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. "- _' _._.: . .....,_ .. ._ ~ . , ..... . CLENELAND PREW '. Cleveland. Chi'o. . Mav 1. 1962 ' .3!l`3n' tb ~~ DAVID DIETZ- th'l V/ ` Virus CausesLwnia~ C~ancer in A new approach to the can+ cer problem has been opened' up by the researches of a'team of, medicali scientists at the Baylor College of Medicine in Houston. . The team told the Atlantic, City, meeting of the American, Association for' Cancer Re, search of experiments in which ; extremely virulent lung can, cers were produced in hamsters with a virus Ani mals At the moment, however, there is no evi, dence to link the adenoviruses with cancer in human beings. It,is important'to keep this fact in mind. A survey made by the Ba;vlor' scientists showed that' more than one4ourth of patients treated for a variety of diseases at one hos. pilali had been exposedl to A'denovirus: 12 at't some time and now pnssessedl antibodies inn their blood which, made them immune to the i virLL3. However, It t, not' yet known how many healthy people have,the virus In their system. It' is known that the virus can lie dormant' for many years following a childhood infection and then break out again in,later life- About 15 years ago, the late Dr. Ftancisco Duran-Reynals at Yale University induced can-s cers inanimalsn with vaccinia virus~~ and a ttace dose of a cancer-causing ehemical- As a result of these experiments, he ad-d vanced,the notion that ordinary viruses might play a contributing part in human cancer. His findings were not'received favorably by most' medical scientists at the time, but the pendit+ lum has been swinging',in his direction in re- cent'yearst sometimes responsible for sore throats, cold- like symptoms, and pink eye in human beings. Dr. John J. Trentin, professor of experl- mental biology, headedi the team which in- cluded Dr, Yoshiro Yabe and Dr. Grant Taylor. Medical scientists have long,known that cer- tain cancers in mice and chickens are caused by viruses. But' this: is the first time that a virus which affiicts human beings has been foundito cause cancer in,animals. The virus used in the experiments is'known as Adenovirus 12_ It is one of a number of viruses which have been isolated, from the - adenoids of human beings. It is now known that these viruses are a common source of I infection among both chil- dren and adults. Outbreaks liave been, par- ticularly marked in military forces among',new recruits during,their first winter of service. . TIDi' RAIEIGH' 7DE5 Ra1;e:igh, North Carolina April 13, 1962 -1n Laboratory Anirrnals in M1 Cancer. Virus Said Produced Hy, FRA1K CAREY provides a nen stimulus to the Assoeiated Press Sedence Writer aheory that , some human cancers ATLAS9T IC CITY, N J. 6APt -~d be caused by viruses-and thus are possibly open to treat- Produetion of eancer, in labora' ment or prevention by vaccines. tory animals with a virus that' But the ACS, in a report re- commonly causes a severe ty,pee leased sunultaneouslywith the of respiratory cold in humans was 'ormal announcement by the: Tex- as Rroup. stressed thatproductioa reported today. *4 ' the hamster cancers with a The achievement was en-: arus responsible for anothlx type nounced by a group of •fexas re- )f human ailment. by -no means searchers who said tumors were ronstitules proof that human ean- produeed in hamsters with one cera are virus-caused. type of' adenovirus - a microbe Dr., John J: TrenLin of Baylor first isolated from diseased hu- University College of Medicine nd' told about lht hamster tumor re- id u d years ago a man a eno s n ne,~earch~in a report prepared f ' Co-authors of the report were 3. The malady, disabting, hut .Dr:,Yoshiro~Yabe:,a4so~of Baylor,: ,.e~ going on too furtherr com-, and Dr. Grant Taylor of the M.D: ptications; lasts longer than an or- Anderson Hospital, University of dinary eold:, Texas. Trenlin, saidtha6'ina separatn Trentin said cancers were proo- .tudy it was:found thal'more than duced in the hamslers by inlect, 2; per cent of patients treated for ine, viruses known as type-12 ad- a variety ob diseases at one hos- enovirus. pital had been exposed'ard were That's one of a, number of the immune to the same klttd of virus various types of adenovirus: that' u~ in the hamster studies. cronstitule a cornmon source of ^It is not yet known; ' said the respiratory infection among both .ltnenican Cancer Society's rernrt, children and adwlts- "how many hcalthy people haw The type of'respiratory ailment' the virus:,whieh can lie d,brmant, causedi by the adenovintses dif- for many years following infcr• fers from the garden-variety of common cold in several bion in ch'fldtood- to break loose res ects:' p ~ again iand again later in lifci • now, known to have vari- the annual meeting',of'the Ameri- f. The onset is usually more ous ttrains. EEfeetive vaceittes can Association for Cancer Re- gradnal., The ACS report said scieniisls against some strains have been would next try to delermme seI one of the worltl's leading 2- The symptoms-ineluding fe- developed. whathec adenoa-iruses could cause . And I the American Cancer So. organizations of'cancer investicat- ver, chills, runny nose, watering cancer in newborn monkeys or h eycs, soce t roat: hoarseness: ciety, which helped support the ors' wheezing. eough and a general other primates-the:better to ap, Texas: research, said the work down-in-th'e-dumps feeling - ana praise whether the Texas work c M h ve lbl niti i ou a any poss - e a ; more severe: eance as rerards human cAnr*r-