Tobacco Documents Online

1n~~ '.~~y'~~~,~y~~~F9- ~°„"T" . .,,,, ~-fa~r~.._.i.._.. ~Tn identifyirig these gaps in knowledge we repeatedly^ ~found that ~the most important immediate "need was to review, w the knowled each one of , us possessed of__ currsnt~ in" detail ,- ge i~ •~--- a.r.r ... . . _..,:.as • ..rS .~ . --" ;V ,.. workowJbcing_carricd~rout~in'the,countrics we represented; whether~published 7or not;' inr'-order to di"scover` wherenew~ ~R-... , work mi ght most;_ usef ully be, concentrated .~~ We decide+d that at. .this task shouhd be undertaken separately by each one of ~, .:. .. ~. ~ { us.prior to a further meeting of the Working Party ~ ~ rktTM~~~~sy~'~ w"~ ~~ _qd~ar 'i"r!!. _ . .:. . , . . .ar 11Therefte we considered, in detail, which specific areas could most profitably be covered in these reviews. ~ ~ yy• ~'~3~J.ir ryci~yai:~~~~Yf-s~i~s"1~ ~' ,: r ."yYFlf°~~ .s,J~#~~Kf~'"~~~t~t~.~~~sy.A~} ,~ ~,y~ ki ~At ~.~ ~~''~ .. ... With fti fd thten veryew excepons; weouna deficicie n knowledge relatedto_ the,lackyofresearch concerning: the~ many other co-variables-besides smoking that are-statisti~ -r cally associatedwith thesamerange of diseases ~most of , which are likelyto have multi-factorial etiology t involvin g . ~. diverse genetic, constitutional, and other`factors-,:~x,The most~ ~important of theseyco variables are4:~diethabits, (e.g~ ~ Vitamin intake)'; weight;:height;' sex; personal history. of ~= ~-- diseases average amount of sleep, fitness `(e g.`, exercise, sp_orts) `Valcohol;consumption;'medications," drug abuse;%- ~ personality~score;~ethnic background;-occupation; income, ,familyx;size; history of~ diseases within the family, hobbies„ •. i- .i . . . . N , . ~~~,fmarriage/divorce • " '. ' `r . ~' ~,~ : f, ~`~ `' `~~,~ f~ • ~ ~F ~-e x ~'.:. r'Y .•viF~-'r t 7r 3.-:~ +~.s'~-, ' ~',It;`~quickly ~became~ clear tous th ~~~,~at the task which we hadyfidecided; to undertake was going'to be difficult 'at the; outset,•` becauseof the failure f on the part of all, of us ~~~y a~;•. . . . . .... ]l recent yearsto, maintain high and :c ontinuous level of ~ communicationbetween thetobacco:industries in different~' . ~sftfie w r aridhli~ o `ldalough part th tis was notcovered+y our~termsof~ reference ;~`weagreed to recommend that furthe ~ consideratiori should be given to the preferred means"whereby; ~. ,: _ , . .: ; . .... .:, . : such communicationse~ in:the specific area of knowledge re~-~ lated to our termsof. reference, might be improved.M; " r„ ~ conclusions in;respect of four areas of research~h~"t~coide fll' as''etectins ;~° cose ..qonsroowsPara seo ~18f~i3.s~~65Fd~iQ-a-8ii.dY L~i-iiih?d.S~.tTLSt9'~i fu.~YiYitt76'LCeiMA.:.1....~iStY_':%2~.r..ri3.5}slCai#~.i103i0tlntiiJ 111M ~W_ ;~''W~~~~'~~' IIIM~ ., 10, We _c'oncluded that there.were defects ~.n knowledge regard ~toN the multi=,fac,.~torial".ynature,;of two entirely, different aspects-of,.,,cardiovascular" disease -whicli' have. been statisti=` { . call, th smokiname ly"~ " ,r.ass `~~~~:= g n • - fi t~e t-Ai4at.~Iirr+.Ha.~n...cSwi•.p f ~ r ~~i~y~. •• ~~ ~,~.'~` gv 'G•Hwys~ . ) j~9 ~r•.. . +.»~~,'~`P,..~~,,..,~l~"YaY• ~~;' ~~~ .f....~: -~. t.Factors which might be immediate causes of death b i - .~ _,r e concluded that the current`evidence ,, related~ ~ it ti~s almost solely to .crude 'overall 'mortality ratios had generally failed to recognise the ng' overridiiig ' importance of takiaccount of genetic '' `constitutional and social'`'variables'between groups4 which have different mortalityratios.,Alternative R,3~„~ t.~. S~ a.a ~f w ~•.. k ~ 4 Y ~ CARDIOVASCULAR DISEASE

INTERNATIONAL COMMITTEE ON SMOKING'ISSUd:S .WORKING PARTY ON MEDICAL RESEARCII - FIRST REPORT htEbIBERSHIP ~ W F~ ~2 ~.'i1Al 'IC,•~Z,..~~it5!~`i.'.,"'af'k~~~1~~ )r. H R; Bentley irr. r .cr. t..0i1Jy ` Dr. D.G.Felton; ~.k!w~.';W ~" Dr . E O Field e S•r~s~~ ~~~„~! ~i~3y, s~ a 'i°r{" ~,~',i•~ ,~;t'tl~•~;w:~~~r'x.~t'~~.'F~,~'F~' . ~ 2A M r. C-. R, L"' M a t c he t t t *'..~re4:at::%}i.•~!S' .•,1u; I.T.L (Chairman ~ R.J. Reynolds ~ B A ~}.'{~+~'.~•~'~~i~C~~ Gallaher R7: H~'a..: rF f+` ~ il ' ;yy x Philip Morris i - Carreras Rothmans Reemtsma ~: I NTRODUCT I ON ~~~:: ~~ ~±F~~~Ar }}°~,~~k}~r Pr~vr~ttl' .~rk~9tY ~r.i+ - Y.. ~4 •.t~~{' ~ . . . C,yy,'~r °{' Ir ~':? ~ < -~ ~"' ~'~d ,~ s~° .;:~ ~ . ;•,,PTe first discussed the concept of f'causality" in the~ = context of theI.C.O.S...I. Position Paper,which acknowledged the fact that."there is a'continuing smoking and health`,; controversy;.~~We recognised that medical and scientific ~Ropinion~Yxsnot unanimous.as'to the interpretations to'be placedupon,thestatistical``associations between smoking. ~, . , 4 ~*` and various disease ~' ~ j~~r~:~~;~~~~~.~ c _.. .. ,. . ~~C '1 _:4.....: ,~s•1kwr+ h i: Afi.~a r-. .,~ e4~ 9~ _ _...._ _ ... _. ... ..... ..., -....;-•. L i~.is . ,,v. .n--.. We then considered briefly,"all diseases and medical`.y conditions that havebeenassociatedwith_smoking" but:'r . .,., ,..:,.. -decided that in order:.' to meet ' our targe , t il o..f producing'.a, first report by the 17th September'`next,-it was necessary 1to;exercise , our.optiorito be 'selective in our coverage`'_ and~in the;reccimmendations 'we„ might wish to make. , Accordingly _we,concentrated upon°;four main areas of concern and considered .. -.., hese in the orde us. t rofpriority which.`we9believed tobe J tified by- the extent"of the deficiencesin knowledge'±`posed> by. each of them:N..t r.vv_.,,z -~, M WA

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