pace, Ph.D. The grantee has requested that an estimated #559R1 Sheldon C. Sommers, M.D. Permission requested to carry over balance of $1.,359•29 from previous grant. ... . ~~~: A supplement in the amount of $3,300.00 Walter M. Booker, Ph.D. The May minutes record the sum approved `7';:j as $17,205.00 whereas the correct amount is $17,705.00.

~PPLICAtIOA'S TO BE CONSIDERED Amount Anticipated 'Last Requested Duration Grant Category Renewa]; Applications 223R8 McKennis .361R4 Gey 3 years 52'1598 58,400 3 years 43,434 CR'`'~e (16 months) cuit;we 30,6og :18,500 32,428 409R3 . Bang 455R1 Rose 523R1 Jones 558MF1 Friedell 561R1 Brinkrnan 566R1. Lynch 567R1 Severi 569R1 Moser 573R1 Loosli . 31,050 12,109 322570 15,000 15,980 51,576 3 years 21, 835 1 year 3-5 years 13,300. 10,000 Cattell Jacobsori , , Bing ~ Little, Lynch x Reimann, Loosli Sommers Reimann, Sommers Jacobson Epidemiol- Sommers, Cattell~ 1 year 362453 2 years 15,653 1 year 27,121 2 years 16,000 2 years 15,137 Carcinogen- Bing, Sommers esis Reimann Carcinogen- Reimann, Jacobson esis Loosli, Sommers Carcinogen- Little, Sommers esis Reimann, Loosli -Cardiovas- Cattell, Bing ~ cular Jacobson, 2 y a ears 53,755 J cobson, Lynch ~R N c~~3 Little Jacobson, Bing~ '';=i'. Lynch, Loosli Reimarin, Jacobson Patho±o tC Lynch Reimanny Sommers Supplemental Applications 456R2 Homburger 6,000 1 year .1+67R2 Westfall ~ 7,500 Modified Application 613M Clark 23,328 New Applications from 338-A Homburger 626 Redi,sch,:- 631 Domino 632 Strong 7Q,000 Kaasfa.y • Little, Jacobson ~ Sommers, Reimann 11,500 Pharmacol- Bing, Cattell ogy Jacobson, Lynch 1 year Little, Loosli aati-e-= Cattell 1003546621 Present or Recent Grantees 55,617 16,795 28,565 20,516 5 years 59 ,096 Sommers Jacobson . ~ , 1 year 12,075 Cardiovas- Loosli, Reimann Bing, Cattell 3 years 33,483 cular Pharmacol- Jacobson Cattell, Jacobson 3 years 17,531 ogy Cardiovas- Little Reimann, Bing cular Cattell, SoLmcrs

jIPPLICATIO\ 3 TO BE C0INSIDuRM , Grant Principal . Amount Anticipated 'Last .io. Investigator Requested D;:ra;.ion Grant 611 Rowlands 46,058 3 years ~~:5~ e Jacobson, Cattell . . . . - . _ ~ ' . . ~ . .. ~ . .. ~ ~ 622 Geller - .. 29,442 3 years e a2 c_o J_ Cattell, Little :; t Bing 627 Beller 26,391 3 years Cardiovas- Bing'r Cattell : cular Somers 625 Brown~ 12,548 .2 years ~ Cardiovas- Cattell, Bing ~ Reimann 624 Noakes 30,900 3 years r:Scsxl"wu `~'~ Jacobson, Loosl •sna tre Jacobe on r=4 ~,~~ 623 Essman 13,570 2 years ~ - g Little, Catt~ ell cular Jacobson Lynch 628 Finley 26,105 3 years (~`~r^dN~ Sommers, Loosli ~^~ ~~~ Reimann, Bing-' 629 Erickson chosomatic ogy - Psy-_ Jacobson • 93350 1 year . . Pharmacol- Cattell, Little 630 Parshley 20,169.50 2 years .rk) ^%flN"Tri.pstre- Loosli, Sommers ogy Jacobson Reim2•nn, Little 633 Boyarsky 61)950 3 years -.Pharmacol- Cattell, Bing 4