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Philip Morris

Experiments Revealed New Tests on Relation of Smoking and Cancer

Date: 19601104/P
Length: 1 page
1003543351
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Type
NEWS, NEWSPAPER ARTICLE
Area
JOHN-WARE,JUDY/SHB FILE ROOM
Site
R22
Named Person
Ballenger, J.J.
Named Organization
New England Journal of Medicine
Northwestern Univ
Request
Stmn/R1-037
Document File
1003543302/1003543654/600000 TI and TIRC Editorial Comment Informational
Litigation
Stmn/Produced
Author (Organization)
Chronicle
Upi
Master ID
1003543302/3654

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Characteristic
EXTR, EXTRA
Date Loaded
24 May 1999
UCSF Legacy ID
eev02a00

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Page 1: eev02a00
'Experiments Revealed ew Tests On Relation . NEW YORK, Nov. 3 - A CULTURE (UPI) - A series of scien- He scraped ciliated cells tific experiments have e.at- out of the throats of young tacked a conspicuous weak- children. These we r e not ness in the theory that likely to have been contam- cigarette smoking is a inated by unnatural living. cause of lung eancer. T h e These cells he cultured in a experiments showed h o w nutritional solution in sealed hmoking might be a cause. but 1194111111 chambers. Air passages from nose to He then bubbled cigarette smoke through these cham- Che depths of the iungs are bers. The smoke of only two Jined with ciliated c e 11 s. cigarettes was enough to These cells vibrate -t h e y stop the rotational movement beat. They form dancing sur- of the aggregate of ciliated faces, as it were, and foreign cells within 5 to 28 minutes, substances are bounced alon he reported to the New E~ng- g land Journal of Medicine. in one direction-outward'. These results he got from 12 This Is how the body keeps gonsecutice experiments. the air passages clean. Ballenger drew conclusions Therefore, if the tars of which are bound to be at- smoke do contain tacked by some colleagues cigarette because there was no proof c a n c e r-causing substances, that ciliated cells in labora- how could they accumulate tory solution behave precise- in the lining cells of lungs? ly the way ciliated cells be- You'd think the bouncing have in the body when mois- cilT3ted' cells would prevent tened by natural body fluids. PROOF DIFFICULT that. Dr. John J. Ballenger That proof would be ex- of No_rf.htugAgrn University, tremely hard if not impos- Evanston; Ill., atacked the sible to come by because of questiom the difficulty of experiment- ing with ciliated cells while they are still serving an or- ganism and its organs. Pre- vious detached experiments were with those of rats and other laboratory animals. Ballenger went no further than to suggest' smoke-de- ranged ciliated cells "is one of the mechanisms whereby tars Tnay collect in the lower respiratory tract and come into contactwith the mucosa. If the person is a heavy and persistent smoker the tars may be assumed to stay in contact with the bronchial mucosa for long periods. "It' seems likely that the decreased efficiency of the ciliary mechanism caused by- smoke plays a part in the productive cough noted by smokers. If the cilia do not keep the airway clean, the blanket of mucus containing foreign material collects and eventually initiates the cough reflex."

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