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Philip Morris

Mouse Cancer Produced with Filter Tip Tars

Date: 19620824/P
Length: 1 page
1003537817
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Type
NEWS, NEWSPAPER ARTICLE
Area
JOHN-WARE,JUDY/SHB FILE ROOM
Site
R22
Named Person
Bock, F.G.
Hartnett, T.V.
Named Organization
Journal of the Ama
TIRC, Tobacco Industry Research Comm
Request
Stmn/R1-037
Document File
1003537539/1003537961/620000 TI and TIRC Editorial Comments Informational Memorandum Releases
Litigation
Stmn/Produced
Author (Organization)
Chicago American
Master ID
1003537539/7961

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EXTR, EXTRA
Date Loaded
24 May 1999
UCSF Legacy ID
hbc91a00

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Page 1: hbc91a00
CHICAGO AMEAfI('~AN . .. .Chicago,IlLinois August 24, 1962 ' ... All' brands of t•ilter tip cigar: ets contain enough tar to cause skin cancers in ~ mice, a medical iiesearch team said today. They moted II however, that filtered i " smoke yields only one-third of the amount, -o ftar in standard cigarett smoke. ~ The findings are based on a one year study in which the tar from machine-smoked cigarets: was rubbed on the shavedlskin . of laboratory animals until ktNeir lifetime:"' • tt>mors appeared. The fiust '- . showed up after 19 weeks ofr ' . tar applications. C , The report, made by a Buf- falo research group headediby P~red! G. Bock, appears in the ' current issue of the Journal of' the American Medical associa- t[onl . , . , It drew ciiticism from T. V. Hartnett, chairman of the To- bacco Industry Research com- mittee, who noted that cancers haie beea'produced in labora- tory animals with a number, of, harmless, everyday, sub- ouse'' Cancer produced . Tobacc~o AgOin AQ ~Lind"to Canc+er rl_~ : . ZHQCAGO.. 7"°' ~~,~ :•24 (M=A ` . ~ . medic'al research tearri said' foday their tests ha.Ne dem+ ~ onstrated ^t`o b a e e o' srrnoke I~,n ctrawn through filter 'tipped eigarettes contains a tiar'sub; ~ ¢tance that can csuse skin f`~1 cancers in niice, but that fil tered si'noke. yielded only one ~ thirfl'di the amnunit of tar in ~ stafidard cWareGte smoke: ; i They saitt t'umors were inr f7uced' by every, br2 rnd of oig, nrette tebted. istances including eggs, glucose I [sugar]' and medicinal skin I creams. Hartnett added: "It is apparent that anim'al. skin painting, is not relevant toto the problem of human cancer, liparticularly lung' cancer. More to the point is this fact, human-type •lung * cancer has never been produced in ani- mals as a result of having them, inhale tobacco smoke thruout NEW YORK TIMES New York, New York August 25) 1962 _~ carcinogenic [cancer osusing]HANGER EXPERTS .STUDY FILTER TIN total amount, of smoke deltv I ered tio the target anca resulted in' a reduction in the incidence of tumors. • Find Cigarette Tars Cause "A parallel reduction in dose ~~ Skin /i;fflliction ini Mice " ers thn"~~` " ougH smoking fewer cig ' .. arettes. Studies of human pop- By DONALD JANSON ulations have shown that men ~ Specfalto'rhe New York iimes, whQ smoke fewer cigarettes `, CHICAC©; Aug. 24-Filter= 'have a lower lung-cancer in tip rigarettes contain enough eidenoe. tar to cause skin cancer in "A reduced intake of smoke , mice, four New York State De- also could be accomplished by partment of Health researchers -a smoker through taking fewer . reported today: -puffs or through smoking the .., However, they found that 'same number of cigarettes filter tips y,ieldedi only a thdrei «hich, by means of filters or the amount of tar contained in othrr devices, give rise to the smoke of standard cira- smaller yields of inhaled tar." re[.[es ana consequenuy pro. T. V. Hartnett chairman of d d fe uce wer skdn tumors and a t tl1e Tobacco Industry Research slower onset of t' h u mors an Committee, issued the follow= r^; - ~fi standand cigarettes. r.: ing, statenient' in response to No • skin tum n o s or cancer i " m d i IV[e ca ical Assoc developed In a control grou of ~'c Amer a+ p tion report: mice that received no cigarette 4+plot having seen the full l ar- ,tyr in the year-lbng experi. -• • ment. ticle as yet, we cannot give " ' The ideal u- comment.- course [for h arty detailed How +~ uac raaearcners con- ever, scientists advise us that cluded, "would be to stop smok- it is important to note that ing altogetHer." The researchens are Dr. Fred cancers have been produced in. G: Bock, Dr. George E. Moore; -laboratory animals with a num- Dr. John E. Dowd and Dr; ber of harmless everyday sub- . Paul! C:Clark of the Rosweil stances, including glucose, eggs Park Memorial Institute at Buf- 'nd medicinal skin creams, Iit falo. Their experiment was re: is apparent that animal' skin 1Sorted in the current issue of nainting is not directly relevant' The Journal of the American to t'he problem of' human can- -~ Medicali Association, published per, particularly Iung cancer. ~ here. "Moie to the point' is this They used six brands of ciga- fact: human-type lunl; cancer rettes„ including, two filter-tip has never been produced in an- types, in an effort to determine 1mal5 as a resv!t of haa+ing, whether the cancer risk had~ them inhale tobacco smoke been reduced by modifications throughout their lifetunrmc.'• made by tobacco companies in recent years. The six brands were machine sF.okedl to obtain the tar. This was then, dissolved in a solvent and applied to thP skin of mice In amounts equivalent to 8.3 smokPd' cigarettes a day. Skin, tumors were produced in forty-one of' seventy-six mice that receivedi tar, from the standard brands; and in fifteeq of sixty mice given.. filter~tipp tar. Nineteen tumors, some from each group, progressed too skin cancers within the one- year period. The first tumor appeared nineteen weeks after the start of the experiment. ' No tumors developed inisixty- six mice painted with the sol- vent, (acetone} alone or in six- ty-five untreated mice. The researchers found that tar yielded among, the stand- ard cigarettes differed by less than 20 per cent. "The public health Jmplica- tions of the data are indirect' but' meaningful," the research- ers said. "The smoke of all of t'he six branrl;; of, viearett'es was

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