Tobacco Documents Online

CLEVELAND PRESS ~ oo -AAj, yq a 3 Cleveland, Ohio May 1, 1962 iDAVID DIETZ- Virus Causes Lung Cancer in Animals C A new approach to the can- cer problem has been opened up by the researcl.es of a team of medical scientists at the Baylor College of Medicine in Houston. The team tuld the Atlantic City meeting of the American Association for Cancer Re- searcli ofiexperiments in which extremely virulent lung can---AF- l- cers were produced in hamsters with a virus sometimes responsible for sore throats, cold- like symptoms, and:pink eye in human beings. Dr. John J. Trentin, professor of experi- mentali biology, headed the team which in- cluded Dr.,l'oshiro Yabe and Dr. Grant Taylor. DIedical scientists have long known that cer. tain eancers in mice and'chickens are caused by viruses. But this is the first time that a virus which, afflicts human' beings has been found to cause cancer in animals. The virus used in the experiments is known as Adenovirus 12.- It is one of a number of viruses, which have been isolated from the adenoids of human beings. It is now known that these viruses are a common source of infection among both chil• dren and adults. Outbreaks have been par• ticularly marked immilitary forces among new recruits during their first winter of service. At the moment, how'il there is no evl: dence to link the adenoviruses with cancer in human beings. It is important to keep thisSact in mind. A survey made by the Baylor scientists chowed that more than one-fourth of patients treated for a: variety'of diseases at one hos- pital had been esposed to Adenovirus 12 at some time, and now pnssessed antibodies in their blood which made them immune to the virus. However, It is not yet known how, many healthy people have the virus lh their system. It Is known that the virus can lie dormant for many years following a childhood' infection and then break out again in~later life. About 15 years ago, the late Dr. Francisco Duran-Reynals at Yale University induced can- cers il animals with vaccinia virus and a trace dose of a cancer-causing chemicalL As a result of these experiments, he ad- vanced the notion~that ordinary viruses might hlap'a contributing part in human cancen His findings were not received favorably by most medical scientists at the time, but the pendu- lum has been swinging in~his direction in re+ cent' years. THE RALEIGH =S Raleigh, North Carolina ApriL 13, 1962 In Laboratory Animals in NJ Cancer Virus Said Produced By FRANK CAREY' provides a newstimulusw to the Associated Press Science N'riter theorythat:some human cancers ATLANTIC CITY, YIJ. (AP)_ could be caused by viruses-and thus are possibty open io treat• Produ¢Gon of~ cancer in labora- menUor preventimn tiyy vacc:nes. toryanunals withavirush thatBut. the ACS,., in arepnrta re- commonlycauses a severe lypc leased'sirnultaleously with h tl:e of respiratory cold mh'umans,was 'ormal announcement bylheTr;;.'s group+,stres<:el'th'at Nrrdvc ton repor[ed loday. . .ff the hamster caneersw•ith aThe achievemenl; wass an-. :irvss responsible for another type ttounced by a group of Texas re- A human aiiment by no means searchers who said tumors weree constitutesproof that:'human ean, produced in hamsters with one cersare virus-caused. type of adenovirus.- a microtxDr. John J. Trentin ofBaslbr °tver sdyfirst isolated from diseasedhu- °tversdy Colte;e: ot' M1tedic me. t' man adenoids nine years ago and told about the hamster lumurre- nmw 4:nowntohavevari, searchh ma repovtp,repared forous, straihs.. Effective %aceines theannual meeting~ of the Amcri- againsr~ some strainss have been can Assodation for Cancer Re- devedoped- search, one of the wnrld's:leading And the American Cancer So- organizations of cancer investika4 ciety„ which fiel orr., pedl support tha. Texass research'~ said! . the work Co-.authors of the report were Dr. Yoshiro Yabe, also of Baylor, and Dr- Gr®nt.Tayloaof the M.D. Anderson Hospitaij, Universitvof Texas. Trentin.said cancers were: pro- duced in Jre hamsters bv mjec~- ing- viruses known as,typa-1'sao-s erovirus. ThatJsone o6 aa number oi thee various typzss of' adenovirus that constitute a arrtmon source of' respiratory infection among both childten and' adults. The type of respiratory ailment caused by, the adenovirvses dif fers, from the garden-v'ariety, of'commoncold in several respeMs: I. The onsett is usually more gradJt.al., 2.. The svmptoms-includimg fe- %cr, chills,, mmnv nose., w•atcringeyes, snce th'rnab, hoarseness- wh~eezihp. cough and' a general dowmin-the-ditmps feeling - are more severe:.. 7. The malady, disablinghtR. ,eldom xoingon, too further com, ••iicatlons, lasts longer than on .or-~iiiuary. coVd. Trenlin said that in a se,navate. ;tudyit.was: found Ith'at more ihan. ^:per centof'7anents.i;cated for a varictyo6dtse-se at.or~e hos- I,Lai:hai bcan eawsF, a^:!.'w.ere Immune.to the same kiit[j of virus u,ed~in~the hamster studies. "]t is not yet known;" said the .Smerican Cancer5ociet,v's repnrt, "how manyhcrdthypoopke havp thee v'irus, ahich can liee dormant for manyycars fo110wing infcr- tion in childhood, tD brcakI~ose again and aga.inlatbr in liic:" The ACS,report said scienllst,, would ncxt Irv to debermme whether adennO tvsescould.causecancer in newborn monkeas or nther primates-the betterln ap- praise w'hethcr the Texas moek . couid havee anyy possible si,nili~ca:nce.as roeardshuman canrer e