Tobacco Documents Online

J~. Hind and G. Gellatly February 1, 1913 W. L. Duinn, Jr. iWicotiine and' Inhalation Impact I am wriitinig thi's to make a matter, of record' our discussions of a deni'cotinized cigarette wfth iinhalatiion impact. , treated tobaccos, a standard analysi's reveal s that the ni coti ne in the smoke is reduced to as low as .2 mg. When these . cigarettes are smoked, the taste differs little from a regular cigarette, but the inhalation impact is dramaiti'caill!.y absent. The regular smoker is not satisfied by the smoke. He reports annoyance at the absence of i'nhalati'on.i'mpact, and'i taste becomes unpleasant as hie increa es puff'volume in an effort to obtain the impact. Another body of related'fact has to dio with the smoki'ng characteristics of uincased burley. A cigarette of 10'0% uncased• burley delli'vers suchi an impact that i't i'nduces a gag reflex. The smoker i s not l i kel y to iinhial e a second' puff' from such a cigarette. Our di'alogue has ratsed some interesting questions. Is thie intense inhailation impact of uncased burley entirely attributablie to the niicotinie? If' the nicotine were removed from uncased burl ey,iwouil d the ci'aarette made from th i s treated The observations whi'ch led to these discussions are as follows. The ammonia steam process is effective in removing up to 85% of the nicotine and other ailkaloids from cut tobacco. When the tobaccosof a Marlboro-like blend are so treated and M'arl boro-1 i ke ci'garettes are then made from~ these tobacco stiill deliver some impact? Are there other constituents of bur1'ey that can deliver impact ini the absence of nicotine? If so, can a cigarette be diesi'gned around d'enicotinized uncased burl ey such as to del i'ver taste and' i'mpact?' I f so, will the habi tual smoker fi ndisati sfacti on from smoki ng the ci giarette? The prospects of a denicotinized cigarette del ivering, ~ taste and impact are conceptually as welll as commerciaJly p . interesting. We can think of nicotine as the vehicle of'two ---ta phenomenai; the i nhal ati on impact and the, wel l-docuimented ~ physiological responses to its presence iin the bloodstream. C!i Cd

2 obvious. Many, of us have argued that it is the, pharmacoloigi'cal effect of the ni'cotinewhiich the smoker seeks. But iit is also a matter of' observation that dissaiti'sfaction is expressed when there is no inhalation impact. Is it possible that it is the iinhaTation impact per se which the smoker seeks and not the pharmacoilogi cal effect? A deniicoti ni zed ci garette which doles del i ver impact woul d provi de an opportuni ty tolanswer thi s signillficant question. Given such a cigarette andl given contiinuled siati s factilon from i t among habi tual smokers on prolonged smoking, i~t would follow that the pharmacological ef'fects of nii'coti'ne are not aought after by the smoker. Were such ffnd'iingis tolemerge, their commercial significance is i f present, i s acceptabl e tolthe smoker. We have agreed that the first stelp.is to make a cigarette from denicotinized uncased burley to determine whether or not there is residuall impact and whethier the quality of thiis ilmpiact, As aifurther observation, we are not restricted to uncased bwrley as the only avenue for del'iverinigi a non-nicotine impact. If the denicotinized' burl!ey does not delliver, other approaches to theidevelopment of non-nicotine impact should be exp]ored. /Jilh