Tobacco Documents Online

CHK-79-46 TOWARD A LESS HAZARDOUS CIGARETTE Banbury Center, Cold Spring Harbor Laboratory, 14-16 October 1979 LIST OF PARTICIPANTS Poul Astrup Department of Clinical Chemistry Rigshospitalet 9 Blegdamsvej DK-2100 Copenhagen Denmark Mario C. Battigelli Professor of Medicine Division of Pulmonary Diseases 724 Clinical Sciences Building University of North Carolina Chapel Hill, North Carolina 27514 (919) 966-2534 Theo Eicher Cellulosig Abteilung M 22 Bayer A.G. 4047 Dormagcn Bundesrepublik Deutschland (West Germany) 011-49-2106-514-854 . Lawrence Garfinkel American Cancer Society 777 Third Avenue New York, New York 10017 (212) 371-2900 Sam P. Battista Senior Staff Pharmacologist Arthur D. Little, Inc. Acorn Park Cambridge, Massachusetts 02140 (617) 864-5770, ext. 2021 Fred G. Bock Director, Orchard Park Laboratories Roswell Park Memorial Institute Box 312 Orchard Park, New York 14127 (716) 662-7618 William S. Cain Department of Epidemiology and Psychology Yale University School of Medicine 290 Congress Avenue New Haven, Connecticut 06519 (203) 562-9901, ext. 208, 224 Louis Diamond Director, Pharmacodynamics and Toxicology Division College of Pharmacology University of Kentucky Lexington, Kentucky 40504 (606) 257-2770 Gio B. Gori Deputy Director Division of Cancer Cause and Prevention National Cancer Institute Bethesda, Maryland 20014 (301) 496-6616 M.R. Guerin Tobacco Smoke Research Program Analytical Chemistry Division Oak Ridge National Laboratory Oak Ridge, Tennessee 37830 (615) 574-4862 E. Cuyler Hammond American Cancer Society 777 Third Avenue New York, New York 10017 (212) 371-2900 ~-h O O W O ~ N N Naomi Harley ' Associate Professor,of Environmental Medicine Institute of Environmental Medicine New York University Medical Center 550 First Avenue New York, New York 10016 (212) 679-3200

CHK-79-46 Less Hazardous Cigarette Jeffrey E. Harris Department of Economics Massachusetts Institute of Technology Room E 52-171 Cambridge, Massachusetts 02139 (617) 253-2677 Dietrich Hoffmann Chief, Division of Environmental Cnrcinogenesis American Health Foundation Naylor-Dana Institute Hammond House Road Valhalla, New York 10595 (914) 592-2600 Jerome H. Jaffe Chief of Psychiatric Research Department of Biological Psychiatry New York State Psychiatric Institute 722 West 168th Street New York, New York 10032 (212) 927-6350 Charles Keith Senior Research Associate Celanese Fibers Company P.O. Box 1414 Charlotte, North Carolina 28232 (704) 554-2000 Michael Kunze Hygiene-Institut der Universitat Kinderspitalgasse 15 A-1095 Wien Austria 011-43-222-430128 Edmond J. La Voie Division of Environmental Carcinogenesis American Health Foundation Naylor-Dana Institute Hammond House Road •Valhalla, New York 10595 (914) 592-2600 Cornelius Lynch Manager, Smoking and Health Program Enviro Control Incorporated 11300 Rockville Pike Rockville, Maryland 20852 (301) 468-2500 Participants - 2 John C. Maxwell, Jr. Lehman Brothers Kuhn Loeb Incorporated 55 Water Street New York, New York 10041 (212) 558-2765 Victor K. McElheny Director, Banbury Center Cold Spring Harbor Laboratory P.O. Box 534 Cold Spring Harbor, New York 11724 (516) 549-0507 Friedemann Muller Cellulosig Abteilung M22 Bayer A.G. 4047 Dormagen Bundesrepublik Deutschland (West Germany) 011-49-2106-51!4-854 Brian Richter Economist, Smoking and Health Program Enviro Control Incorporated 11300 Rockville Pike Rockville, Marylan& 20852 (301) 468-2500 Michael A.H. Russell Addiction Research Unit Institute of Psychiatry 101 Denmark Hill London SE 5 8 AF England 011-44-1-703-5411 Colin J. Schwartz Professor of Pathology University of Texas Health Science Cente. 7703 Floyd Curl Drive San Antonio, Texas 78284 (512) 691-6121 William Selke Director of Research Schweitzer Division Kimberly-Clark Corporation Lee, Massachusetts 02138 (413) 243-3550

CHK-79-46 Less Hazardous Cigarette Participants - 3 Saul M. Shiffman Associate Director Laboratory for the Study of Smoking Behavior Department of Psychiatry and Behavioral Science Neuropsychiatric Institute School of Medicine ~ University of California, Los Angeles Los Angeles, California 90024 (213) 825-2410 'Richard Stewart Corporate Medical Director S.C. Johnson and Co. Incorporated 1525 Howe Street Racine, Wisconsin 53403 (414) 554-3675 T.C. Tso Chief, Tobacco Laboratory Beltsville Agricultural Research Center Agricultural Research Service, U.S. Department of Agriculture Room 104, South Building Beltsville, Maryland 20705 (301) 344-3477 Benjamin L. Van Duuren Professor of Environmental Medicine New York University Medical Center Institute of Environmental Medicine S50 First Avenue New York, New York 10016 (212) 679-3200 James D. Watson Director Cold Spring Harbor Laboratory P.O. Box 100 Cold Spring Harbor, New York 11724 (516) 692-6660 Ernst L. Wynder President American Health Foundation 320 East 43rd Street New York, New York 10017 (212) 953-1900, ext. 212

CHK-79-46 RCWAM A LES.S HAZARDOUS CIGAFEI*EE Barbuty Oenter, Cbld Spring Harbor Iaboratory, 14-16 Oct,ober 1979 S~ayc3ay, 14 October Aftenxoon - Arrival at Robertson House, Banhuy, for registration and assigrment to quarters in Robertson House and at Fort Hill 6:45 - • 7:30 p.m. - Cbcktails at lmbertson House , 7:30 p.m. - Dinner at lbbertson Fiouse 9:00- _. 10:00 p.m. - C)pening session, Meeting House, Banbury Welcane - V. K. McElteny, Director, Banlury Center Opessing remarks - J. D. Watson, Director, Qold Spring Harbor Iaboratory ~ Introduction to the meeting - Gio Gori, National Cancer Institute Monday, 15 October 7:30 - 8:45 a.m. - Breakfast at Fobertson House 9:00 - 12:00 noon - Session 1: Introduction and epidemiological trends (15 minutes per speaker) Chairperson, E. Cuyler Haimond, American Cancer Society Ern.st L. Wynder, American Health Fbundation, Epidemiological perspectives 41-1 N Oornelius Lynch, Fhviro Oontrol Inc., Non-detectable risk levels in cigarette smking ~ cancer cases and eocAtro s E. Cuyler Haimmnd, American Cancer Society, The long-term benefits of reducing tar arxi niootine in cigarettes Lawrence Garfinkel, American Cancer Society, Changes in the cigarette eonstmption of smkers in relation to changes in E.a tar and niootine vontent of cigarettes s~ked O O Michael Kunze, Hygiene-Institut, University of Vienna, ~lds ~ of tar exposure: analysis of smking histories of msle lung ~ 1

CHK-79-46 Less Hazardous Cigarette 12:15 - : 1:00 p.m. - ILtmcheon at Fobertson House 1:15 5:15 Program - 2 Zbx.ioological dimensions (15 minutes per speaker) Chairperson, FSced G. Bock, Fbswell Park Menorial Institute Sam P. Battista, Arthur D. Little Inc., Inhalation studies of. toxicity of tobacco sroke Mario Battigelli, University of North Carolina, Reversible versus fixed obstructive disorder of the airways: A current dilemma Lfluis Diamond, University of Kentucky College of Pharm3cology, Puhmnaxy toxicity of nitrogen oxides Fred G. Bock, Roswel1 Park Marnrial Institute, Co-carcinogenic properties of niootine Benjarnin L. Van Duuren, Institute of Enviromental Medicine, New York University Medical Center, Co-carcinogens in tobxcco carcinogenesis Richard Stewart, S. C. Johnson and Son, Inc., Racine, Zbxioology of carbon monoxide in cigarette smoke Poul Astnip, Rigshospitalet, Copenhagen, Carbon monoxide as a oontributor to the health hazards of cigarette mmking Colin J. Scfwartz, University of Texis Health Science Center, Cigarette ssroking and cardiovascular diseases Dietrich Iioffm3nn, Naylor-Dana Institute, Airnxican Health Foundation, The role of wlatiles and nonvwlatiles and nitrosamines in tDbacoo carcinogenesis Naomi Harley, Institute of Environmental Medicine, New York University i•Sec3ical Center, Poloniurn 210: A questionable risk factor in srroking-related carcinogenesis Iawrence Garfinkel, American Cancer Society, Changes in bronchial epithelium in relation to cigarette smoking: 1955-60 versus 1970-77 5:45 - f„h 6:30 p.m. - Oocktails at Robertson House ~ O 6:30 - - W 7:45 p.m. - Dinner at Robert.son House ~ N ~ - p.m. - Session 2:

CHK-79-46 Less Hazarc3ous Cigarette Program - 3 8:00 - 10:00 p.m. - Session 3: Risk reduction achievements and future directions. Open discussion. This session is interded to review the extent to which risks of cigarette snoking have been reduced by concurrent efforts to alter the cigarette product anc3 to persuade people either to stop strnking or not to start, and what the implications of these trends are for further efforts to reduce risks of smoking. Chai*pe,-son, Michael A. H. Russell, Addiction Research Unit, Institute of Psychiatry, Inndon 4laesday, 16 October 7:30 - 8:45 a.m. - Breakfast at Robertson House 9: 00 - 12:00 noon - Session 4: Cigarette engineering (15 minutes per speaker) l'Chairperson, Gio Gori, National Cancer Institute ~ T. C. Tso, Beltsville Agricultural Research Cen'ter, C'.henistry of tob3coo, and the effects of agronceny and curing M. R. Guerin, Oak Ridge National Iaboratory, Chenistry of tobacco i sRoke ~ William~Selke, Schwieitzer Division, K;.mberly-Clark CbYporation, Reconstituted tobacco sheet Theo Eicher and FYiedemann Muller, Bayer Industries, Dormagen, A co-tobacco material, RQ1 V Charles Keith, Celanese Fibers Qmpany, Physical methods in modifica- tion of tobacco stnke (filters, papers and ventilation) V William S. Cain, Yale University School of Medicine, Sensory attributes of cigarette sroking ~F.dmnd J. Ia Voie, Naylor-D3na Institute, American Health Foundation, The less harmful cigarette and tobacco srroke flavors N Gio Gori, National Cancer Institute, Overview of changes in the ~ cigarette product 0 C~J 12:15 - ~ 1:00 p.m. - Ltnlcheon at Robertson House ~ N OPA Nj

~ CHK-79-46 Less Hazarcbus Cigarette Program - 4 1:15 4:15 p.m. - Session 5: Behavioral and eoonomic issues (15 minutes per speaker) Chairpersen, Jeresne H. Jaffe, New York State Psychiatric Institute ~ Saul M. Shiffm3n, University of California, Los Angeles, Schooi v of Medicine, Reduced sn-oking, withdrawal syaptans, and cessation: A cautionary rnte . /Mic1ae1 A.H. Russell, Addiction Research Unit, Institute of Psychiatry, London, Dependency on niootine: relation of niootine yield and blood niootine levels ~erome H. Jaffe, New York State Psychiatric Institute, Preliminary observations of switchers: some physiological and biological findings J John C. Maxwell, Jr., Letman Bxothers Kuhn Ioeb Inc., Trends in cigarette consuption . v Jeffrey E. Harris, Massachusetts Institute of Technology, Taxation of cigarettes according to tar and nieotine contents Brian Richter, IIzviro Cbntrol Inc., Macro-eeona*ucs of the prevention U of tobacao-related diseases Oenference suznn31y: Gio Cori, National Cancer Institute 5:45 - , 6:30 p.m. - Cocktails at Fobertsan House 6:30 p.m. - Dinner at Robertson House Wednesc3ay, 17 October 7:30 - 8:45 a.m. - Breakfast at Robertson House Departure