Tobacco Documents Online

Dwarm..em of aioclwniaey, a~o;l~s~cs and G,~ics, University of Cok~rado Health Scie~ea C~, Den~'er, CO 80262.

Overlapping direct repeats stimulate deletions in specially designed derivatives of plasmid pBR325 in Escherichia cell

Department of Biochemi.~try, Biophysics and Genetics and Colorado Cancer Center, Univ.ershy of Colorado Health Sciences Center, 4200 East 9thAvenue, P.O.

Participation of the SOS system in producing deletions in E.

D@~'onen~ of BiocAemLq~j, Blol~hysic~ and ffe.nez~s, ~n~,ersity of Colorado Health gdence.¢ Cen:o, Denver, CO 80262.

Last July I submitted to the Council for Tobacco Research the preliminary outline of a project entitled "Mechanisms of Spontaneous and Mutagen-lnduced Deletions", which was subsequently approved by the Executive Committee of your Scientific Advisory Board for consideration of a more detailed proposal. I have recently been informed by the National Science Foundation that they will be willing to support this project beginning approximately on January l, 1989.

Your recent inquiry concerning suppor~ by this Council o£ a proposed research stud7 has nov been considered by the Executive Cc~n~ttee of the Scientific Advisory Board.

Attached are copies of key documents concerning this inquiry.

In compliance with the requirements for the first step in your application procedure~I am enclosigg the preliminary outline of a project entitled "Mechanism~ of Spontaneous and Mutagen-Induced Deletions", for which I seek support from The Council for Tobacco Research.I am including the following appendix material:l) a manuscript in press in Mutation Research, 2) page proofs of an article to appear in a Symposium volume, and 3) a table summarizing results which are being prepared for publication, and which I refer

Give the following] ~nformat~on for key professional personn~| listed on pa.~ 2, b~jinn~n;; with Principa! Investigator/Pro;Faro Director. Photocop,t this pa;p for each person.

This article is no;v in press in DNA Replication and bluta~enesis, a volume

Elias Balbinder, Cheryl Mac Vean and Robert E.

Attached are copies of ke7 documents concerning this inquiry. Please indicate below your reco~ended action, an~ return ballot in envelope provided.

This article is now in press in DRA Replication and Muta~en~sis, a volu~e

In compliance with the requirements for the first step in your application procedure~I am enclosing the preliminary outline of a project entitled "Mechanisms of Spontaneous and Mutagen-Induced Deletions", for which I seek support from The Council for Tobacco Research.I am including the following appendix material:l) a manuscript in press in Mutation Research, 2) page proofs of an article to appear in a Symposium volume, and 3) a table summarizing results which are being prepared for publication, and which I refer

G~ve the follov,~ng information for key professional personnel listed on pa§e 2, b~nning with the Principal Investlgator/Pro~ram Director. Photocopy this pa~ for each person.

This article is now in press in DNA Replication and Muta~enesis, a volume

Elias Balbinder, Cheryl Mac Vean and Robert E.

While the role of sequence homologies in the formation of deletions is well estahlished, we know nothing about the mechanisms which bring them about. The mlsallgnmenc models leave this question entirely open. ~osc of what has been published to date is mainly concerned with the roles of legitimate versus illegitimate recombinakion (4, t9, 20).

Institution ~ address: CELL B~OLOGY & ~T~OLISM B~CH/NATIO~ I~ST~TUTE OF CHILD ~TH & ~ DE~LOP~ ......

Your recent inquiry concerning support by this Council of a proposed research project has now been considered by the Executive Committee of the Scientific Advisory Board.

Atta=hed arc copies of key documents concerning this inquiry. ~lease indicate below your recommended action, an.d return ballot i~ envelope provided.

The Council for Tobacco Research-USA, Inc.

Studied for the M.S. degree in Microbiology, Tel-Aviv University, under the supervision of Professor I.P. Witz Thesis Topic:

Disulfide Linkage of the ~ ~d ~ Chins of the T Cell Receptor POSS~LE ~ENTIFICATION OF ~VO S~UC~ C~SSES OF ~CEPTO~"