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Archives (National Archives and Records Administration)
Bayer
Fuller Fund
Olin
*Scientific Advisory Board (SAB) (Only use SAB with name of specific org.)
Temple University
US Army
Named Person
Damon, Albert
Delaney, Olin P.
Fuller, Ann
Gross, Arthur L.
Lyn, Merrill
Mcken, Herbert
Palmer, Albert B.
Warner, E.D.
Date Loaded
11 Jan 2006
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0411

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O~ 0 0 "-,,,I c.j'l ,,/ "llll.: (:~}tJl~[ll, I.'(}1{ "l'()l| ~:(i(I I(1'].~1'[~,1{([11-! .~ ~.
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0") 0 0 ..~ (.,n C~ '-.,4 SCIENTIFIC ADVISORY BOARD to The ('oun<il for Tobacco Re,arch-t) S.A.. I~. . ~ ]unc 30. 1971 SIIEI.IXlN C. ~MMERS. ~.D. Chair~n C~um~ U~mily C~It~ ~ Ph~iam ~nd Sub,cons Nc~ York. N~w IIOWARD B. ANDERV~, ~i¢~ti~c F~;I~ (r~li~d). ~ I~£ ~ Ihc Nal~n]l Ca~cr Imlilulc RICtlARI) M. BIN& Lm An~l~ McKEEN CA~EL~ ~.D., M.D. Pro~ess~ E~rlrm ol Cm~ll Unlve~ly Medical C~, New Yolk. New Ymk RORERT I. llUEBNER, M.D, Chl#. Viral C~i~ BrB~h D~ of r~ D,,b~n ol Bi~o~icat CLARENCE C~)K LI~L~ ~.D.. LLD.. l.~t.D. Ct.A~ON G. L~SLI, ~.0., M.D. KENN~II MERRILL LYN~I, M D., ~.D., LLD. WILLIAM F. RIENIIOFF, ~., M.D. Johns llopklm Unlve~it7 ROBERT C. I1~, A c#q ~l¢nli~ [~i~ctor I. MORRI~)N ~RADY, M D. ~OIIN CI.ARENCE (;(~OK UTTLF_,, S¢.D., I.I..IL, l.i,. I). 1888-1971 Dr, Clarrnc¢ Cook Liltl¢. intemit~o~-II7 kno-m gcr~tidtt cana:r r¢~il'chcr0 died [~c~mber 22° [97I. Ik hid ~n ils prcdeccsmr zi~ ~ly dirt I~ lall¢(I mll~izh~nl in 1934 vimey ~u(I. an e~ive ~t~ ~ wh~h ~17 ~ld v(~e. Former ~¢s~n( ~ ~h I~ Uflivmily d Mii~ (1922. 1925) a~ Iht Univ~ ~ Mkhipn (192~1929). ing figuR IS I rain a~ ~ I K~ntilt. Warn, dy~mk, in ending ~ality with a sha~ wit. ~. Litlk ~ll o~ ~ the ~.t ~knli~ll led ¢~enlually to ~ ~r~ vi~ I~ ~ ca~cr. d~ p~ring work ~ immu~ l~ wU ~ ~ marc~, into I~ #~IE ¢~= ~ ~hl~. ~. UIII¢ the wOr~-fl~ JKkm ~1~ in B,r Ilu~. M=im. In 1929. Ik ~rvcd =s ill ~i~lm until 1956 =~ =s di~tot e~dlul unlil his ~=lh. i1¢ fm~rlp w= M=~E~E ~1~ (1929-1945 ) ~ I~ A~an A~il~ f~ l~ C~I~ d Ca~er, I~I Ao~m~ ~ ~ ~ ~ ~m~r ~ nu~ ~nli~ ~N~. Ik ~u~d m~ny ~s ~ ~ ~ his 1939 ~, "Civil~ti~ A~insl Ci~;." b Ctill c~m~ ins~ ~icnli~ l.~hlp i~ ~. Hit ~l~i~l~ many .nd im~t~inl, ll~ will ~ ~ply mi~d.
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0") 0 0 "-.I C~ O0 CONTENTS Inl,oducl~nn .................. /r'h~ Cancer Prc~lU'mm ............... ~ ,~rdbv~scul~r R c',,~ ~r ch .......... II ./Nrurophysi+d~y. Ptychnphy~ok'~y =n~ Ph~tm~c~lotl~ . 14 I~ Olhc+ Studlc~. Introductim) Prcvious Annual Rrporls hive Staled The Council for Tuhacco Research-U.S.A., ~icnlific Adviso+ ~rd. ~ ~l~i~, wh~h ~nlin~ Io ~ lhe p~o~am. ¢mph~size study of l~ Io ~ rcla~¢d s~alisllcally in I~ir i~cnce Such di~a~s, cs~ci+lly c~r, c~t~+~l~r ~il~nls ~nd chrnn~ A~ new ~CCpII ~vc~ with ~c~t to /l~¢+kll m+hlnilml lhll m~ ~ in~vcd in lhe ~ ~ ~ mmlitul~B d+mm~, lhcm con- ~s in lure lu~sl new ~ I~I cl~o~al u~nt~in[ advam~ to tu~ l~ ~ and in~u~tr wi~ ~ ~ M m~7 ~ ~ ~ any ~ ~ ~n ~Mly ~ ~ ~nt uny~in~ ~m~in~ an inte~ut~ p~um ~ l~ ~l~ R~n~in~ I~ lim~s~ we h~ et~mpl~ only Io ~09~ in In lhc ~tu e~d lu~ 1971. ~ ~1~ cnle~rd Ihc "pu~ ~in'" ~ ~lo~ in Ibc msny di~i~i~l inv~ved.
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O~ 0 ~J O~ The Cancer Program Virtues and Cancer Viral n$~c~s ~ c~r¢'~'. |ncl~din$ ~ hum.n di~a~, ~re ~ing in- tern. Ire clu~ ~ ~rll f~. Pcr~ ~ ~c~l~t ~omincncc in th~ until. ~nr ~ ~ ~ ~ns ~lill I~rKcly unk~wn, il ~c~cs ~clivlled m "'~rcprc~d" I~ Iri~ 1~ ~lopmenl ~ c~rr in looms dc~r~mi~d Ey Kcnct~c pro~r~mmin~ ~ I~ slrain or ~cics. l}roelOlamenl o/• Tea~ Sy.~em A C~un,cit'sl~n~d study h~t ~n ~i~ *~ devel~nt c~ su~r- ~Icnti~ll ~ wr~ c~m~ls, in ~ll~t~ with t~ vires, to pr~U~ "mali&nant Ir~nd~m~(~'" ~ ~lb. F~ e~lm~, rml emb~o cells inf~lcd with RuUK~ ~ktm~s ~ h~ ~a t~at~ with var~ ~ ~ Irl~f~mlt~ in unin[~ ~t cm~o ~llz ~milzdy Irczl~ m in inr~zcd from like trt~t~nt with t~ i~t~ ~ DMBA-I~I~, untr~*,~or~d ceils, ~ wo,k ~cd ~lt ~ thh ~I, It ~ut, ~lh chemist .n~ vims kcmi~ vires worked I~l~ ~ inh~rm.l~ for t~ n~aliKnant tl ~n~folms~km. It must be recognized th~l th;- model do~ not dupl~alc real tifc ~ke of su~r~nsilivley. ~ eff~ ~ c~m~ls on cell I~ansformati~ ~cady enhanced by priming with vi~ w~ I~ ~li~e cffecls ~cled Io s~w ~iliv¢ eff~ll by chcm~l a~nm w~h. ~ Ihe ba~ls m wvo Icsl syslcms, h~ ~n c~si~Rd I~lly I~tive ~ "c~rci~m " simply ~ ~ulom:~:lly im~y lhll :~h :u~l:~ s¢ eilh¢: "dan~rou¢' ~ "sale." T~ ~1 b ~ly ~ m l~ Ihst ~ov~ c~ralive c~- ":ctivily Ki~" ~ ~! ~ ~1~ ml~ ~ I~1 will ~¢mll ~ • ~ mi~tur~ wilh I~ ~ hi~ ~ivi~. Any itl¢~ to C~trs~dstc fi~inp [t~ ~h ~ ~! Io RII life dl~l~l, e~i~lly Ihc human, will r~uirc even grellcr ~R ~ d~t~ t~n including human lis~ cuhu~ in I~ ~lem [or ~mpari~)n a~ conltl~l a~in~ I~ rclallv¢ ~gr~ ~ ci~ I~ibilily in human A~t~r vires-related #l~y ~ ~ C~il, com~clcd dining the year. ~t to ~lc~i~ w~t~ s Rlml~mhip could exit ~tween the ~cme~c ~ cm~e~ in huma~ rand I~ pr~ ~ ca~cr vies in hou~- while C-ty~ vir~s in ~n ~i~ ~at¢ ha~¢ ~n fou~ in the ~m~s~c cal. cal. II l~a~. u~r ~lutll ~1~. ~ll leli~ C-ly~ +~u~l in.riled as indi~ I~lenl ~1 wh~h may ~cliv~t¢ tn I~ [clu~ or I~lcr ~ ~ ~ntlst. ~inI ~ ~ (s~l ~ t~ ~ludy, dialed ind~al~s Ihlt feli~ u~ vl~ tin Irl~o~ humln ~l~lrcoml Fi~inM ~i~d b7 lh~ in~liMt~ In I~ ('~il-~up~.~d In ~hlch human c~cr ccllt wc~ In~cl~ into I~ fcluv~ ~ff ~r~n~ c~ ~)mc (~ I~ cn~ ~clu~s dcvcl~d lU~rs c~ human cells m which
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C~ 0 0 O~ O) 0 found particles ~milJr to Ih¢ known C.t71.~ cancer virus p~s of ~vcr~l Ihe ~n~ ~! human cs~r vies ~r~clcs. !1 this findin~ is canfr~d. il s~uld ~llJ~ flcilil~tc IcstinE in m~ ~ many impl~lmns ~ t~ viral in~c~(~ p~u~ in ~ve~ ~nim~lL I~ mi~t ~1~ make ~sib~ I~ ~ddi- ~n ~d. The Council h~s (~vek~d I mchin~ which ~s ~n u~r~inl in ~u~ pro~c~. W~ tt ~ ~md7 ~lt, ted ils v,l~ ~ ~ver~l ~c~s. ~ humor ~ mU ~t ~gnt improvc~nls ~urc~nls ~rc ~ing c~ ~l wi~ ~ ~. ~ m~hi~ ~w ~inI ~-t~l~ ~ ~ ~1 E~mnl~
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(7) 0 0 O) C~ c) Expoaure oI Cultures to SmoAe In one smoke study. Ihr~ ty~l ~ primg~ calluses from S~II kiddy liSs~, cm~onic lunR organ a~ lun~ c~planls~nd ~ cr~l I;~ fe~ Swiu mice ~t u~d ~o ~y ~ ~cal e~c~, tn vitro. ~ {~ ~s ~ fr~ chmr~l-fillr~ f~ ci~rcltr s~c. vitro St~ a~ m~inl~ ~ul ~ ~S tO ~ in~ctal~ N w~ ~v~d~ ~1~ l~t ~1 ~, with ~ml ~ ex~es~, ex~d ~ t~ mni~ ~ve~ ~u~l ~11 lung t~, M~ ~ n~thef ttr~n. IKkin~ ~irsl ~ e~. ~ a dramatically In ;nflue~ vi~s a~ ~ el~ t~m i~ coni~ol m~c I0 su~leihal ~ hill7 klhM ~1;~ cl~ ~ f~sh vi~. ~e controls s~cum~d qukkly W ~ ~lh~l cl~ d vi~l a~ had cxlcn~ a~ ~1~ ch~n~ IN~nE t~ ~o ~1 c~s. ~ immun- ~ m~ ~ ~17 mi~y ill ~ ~i~ t~ le~l cl~, t~ ~1. ~ r~rc~r ~ed ~t immun~l~, ~h~ ~ ~vcnlin II ~ k~n thai m~n7 ~ ~i~ ~ ~ in t~ ch~al~l~r ~ ~Mrd~ ~ ~h~l b, ~ b ~. ~ Io ~cm. Ih~ ~t~. I~ I~ ~ ~i~ In s~lily ~ ~ ~ to ~li~cl~. ~ RAI B/c/~/~ m~ were Im~led wilh ~lhyl:ho. lanth~¢~ (MC) ah,~ or mixed with ~ ~r in amccntrat~ of t : I 0 I0 and I:100. Th~ fragm~nts were II~n Ir|nlplantcd inlo Ih¢ su~utancuul Results i~attd that t~ ~miti~ly ~ ~o~h~l~mlv~la¢ epilhelis la1(¢¢ were not wholly ~isllnl to tu~ growth MIct imp~e~ml~ with ap~ar to ~ ~c diffeee~ A similar ex~ri~nt wilh ~u~utl~s ~l~I ~ Im~Jl, I,~Fg, ti~ s~i~ efl~l ~ Ih~ ~lmr m~nl a~ eu~linI Ihml I~ m~nt OtAer C~.¢er Studio. In ol.h¢~" wo~Ir ~lalcd to ~r, ~ C~mll E conlinuinR ~ll lun~ cm~et in animals. Gu~ li~ l~ few ~ ~is ~, but if ~ ~l~ul in may ~l~h I~. If lane ca~ ~ ~ I~ ~rl~ ~. t~ A~g o~r ~ng ~ ~inl tu~ed m~: ~ler~trlm. pl~nl~l~ ~ud~ whh human lun~ ~r. I~ p~l~is N urclh~nc- i~ lun~ ~nom~ in m~. ~ ~I f~clo~ in lun~ ca~cr ~ lun~ ~il~nts. Cardiovascular Research
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0 ~-gmcnts o~' human iliac arteries incubated with human s~rum .C,,mples wcr~ ~ated Io i~iv~lc I~ e~y~ I~hhln~holcslc~ol-acyl.lra~ ~ results lu~! lhal I ~ in ~m ~rcc c~lcsterol, could b~ I ~eum ch<~cstcr~ ~lr~tTinI e~, ~i~y im~rt~nt in pekinE I~ ~1 ~ f~ c~lcs(cr~ 1tom w~ll. A~ordtn~ Io ~c inv~fiE~ ~ ~d I~ worE, lhc ~csul~ • rc consislcnl ~hh findin~ Ih~l ~ i~ the ~eum In ~ hi~er in ~ with h~cstcrolemia 3~ m~/I(~ ml. which m~y ~1 I n~h~nlsm for ptotcclin~'thr ~r~crial impaired in ~m wi~ Icutc mT~ inf~l~ ~ chr~ c~ a dcfic~ ~ c~rsl~ ~t~f~n& e~, im~tl~nl in I~ ~1~o~ or ~tc ~ ~vc~nl of al~r~ler~is. 17 flow by means ~f a coincickncc counring syslcm mine rubidium.O4. Wurl, inl¢ with this syslem, the Et,,nle~ roun~ thml no~¢pin~prin¢ c•used • dlspro1"x'.. tionatcly ~rcater incrcas~ in total ms compared wilh clTcclive flow, and same result also occurred with nicolin~. |~opro4erenol, on lh~ otl~r hand, led to a prOl'~ortionate increau, in bolh nutrit|nn,,l and ¢ffcclivc flows. In ~n~lhcr Council-supporlcd sl~ly, mongrel do&l wcr~ cx~d to (:g~rcflc s~kC inhllll~ ~ II~ to in~l~ ~ Vlr~ pharm~cnloE~ • ~nts, A rcducl~n in ~o~ b~ prmum durinE s~klnE b~ lhc Ihcli~d animals wll ~n. ~is was IIl~i~lcd in p~ In Ihc c~ccll nic~i~ on ~ cenlrml ~s tTslcm ~ in part to vm~ilmli~ cmu~d bility ~u~ing i~ndy ~ k~wn ~iul~ tysleml, ~ I~ I~ming ~lcm ~ ~ing in~li~tcd ~ ~ ~i~e hu~l ~ni~m ~ Ph~ml p~ ~ t~ ~n~ ~ I~ ~nin-rorm~ sy~em ~ compar:~. I! il ~ Ih:l Ih~ work ~ill i~:lc Ih= su~l:~ ol ~ sta~ ~al may afro! inflammal~ ~scl~ns in I~ lun~ pa~liculs~ly In hy~nshivity stat~. ~ Coom;il hu m~ I ~nl rclll~ to t~ F~mJn~lm }l~rl • n investlgal~ ~ a~klng cla~ ~ f~t~ a~ cmrd~v~ulur di~a~ in the ~tallon ~ing f~d by t~ ~. ~r u~ud~ ~ing fl~e ~ ~oLin~ ~ flow in ~okt~ t3
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0 0 Chronic Respiratory Diseases Hyaline Mere be,me A significant riffling in reg-rd to hyaline membrane di~a~ (lIMa) hat co~ from J C'~mil.#u~ ~l thai c~ompa~d I~ mn tlysis adrenal gla~s wcrc 19 ~nt I~t~ In ~n~l~n with lwdKllnt, whkh m~ to play In im~rtmnl role in this di~l~, it is ~lc~ng ~#t ~mllc ~nat~ w~ h~ lilllc or ~ adranat fetal ~1 ~ fou~ to h#~ o~y 45 ~nt ~ mmu ~ ~il~ ~an~ in pul. c~ul~ ~ ~I~ ~up~cd b~ the ~t~l[~ lhlI A q"'nlitalive morpl~of, ic iI~y wu u~cn ~ lung t~ hcm~ ~l~lum in 322 A~ch~n ~ ~ ~ cl~i~d by ~. du~ ~ mininl t~um. r~ ~ ~ mi~ ~ ~inB h~bi~. Rill vcnlric- ullr hy~y as ev~ ~ ~ ~a~ wu ~ alice arc 50. ~e v~u~ ~ mmcular d~t ~ I~l~nE m~i~lcd silka cryst#ls. Ebtmi~ a~ ImM cmph~m& i~t~ with ~ ~ I~ de~l Ic~n~ wczc ~t ~t~d to ~ ~tcl7 r~ (~ d~la ~ mi~rs with dy~p~ tile workers, and nc~n~Jng ~ ml~ ~v¢lc~ I~ di~rdcr~. 14 Ate,re-ground ~'ir pollution rely play ~ Idle s~nc~ the wives ~ ~ luminous mi~rl ~em !o ~ ~arly as m~h'lflmled ~ I~i~ husbands ~oniosis with c(~al rank was f~ to ~ fo~Itom. Mierocirculation ol the Human Lunt, During the year a Council l,r~nlex: publilhed i ~ ~g ~ and lymph~ m~r~r~lml~n ~ ~ humla lun& that ~vi~# n clear, c~i~ lummal~ ~ ma~ fi~in9 ~ ~is papular fidd. ~e invetfi~l~, kmg involv~ in lung ~a~ch. ~ I~ rcaul(~ ~ mKt~ i~ mkr~ II~ ~ I~ Im~ ~ humns, ~m~c ~p ~ngttl ~g~. 3~ ~1~ w~ ~i~y ~e~ with mn~a~hi. I~lural relat~nshi~ ~lw~n ~ ~I s~ ~l~a~ vm~ul~ m~ ~hial macros are di~lly ~ ~ ~ o~r, tsla~ing "'parzllcl" v:~ulzr Supply. ~ ~himl ~m ~ f~ ~ ~i~hi~ pul~z~ arteries zl~ ~mmun~stt in ~e ~ th~ ~ ~m~ cz~llz~ ~lwork. adult lunp ~ ~z~ ~t ~M l~y ~m Io ~ ~mzll~ ~nl in ~ t~ human fetus m~ ~lmnt. Itc u~ I~y pr~y vlnish In child. ~ ~l ~ea~ar in t~ adult lung with the ~t ~ even minimal ~na~ inflammat~ ~ ~ • ~ ullr~sl~utll cE~t~l~l~ ~ ~1~ ~lh in I~ lunE ~l~r ~o~lh ~nd in ~ull~ ~ ~1 ~i~ ~d~ul~ ~d~lli~. ~ Ih~l !~7 m~y ~ly • ~ in ~p~l~ di~l~s ~ynd~o~. Pulmonary A l©~,olar M~cropAafe. which cempei~ ~ major dc~cn~ m~h~ni~m of the lung ~ U~uncd.lu~ 13
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C) ported study h~s eli¢iled evldeoce to indicate that at le~sl m~r~ag~ ori~na~e fr~ ~ m~row. ~ sludy u~d ~6c~ly originate in ma~ow ~¢m ~llt. S~c~t ~ ~ e~ri~nt ~ted on the marker. [.¢lhml x.irt~iat~n m~ ~s ~ ~ mm~ow {r~ I~ mice ma~. ~it pm~l~ w~ w~ ~ ~ a A~t ~t ~n~ ~d ~ ~pti~ ~ ~ the a~ar- and ~ ~tc~y st~ I~l=~s than a~ ~n~ ~ ~ within in llva~ ~. Fud~r. ~ ~r u~. ~r =1~ ~ lung m~a~ have ~n ~t a ~CafCf humor mac~=~ f~ s~kc~ ~ unlm~ v~lro. , Neurophysiology, Psychophysiology, and Pharmacology Foe tcKrll ~1~ ~ ~l hU ~n suing r~h Inlo ~ 16 electric shock' after a training Scssiofl, they lend to "unlearn" cvc{ylhm~ thcy had previously Jcquitcd. Apparenlly the shirk cau~d an :m~siac co.ilion an~ prevented con~l~ali~ ~ I~ ka~ning pr~css. Whcn ~hc ~nimals were Ircalcd with nic~inc p~ior to a ~ss~n. il was found that the su~qucnt electric s~k d~ nol ~nmry con~lldal~n; I~ animals lir#ly rclii~d ~h=l Ihcy had apparcnlly ~cau~ the n~in¢ bl~k~ any eff~t ~ Ih¢ I~k. "1 ~ ~ n~olinc Itell~nl wll im~anl in this ¢~nlal pr~cdur¢, effect ~nK ma=imal ~m¢ ti~ liter ~m~n~trit~. Collnine. = nicoli~ mcl=~ilc. =l~ wls c~iv¢ im~dlxtcl~. ~hich lu~sll Ihal I~ su~la~¢ may ~ the ~fiv¢ =~nt. ~r ~s ~ Ihc p~o~t i~lu~d ~cstinK {~ sole =ff t~ ~l~in precu~. $-hydroxylrypl(~n~ I~ c~cs ,~ Ihc animals; ~iffc~lill ~using; ~ br.in imi~ levels; Ind ami~ chan~ II I~ ccllullr chronic treatment with n~ ;~ In i~d ~ur~vcr ,.¢c ufifizat~n ~( ~rad~e~Gne in I~ brains ~ ~U. Prct~m~nt with ap~arcd Io stimulate ;he ~Jins ~ the rlt~. ~king Ihc anlmsls funcli,m m~ec effectively. Sex Ilormonej .4 A ~tcntiully ~i~znt ¢c~ during Ihe year cm~ from z C~mil grantee w~ h~ ~n w~i~g ~ t~ ¢x~ti~ntal i~lion ~ emphy~m~ in rzls. I1¢ hit mu~l Io ~lcmi= w~l~r I~ i~¢d dim=~ kid Io pulmon=~ hy~¢m~ I~ ~ ~l~c u in mzn, II ~droxy~o~slero~ (in m ~ I/5~h Ihal ~ ~ler~) prcv~lcd A~l~r grant~, tr¢llin~ rill dilly wilh n~;~ in~clions, found ClCVll~n in urin~ cxcrct~ ~ ~ImJn~ lhll Flk~ MItt lhlr¢ in I~ uHnlry Ic+cll, IM b~ II dip lhc ~l~l.mi~ excretion 17
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C~ 0 0 O~ cztccholamin~s resulted from incr~,,s~d me~bolk: enzyme zcUv~y ~h~ in lurn led to f~stcr ~(~lism ~ ~c c~t~l~m~es ~clc~d f~m I~ Other Studics I.onK.Term S,~ly o/Ve~erm~ Tht Council hu ~n ~~ In s km~-Icrm study lh~l cn- ~ ~ ~e ~o~, wh~h ~ Iu~ m~inl7 b7 t~ Veterans Adminislr~- I~m. b Io inv~li~te a ~ tsn~ ~ c~n~ that ~ur in he~hhy ~s st t~7 #~. ~ ulllm~lc ~ N I~ ~vcsti~U~ Io ~grn whtl It~ rely ~ ~llv¢ ~ ~vil~ or consul In ~is s~udy I~ Inv~tiMl~ ~i~ iw~tc ~ "~ulatily wi~lF r~nlc~. ~pl~lin& f~ct~ in ~tudi~ ~ human • ~t exte~ over ~l~fi~cl~ ~[ ~ ~ llmc. ~i~ io wcU-dcsi~d • nlm~ cx~mcnl~ cnvirnn~n~ c~n ~ icp( quite conslanl i~nl vae~blc ~ ~ ~lud~, ch~n~g cullurxl and Icch~lo~c~l ~s~ ~ human Gfe intr~ ti~~nl ~¢r~tion~ Ih~t ~rc often ~t I~¢n inlo were ~ ~cn, t~7 ~ ~t~ ~l Io t~ ~lil~ in~ ~tt ~cultt. ~17, "~tt I~ t~rl~r ~g~ ~ t~ that t~k~ I~ I~ I~t i~t~ c~ll~ ~11 d~ Io ~ fKI ~11 ~ey were ~n bier ~ lived ti t li~ w~ I~tt wu ~c t~kin~ ttt~r t~inI ~u llfc-~o~in~." ~ ~17 ~u~ ~ cff~ ~ t~inl ~ I~n~vity sl~c ~ ~o~ tbilily ~ • Ei~o I~ugl ~inB • d~reltc t~kcr or ¢n~ the tcsuhs ~ mtn~ l~t~intl h~tn ~pulal~n stud~ IS In t conlinuing study sup~tlcd by ~ ~u~il of cctlaln bh~hcmical ¢ffcclt o[ chronic tmnic inhtlal~ by ~i~ pi~, t re.lecher w~s able to dc~cct ¢~ec~s o~ stress and ~k¢ inhtrtl~n ~ lunt mil~mdeiM p~phorylafi.n. The nuslrils ~ I~ animals ~ere ~¢l~d wilh warm, ~dlcn para~n or a quick-~tfin~ liqu~ ~li~m ~b~t ~o inlu~c mnulh btc~lhinR. 5ham.e~d tnimtlt were gub~led Io ~ plu~n~ con. fi~mcnl ~nd m~chint ~i~ wil~l pi~ mil~nd¢iL Ilowcvtr, ~uch ~ ~ e~k~ ~11 con~crl~ ~. ~is Wilh financiM aid from TI~ Couacil, ut ~l~l~sl sym~um Iwin zl~ies w~z h~ld in ~n J~n. P~o R~. ~m~ I-4. 1969. di~ with pa~ulaf tefc~ tO c~rd~v~at z~ ~lmon,~ d~.~," was ~ishcd in Acll ~1 ~l~i~v~l, ~lc~nlum 523. 1971. ~ rc~ di~ ,~a~h inlo s~in8 that involved twin ~- It~ in Sweden ~nd I~ Untied Stales. II u~ I~ clin~tl Iwin tludkt "~ ~rum chokMcr~. ~ Iri~y~r~/ Ic~ Io ~ ~tcltlcd ~l~ccn ~c ECG wctc I~ ~mt in ~ twin ~tn re~l~ ~ ~kin~.'" ( I~Eg-I~)." . AI~ in 197 I, • ~d lu~l ~ I~ 1961 ~ph, "T~o t~ i~lu~s pu~it~d ~ ~ ~th e~nl~l and clinicM sludiet 19
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0 C~ C~ Abstracts of Reports Following are |l~ltracf|0 •ppro*ed by the authors, o~ re~ts on new ctw~imcntal tese~ch ~ck~w~dging su~rt from The C'~u~I that have apWa~cd in ~nlific ~rnlls ti~ pu~Callon (ff the 1969-71) na~ o[ the ~cipienl i~ i~ il~lic~. The a~lllcll ~rc g~ou~d u~¢ t~ ~din~: I. psyc~physiolo~- Res~rm~ System. V. Ti~ ~ ~ Culture. VI. Sludics tt the Cellular ~el. VII. Ph~rm~ I~ ~ye~ha~mlcoloRy. VIII. laddie Slud~. IK. t~emat~ a~ Bi~mi~. and X. l~pi~miology. !. PaychophysloloKb'~ Sludlea rSYCIIOL(X;ICAL ASPEC'I~ OF C|GARETI'U. SMOKING IN MIEN: A CI.INICAL EVALUATION Cc~ain ~7c~1 fKt~ Infl~ ~king ~hav~ ~yc~o~al fKlm~. I~ u~ m olin. ~rc ~ involved in I~ hnul~ d I~ hlbil. In thil a~7. ~avy ci~rctle s~kin~ io ~c~ Clin~l intt~wl wdh 130 sub~s, trpre~nlin~ am-. lo~mt~, mild. ~I~E¢~, lu~ed ~ev~s q~sl~nnlire finding.that t~¢ lest ~oup is c~Kter~ by {e~tu~e~ ~: ~fiance, d~n~-~ekmg, neurol~ I~bdh~. ~ ~l ~up~lion. I~. thi~ ~m~le. ~ere t~ othee gr~" ~tetn~l ~l~lmn~hi~ Imtns~*e lo~lo~-up interv~ws with • ~11 ~l~l~ d ~ub~l~ ind~l~d l~l~s ~i~ted ~id~ s~aaing ~ sl in~ s~in~ s~ mn slternsle ~nalit~ paHe~n in heavy ~moke~s orcv~ ~n ~ lsl~ ~p~v~ ~ t~ q~g~nsirCs. Th~ subtopic ~ctuall7 Ih~c~lcncd. ~th life e~nts ~nd Iscl~ ~ ~a~ r~u~ful~ss ~r~ ~clcv~nl in u~cr~ll~inK wh7 ~c ~n c~n give up 1he h]bi~ olhces cl~n~. p.~t.h.~ma~ic Medicin¢ 32 ( 5 ) : 469d~ 5. 1970. From the ~vislon o{ Psychlmt~. ~ton Unlve~hy ~h~l of Mcdicinc. pre~nt when he smoked for the first elms. The sample consisted o( • Iotal of 2.729 jun~r hi~ ~ II~nls. A~fl~ !o thei~ answers. ~e- s~enls were ranked us ~s~e~. ¢x~d~lul ~kcrs, o~ re~lar smokers. Results showed that s~ing by p~rdy a ~u~tinn of s~klnK ~ by I~ir Wc~ailln~ m~cls since ~ ~ the ~s( pred~lo~ f~ children I~ir parcnls s~ke. Rc¢ullr s~in& hiK~st pr~km ~ pleents s~ fronds s~ked with olher ~ys whik ~rls mllnlai~ ~r EMs. Neither pseenls ~ siMIn~ we~ ~)inR Io try to #~c h~ slre~7 ~l Ir~ to s~kc by l~ m~ ~ 14. Girb ~frst~ fr~ s~n~ N I~ ~lily ~ parenl~l d~o~ ~hik ~yl were ~r~id ~ ill ~tnllal e~ccl ~ Ihe~r alh~ ~ls. ~ln~ in I1~" s~klnK slslus ~currcd in spite ~ I~ir b~w~ I~r I~s~nl 01 p~Rntll di~ovll. ~Ul t~ ~Inin~ I~fi~d Io Palmrr. A. g. ~i~ ~ienc¢ a~ MrdiHne 4:3 J9-3~, 1970. From the ~paa~nt ~ Psyc~, Uni*¢~ ~ ToI~. To~, O. VISUAL DEPRIVATION AND PAROTID RESPONSE TO CIGARETI'E SMOKING Smoking while blindfolded dgniflcadlly and consbtcnlly Itduces livary flow rates compantd Io ~ rain a~oci,,tcd with rmrmll smoking. In this cqxrimtnl, cigartlt¢ smoki~| ligniflcanlly |ncrtated parolld salivary Icx:rclion in eish! smokers I~<l eighl no~smoken. Obslruclin~ vlsi~m by wcarint~ op~tlue hm&gles conti~tently reduced the Imlivary rcspon~ to retook- inK in all Ib subjects. IJnstlmul•lcd eeslln& kvels were lower ~hcn was billed, su~csling • ~c ~c~al p~c~m lhan mc~cly N I~ si~l ~1 Ihc slimulusmb~cl. ~inE cig~cllc~ Ih~ou&h a Uamh~id~ exhaled smoke invisible, h~d ~ efl~l on salivary ~cl~n. Tbi~ Ih31 I~ smliva~ stimulalltm ~iv~ Ir~ i,itatinR matt~ills pha~ d the smoke. Phx~iololy a~ B~havh~ 6 ( ~ ) : ~ 59-56 I, 197 I, Flora I~ [~pa~lmcnl n[ F~ ~;C~C and Tcchnoh~Ry, II,ivc~,ly ~n F¢anci~o. 21
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0 0 SOME CIIARA(.'TERISTICS RI:.I.ATI~.D TO Till". CARFER STATUS OF W(.)MFN PllYSICIAHS l~lwccn l~ 7c,~ 194~ rand IqSR. 81 women gradualcd from Johns IlopEins Medical Schocd. o4tcn w~th Fradc records surp~sin~ O4 their male cl#ssmmlcs. (:~ lh¢~c El ~o~n. 69 w~c in mcli~c pCac ice in 1967. ~er o~umrlet hind mll#i~ ~i#hy cerfifical~n ~ 21~ held pr~e,i~al m~)inlm~nls; I~ two criterim were lak~n Is a c~de m,:asure Ind famil~ ~. ~in~ ~rri~. o~,II7 sl ,n ~,rly ~, wCs wi~ i ~ s~ful c.~. ~ wls l~i~n~ [amily si~. Allhou~h ~o~ I~km'" Ihsn t~lr ~. In I~ t,o r~,~cl, Ihc) physicimn~ wcrc ~ llk~ Io ~ In ~KI~. II ~ su~slcd thai ~,lft the rc~ ~n ~dic~ ~du~t~ ~ ~ ~l~e I~ir full ~l~rd:l in lutrr cer~ I~ in t~ v~ ~ ~ ~ ~ty. TEe I~ ~ M~I ~I 12715):~73-2~6. 1970. Fr~ I~ ~rl~nl ~ Envir~nlal Mcd~i~ ~nd Communi{y Health. Slate Uniwc~i;7 ~ Nc~ Y~. New Y~k C~y. u~ t~ ~purtmcn~ ~cd~i~. ~c ~ ll~kins Unlvc~t~ ~h~ (~ Mcdic~, ~It~morc. PERSONALITY CIIARACTERISTICS OF MEDICAL ~TUDENTS AS REFLECTED BY TIlE STRONG VOCATIONAL INTERF~[ TEST WITI! SPECIAL REFERENCE TO SMOKING llABI'[S ~ ~ro~ Voc~km~l In~n~l~ Bhok (SV|B), I plycho~al meas- urement IOOI. wu# ~mlr~lc~d to lohm lk~i~ medk~l students in ~vtn com~cuGv~ cl~'~ ~'~d--tint io th= period 1938-1964. A to~l O4 ~hltc m~ utudtnt~ with kno~rn ~n~o~l~l~ h~t~ ",t l mcln ug~ o{ 23.:2 yc,,r~ completed ~ S~IB. Ul~n~ th~ SVIB Ind l~ob.in~ m~urcm~nts, di~crim- inunl ~ unul~is f~ two cd~ ~ w~ ~d ~t by ~ins ~ ~ mulHvuriute ~. R~I~ ~ that ~c~ ~ hud si~i~in[l7 ~iff~r~t ~ali~ ch~rbt~ u ~u~d 5VIB; th~ overall diff~ w~ ~I7 li~i~unt. W~n tinkle 5VIB e: ~cll. Pi~ I~ke~ ~ sicily ~ffcrcnt Irom ~c~ in ~d 22 srn~kcr~ in thcir voc,,tion~l intr~ll whih: in ~1 ~1 ~an did t~ ~ ~¢rc c~l~nu~n~ Io s~kc. Tko~. C. B.. Fargo. R. Ind E~cin. K. The ]ohm llop~in~ Medicol ~o~ 127 (6) :323 -335. 1970. From Ihc ~pa~mcnt of Fq~i~, ~ Johm llo~ins Univc,ity ~ CIIARACrERI~TICS OF MALE MEDICAL 5"TIJDENT'S RELATED TO TIIEIR SUBSEQUENT CAREERS tOKII XhO~)l ll1~vl 11111 K~cmk: llan4~ng llnd I~ It $,uduatlon clo~ly muociltcd wilh l~'otculoa~l ClI~11. ~ I~q~ O4 prKl~--'t. • ttainm~nl o4 qx<i,,lly bo&rd~ ~1 Io ~ =xl~,f~ Ih~ ac,,d~mic & throe on ~d~l ~ ~11~ ~ ~11 ~d, ~li~ in ~ ~m- ~Y~'~ "~ ~ ~ ~,. ~ ~i~.,,~ ,¢:.,~ ,~ :%;; c..~. ~sr,lJl ,Istus dur:nE ~1 ~ ~ tO hmvc ~ nli ~y ~o~l ~ ~m ~ ~fl~lely ~lcd to ~tcr ~h~vt~nt t~y ~ ~m to in~ ~. ~t ~ ~ lnR~c for gt~uale Iruinin~ u~ ca~ ~ls Ihut ~ ~ ~uld ~ ~ ~ cou~ a~ truining s~uule to Ihc vl~y ~ ~tivi(~ ~hich ~yli- ci~ arc ~ cx~l~ Io ~. T~ ~o~ Ho~i~ ~edic~ ~ 127(~) :~4-272. 1970. Fr~ I~ ~pmfl~nt ~ ~r~nlal ~ m~ C~muni~ llcJl~. ~lc Unitary ~ N~ Y~E, N~ Y~k 0~, ~ I~ ~pa~nt ~ Hcd~i~. ~ ~ ll~in~ Uni,r~t7 ~ ~ ~i~. Bil{i~. !!. Cerclnol~ene.i~ Studie. 23
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0') 0 0 falc. lhe incldcnce ~ pulmonary tumors in gnnad¢ct(~n:ized BA|.B/c/ ~/~ m~cc w~s ~ low ~s d w~s ~n Ihc ~nlrols. ~v. A~at ~a~. PeruEio 30(2): 113-11q. lqT0. Fr~m Ihc ~v~sion ~ C~cr Rc~rch, UnivcnRy o[ Pcru~i~, I~y. TI~MORI POI.MONARI ED EPATIC1 DA I~RAT.INA SOI.FATO A I)OSI RI|X)I-/F. IN TOPI BALB/c/C'b/Sc In Ihe~" ;nvcat;l~tions. th~ |nck~cncc o~ spoe[•ncous pulr~onary tumoc: was low (24% in malcx. 4% in femaks) while Ihal was Zero. Ilydrarlne sulfalc Idminialcre, d in ~d~ed ~# feeq~y ~ ~l~mr? lug# H hd~l: 0 ~6 mR (~1~1 m~ RI). in re#lea m~ 76~ in femur; 02g mE (l~#l mE 42). 62% ~.d 0 14 mE (~o1~1 mE 21) 54% #~ 32%; 1.13 m~ (Iol#l m~ 7~%. ~ md~cd liver lug: 0.56 m~ 7% in m#l~ and B% in h males; lum~ was ~r. liver tu~ wcee ml~ ~cd. ~orp~lo~elly the were hilly vm~ulm~d hep#l~#rci~##. ~ ~ibifil~ ~ ffducln~ ~aul~#~ m~ liar lu~ m m~c with ~r-iilo ~ ~g hydrazi~ ~ul- IC. ~u~v~lenl to t~ ~r-kdo ~rivcd from {hc admini~lrat~n i~i~ in man. is im~t~nl ~or hs appllc~lity to the u~ in human ~v. A~t. Pat. P~ue~ 30(2):gg-~. 1970. ~lher ~p~r~ Ann~ Fuller Fund. From [~ ~visi~ ~ C~cr Rc~h, Unlvcni(y ~ Pcru~h, OVARIAN INFLUENCE ON PULMONARY CARCIN~ENE.SIS BY HYDRAZINE SULFATE IN BALB/c/Cb/Sc MICE Alterat~,n o~ the bocmcmal stale o( mlct influenced the incidence o( pulmoear7 tumo.~ induced b7 hydr~Jne sulfalc (IIS). D~ily adminlslra- lion d IIS to BALB/c/C'o/Se fcmal© mi~ in v~s hm~,l lilies I(N)% a~ 14; in ~a~ m~. ~.0% ~ S. II~l~o~ally. in inlacl ~irgins. 3.3% were c~ a~ 96.6% wctc adcnomas; ifl btcc~n, 47.2% wc~ ca~ a~ 52.7% wc~ ~c~as; in ~nl- declomi~rd mke, 4% were ~ I~ 96% were a~maz. Many pul~ary carci~az hd~ h ~ ~filtraled the t~acic wall a~ the mtdoa~t0nal ~gmm l~ ~lls~ to t~ adrtn~l gl*~s m~J my~ ca*dium "1 he im'~*~ bk~lo~c mM ~o~ malignm~7 d puh~maey 24 as ~:currcd in breeders, accentuated Ihc already existent sus<eptibd~ty tn pulmonary tumor induction in BALB/c mice. Whelhcr Ihis is ass~cialcd with an inhibition of the immu~lo~c ~1~ temalns to ~ determined. Bioncihori. C. laurel ol the National Cancer I~itut¢ 45( 5 ) :96~-970. 1970 Ol~er e~p~rl: Ann• Fuller Fu~. From ~ ~vision at Ca~er Re.arch. Uni~ffy d Pe~oa, haly. CANCER(X;ENF-SI DA IDRAZINA SOLFATO IN TRAPIANII ISOGF.NICI TRACIIEO-BRONCOPOLMONARI IN "roPi HAt.fllc/Cb/S~ ('arclm~l~nic activhy o~ hy~lL~ine sulf•te on Ih¢ trKhca, bt~m~'hul. and lung hag•this ~ nc,.tm~n BAI.B/c/Cb/~¢ mice. Iransplanlcd Io sam, c strain, was studk.d In this expctlm,~n¢. The lung (ragn~nts by Ihcm. selves showed 35% adenomaa and 13% caccinoma~. When Ihe lane IraI. menls were Iransplanted. ~ydtazine sulfalc induced lumoes, which sTho~¢d greater mali~ancy, i~ • ~o~et time in the newborn lung fragng'nt~ than it did in Ihe lun~ o/ Ihe adult hosts, h would ~m thai ~his was caused b? Ihe marked suSCel~ibKhy o~ newborn mou~ tissue Io the carcinogen. Ealdanatioe ~ the findir.~ wilh regard Io the diverg~nl (requencie| wh.lch the trachea, bronchi, and lung parcnehyma devdnped~un..s ~r- qmrcs further research. gianei~ori. C. l~v. Anae. Pal. PeruRia 30 ( 3 ) : 137-146, 1970. From the Division o~ Cancer Rematch, Univcrllty o/Pcrugla, llaly. TRANSFORMATION AND PRODUCTIVE INFECTION OF IIUMAN OSTEOSARCOMA CELLS BY A FELINE SARCOMA VIRUS The studies ~porled hem indh:al¢ thai feline ufc,oma virus (FSV) can transform human o,.st,.".~:~rco~ cells; two lines (M'I'-FSV and MT- FSV. subline 2 ) o~ Iran~l'oemed cells now have bccn established. When compartd ~ith the parent MT rill line. Ihe FSV-Iransfoemed lines have. in early pas~.a~, an altered mo~logy, incited ul~ratio~ density, in. crta~d growth ra~e in 2% ~¢rum, and Inere~c'd plating elT~ieney in apt. The lean,lamed cell linc~ conl,,;n C-I?p¢ viru~ parllclc~ and lelln~ vh~s Inllgcnl m)~ detected |11 the Mr line. Particlel vtlcamcd ham Ihc Iransformed llnc~ have • h~t ridge (_(~g and human cells) similar, Io thai o{ the parent FSV. 'Cells o( subline 2 m ~venth pa~aag¢ Induced sarcomas in I~enalally Inocul~led Eitlev~; Ihe tumor ccll~, adjK~nl m~cle cells, and sul~na=illa~ gland c~lla ahcd C.tlr~e parllck~. In m ~ec~d ~¢1 rapcrlm~nls, the cells o[ the omtto~w~m• c¢11 lin¢ In pa-,,,g~ 7 h,,vc brcn transformed by each o4' two IloeEs ¢~ FSV [lht stork ul~d in Ih¢ sludy and one derived lt~)m a llne (4 FSV-tllr~formed heaRl¢ ¢¢11m) "lhr~ Iranslormed cells, mS Iht~S¢ in Ih¢ first esl~rimenl, c~)ntalncd IHin¢ ('.1),|~ 25
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C~ 0 0 C~ virus .,miens, shed pm|licl~ ~,ith focu~.forming aclivily on ~a~le and humzn cells. ~nd exhi~led C-I~ vi~s ~holo~y ~nd ~ den~,ly of ~ ~c~llister. R ~. FiI~H. ]. E., Ni~l~n. ~. O. Ron~cy. R W. ~ature New ~i~ 230( 17 ) :279-2~2. 197 I. REDUCED LYMPIIATIC DRArNAOE FROM IIAMS-TF.R CIII-'.FK POUCII: A PROP~;P~D EXPI.ANATION OF ITS IMMLINOL(X;ICAI.LY PRIVILEGED C'IIARA(~I'ER To ,rower Ih~ q~c~on o~ ~.c'thcr o¢ no( s dlrt,Cl tOulc the hmmsler's check Ix~ch ,,rKI i~ ~1 I~ ~. ~ kfl ch~k lymph ~. ~ li~ ~ R~ ~ h~t~m~H~ ~0up ~ ei~l h~lc~ ~inK a~ ~1~, ~i~ O. I~ 1o I~' lip. ~ ~ultz Ind~a~ Ihat while ~ c~k to lymph ~. d,i~ vi~ this ~t~ ~ rcd~d mun~ully, th~ ~t~t~ ~ ~ ~d~ s~ ~laycd drzina~ hom hzmstcr c~ ~h zff~s f~ip Fzf~ in tab for W~ zo~i~l. Goldenly. D. Ex~ientl¢ 26(8) :~7-~. 1970, Feom t~ ~rl~n( ~ Pa~. Unitary IIIST(X3F_.NETIC REL.ATIONSHIP BETWEEN CARCINOI[~ AND MUCIN-SECRETING CARCINOMAS OF ~LON AS REVEALI~D BY }I~R~RANSP~NTATION A human ~k ~ wl~h ~c chzrzc~crisfic~ (,f = cmrci~d wins =~f~l7 I~=nt~ to C~k ~ ~ adult ~l~n 26 Sive ~row~ charactcrist~ in xe~ ~ for I wilh views adv~lin~ a histo~t~ ¢¢lml~nship ~twe¢fl c~on~ cz~cim.d C;o~den~rR. r). M. and F~r, E. ~. British ]~r~l of C~ 24(3 ) :61¢614,'1970. ~ker lmp~rle U. S. ~M~ Helle ~. Mcd~i~, z~l~ V~ler~ ~inizlrat~ H~il~l, RE()UCEI) I.YMPIIATIC DRAINAGE FROM IIAMSTER ('IIEEK POUCH A lmnsl~rtflt isolmtloe ~m~r ~i~fll ~tin~t ink rrm t~ c~k ~h wall to ~ m~ ~1 i~llleral ~ conlrm- ~tc I~ cx~.i~ e.~ ~ dye ~ ~l ~ ~ntml lym~ wls fi~ ~ 20 ~ oiler ink~: ~z~ ~zt tkrc ~ z ~lz~ 17m~zl~ dm~ fr~ I~ c~t ~h, Pr~ee&'nxs o/the ~ety ~ Ex~r~nt¢l B~loty ~ Mediri~ ! 33 ( 3 ) : 724-726. 19~0. M~ici~. Pius~r~. RETENTION OF IIUMAN PROPERTIES BY A XENO~RA~-rED IIUMAN COLONIC TUMOR. GW-77, PROPAGATED IN UNCONDI'I"I ONI:.D HAMS"TF-RS GW-77. • ~wly ~luEdilhed tmnlpimfllsblc neoT4~ o~ human colonic orion, is cm~bl~ o~ elpamiv~ I~welh In m~o~dilio~cd, -,dull g~l~cn hamster. "l'hls unuaull I~owth-bchavlo~ o~ ~W-77 ,ai~S • que-~lk:n "s Io the luw~'s ,,poc~c~-k~cnhly. In ¢h¢ preston! ~udy, Ihls qu~s~m was • tud~ed by {mmu~uot~nt S~ b~m~d meanL ~(h Ih( dH¢~l 27
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0") C) paHern ~evealed the hum,n species-specific character of GW-77. The Icnl~m nl ils ~wi~mal s~i~s.i~n~ily is consis~cnl wHh GW.77's ~clalivcly Ihc hamsl~r. ~ddenherR. D. Af.. ~han. R. D ~nd P~vi~, R. A. Pr~eedmR~ of the .~tet7 [~,r [x~r~men~al Biology and Afed~cine ( 3S( 3 ) 657-659, 1970. F¢om 1~ l~par~nl d PathoS, U~ity o{ Piltsburgh ~'h~ad Medicine. Pillsbury. STATtlMOKINE'TIC EFFECT OF C~)I.CEMID ON A PRF.~UMI'|IVF. IIIJMAN.|IAMS1F.R IIYBRII)ll)MOR. GW oH~n~lly a human Ilcm~tll lym~a pm~ted in hamstc~ check ~uche~. was c~red In ~ ~ct~ ~ F~l~r's hamster mmelu~l~ mclam~ma A. Mel No 3. ~ two lu~r ~ ~xhlbilcd sl*ikin~y sl~th~ki~¢~ *~n~s ~o t~ alka~ C~mid. T~ ~rcenlagc ~ un. trolled a~itcs lum~ ~II* in ~tapha~ w~ fouM to ~ 0.98~0 I~ and 0.9~.'OZ] for (;W~7AA aM A. Mcl. No. ~, r~cilvtly. ~ &~ o@ ~ m~/ig Column. ~hi~ i~ m~c for GW.47~A ~as at 20 m~ig ~ r~0ltl, ~h~h ~c~ quite u~a~tcd, i~icalc that a~i(cs (u~ cells ~l~ In C~cem~ ~rc as human than as hams(er c¢lls. II m~mrs, I~fort. thai gl~ GW~78. a hilly mali~anl pto~rli~, it lacks ~e S~ian hamsttr*s ~ncl~ally c~lrollcd Io ~is c~chicine ~rivalwe. Thi~ lu~r su~s ~ hybrid character lion ea~ri~nts with Syrian hamster and ~r acnc~ cells. Gol~eaberE, D. M. ~a~eimen~al and Mo?ecubr Path~oRy 14 ( 1 ) : 134-137. 197 I. Ol~rr ~wp~rl: Nltbnal Ca~t Institute. From ~hc ~mcnl ~ Pal~logy. Temple University lffahh ~icnccs Center, Ph~la~lphia. INIIIBII"ION OF MUR|NE SUBCUTANEOUS AND INTRAVENOUS BENZO(R~)PENTAPIIENE (:ARCIN(X;ENESIS BY SWEET ORANGE OI1~ AND d-LIMONENE mk~. "T~ *ntica*d~~ <~ ~t~ toe.net wcrc d~t~vcrcd durlnfi I~ cour~ ~ Ilud~ ~=i~d Io evaluate the ~siblc c~atcm=~ 28 ~cnlcity of nalutal leTpencs (citrus oils) and of purc d-limonenc in sub- cutaneous inj~cti~m sites and in the lun~ of mice. In Ihe sludges Tern,ted here, injections of orange oils wilh low and high lerp~ne CTmlcnl. d-hmo. none, and a m,xlurc of d-limon¢~¢ and 6% ol ill hydropcroaidc wcrc made into the same site of C57BL/6 Jan mice 24 homa after suhculaneous in. ~ectlons of :25 ~,g DBP in trka~lin. ~b p~edure reduced Ih¢ lunm¢ inci~e ~o less ~han 50% a¢ler 30 weetl l~d wilh 80% in c~- I¢oh receiving ~ carci~n a~ ~ I~ ~tci~gen followed by captylin). "lh¢ li~ N lal¢~ ~ m~rt~ ~d~d. In A/Inn carci~n, orange oils, aS well at limo~, ~duccd the incide~e of lung =dc~as when given w~kly !~ from 13 to 16 wcek~. Xh¢ Iccclc~al~n of tum¢~ grt~lh usually o~¢~d f~lowing t~ lean,el ~ mulltplc catcim,~n in~clhm silcl into ~W ~tl= was inhibited by orange oils tfom6uvlrr. F., "l tegc~. A. and ~)~l, E. Onmfi~y 25:1.10, IqTI. ~k~r ~p~rl: A~fic~n Cl~r ~i¢ty a~ O. S. Public Ilcahh ~tvi~. From lhe Bi~Re~arch In~lul~, ~m~. EINFLUS.S ClIRONISCIIER INIIALATIONEN VON FRISCIIIIF, M ZIG&RETTENRAUCII UND D~EN GASPIIASE AUF DIE ENTWlCKI,UN(; VON LUNGENTUMOREN BEI SNEI.i,'$ MAUSEN Chro~ic inhalatin~ ~ :rc~h ci~rtlt© Imokt and ol the ~'as I~aS£ ilon¢ contriholc Io the carclno~enesi~ o~ glandular lung lumor~ in .~ndl mice. In experiments rclX)¢lcd he~, o!~ group o[ mice wit eapo~d chronically, i.e., over the longest Ix~tibl¢ lime span. Io tolal clgar¢llc smoke, and smother group Ior an equll kngth o1' lime In o~ly the gas phag tmokc; a third group o( S~II mica scc,~d u • ~lrol. Two types glandular lung lumori, adcnomas and ad~m~a~lnomis, weft in lhes¢ animals. In the conlrols. I1~ male anlmala eghibilc~ twice is many ll~n~ tancous lung lumoes as the lemalc~. After iohalalion of clgaTelle smoke number o~ lung tumors w~ increased: thin increagd hcquency of tumocs was particularly notic~bl¢ after inhalalkm of lhe gas phase. The ¢ffccl was more marked in male than in female mice. II is inleresting Io hole that in Ihe controls, mo~t o( Ih~ lumo~ wen: observtd only in mice which were more Ihan two ~llrs O~d, whcl~as in Ih~ majority of i~rimenlal mice Intones were |o~nd ii i m~h tariff l~. ca~clm)ma. *uch as Ihat wh~h Ii~nlly ~ in heroin ciglt¢ll¢ imui- era. was ~vcr o~fvcd in I~ m~. ~ I~ll lad wc¢c found in conlroh 11 well It in ea~i~nlll m~, it rams ,clumablc in su~sl Ihll inhlllli~ ~ dgl~lle I~¢ by mice enha~es mo~¢ or Ic~ [~u('hlen~rgrr. f~ a~ l~hlen~r~r. R. ZeiH¢'hrilt [ur frour,~i~medizl~ 17:457~62. 1970. From the Swi~ l~tstilule for Ea~dmenlll Ca~ct Rc~a¢ch. I.ausann¢ 29
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O~ 0 C~ O) EFFECTS OF CIIRONIC INIIALATION OF WIIOLE FRESll CIGARETTE SMOKE AND OF ITS GAS PHASE ON PUI.MONARY TUMORIGENESIS IN SNELL'S MICE Doe~ chro~c Inhah.tio~ o~ f~ ~e ci~areffe s~c conr.~ning padiculule matter ~vc I~ ~ ~ ~ differen( bkd~ic~l cff~l than that ~ inhal~t~ ~ I~ g.s ~.~ ~ f~h cigarette ~ke? To ~swer this queue. 467 puff~ ~ w~¢ [~sh ciEuRlle ~e m ~ i~ ~u ~ ~1o~ f~ ~ year ~lln~ with ~ir. mk)~ ~uhed in an ~r~r ~ i~ m hi~r ffeq~y ~ ~lm,~ular pul~w tu~s when ~ whh t~ ~ ~lrOIs. ~ rnhl~e- ~fll ~ ~l~ary lu~F~is wu ~larlT ~lriklnK meier r~ure Ma~s ex~d to t~ ~ ~a~ di~ ~ ~ly m ~ificanl ~if, from putm~ry m~n~ae to c~m~ ~m~ 23~. ~ml ~ fi~ ti~ ~ml~ Ih~ th#l ~ co~ffols, which Term : U. S. Atomic E~r~ ~m~. 1970. ~ )29-346. Fr~ t~ Sw~ lnsli~lc f~ P~n~l C~r R~arch, ~u~. EINFLUSS VON FRISCIIEM ZIGARETTENRAUCll AUF DfE ENTWICKLUNG VON LUNGENTUMOREN UND AUF LUNGENKULTUREN BEI DER SNELL-MAUS "]"hk~ Icpo~ dc~s widl the ¢~oc~ c4 chro~c inhalation o~ ci~trctt¢ smoke o~ the devck:)$~'ncnt 04' Ira| ~ I,,, ~mcU'l mice. end lh¢ O{ C[~t¢ mnoke o~s m.l~ssO~' ~¢I I%owi~ O~t |rom |u~g expiant eultur¢~ o{ S~¢11"1 mk~. R~sul~l o{ ~ ¢lpcdmcnB ~o~ed ~hat chronic inhalatkm o( whole fr~h dg~R'~ ~mke, o¢ o~ i~ ~ ~ ~, ~- ~ ~ ~d~r ~ ~ hi~ [~ d lung ~ in filte~ CJ~RI~ ~e ~ ~ ~l~ f~ ~re eliminated. ~ • glaive ~ma~ to ~ ~ar m~r~a~. Alte~ 3O hand the importance of th¢ gu phase foe t.~¢ stlmulaKon of cell mclaINdism o( alvecJar macrophagcs. L.tuchtenhe~,ger. C. and Leuchtenbctg¢t. R. Schweicerische Mrd,zi~srhr Wochreurhri#r IO| (3g) : 1374-138 I, 197 t Other .upporr: Associatkm Suis.~ dea Fabricant~ de Cigarettes. From the Swiss Institute for Etpetimental Cancer Re, arch, LYMPIIOSARCOMA IN "THE RABBIT: GENETICS AND PATIIOLOGY L~,mph~arcomas ale Ta~e in eabblta. IIo'wcvc~, sk¢ 1962.29 ,~bbha d sltmn Wll al 1"~ Jack~ ~mlory have exhlbiled lymp~arct:m.. ~Ca~ ~ this un~u*l a~regml~ ~ lu~tl. Ik ~dig,ccl o[ the affected ~ ~fcr~nE su~c~i~lily Io lym~r~; thb ~nc w~s b. ~c ~ls ~c~c compatible with ~h ~ls ~ ~ncl~ su~epli~lity Io snimMs. ~i~ally, it ~mMed in ~ny w~yl vi~rll lym~om~l~ s~ ~ cats wh~h hat ~n ~ u~ui~lly ~ k clued kukcm~ vies. ~ciu~ ~ I~ wit i~nl ~ ~~. b~al r~a~h. ~ fi~ing ~ lym~m l~ its hrtcdit#~ Wov~s • ~w n~ im~ant ~1 [~ sludks ~ t~ palho~ncsil ~i~, C. W. ]o~l o[ ~ Nal~t Ca~r InJliluw 1970. MALIGNANT TRANSFORMATION INDUCED BY ?.I2- DIMETIIYLBENZ(a)ANTHRACENE IN RAT EMBRYO CELI.S IHFECTED Wl'l'tt RAUSCHER LEUKEMIA VIRUS Mocphotog~cal ilte(ltlonl o( celll Ind in lboofmal growth paltern were noted 42-4~ days |her treatment of Rlulch¢r k:ukcmis virus (RI.V) infected rat embeyo (RE) c¢lll with vark~ua levels o~ 7.12-dimcthylbcnz- (a)anthemcn¢ (I)MBA) for ~'~n d~yL Un~nfcded calla treated with DMBA and RI.V-infecled RE celia untreated with DMBA failed to show any ¢~(~:~ce ol transformation. When $tai~'d with Giem~, the transformed celia consisted o~ randomly oei¢oted ct'|tt-cn~alng |p~ndl¢- i~al~-d cells having much mor~ rapid replieallon rat,~ than the and untransfo~med Rt~. ca|Is. The t~ans{orn~d ,,-~lls were more resittanl 31
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to th~ to~ichy nl DMBA lhan were lhc unlrcal¢~ RF. cells and n.dy ~hc han~formcd cCHS wc~c ccl~s derived from l~ lu~rs, llkc the tour liSs~ i~If. conla~ncd ~roup- s~cific complcmenb~in~ #nli~ns chara~risilc at [h~ •urine Icu~cmla- sarc~m~ ~ifus complex m~ I~ C-ly~ RNA panicles. ~c~ rcsohs, which #hawed ~h#l ~h chrm~ml su~sl that I~ C-ty~ 0~o~ inf~mal~ {~ the m~liRnsnt tfsns{ormaS~on. ~him. J. S. Vlss. Internadonol Jour~ ol Cancer ~:6~-74. [ 97 I. From I~ [~parln~nt ~ Vlr~ R~a~ch. M~¢~ogkal As~l~c~, Inc. and Viral ('arcim~6t Brash, NII~ml Ca~r Institulc, ~hrsd,~, Md. POI.MONIT['~ INTERS'rlZIALE CRONICA IN CORSO DI SARCOMA MURINO DA ME~ILCOLANTRENE tlillo~ogk'al ezamln~tlon o~ Ih¢ lungs o( 147 m~cc with mclhylcho- lanthrene.mduced Urcocnaa o¢ franh'~am~ ~ the same furrows revealed 24 5% chronic intcrst*tial p~cumo~ia Mi¢¢ usz-d for Ihis atudy were of the C31t,B/C'o/S¢. RIll/D•/,%, CBA/Cb/~c. and FI[C311.BI(,'b/S¢ X RIII/Dm/S¢) steal• ~ pocum<'~ia sccn in thcs~ m;~e d~ffc~cd {t~m bronc~um~ia, which is {requcnlly ~n in ohl m~cc, by rca~,n of Ihc l~ of ~{. lh~ a~'¢ o( alveolar flotilla, and I~ inlen~ prohfcrathm ~ ~p~al cells. Mallecff. N. (Seeerl. L ~ ~v. dnot. Pat. Perulm 30( I ) : I 5-25, 1970. From the ~;s~n ~ Ca~¢ R~a~h, Uni~nR~ o( Pctug;a. haly. I TUMORI I)EI. POLMONE. DEL RETICO1,O E DEI.I,A MAM- MEL|.A NEt TOPI BALB/c/C~/Se DI$CENDENTI DA GENITORI TRA'I-I'AT! CON URETANO NEL PERIODO NEONATAL[:. Two ~ro~lpS o[ BALI~/c mk~ were tt~|t~.d as newborns with one and five mdligrams of urtthane reslx'~:ti~el7. and then mated. Offspring o( thc.*,c treated mice wcr~ follo~tc~d in • stud). ~ Ihe in<idcn<e o{ sponlancous tumors, [:)¢s~cendants •hawed In Incr~l~¢ o~ lung and r~llcular tumors, in male and female, virgin and malcd mice. A dis~us3k~n (ff the mcch~nkm through whk:h urelhan¢, in<~ul~ted inlo newborn mice. cnha~cs Ribaccht. R. (.~vert. L ~ I~v. Aaat Pot Pe~ulia ~0(I):27-~9. [970. From Ihc [hvisum ~,{ (.'a~r R~a~ch, Univcnily ol l'crugia, Ilaty ]2 DF.TE(q'ION OF A LLING TUMOR AGENT IN BAt.ll/c/(so/S¢ IRRADIA'! I'll) MICF. In this invcstlgatlnn lung tissu¢ from newborn micc was graflcd into adult syngeneic rcctplcnts prcvimssly panl,adlated in an attempt to the most suitable capqrimcntal conditions for th~ ~t¢clion o~ end0gs:nous lung tumor agcnls, or the 29 rccipicnl$ irradlaled b(for¢ graftirl~, 21 had recoverable long grafts .n¢J five o~ Ihem. or 23.8%. •bowed alveolar adcm~nas in their lung grafts. The number 04 lung ~ralts r~covcrcd hum irradiated rccip~nts was 44. No tu~s we~ o~¢d in I~ 4) g~alls Of ~w~m tu~ recovered {¢~ 23 ~-[redil~td conical rccip~nis. llrong a~iat~n wal o~d ~lw~n kuktm~ ~ irradialed ~ ~dc~s in I~ lung ~afls. AII~ f~r ~ I~ ir~ialed ~ecipi~nl~ d~d s~nlo~sly ~ lhym~ kukemia ~nd Ihc ~o~c~y ~ lung ~afls mH ~si~. hmr other mice were kukem~ w~n killed I~ Ihrct =~ II~ BALB/c ~uattlnl. F. and ~lis, G. B. f~vr~i. ~v. Aaat. Pot. Perulia 30(3):125-12~. 1970, From ~he ~vis~n ol Cm~cr Re.arch, Unlvcnity d Pc,u~l, Italy. DIVERSA SUS('E'r'I'IBILIT~ DEGLI EPITELI AI.VEOI.ARE E TRACIIEOBRONCIIIA[.E DEL TOP<:) BALB/c/Cb/S¢ AI.LA IUMORIGENESI DA URETANO NEI TRAPIANTI ISO~ENICI Dill rel~vant Io the susc~p6bilily o[ al,~lmr and trmchcol~xmchial mouse ¢phhclium Io u~lhan¢ lumori~l::l~:~l arc i'~por~d. GrafU ol Irlchca Io~¢thcr with the lower =¢¢1ion o{ I=r/n~. o[ main tnonchi, and o1 lung 6ssu¢ o~ newborn BALB/¢ mice w~rc aubcutaneously implanted 2.m~mth-old is~gen;c mice. Five days •leer ~'~ting, one Rroup of mice treated intrapcrihmcally with a single in~'s:llon o4' methane at Ihe d~s¢ o/ I m~ o~ body wright. Another ~'oup o~ unlrc-tcd mlc¢ was used ms control. Sia months later. 86.4% o{ females •~ 96. I% of males developed lung tumors o4' alveolar origin in [he grafted lungs. No h.yperplastic. prencoplasGc, and/or nenplal6c Ieshm taus~d by the c|rcms~gcn observed in the t~-',cheal, laryngeal. =nd bmnchi=l Na~ts No lunmr$ observed in the controls. Ribacchi. R. (.~rveri, L~v. ,4 nor. Par. Prr,~ia 30( 3 ) : 147-160, 1970. Fro=n the D~vision ~)[ (,',,nccr Research. University ¢~ Pcrugi=, h~ly.
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I|I. Cordiovaecular THI". EVAt.UATION AND ~REA~NT OF ('ARI)I(X}I~NIC SH(~K therapy ~ c~rJ~n~ s~k and ~nls ~w m[o~m~t~ wh~h could diaRn~l~ pur~ shoe cl~i~s. imp~o~ ~urvival. An ¢iRhl-~nt, ~ the s~k slate ~ ~nt~ ~. In Ca~n~ ~k. t~ ~,~ of c~mtro~rsi~l sub~cl ri~t ~. V~li~ ~nts di~u~d in ~l~i. hcrc mclhamp~[~mm~, ~nd ~mi~; sit,Dials ~nd ~nli~s ~1~ arc con- ~d~col Timr~ 9g(7):137.152, 1970. O~her ~up~rt~ [l.S ~blic Ileallh~rv~c. From the New Y~E Unlvcrshy ~l ~ Medicine, New York City. TIIE LUNG IN SIIOCK: ALVEOLAR-CAPILLARY GAS EXCIfANGE IN Trig SHO~K SYNDROME In *n attcmp( to del;neate the ciTes:Is o( circulatory collap, s~ on pul~ncml~ ventilalion, thh paper review~ c~r~ain ph~siolol~c co~siderltion~ teleran[ to atmormal alveolar ps ezch~n~ in t~ paten[ wilh s~k. AIv~lat ~ eschan~ in eiOt ~nts with ~k ~ealed marked ~educ- li~ in erleHal o~y~n tenure (P~) o~7~n differe~ while I~ w¢~ ~alhing t~ cir, Failure to a~qua~cly i~a~ Pa~ while ~eathin~ I~% ox~n i~aled siznificanl i~rca~s in ~ierlal shunting end ~sffa~ ~ntilmtcd lung uni~. An t~ diffcrc~ i~tcd ~ ~l~r ~l~l:r unlit ~c un~u~. C~lln~ ~u~c ~c~thing im~ovcd ~d~e Io~ic prc~u~. ~ ~it~ ~u~l lhal lltcralEms in lung 34 Icfl atrial prc~,~urc, and pulmonary ven~:onsl~k:tlon nee all imphcalcd Progrcssivc pulmonary changes may preclude: levc~sd~ilil~ o[ lhc sh~E ~?r~. 5. ~.. Mucllcr. II, Gisnnelli. S., J~.. Fleming. P. and G~acc, W J. The American l,.trnul o/ Cardiology 26(6) : 58B-~94. ~ 970 Other *rapport: L). S. Publ~ llcallh ~rv~ and New York llcall As~iaii~. From Ihe ~par~mcnls ~ Medici~ ~nd Sur~, ~. Vi~cnl's Ilospilal ~ Medial Ccnlcr ol New York ~nd New York, Univc~[y ~hmd o{ Medici., New York Cily. MY(X':ARI)IAL AND SYSTEMIC RESPONSF.S TO CAR BOX Y I II~M(X;I.()IIIN 'This pil~r levicwl ccrLlin theoretical a;l~cls of syllcnr~ and cardial oay~n eachan~,~ and lUmmati~a a l~ri~s d eaFrin~nlal eludes ot' the p~ysiolog~cal eflecla o( ~lati~ly ~all I~fllS or ca~y~ ~ hjman lnd cani~ sl~ ~f~ a~ after I~ IdminiSlrll~n ~ In~unls ~ ei~ 5% ~ 0,1% c~ ~=~ tu~nt to rai~ ~)II~ wcr~ ~c~ca~d b~ admin~It~ ~ elt~¢ co~enlrafion I~ ch~n~ could ~ i~ndEcd wilh C~HB glulll~l ~I~ ~%. Cardiac oolpol and minute ventil~l~n incrca~ w~n ~HB w~ clcv~sed by breathin[ unif~ml~ ~rea~d ~ c~ ~ ~w i~rr~d when (~IIB ral~d to ~lwccn ~ I~ I0% ~[u~l~ wilh ~il~r g~s n6~lu~r in human sl~s. Cc~[lln p~nt~ wilh ~ m~e~ di~ ~vc~d su~stin~ m~di~lh~xiL ~i~nt m~rdi~l ch~n~s w~ ~n pal~nll wkh e~vai~n ~ ~IIB ~e 6% ~IIB. T~ canlnc prcp~rl- t~, in ~trast, was ~y ~R ~nt 1o ~ItB I~ sign~nt ~tJ O? ~he New Ym~ A~e~ of ~ie~e~ 174( I ) :26~-293, OIk~r *mp~r~: NaGo~I Air P~lul~n ~t~l Adminlsttst~n s~ N~- t~nsl llcu~ Imtitute. From the ~plrlmcnll ~ M~ I~ ~f~, ~. Vi~nl'l II~pilll Mcd~l ~ntc{, New Yo~k City. IIEMODYNAMICS. CORONARY BLOOD FLOW, AND MYOCARDIAl. MI-:rABO[.ISM IN CORONARY RI-:SP()NSI~. 10 /.N()REPINEP|IRINE AND l l.s pat'x'r l)rescnls myocardial mclaholism end lyslcn6c ~.~.~y" 35
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0"~ namic data in IA pit,hiS with .-a:verc coronary sh(~clc. Cardiac index (('1) and st,okc inc~x w¢~¢ markedly rcd~cd in all pal~nls. ~can arterial Wcs- SU~r ~d f~om 40 to 6~ mm ItE ~hi~c l~stcmic ~ul~ ~c~stancc widely ('oronmry bl~ ~w (CRF) w~ ~rca~d in all but thr~¢ p~l~nls. While my~a~d~l oxy~n c(msumpli~ (MV.,) was normal or inc~ca~d, my~ardial ne~n cxlr~l~n wll ~vt 70~ and co~na~ sinu~ oxygen ib~rmll oxyEcn pitlcrn in ~ilc ~ ~in~ o[ mixed cor~iry wnuus cxlracl~n ~s ~ I0~. ~ ~ ~ I-~r~ne~H~ was in ~vcn C~S ~nd I~ ~ tO ~c~ in (~r. (:~ns~r~l~n ~h hc~n~m~ ~ ~I~ flUX ~II ~SlS thal l-m)rc~p~d~ u,lu~ ~ l-m~c#~dm, c=~rully ~lml~ h~ inttm-ittct~l procure ~i~minK to ~c~m c~ i~ ~ ~nlr~ullr work. mtK~t wcll T&e ]ow~l of C'[inkol [e.~tl~ni~ 49( !0): 1883-1~2, 1970. ALTERATIONS IN :2-3 DIPHOSPIIOGLYCERJ~TE ANt) O, tlEMOGLOBIN AFFINITY IN PATIENTS UNDERGOING OPEN-llEART SURGERY Since it has been ~ that hemoO<~in s~nigy for oxygen b inversely related to th~ Icvtl o( Rd blood c¢11 (RI~C) DPG). bo~h o~ th¢~ parlmeter~ were melsured in 14 ~llicnls undrfg~ng hcarblung b~pm Io ~-flnc d~c infloem:¢ o( Ihb p~oc~dur¢ on 0: delivery in patient, unckr~,oln~ o~n-hcart au~r7. RBC ~-3 DPG £k'cr~ascd wilh |nstitul~on o{ b~pm .,~ continued to d~s~ du~ing bypm. "1h~ day f(Rlowin| heart-lung bypm RBC 2-3 DPO lower thin ¢~'x~crali~,¢ co~tro~ vil~. El~n ~nil7 ~ o~7~ i~ pal~n~, linear. It wu (~ ~at t~ i~ a~nity w~ less than and that a p~o~c~i~ ~ In R~ pH ~iall~ c~r~tcd the ~Itrra- twin in 0~ a~nily. T~ d~[~ lu~l th~l ol~¢ lectors such as car~. n~m- 36 Bo, diuk, !. M,, McKcnna, P. J., Giannelli, S., Jr., and ,4 yreJ. 3 M. Supplcmenl [ to ('~r( ulali,n XLIII and XLIV : I - 141 ~ I - 146, 197 I. Olh.'r .uppore: I]. S Puhl~ Ilcallh ~rvkt. From the [~parlmcnls ~ Pcdialfi~. Pmlh~o~y. Su~ry ~ Medicine, St Vmccnl's }h~phal and Medial Center. a~ New Yo,k Unlvcn,ly ~ TOTAL AND NUTRITIONAL CORONARY FLOW The tint part o/ Ihls m~l~x~ology ~)~p¢~ de~cribe~ a new Icthniq~ for dclcrmining I~ vc~ily ~ ~d c¢111 In I~ cl~lllrks. S~h ~nl is acc~phshcd by ~lcrminhg t~ rra~ IO Ill~ ~oFmS ~ i~i. vidual ~cd cclh In m*in~lm~ ~ I~ ca~lla~. ~ nitfoglyccfi~ slows I~ ~ ~ I~ capillarY. I~ thai lulls in I~ complete ar~l m~ e~ rel~ ~. ~ ~mlin~l tc~ is ~¢fncd with t~ ~uuR~nt ~ t~al u~ nutllti~M ~lry Nulrhmnal iS well Is ~a[ ~S~ ~ C~ ~ ~lcrmi~ by ~sl~=lc I d~holomy ~ I~ ~nl~ ¢i~ul~l~ ~ illusl~[c thai I~al and I~al ~w. N~c~¢im Cl~ I dis~l~nalcly ~ellcr TIlE EFFECT OF INTRAVENOUS ETIIYL ALCOIIO[. ON 1lIE CORONARY CIRCULATION AND MYOCARDIAL CONTRACTIt.ITY OF TIlE IIUMAN AND CANINE IIEART In thie altcmpt to examine clo~ly in IRI o~ ~ capcrimcnlal con- bh~d flow, cont:aclility, and hemodynamk'l wcr~ invcsli~lcd .i.n IO.pa- Iknls and in 23 an~lhc~ized do~. Rc~ull~ o~almd in rain w,lh o1' alcohol co~parald¢ to that comaincd in t~o to thl~: ounces of whiekty ehowcd ~ conatltcnt hul nol ilgni~canl i~¢rea~e k~ effeclive coronary Kcompanicd by • fill in co~mar~ vslcullr R'lilllnc~ whkh was al,m i~&niRcanl. "l'hcn: wa= no eiRniflcant chan~ in ca*diac |ndcx, hce~t Ihowcd thai when small amounts of alcohol were infu~'d Ihe
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coronary flow r•Ic diminished slightly but not sitmificandy, withoo! siKnifi. canl ¢h~n~! i~ co¢~ v~ul~ rts~stm~e. IIo~cvc~. whrn Ihc this diminlshed my~ardial c~tr~l~l;ty arc ~t clear. /~rnal of Clinical P~,~o~ I I (3) : 165-176, 197 I. I~FFt".CT OF HI'IR(X'JLYCERIN ON TOTAL ANI) RH(;I(}NAI. C~JR()NARY Bl.(>()l) FI.OW IN TIlE NORMAl. AND I.~'III-'.MIC CAHINF. MYOCARDIUM In ¢~tim•le the leKional di~ltit~lion ol cor0~ar), ~ in •dull mcmgtcl Wilh Ihls mct~:xJ, l~ ¢ffc~l O~ nilroL~ycrrin on tolsl coronary I~w rcC;on•l d~tflbuli~m w•l d¢l©rmincd in flormsl conditions •nd in myo- cardial |schcmi.. In r~rm•l he•tel, c•pill•ry flow was 9.~% higher in inner Ihan in Ihc ~utrr mTocardi.I hill. When pallial occlusion of • rlerics w•S Iollowcd by inlu~'Km o~ noradrcn•lin¢, su~n<loc•~dial Row was I¢~ thin capillary flow in tubcp~cmrdill layc~ lu Ihc~ co~lilicms • dminislration o~ nitrx~Kl~e~in rcsutlcd in a redistribution of capillary flow Io,~srds normal. CorJiov~B@or R~to~h 5( I ) :54-61, 197 I. ~k~r ~=p~: M~hi~n llcm~ As~iml~. A~r~can Mcdicml A~ia- F~ 1~ Wzy~ S~Ie Unive~lly ~ ~ M~i~, ~troit. TIlE ESTIMATION OF BL(X)D PLATELE'T SURVIVAL: I1. TIlE MULl IPLE lilT METHOD ~en r~d. ~ ~ thmt ~ h tie-ins a~ im~i~rim- inzle. II~¢ver, = ~lt man7 It~ hi~ ~ ~Mi~ed in wh~h the p~tlem ~ ~Sy, ~h i~ mt~ I~ ~n ¢=~¢i~fltml Iflimall. c~(orml well l. = "lin¢=r" ~a7 p=t~m o~r I ~r~ ~ I0 d=~ ~ ~. 3hi~ dcvclo~ f~r ~ls f~ eslim=l~ ~ ~ plmlckl survival. ]~y are printed ~ =s c~p~ly ~alis~ ~l u ~l ~lsl fi~l or~r • l the same time circumvent the subjective element i. •nalyzinR the data with the attend=hi bla~s =~ al~ prov~c m u~fy~l I~o~y h~ Ih¢ ~vcral different m~ls which var~s in~li~lm ~v¢ ~r¢ or less tzpl~itly ~d in I~ past. ]he m~ls m#7 ~¢ha~ ~ I~l ~ as s~,lh;nE u~l~ns to .on out Ihc hi~ r#~i~nlml ce~ in~rcnl in Ihc sludy ~ ~altltl so~iv~l. P~imarily, mn mllcm~ h~ ~en m~ here Io con~leucl ~1 ~ Ihc hm#~ ~ penni k~wkd~ ~ I~ ~my of Ihc plalclcl rand Thr~ e~ Dm~ke~ lle~ 25( I ) :53-80, 197 l, Otk~ .~p~rl: U. S. Pu~ l~lh ~. Fr~ t~ ~ntl ~ M~I~ and Bi~lmt~l~, ~ /ohns Ih,l,kin~ ARRllYTIIMIAS FOLLOWING INIcUSIONS OF FAI"I'Y ACII)S In experiments reporled here, l~I/k&~ m I in I,~ w/v s~ we~c ~fu~d ~to ~ over a 6~nu~ ~r~. we~c pal=de, Sleaze, ~, I~, ~ ~t~s ~ nlc~-~lmit~ • ~ ~-Utar~. A I~al ~ 178 ~ weR u~ in I~ Cuds=. A char- ~ infus~ N ~g<bi~ ~lu~l~ fitly ~ (dears. palmitk). In It~ to In inju~ ~rRnl, el~r~l~ ch~s weft ~n~ ul~ ~k, l~u~ sl~lill, ~ ~ele ~1~1. Simill~ i~u~ inr~ ~ Isr~ qusn~l~ ~ ~ng~h~n ~ day afler day pg~d ~ unl~n~ clin~al cflccU. ~ diffegc~ in efl~l ~tw~n I~ ~lurltcd and un~luraled fslly ic~s and I~ diffe¢~ In ululated lilly Ices mi~l ~ d~ Io di~eR~ in I~ ~ci~ Io ~l~mln. A~e~iro He~ lour~¢l ~0(5):671-674, 1970. SIMULATION OF "LEFT ATRIAL RllYTIIM" BY RI(;IIT ATRIAL PACING This c•~ hislory reporl ccmccms m patient wjlh (I) Ihe crilrri. (l~ the di•gm~is (~ ~o.cslted k(I Illalal shylhm •nd (2) • |imils|" pstlrrn p~duccd by • catheter I~'¢mller slimulellng I~ will ¢~ I~ m~ tlgl'l ~galing a left atrial site for ~cemlkce gfvily, lU~#II i ~,~ likcly site
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:2: IN|:I.UENCE OF ANTI(T)A(';~It~N'TS AN[) A[ri'ONOMI(" DRUGS ON PLASMA FREE FATTY A(.'II)S AND "The inili-I level of frc~ f,,tt7 ~ (FFA) in the do8 may Ix: • Itct~¢ in dctermlnin~ wh~ther ~ no4 anticolL,~lants will cscr~ lipolytic ~ctlvl(7. In experimen= r~otled herr. anesthetized dop, which hld txcn |Isled o~rn~, rect~J kno,~n quantifier o( ~parin ~7Jnhyd~a~u~ ~ s~futc (Manu~s(c) in dilute ~lu{~s. comp~r~ ~ ~ ~i~i~lnl ch~n~ in FFA or ~ ~cur~d after idmini~trl[~ ~ ~pa6n or MInuronllc *Io~. In o~cr ~ou~ similarly ~t~ ~ ~ivinE ~rin, Ihe intrados infusi~ of nicod~. ~phri~, ~ ~tere~ i~ clesHy si~ni~ant cleval~ml in plasma FFA a~ with i~rcl~ in ~llml ~. N~-ra~cd do~, ~ hl~, Ih~cd hi~ initial ~vcl~ ~ ~uma FFA ~hat wcrc fur~r incrca~d with ~ vlrlabilit7 by ~pa~in a~ whi~ ~o~ ~vch wc~c unafraid. 1~ r~ul~ i~kaic Ihll. u~r the rx~rimcntal condili~ms hc~rin ~ M~nur~e while ~yin~ I~ influc~c on pla~m~ FFA A~hivel i~trrnoti~tes de Ph~ynomie rt d~ Th/rapie IgT( I): 4~1, 19~0. F~ t~ ~r~nl~ ~ ~am~ ~ C~rd~lo~y, Temple Univcr- POS.51BI.E MECIIANISM OF EGRESS OF FREE CIIOI.F.SIEROI. FROM "TIll:. ARTERIAL WALL II an r,quilib~ium c~ts bctw~m |me ch()ksterol o( the ~rum lid of important I~t~r in alk~,~Ing more c'ho~ter~ to k~vc t~ aHcri~l wail To t~t (~ hy~h~h, ~cntt ~ human ili~ ~ri~ (Irca~cd ~ un- 4O treated) were incubalcd with human s~rum (try-ted and unlreated) In medium, virlually only frcc c~ICr~ Ell I~ I,IcHII will. whcrc, l when zuhz su~sl lhal a ~rcl~ in ~rum fr~ c~te~, clued by z ~m ch~lc~ol tslc~ifyin~ e~y~. ~i~y ~AT. might pro~lln~ I~ rc~vzl ~ f~ c~c~ f~ i~ zm~izl walt. Si~e ch~Icr~ cslcr~al~ h~ ~n ~wo ~lly Io ~ ziKni~zn~ly Im- paired in zub~ctz with zcmc m~z~dizl Infa~l~ z~ chronk ~onz~ ~ [.CAT, mly ~ ~m~tanl m I~ cliol~ ~ rile of ~vclo~Knl ~alure 2~0: 123-12~, 1971. Ol~er ~wp~rl: U. S. Publk Hezhh ~. From l~ ~mcn( ~ M~ci~, Tcm~ Univ~i[y Cooler, ~ilz~l~iz. STUDIES ON FIGURE DRAWINGS: BIOLOGICAL IMPLICATIONS OF STRUCTURAL AND GRAPIIIC CIIAR~C'TERISTICS The F',b, urc-DYtwing Tc~ hit been us~cl since 19:51 in the S~udy o/the Pr¢cursorx o1" Ifypcrlenskm and Co~onsry ~ Io J~e whether drzwn in younK Idu|lhood by lUbj¢¢|l who (~vt~o~ hylx,lcnskm or coe- onsry di~ss~ in middle life are slgnifi~antly differ~n! horn lhc.~ o~ ,ubjocu who remain ffcc h(wn tees,: disorders, l~d to k~ntt(y the nsture differences. Figure drawinp by 83"/lohne Ho~inl medical students in lh~ clu~:~ o( 1952-1964 ",~ im:l~d In I}~ l~'ten! in~l~mi~. The bulk o~ II~ drlwin~ were by 72~ while m.,le llt~l~ll in lh~ cl,,~ ol 19~2-1963; dra~in~ b,/ $0 white won~n ~lud~nt~ In ~ clIm~'~ wer~ u~(d [o~ lh,- • c~ comparison, l~'lwin~ b7 62 while n~le .ubj~cl~ in th~ eli.. nl Ig64 were added to I~ origin-I miIc ~'o~p |o*" comp,,ri~oe~ tn,~olvin| physio- k~cal and mctat~lic varii~cl. 'The rctulll of Ihb aludy indicIte thai the #tructurl| lid Rraphic chl~'mcteristic# o( fl~ur~ drmwlnp my inked have different kinds c4 fibres. Foe exempt, n~n drlw Ihe male fiB~ first more o(tcn thin do wom~n and thin peo~ draw fl~lr~l with beltl mint O~len Ihafl do |al I~'~IC. In v~w o~ ll~ flirly talensiv¢ lileralure on IWr- so~alily differences hetween ImokePl Ifld r,~n'ln~kcn, il is purzfin8 thai t~ir fi~,um drawin~:J Jh(mcd ~o few differences. The linal siMJificlm'¢ (lf the ttudy's findin~ vemnin5 to I~ as~:ertaincd in view ~ Ihc hyl~|t~si|-s~ekinK 41
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Thoreau. C. R . Jones. I.. W. and Ross. I) C. Pfych~etric (~ua.rrly Supple.an! 42 ( 2 ) : 223.25 I. I q~ ~ lnlcenat~n~l ~usi~u ~lch~ C~ral~n. l:rom t~ ~p~n~n( ~ Mcd~i~. ~¢ J~ns tlopkins Unlvc~shy ~ch(ml EFFECT OF CADMIUM ION ON RESPIRATION AND A7 A('31VITY OF TIlE PUI.MONARY ALVEOI.AR ^ MODEl. FOR TIFF. s'rUDY OF I:.NVIRONMI:.NTAI. IN II:RI:[:.Ri:.N('I:. WITI| PULMONARY CI:.|.I. FUN(.'II()N inllcI PAM cells m~ i~=l~ mlt~r~. A~oximalely ~mM '~'d inhibilcd e~m rc~l~ in PAM ~llz =~ 05 mM Cdt~ inh.~tcd ~rt~ral~n in I~ i~lal~ mit~ri=. In mH~iml electron carrot. ~t~d I~ Cd~ *-inhibited ~piral~ ~111 and mil~ria, ind~mllng thai Cd~ pr~umably ~u~ ttSpitl~ chain com~.~s. Cadmium ~ tl~ inhi~ted the of Ibis invcsligalion have qu~ntit~led in w~ro t~ inhibilo~ ¢ffCc~ (,f ~d SU~cllull¢ bi*<~m~ll p~c~l ~ the PAM cell. Allhou~ =~ing In vitro mn ~l~t~ ~ tm~t=nt lung ~lt s~stcm a~ li~. C~o~, C. E., I~=him, A B.. ~h~, M. ~ ~ust~=, ~. G. ~n vi~o~ Rt~o~h 3 (~-6) : ~ 12.520, 1970. From t~ ~part~nt N Intcr~l ~i~. Uni~ty ~ Citi{omi= ~h~l d Mcd~, INTERFEREN~ OF ~DMIUM ION WITll OXIDATIVE M~A~LISM OF ALVEO~R MACROPIIAG~ Mml ~ t~ e~-~uidng ~ ~ ~l~na~ mlv~lar mmcr(~ phm~ I~ ~flt ~ ~ ~la~m. In v/lea SI~s • =1 ~ ~llt ¢o~ 0.1~ ~ 0.2 p~lr O=/mg W~cin/~. Mit=~ 42 oxidaGon is coupled to pho,sphocyladon; adenosine diphosphatc (ADP): o~y~n ¢=[k~ arc apWoximal¢ly 2 for ~=vin-I~k~ =n~ 3 fur n~le~i~-Iinked su~tralcs. Cad.lure ~n, I ~ =it ~lulant a~ I rcp¢lcd tom.merit ~ ci~¢¢tic I~e. ~ve~ly I~¢¢1s ¢cs~rit~m oxy~n u~akc st 50 prewar c~cntrst~ s~ u~ o~alivc phi. cat,s, like Cu* *. Ilgt *, ~ntt m~ ~*+, aim inhale a~ine ~phata~ {ATPa~} activity ~ ml~# m~a~#. Sin~ metal 1~ oti~s 1,¢ ~ air ~,u~nt#. m tt~y ~ this re)r1 nG~t ~ov~ inf~mat~ on ~hunisms at I~ ~hemkal level ms to ~w tox~ inhalants iniliale pul~a~ ~1~. Mualafa, M. G., f'r,~*, C. E. I~ Tykf, W. S. Arrives of lntr~l Meddler 127(6): 105~1058, 1971. OIh~r *~p~rl: tl~ S. PuI,I~ Ilemllh ~i~ ~ California ]'ut~cuhn~ ternal Medici,. =~ Anally. U~v¢~ily ~ Calilmnim ~h~l' ~ Medici~ a~ V¢lerinaey Mcdki~. TIlE ORIGIN OF PULMONARY ALVEO~R MA~OPIIAGI:~: ~UDIE5 OF ~FEM CEL~ USING TIlE ~2 MARKER OF MICE this ti~ m ~skk~bk ~lro~ny ~rnlng t~ ~llulir ptccuru,n the ~si~nt PAM ~1=~, In that =ttcm~ to ~mify ~ p~u~t, u~d to in~ti~tc the ~i~Gty ~ PAM milin [u~ marrow stem ~ RF/AI (+) m~ cmr~ m ~i~ Rmday ~ntifimb~ plcilhumin ~efa~ marker. ~-2. R~i~l ~i~r~ am# p~cd by mdmlnltle¢- q~ntly in~fing l~m ~th RF/AI(+ ) ~ m~. m~ (2) RF/AI( m~e ~ ~nlly in~g ~m with RF/AI(--) ~ mmr~. Ei~t w~ks dice i~diml~n ~ ~l~ wc~ ~ml~d while PAMs ;r~ t~ RF/AI(+) mnimmh given RF/AI(-- ) ~ had all ~t ~t thei¢ ks-2 marker ~nd, w~h ~fi~ t~ marrow oH#n ~ PAMt. Bmnslctlcr. M-A.. Ilmrd~. J. A., ~iff, R., ~h, ~, P. and C~o,. C. E. Arc~v, o/ Intent Med~l~ 127(6): 1~-196B. 1971. m~.
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O 0 PUI,MONARY ALVEOLAR MACROPIIAGE: MEMBRANE A,~OCIATEI) SODIUM ION. POTASSIUM ION. AND MA(;NESIUM ION ADENOSINE TRIPIIOSPIIATASE SYSTI:M This p.pcr peck'nil one ~ ¢g cc|lu|*r ATPa~ syslcm, s sysl~m which I~p~ Io bc k~c~lcd pc,maNly oe Ihc plasma, membrane. Io t~ acfiv.lcd by Na ~ ~nd K~. ~ ~i~.ll~ ~hlbilcd b~ lhc c~rd~ Bly- c~idc, ouablln. A~tdi~y, ~ c~ I~llcm is prCsuma~y • p~tl ~ [PAM) cell ~m~m. ~ c~l~ ~ Ibis ATP.~ s~lcm w~rc ~cli~t~ by N~' ~ K~. ~ik N~~ ~ K+ .b~ h.d. lill~ r~cl on ~am ~ ~n ~ ~ ~1 30" C. ~ ~m~-~i~l~ A~'P~ ~m~ ~uu~nt sui~.~ [~ .1~ ~ 1~ inler~ti~ d air ~1- LOCALIZATION OF NA ~ -K ~ .MB ~ ~ ADENOSINE TRIPIIOSPIIATASE ACTIVITY IN PULMONARY ALVEOLAR MACROPllAGE SUB~ELLULAR FRACTIONS • Pulmonary alveolar mscrc~h..~c~ pos~ 111 cnzylt~¢ syslcm, Na Mg* ~ ATP~¢. th~'t m'7 ~¢ tt|atcd to Kti~¢ cation ItlnSpocl lt-,d bulk Ilow m,chani,.n~. F0¢ Ih¢ ptx~nl studi~s, pulmonary alv¢ol,,t mlcfo- m~rnphs~ ~llul.t pl.~ma ~m~s~ .~ cxhi~lcd t~ hi~l ATPa~ ~tivity c~p~d to ~r ~m~ [r~l~m. Ou~b~in inhibited proximately 30% ~ H~*-K~.Mg* *ATP~ ~fivi~y in ~th [n~ac~ cells ATPa~ ~u~ ~lv¢ c~l~ ~rt ~t~ t~ ~1~olal mlc¢~ha~ (o 44 Musllfa. M. (;. Cross. C. E. and Ilardi¢. I. A. Lile Sciences 9( I ) :947-9S4. 19"/0. Oth..r .upport: Tu~rcuh~is I~ Rcs~rilo~ ~a~ Asn~ialion Califotnla. Fr~ I~ ~parlmenls ~ B~l~al ~cmisl~ I~ Inlctnal Medicine, Uni. versify ~ C~li[ornia ~h~l ~ Mcdkinc, D~v~. ~FFE~S OF DIVALENT METAL IOHS OH ALVEOLAR MACROPilAGE MEMBRANE ADEH~INE TRIPH~PilATASE A~IVITY ~ % ~' '. a~ ~ ~ + in~i~¢d ~ ATP~ ~I~ by 30% ot at O,S to 2,0 mM ~nlra¢m. ~t ~ ~h ~ ~ ~. Ca~ +, Mn * +, • ~ Hi++ w¢~ ku inhi~t~. Si~ ~mium (w~ch is ~th • com~ ~a~ ¢mph~ma I~ ~1~ fl~ in man. I~ eff~ ~cre ~d in ~ea~cr ~lail. ~ e~ oxy~n u~alc ~ PAMI ~cnttal~' ~ Cd ~ ~ ~p~tcly b~k~. 1~ oa~afi~+ ~ su~in.lc o~so~uts~te, and a 3 ~M~nlral~ ~ Cd a~cd l~ ~lation a~ ~s~¢at~ ~1~ In PAM mit~tia. ~ the ~oun~ ~ th¢~ results. • tcla~hlp ~t~n diva~nt cat~-i~u~d injuff PAM b~m~al machi~ a~ t~ ~kter~s ¢ff~ d c¢,tain divalent ca~s on ~l~nsff tlu~ h ~ted. M~ta[a. M. G., Cross, C. E.. Mu~. R. L ~d Ha~. l, A. T~ I~enal o~ ~a~y ~ C~I Medicine 77 (4) :56~-57 I. 197 California and U. S. Pu~ Ilcalth ~. From t~ ~pa~mcnts ~ B~d ~mist~ a~ Inte,sal Mcdiclnc. Uni. versify ~ California ~1 ~ Mcdkinc. Davis. DETERMINATION OF ALVEO~R SURFACE AREA AND ~'EHSION FROM IN $1TU PR~URE-VOLUME DATA ~is inv~ti~hn ~t ~t ~nt to ~l~ml~ t~ t~a[ .lvcol.¢ eros ~ ~c cat lung l~om t~ In ~ ~u~-~u~ (PV) curves ~ h~lh &flsti~ and infla~hm, a~ ~1~ to d¢tctmi~ the alv~ht suff~e ~ ~ In silu gas a~ Iq~ PV data. To ~ish th¢~ ~rc a~st~Zcd a~ placed, wlth t~ ch~t ~md. Ins~ s p~lhTtmnKr~ph. In r~ordinB g~l *nd I~uid PV cm~l. I(~ ~n ~nd RinKe~-~kc ~dufion were u~. (;a~ ~nd liqu~ flows wc~c varied 4S
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0 0 ~J 2.9.60 ml/~c and 0.$-50 ml/scc r~,~pe¢lively, whh no ch~n~ ~hc hystCtcsls ~r I~ sha~ ~ th~ PV cu~e. ~ conslsnt, K, wa~ dclc~mm~d d~/cm. ~ mean v~ f~ K in ~i~l rx~rimcnls was 1225 ~EM. At ~ functional r~idusl ca~it~ ~ ~ ml ~ alveolar sur(~c¢ c~ Ihe c~l/kK ~ m~ ~t 1.0~ • 0.~ mt. 5urfz~ lrnsion w~s c~lcu- lalcd du~inK inflal~ m~ ~flml~. ~ ~lls i~ale thal su~ce a~roachc~ ~ro at ~w lun¢ ~u~ ~ a~ a~ i~ always ~wcr durinE ~flali~ than du~n~ inflat~ mt m ~n ~u~ ~ area. Fisher, M. ].. Wil~. M. F. a~ Wr~f, K. C. (Student Fellowship Rc- ci~.~ ) Envir~nlal C~lrd Admin~t~l~. A~lmhlan ~at~ r~. phil, West Vir~ni~ Unive~t~ ~al C~Icr, M~gant~n. INFt.UENCE OF CIOARE'I'TE SMOKE ON GUINEA PIGS: EFFECT ON PULMONARY CELLS AND SERUM ANTITRYPSIN LEVEI~ A Iolll of 50 mm~ ~i~s ~ wu eX~ to t~ I~c (~ two ~ks ~ cigarettes ~r ~y fm t~o ~k,; th~ c~u~ w~ t~n ~u~d A cor~in~ ~p ~ ~0 u~la ~ as c~t~. McIsuoc~nU ~crt ma~ ~ t~ ~lt, ~o~va~ I~ t~ lung s~ t~in kwls in ~(h ~ ~ ~i~m ~. Rc~at~ ex~urc to ci~- ~t~e s~¢ ca~ u ~ni~snl i~ in I~ I~ humor ~ cells rx~ to d~te ~¢ h~ an ~ nm~r i~a~ was ~pan~ ~ ~ c~n~ In ~m sn~n kveli over ~a~ ¢mph~ma in in. FffnL G. [.., Maxw¢ll. K. W. i~ Rc~d, A. D., J~. (~u~nt Fcl~wship R~ipicnl ) A echive~ ol E~vi~emal H~th 22( 3 ) :~369, 197 I. Vctcflnl Admin~Im }l~ph~, I~ Uni~nily 46 TIlE tILTRASTRUCTtlRE OF ALVEOLAR. MACROPIIAGES FROM IIUMAN CIGAREnE SMOKERS AND NONSMOKERS Alveollr macrophaE'ct of cipr¢lt¢ ~okef~ ~nd no~lmok¢~, oblala<d by endob~onchlal lavage, weR el|mined with th~ electron micro~col¢. The macro~higcs ar~ chiracleriz,'d by luff~ ~s, ~y~ic nuclei, an cxlensiv¢ ~lgl m~rlt~, cyt~ 61a~nts, and var~s favm~ um~. f:url~r~, ~ lu~ wh~h a~ phm~yt~ ~t ~ di~stcd ~ohabf~ ~umulate In t~ liter ~tcro~ous inclusions P~tt, S. A,, Smith, ~, H., ~. ~. J. ~ ~ntcy, T. ~. Fr~ ~ ~nl, ~ A~I~y a~ M~i~. ~ Univc~il~ of Tile JUXTA-ALVEOLAR LYMPIIATI~ IN TIlE IItJMAN ADULT LUNG: |llSTOLOGIC STUDIE~ IN 15 CASES OF DROWNING A c~ur ~finiti~ ~ al~ lym~l~ b vital Io t~ u~tanding dr~nLn~ ~ lunp txhi~ el~lknl ~ml~ m~ ~lcn air.lit lym~al~, a ~a~ di¢i~l~ wB ~ In Ihb M~F ~tw~ hbl, ~ ~ri~l~r ~8~ ~. ~ ~R ~B~ ~ "ju~- ~ inhalcdmalc~als vi~ the lung lym~a~s Ihe! ¢venfuoffy d~ain I~ bh~ s~m. 47
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0 0 O~ Oo 0 ARGYROPIilL. FLUORESCENT AND GRANULATED (PEP'TIDE AND AMINE PRODUCING?) AFG CELLS IN llUMAN INFANT BRONCIIIAi., EPITHEUUM. UGIIT AND ELECt'RaN MICROSCOPIC STUDIES t.l~h! ol~cal, hi=tochemic~! and electron micro~opic=l =tudic~ ~cwbom human infants haec d~yml that the el~thelium o~ the b~,mchi c~m- taint an |mp~c~l,~ ~mb~ o~ d~tinc~l~ a¢~r~hil, time's'cat frec~e-dryin¢ and fmmal~.hTck valor treatment) and granulated c~lls. ~ AFO cello c~nlnln humdrums roun~l opaqt~¢ 6¢ntc-cn¢cd ~'~1¢1¢t. Intra~l nc~c cndin~ =re al~ r=r~nt, ccl1~ in ~ human lun~ =~ ~l=t~ Io ~ ~in~ list d prrsum=bl~ ~11~ ~ld Intc~cm ~ilh vm~ ~1~ ~¢~. such ~ br~hi=l fmilu~) ~ I~ ~ ~1 birth, ~ ~l~a~ oncolo~ (ca~c;~ and oat ~11 tu~), U/e ~e~t~ 9. ~ I (24):1417-1429. 1970. ~A~ ~p~rl~ ~f~n N=t~1 F~s v~ Wctcn~hsp~l;jk On~- Fe~ t~ E~n=l ~t~ ~ C=~ul~n=~ and Gcnil=l L'~JI.TRASTRUCTU~RE DE LA CLOISON INTERALVI~Ot.AIRE DU POUMON APRES CRYOD~CAPAGE The roctntl7 developed freeze.oh t~chnklu~ was applicd to an Hcc- Iron m~'oe¢o~l tnvclli@ltoe o( the iatcrtlvco~ar icplum and th¢ air- blood b~l~c*' ¢~ lun@ O~ I~dldt mi¢¢. ~ulOCa I~p, and rats. "['his t,.'chnklu¢ k diffcrcm |n~ tr~litio~l tlcctrcm mlcrmcopy ~usc it avoiC~ ~ Iml~ ~ =~ ~Ith ~ ~ ~ 170 ~, wh~h ~ ~ o~ ~cd wi~h tr~dlt~l ~[~ m~7. ~ dlata~¢ ~w~n two 48 succc~ivc lamclla¢ is remarkably coostant. Their conhKuratmn str=kin~Jy resembles th~ frcczc~lch ulwasI~U~ ~ syfllhcliC li~,~dein ni~cllcs (and of lip~ recluses ~ yrasl cells), su~stin~ that the small plaq~s c~td tcptc~nt t~ ~otcin lr~t~n ~ 1~ la~tta¢ ;~tusions. ~hd¢ the I=~11~ Ihrms¢lves could coal=in ~=u~eryns, ]. ~nd C~m~r-~m~t, ]our~al de ~icro~oFir I O(2) : 139-148, 197 I. From t~ ~p~l~nt ~ P~l~o~. Univc~t7 ~ ~u~cn ~1 ~ Mcd*. cir. ~uvrn, ~l~um. t,'tIL.TRA,TIRU(.:TURE DE L'EPIT|IELIUM BRONCIIIQUE !='1" IIR()N('IIIOI.AIRE DIZ LA SOllRl$ 'l'hc ullraq.tructu|¢ e4r the bc~nch|al and bn:~chkAa, cphhchum and rslxclally ~d' the Cl,ra c~ll= liKht andlhc clcctr~ microtceg¢ (a~te¢ ~latioe ~,ith osmium tctroayd¢), The ullraslructurc o~ Ihc cilisled c¢11~ cmtfocms to the clmlcal dala. TI~ C~ata c¢lb a¢¢ characlc=izzd d this presu~d ~t~. M~vcr. • n adult form (t~ mu~l lye) ~ In in~lul~J~ phJ~ (the dcn~ lye). Fr~ ~ ~p~rl~nl ~ Pat~, Unl~7 ~ ~uvcn ~ ~ ~cdi- ci~. ~u~cn. ~l~um. TIlE BLOOD AND LYMPIIATIC MICROC1RCULATION OF TIlE LUNG Thi~ c~say sy=the'=iz:¢= the rc=u~ obtained whik ~ludying one o( the mo~t intHg'ui, g and peq}lexl~| I~oblema o~ the human lung. i.e.. i!.= .blood and lyml~t|llc mic~cin:ul=~. O~¢ Ihbl| that It rt~mlal and ~ic Iludiel o~ !~ lun@ of human. ~=~1¢ ~)M, =~ mu"R~cl 49
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pr¢~cmcd. Primarily. lhls sludy it concerned ~la~mnshi~ ~n ~e b~hi~l ~nd lhe pul~ma~ v~ular s~s~cm~. The ~rl~ionshi~ ~rc d~li~ in c~ch circul~l~ nc~ork. T~ h~,nchial ~rl~r~ ~r~ d~cctl~ c~m~ctcd oE v~ular supply. T~ ~o~hi~l veim sl~ fo~ Ihc ~ribr.~hial vcnnus pl~xus. In Ih~ pul~m~ clrcul~Uon. ~rl¢~ ~1~ commun~tc in cap~lla~ ~(wo~k. ~s extt~el~ d~. o~r~ be~ul~ns~ s~c~ ~ l~c~vc~us anxslom~s in cn6rcly ~1 sdull lun~ in I~ lunR N I~ human Icl~ .~ inf~nl. P~Ny I~y di~r durin~ child--. !o ttl~r t~sg~ tn I~ ~uh lun~ in I~ p~c~c ~] cvcn m~r~ircul~ti~, m~n~ ~ml I~ ~nlcd ,~ c~rcfull~ consi~ecd ~11c~ ~rc ~nswc~ ~nilcl~. In ~. S. C. (cd.): P~o~ ~n~l 197/. New York: A~lcl~- Fo~s v~ WclcnKha~lijk ~k. F~ ~ ~p~n~nl ~ P~I~, University ~ [~uvcn ~h~ or Mcdi. AIRBORNE INI:LUF.NZ.~ PR~.A VIRUS INFECTIONS IN ACTIVELY IMMUNIZ.ED MICE Ci~uh|lin~ .ntitx~y in icliv¢ly Immun~cd .,nim-,Is cln ~ c~ivc in the p¢~i~ ~ gir~ ~1~ vi~ inl~li~s, yount ldull whhc mi~. immun~ ¢u~ull~ wi~ [~sl~ ~c-lun~ SUS~nsk~s ~ in~ PRE-A ~i~s (~ m~), ~ with ~rr~in~ unim- m~niz~ (~lr~) m~. we~ ex~ to su~eth~l ~nd hilly ~ virul ~ e~lcn~ ~nd ~nislinl ~l~r~ chan~ fol~win~ cx~u~c Io ~ub~th~l ~it~l c~d~. ~ I~1 ~ ~1~ ~1~ mildly ill ~ ~uevivcd ~n& wss ~l ~cn in r~ m~. ~ while ~t ~cvefllinE inf~6~, c~l~ ind lun~ pil~d~sl R~in~ ¢~ t~ m~ cx~d In Jh~fnc in- ~0 Oeher .upp~rt.. U. S. Army Medical Re~e..~rch .nd Dcvch,pmenl Com- mand. U. S. Public Ilelllh ~. Hu~ ~oyccl' Gi~c Once ¢~ub, a~ II.slin~ Foundal~n Fu~. From t~ l~pa~tmtnt~ o~ Med~i~ a~ Pa~o~. Univtr~ily of ~ul~rn California ~ml of Mcdklne. ~ An~ I~ Unive~ily ~ Chica~o ~h~l ~ Medicine. GLYCOPROTEIN SYNTHESIS BY TIlE TRACIIEA Bc~'us~ ~.lyco~ins rake up a m~ ~ ~ Iht u)lidl ~ sludkd by u~in~ ~ld~clively b~ ~mi~ sl ~ su~l~slc, in~du~c in ~dd clh~yl, C~ I~ ~ Irkh~l~ Ic~, I~ nol inilislly, and Ihe s~ndin~ limb ~ a ~ s~. Pu~?~n ~- hi~l~i~ral~ ~ r~i~ly f~ ~mi~ by 44-72% s~ I~om h~ I~ hig~t ~i~ ~l7 ~ t~ su~Rolmr frmct~ Ihr~g~l • ~bla~t to hysiu~s~ ~t w~ m~ ~u~ ~y P~. W~n I~ac~al sl~s were ~ubat~ wilh ~i~-~]H ~ were ¢x~mi~d by A~ic~ R¢view ol R~l~7 D~ IO3(2) : 188-~9T, 197 I. PULMONARY ARTERY LIGAT|ON: EFFECT ON IN VITRO PROTEIN SYNTllESIS I.cll pulrnon,~r~ artcJT liMtkm o( booh s~xet. The (k~X wer~ kgled st vmrlo~s interv-ls followin& liptto~; lung sli~es Irom bo~h i~ubalcd Archives o~ Inlrrno~ Afediclne 127(5);E61-R62. 1971. 51
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0") 0 0 0") O0 DIFFERENTIATING TYPE I AND TYPE II ALVEOLAR CI:.tLS IN RAT LUNG BY OsO,-NII STAINING A hisl('~bemical method o~1¢ri~ a ~ diffcrential slain for t~ ly~ II air.tar epil~lial ~ll is ~c~n~ ~. ~ fixing-slainln~ mlxlurc ~d in thit inv~lig,l~n ~s~led ~ ~ ~ ~ 2% aqu~us (~O, anti Ih~cc ~ ~ 3~ Nsl in dislil~ wslcr. F~ ~t lun~ wc~c cul inlo 2 mm (~onlr~s wcrc fi~ed in ~ffc~cd ~0, mlo~. ~l~li~c ~llinm~ of lYl< II conl,ols No ~il~ml sl~nlnR ~ ~ ~t~ wmm ~uired. and t~ ~kc- livily was ~ad,ly o~#~ in ¢il~r pJrm~n ~ Ar~dilc ~cl~s by hKht M~Nory. W PJ. J+ ~ IU-~r~ni. A-W. S+oi~ T~+h~to#y 4 S ( ~ )+ 215- 219. I ~70. CIIRONIC COR PIJI.MONAI.F+- IT~ PATIlOGENF.SIS IN APPALACIIIAN BITUMINOUS COAl. WORKERS This slud7 ptc~nts • qu~ntil~li~. ~l~lem ~nal~ n~ c~rdiac ~nd pul~n~ry v~ul~r sl~lu~ in 17B App~l~hi~n ~! ~1 wotkc~, A Ioiii ~ ~8% ~ Ih+m o1~I ~lumi~ mi~ with coal workel's p~u- ~i~il ~d Inflate ev~l d ~rll¢ ~ ~VCtC chronic ~r ~l+ale at ~th. ~ ~ ~ ~ ~l~ale ~l#tcd ~l with I~ ~ni N lunE c~p~ ~ ~1 ~if ~ ~h~h is • ~surc ~ co~ ~1~ ~ I~ volum~ d du~ m~s, or ~ ~nlcnl ~ blrt- mi~ ~i~l m~le m~ ~ sm~ll ~1~ ~rri~ ins~ dual macule• ~1 2.3 li~ I~ ~ I~ m~. ~ ~s d~ m~inly Io hy~r- ~ mild ~l~ry ~rlc~l hy~cm~ ~ ~r pulmonalc of many No~. R. ~. ~ IJq~ur, W. A. ~rchlve~ ~ ~a~o~y ~:487-493, 1970. N Mcdki~, Ilcr~y EFFECTS OF SMOKING ON LUNG STRUCTURE OF APPALACIIIAN COAL WORKERS |.~mg-lcrm cigarc|lc smoking milers Iom~ I1rucluriI Italurcs ol pntu- m(x:cm~osis in soil cnal wo~kcn but his lillk: effcCl on Ihc di~as~ procc~, in Inlhracilc minces. I his appriiull is tm-.ed on I quanfilativc, morph~h~ic slUdy of Ihe poslmorlcm ~¢al'! •od lun| Ill~l¢luit: o~ 144 Appal~ch,an un~',:tground coal workers. Of Ihese minces. :32 hid • lilctim~ history ol no~smoi,ng. 24 smoked • pipe o¢ cigari. •nd gg im~ltd ciMfcllcs in vari4~$ amo~nls. Rcsulls L"m~cd Ihlt Ih~r= wls Ito influence o~ sn)oling i'm Ih(: primar~ cnal dual mlculc and ill dh~'l co~l)llcatlons, bu! ~tuminous-coll mincrl who Imoked hid • 17%, Io 3:)%, get•lee dcg~c¢ o~ c(~ pulm(male. 9%, 1o 2~%, mo~ tmph)'~ml, b¢~nchi~lar ~blct ctlll u ~vid~nc~ o~ chlo¢ll¢ bronchinlilis Ihln ~mklng hhumln*~us-c~al sinai1. No li~nificanl efl¢cl ~ smolin~ on lunK lnd h~Itl llru~IUlt Wll |u~Irld I0 anthracite mincrL ~oeyt. R. L.. Mahtm, J. K. ~nd D, cllingrr, W. S. Aechive+ o[ Environmemol Ile~llh 22:190-193. 197 I. Olker luppor(: U. S. Public Hedth From the D~parlrn~nl of PaLholo~, Pennsylvania Slal¢ Univcrsily College o~ Medicine. lice•hey. RANK OF COAL AND COAL WORKERS PNEUMOCONIOSIS This ltudy prclcnll cvid~nc~ thai tl~: much-rtpoelcd •s~oci,,ll(m be- tween coal rank and pncumoco~ioeis Is I~'obllbly |o~uiloul. R¢#onll differcnc~ in tl~ prevalence and leve~/ty o( coaJ workers Im~umoconio~is orlon have Ix~n allHbulcd Io Ih~ t~k of coal mlne.~; lh~ hiBhcr Ihe ~anlr of Ih~ coal. Iht quanlil"livc, morT)holo~ic ~l~dy w-, un(Ic~aken of lunE and heart Ilru4:lut¢ of 312 Appalachian miners who wer~ cll~tifitd by rink of coal mined. A tolal N 390 co(rcq>ondlnE co~lroll w,,~ Iludied aim. Among Ihc mine~ chronic cm pulse•ale w~- common in ~11 ~'OUl~. Pulse•an/ 5bmli~ in- crtas~d with th~ number (~ partnchyml liJicl cl711111 Ind wilh h~onchiollr goblet cell hypcrplasia. In evidenc~ of chronic be0echilis. The actull volum~ o~ coil du~ rctlin~d in have only a small effcc! on Ih~ d~vrlopm(nl of cot pulmonalc Ind ,yap- toms o( pulmonary insulT~i~nc),; Ih~ I~¢valcncc and ~vcdty ol pncu. nmc~nk~s~s arc nmrc likely ~lstcd to chroqic I:~'onchitis and ¢~pusum Io lilac• than Io rank o( c~al mined. Norse. R. L.. Mahon, ~. K. Ind DtlllnRer, W. S. ,4met;can Rtvirw o/ R~piror~ Dl~o~ 103(3):3~0-3~. 1971. Ollter #upportr U. S. Pubtk: Iltallh ~rvic~. From Ihc I)~partmcnl o( o( Medicine. lice•hey.
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ADRENAl. GLAND STRUCTURE AND TIlE DEVF.I.OPMENT O|: IIYAI.INE MEMBRANE DISEASE There is • ~:mon$lrabG: Rlatior~hip E~tw~n |dr~nal ~a~d ~ltlrc ~drcnal ~lands wctc 19% lighter in infants ~ilh hTali~ ~mbra~ di~a~ ~h~n in ~ wil~u~ t~ d~r ~inE to • Mc~tcr humor co~l cells in Ih~ I~/l~r infant. A ~li~ ~el~n was [ou~ l~ pe~nc~ ~ infecfi~ .H~n~ ~ ~h m~ I~ m~ ~ hyah~ ~m~hilic ~mnulc~ in ~l~m~ l~ II ~mr ~llm mm did redim~ 47 (4)6~6~ 7. 197 I. ~ I~ Oly ~ New Yo~E. From l~ [~parl~n~ ~ PaI~. Pennsylvania State Unive~ity ColIc~ ~ Medicine. Iler~y. ~ I~nt ~ Pst~, Column• Unive.dy ~le~ ~ ~yskian~ a~ Sur~ns, N~ Yo~k City. ACQUIRED ATTENUATION OF OIEMORECEPTOR FUNCTION IN CtIRONICALLY IIYPOXIC MAN AT IIIGI! AI.TITUDE Chronic cxpo~uc¢ Io h)poxia during •dulthood pcoduct's allcrml~)ns in • I~r~on'e control o~ breathing. ~tcmcnt~ o~ the resting vcnlilmto~ tcspoes¢ to hypoxtx in ei&h! p¢¢,~'~ native Io high altitude, tO kmg-term noe-nad~ high ,qtitude high •lti~ude living r~sults in • dial•heal ~ntih, to~ response to hypoxis. ~ ~c~'¢ o~ ,,tlenu•t~ i~ ftl•t~d to the I¢~,th o~ lime spent It high • lSgud¢. Simil,,dy. hypcrcapeic ~mlil•tm'7 dri~ il reduced in non-••five hi$h •llilude ¢t-~cnt~ -. it is Io • ~.alrf d~t¢ in high •kilude natives. In co•level with Ihes¢ flndlnp Imxluc~ in both gi~Ul~ o~ htEhL~$en, •n increase in ~-~t,lat~oe ,c~.. - pat•bin to th•! In the co.troll. Thil sul~ll Ihal ther~ il • marked d~s- c'~:panoy t~twe~n hylmXic ~ dm~ng c.~crci~ sad hyFoxlc drive..~a! fell, which is pc~um|~ medm~..~d O~l~rval~w~ ~l~re that hTpoa~c whik hypcrcalmic d*i~ is o~ly pmrt~ll~ rr~lctd puralleh ~ncrally accepted vk-~ |o~ virtually •11 04' the r¢l~tng hypollc drive •rid ~ghly half o# ~hc hypcr- capnic drive in man. "T'hh wuglli~lt I~t the idlermlio~ In ventilator7 control at high altitudes a~r duc 1o fail•It d petlphctal chcr~c~¢p~or function. ~4 Well, ~, V.. Byrn¢-Q~inn. E., Sodal. !. E., Filley. G. F. and Glove,. R F. The/our•el o~ Clinical Inve~ti~¢i~ ~0( I ) : I E~ 195, 197 I. OIk~r ~ap~,: U. S. Army, ~pa~nl d lie•lib. Ed~ali~, and Wcl. fa~e. U. S. Publ~ Ilcahh ~vict, a~ A~r~an ~ ~icly. From Ihe department of Medici.. Unive~ity ~ Co~r.~ Medical (~cntcr. [~nv~r. V. Ti~•ue and Orean Cuhure DIFFERENTIAL CYTOI,OGICAL AND CYTOCHEMICAL RI".gPONSES OF VARIOUS CULTURES FROM MOUSE TISSUES TO RI:.PEATF.I) EXPOSURF~~ TO PUFFS FROM TIlE GAS PIIASI'~ OF CIIAR('~)AL-FILTERED FRF~II CIOARI-'.'I"rE SMOKE . A ~.o~a.I o/ thr~ type• o~ i:~'tm•ry cuhur~, nmmdy kldney tluu¢. e.mo~tomc .lung oegan, and lung e•plunts f~m Sa¢ll mice. •nd o~ ~t,,b- hshed c~ll hal, 3T3 cells lrom Swi~ mica, weR •led to usmy lhe effectl o' Ihe Bat ph~sc from charcoal-filtered fR~h ripe•tie ~oke. Re- p¢~.~.¢d e.x..pesur¢ to puffs o~ the g~ pb~ o( chu~o~l-EIt¢~d {~xh clg~e.c smo~e okl no4 evoke a llgnlScanl •lle~lfion o~ gT~,lh in prim•ry kldn~y lis~u¢ -rid emb~Jon~c lung oeg•n cultu~el lrom Sf~ll'l mice. Thee© was also no cffec! on Snell primary lung explantl, and on ehe|r oetg~owlog maKto- ~pnhagel |nd epilhelioid cell•. There w•a. h0~ever, •n elf•el on 3T3 ccll~, Ih•t elpo~d 3T3 calluses Iho~ed ,,n enh•rK~n~n! o( ~'o~lh, of milolic inc~x, •nd o~ cellular •typism, including v•ri•liona in DNA content. In n~,ne o~' Ihe exposed cultuR$ w~s ,, mmphok~ic•l c¢11 t~,,mXmmathm ob- /z~chtenherger, C. ,,nd t ~uchtcmbetSgr, R. E~perimenl~! Cell Re~earch 62 ( I ): 161 - I 72, 1970. Olher .upport: Auoci•6oe Suite de~ F,,bricanta de C~gstette~. From the Department o/C3,tochemialn/. Swia.t In~itutc lot Ealx:rimeneal CanCel Res¢•rch. Lausanne. TISSUE CULTURES In this first o~ • Ice,ca o~ moeoerap~ oe •the~clem~ts, I1~ ~:ld ti~ cultu~© am ex•mi~¢d from i~ In~%~fion ~rml~h |t~ dif[cRntiallo~s to ils future polsibilitie$. There ~ s~ven sc~t~ons 0~ Ibis book •$ I. Baekgrou,Kl; II. V•~:ul•¢ oegln cull~m; Ill. Noo-v~cul-~ lis~ue cul- ture's; IV. V~seulir th.su¢ ¢~llum; V. Cell •l~Rpdon; VI. In ~ivo ~•s- cul•r tlssu¢ cu|turc~; •nd VII. Review. ~-IIo~ IV. the Iomgest division Ih¢ book, ¢onsk~crs such •~'% o~ leas discipline -- hlitory, m¢lh,~b~hqq,. quu~tltuli~ aspects o( cell cultu~-.~, mixed cell ~M~ul•tE:me. sial.It celt p~p- ufal~o~, lipoid transport by cells, metabolilm, eyto~hm~acology, colo87', cylugenetlcs, and atheroti~ncsi~ •rid in vitro cuhu~es. SummaH~ing ofi$inal 5ndinK:~ and survcyiog the wofk reported in the lit•relic, ih~
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O~ 0 0 O~ STREPTOVARICINS INIlIB|T RNA DEPENDEN'~" ~)LYMERASE PR~E~ IN AN ON~IC RNA VIRUS ~ ~tovm~fl ~z & ~ eztR~ly ~cnt ~hibil~ ~ l~ ~i~d mu~m ~k~ie ~. ~o~ C ~ ~amycin S~ are ~ukemia vi~ w~ ~ in l~V9 ~11~ a~ ~6~ ~ing a ~r~ M~nl ~nlrifu~n. E~ m~y ~ I~ purled bac- 0.~.75 m~ml. ~ ~ ~ In~I~ ~ ~w~ thai ~ sl~pl~ vlt~in c~p~, a mi~lu~ ~ ~n ~cr~i~ (~u~ u~lcrmi~d ~nl~), ~ a ~rnt i~i~l~ ~ t~ ~LV ~y~a~ ~. Mo~ C~te inhi~ ~ ~ ~a~, ~c~, ev~ with ~nl~ati~s ~ 4~ ~ml. ~re~ova~in C, a ~ m~, ~as al~ quiI~ ~tiv~ ~t ~ma~ W. W., C~. W. A., ~, ~-11, Rc~r, F. and N~hol. ~. R. ~m~ 2~0(~ 291 ): 249-2S0. 197 I. COMPARATIVE PRODUCTION OF INTERFERON BY ItUMAH FETAL, NEONATAL, AND MATERNAL CELLS Thi~ report crm~psr~ intcrfero~ (IF) produ~iion in nin~ primary human fetal c¢11 linc~ wilh tbc|r oorR'~xmding mltern-I cell lines. Ran- ~6 double-stranded ~ibopolynuckotid¢ (poly d:~). Results surest that (ctsl cclls display, in tissue cultu~, i~rea~ ~c~vene~ to ~lh i~ucen Fclal cells rclc~d 3~fo~ ~ IF Ih~n ~tetnal ~lls ~n c~u~c Io ~y rl:~. ]1his ¢nhu~ed cm~ily lot IF ~KI~ wm# consislrnl in cuhuees ~lo~d #tom fetal skin o~ai~ ~n the I~h a~ 2~h gcslalk)nal week. ~ rcs~n~ w~ Rlalively stable. ~isling in castle d~i~ vbus, f~il ~lia ~, ~ l~ i~i~. 4 ~o 6 5 li~i ~t ~ the rat~ ~ o~rall~n synl~s, M M. Inlecll~ ¢nd Immunity 3(5):671~77. 1971. Ma~la~ ~vis~n. a~ Nat~ Imzilul~ ~ ll~Ith. From ~ ~n¢t ~ ~i~, Mic~ and Pcdia(Hcs, STRUCTURAl- REQUIREMENTS OF RIBOPOLYMERS FOR INDUCTION OF IIUMAN INTERFERON: EVIDENCE FOR INTERFERON SUBUNI'I~ The bind/ng o~ ill iabck:d poly I:CDEAE.dtxtran ¢ompl~s¢~ to ctlls has be~n n~sured. Low I©mpcralurcs we~ ~ to M~rlle Ih~ binding re~cllon I,om lurer steps involved in ttll uptake. About 0.3% o( uncomplcxcd poly IC |s Ix~nd ,it 2" •tier ate hour; 20 tim~ more of the macromolecullr ag~rtpIt i~ lx~llKl whc, n OEAF.,-de|lr•fl k prt|cfl(. Thu~, this eflh|ncct potenlillCl hunuln inledcm~ (IF) rele~e by delivcrin| more ol the ,,ctive poly IC complex to the tdg;~tr|ng~ile. T~e IF I:,~olelns indoeed by boih virus and synlhelJc ¢ibopolymcrl have been purified ,,nd th,-ir apparent subunit structure dttecled. A'~ In initial step in Ihc chmractcHz,,- t~on o~ IF'a, Ihc IF'S have been ¢~ten~iv¢ly purilted by scans ol the new technique ol clcctrc4oc~sin~ in poly~cryiamld¢ gels. In gel eh;omztop,,phy o( unpurified IF's. mouse IF behaved ms • single molecullr II~Clct wilh • MW of )~I.(XX). Iluman IF elated I~cdomin•nlly in z pos~llon correspond- o( 12.O00. The d~flercnl isoclc'~lri~ I~nls fo~ Lhc din~r and mrm~,me~ sug~c'sl U~,t c¢~aln SU~fK~ ehurge~ must Rarrange during oliL~mcr form~. llon, b~l wilhoul infl~nclng ~clivily, since IheR ~ n~ seem to bc 8 mcmsurlblc co~cr-livc effect between Ihc subunl~l in the dh,|¢¢ (¢,rm ll~ rn~h~nism c~ lhe ¢onv¢~s~¢m Ii currently under Mu~7. 37
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0 0 O~ O0 Car,~er. IT'..4 and P~tha, P. ~1 In Beers. R. F., ,tr.. and Braun. W. (¢ds): nueh'ntide~, New York: Sprlnb'cr-Verl,~. 1071, pp A0-105. OIher eupp~re: U. S P~blic lie,lib M~ryl.nd From the [~cpartmnls (~ Mcdk:inc and Mk:ro1~oh++y, The h+hns Ih+pkin+ MEMBRANE-AS3~X:.IATED DNA IN TttE CY'TOPI.ASM OF DIPLOID IIUMAN LYMPltOCYTF~ To Ck:lermi~c wh¢lh¢r ~mil~r~l, cyl~l~sm~ [)NA ~xisl~ in DNA w~t un,f~ml7 II~ wi~ (2-~'C)lhym~mc. I~ cells wcrc ly~d with the ~nk)n~ ~lc¢~nf NP-40. ~N ~ter~nt ly~ the plasma mem- ory; n~kl can ~ quanti~ti~ly ~d f~m I~lcs by ~nlrifuEal~n. ~ lyric ~ ~[tcr ~val ~ n~lci was into ~tal f~act~. Virtually ~11 cTl~la~ DHA w~ found in I~ ~di~nlin~ a[ 13.~ X ¢ I~ ~ Ih~ I~lhan 10% was tu~rc~d. Thb cyl~lasm~ DNA. I s~ lhat it a~arcnlly ~s~ia(¢d with plllm~ ~mhr~ ~ dip~id human lymp~ytca Ihlt ire conlinu(,u~l~ ~rowin~ b ~ri~d. ~is ~A differs from nuclear or DNA by vi~ ~ its I~1~ In ~ ~11. li~ ~ ~ynthcsis in t~ cell cycle, and w~ous ~sic~l ~r(~. At p~nt. t~ role ~ this I)NA k~wn. ~rner. R. A.. Mcinkc, W, ~nd C~lcin. D. A. Pr~eedia¢e of Ike No~i~l A~em~ ol ~ie~e~ 6fl (6) : 1212-1216. 197 Olker emp~rl~ NaI~! lmdtutn ~ II¢~lth. National Caner Institute From t~ ~pl~t~n~ ~ ~ntal Pat~W and M~ro~olo~y, ~i~ Oin~ ~nd R~h F~at~, ~ ~l~, Cal. OXYGEN TOXICI'FY IN TIlE NEWBORN GUINEA PIG I.UN(';: TIlE INCORPORATIOH OF TRITIATED URIDINE INTO MONORI BOSOMB5 Wc ~ ~hs! oxyKCrl Intcrfcccs i~ l[h¢ ¢ooloKy o~ cellular, y.opul.a- lions o~ the lun~ ,,nd hl~ (~-~.i~"d a varify of a.p~o~.hcs Io Ih,s th~s,s. In this eal'~lln'lCnt, ncwt)orn ~,'~i~r.a p;p ~ ~d I~ four d~. Wh~ ~~ ~ep~ !~ I~r lun~ wcrc cxlmm~, u~n~ I ~1~ T-u~i~ Im~l i~ v,v~ m~ ultraccntei(uKal~n t~hn~uc. I~ ~sultt lU~t~ that ~ mlf~ the ~vcll~p~nt ~ b~h~lmr m~al ~(r~is. the brom:hiolar mct0ph)sia, thc appcarancc o~ iI~xoalous r,~n,al pr,,tcin. and a severe dcprc~n in DNA lynt~s. ~hus. l~ ¢~gcnce ~ # new cell ~pulalion ~s tkd Io c¢~ain ~Iccula~ chan~ apparcnUy induced by a l.x~ cnvironmcnl, and ~rmancntty di~,tcd pattern, whkh i~l~s emphy~ma. The o~vat~ms rc~c~rallon in O~c lun¢ k)~M, part~ulmrly l~ ro~ ~ ccll ~pulalions, mad surest ~ ~cd for improved ¢x~6~tal ~clt ~ on ~Icculm~ lcchn~ucs. An inc~cnlal a~ #urpri~n¢ di¢ovcry wal the sharp m~olutc rcd~t~n in ~i~)mc synl~ ~c~Ir~ m~ cx~¢i~nl# by ~hc fourth day or B~r. M. M.. ('o~n, M. G., ~, T. C., #~ Roan, R. C. Ri.l~¢;a Neona~.~m I~( I-2):~5~3. 1971. From I~ P#lo Alto, C~I. Yil. Pharmacology ond Paychopharmacolo~y ANTIASTIIMATIC ACTION OF SYMPATIIOMIMI~-TIC'S: A R~V1EW OF TIlE LII"E~TURE ON TIIEIR B RONCIlOPULMONARY EFFE~ In thk ~view ~r. lym~t~i~t~ ~;luto~ a~ ~d into s~i~ catc~ ba~ u~ I~ extent ~ that aciiVity on ~r~ rc~o~. In t~ bro~l~ lyMcm, I~R ~ two ty~ can ~ activated ¢il~r di~ly ~ i~i~lly by ~ R~m~ sym~t~i~llc ~~t~ ~n ~ d~v~ into f~r clips: d~ ~1~ ~pl~. d~r~ stim~sn~ sfl~t~l ~ininlly olldm r~¢pion. 16 sym~t~mi~ ~lll~ wh~ am ~ul ~n I~ t~st~nt b~hial asthma m~c: (I) ~ ~t4 stimulant: epi~hri~; (2) ~t~. lournal o~ ('linicot p~r~olo~y a~ the J~rnol o~ New I)ru~s IO(4) 217-22l, 1970 From I~ I~p.rtmcnt c)f ~,rms~h,gy, ~Inivc~ity ~ P¢,msylv.m;s ~ 1.~,1 of Mcd~inc. Pl.ladclphiL 59
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CD OO HORMONES AND PUI.MONAR¥ EFFECI'S OF TOBACCO: CORTICT)SI"EROII)S IN ANESTIIETIZED DOGS Pulm~nIry complimnce thclicC'd (Io~:1 in this StUdy Ot cigarette smoke. A single in~"ttion I~,¢ cl, u~'d • dight t~t dc6nlte (.,ll ifl l~llmoelry fcsist,,rlc¢ to IoW:r Ievtls. "Ib¢~¢ ¢orlico~tcroid, pcobabl llon O4 smoolh musics ¢,( 0to lir~|~. R¢llctl~O¢l ot' Ih¢ dog'= bcoechia| smoolh mulclcs by coct~co=l~m~t= ¢=~ld no( be mltrlb,Jled to potentiation O4 the mTmpmlhetic bro~hodil=to¢ mechmni=m ,¢r¢ ¢Ifciled in r~pon~c Io ilol~oler~nol, compound IS-RO (i hi$1iminc lib~rilo~). =rnl~ni~. hislimlne. Inhlllllon A~hivr~ of Envi~n~o~ Hrat~h 21 (2) : 149- I ~3. 1970. From I~ ~pltl~nl ~ Ph=rm~. Untidily ~ Prnnsylvani= ~h~l tn INCREASED RE'I"I:.NTION OF NOREPINEPIIRINE-'~I! IN L)I:.FI:'REN$ DURIN(; NERVE STIMULATION This stud)" reprcsenls In mile•IN to ~¢lermln¢ qumnlilmliv¢ly the im- [mrlir~e o( increased uplskc du¢ing nerve I~imullllOn 0( Ihc isolated ~O sh*~ks/~¢; 1.3 program nf slimulll~m ~/mln. h ~=s inhlhiled ~n=ami~ was =~ 1~ results i~at¢ Ihat i~rc=~ wit ~I ~vcd w~n ~mi~ o~a~ inhibil~ wins ~¢~nl in ~ orS=n ~lh. ci~, 51. ~uis. INFLUENCE OF CIIRONIC ADMINISTRATION OF NICOTINE ON TIlE TURNOVER AND METABOLISM OF NORADRENALINE IN THE RAT BR.AIH ~linK an i~c:~ in inlr:~u~l ~sminl~. ~ ~ ~ li~ ~li~ in ~oli~ ptclrcal~ :lll is si~l~lnU~ Mcslcr thin Ihsl =Clans ~ ~d=five. =nt~nL =~ ~nl~l =limulsnl d~u@ in Ik =nd =celylcholi~ si~i~=ml~ ~ the ¢~ ¢~techollmt~l in I~ r=l br=in. ~! ~re=~ m =m~ levi k Ik ~ In ni~i~ i~ control Inimatl. "l~c ~ulls ~ I~ ¢=~H~n~ i~11¢ Ihll chronic ~dminislt=lkm ~ n~olinc i~rc=m ~ldrt~li~ lu~vcr in I~ h.iin rand 61
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I-'.FFFGT3 OF C'IIRONIC ADMINISTKATION OF NI('tGTI,~IF ON DRUG-INDUCI'~I) llYPNOSIS IN MICE The pl~/~nl iludy sill uni~r£1ke~ to (Ictcrmi~¢ the cl%ct ol ihronic Idmlnillraiio~ d nic~tin~ on Ih~ phirml¢OlOllcll res4~'onslvily of niiec Io Iitiiy o~ i~ lil~ of ~I~I ¢~lfy imo II ~li~. Ilciobll~lil, lol~olimi~ i~ clhl~ *t~ ~ Io Itil Ihc illtfllh~ in Ik d~ut ~miin~ llff~cd. ~ ~ulll lutll thll chicle ldmlnisiri'm of in ~lh chron~lllI ~.p~Ir¢llr# m~ i~ ~lr~s, ~icoli~plc- I~ll~nl IilnificinllI l~i~ I~ durll~n d ll~nI time ciu~dhy ¢~ II~ tlo~c~r. ~n lr¢il~nl ~ nkofne continued for • Ion~r ~r~ ~ Ii~, the duritbn ~ hyp~is inducrd hi ttki~l returned Io ~nilol kv¢l. Bhoim, B.. Bayer. T. ~ Li~, C. P~hophar~oh,~ia (BeeI.) 21 ( 3 ) : 287- 293, 1971. SOME NEUROCIIEMICAL CORREL.~TES OF ALTERED MEMORY CONSOI.IDATION In Iktl ~undup d ~m~ ~idil~ ¢l~rimcnts. ~vclal ~ur(~ e~Ci~ Iilh i~¢ tllc~! Io l~ic~ c~i~I i~ ~iln lllll~i~ Iclcl, il ~r~in ~u~r, 5-hydmiyt~an; 2) I~ diflert~cs; 3) O2 5.hydro~yir~pt~minc in the mcdlallon ol it least one phase of the mc~l~ con~lhdalhln payless. ]tie i¢lil~lhi~ ~iwccn changes in Ihls anli~ in wholc brain, in ~c~ln~l sil~ wilhin I~ ~iin. ~ on a c¢llulir level, certain ~h¢i cvcnls implic=t¢d in ol~i ~ ~ I~ n~¢~ pr~css IRNA synl~sis piolein lynl~, I~ I~ir inici~ndcnc#) h~v¢ ~¢n shown, un~r'~¢lil ex~ri~nlll ~dii~ni. l h¢~ shi~ may consiilui¢ a ~I siithin l~ frl~k of which may play an ini~stlanl role in normal ~m~ ~o~idllion a~ in c~,adil~ns whctcln i~ ~ con~l~i~ pi~ in lmpai*td. E~man. W. R. 94~-9~3. 19~0. ~ 7~1, I lu~hint. TIlE ABILITY OF VARIOUS NICOTINE AGENTS 'rO REI.I:.ASE ACETYLCIIOLINE FROM SYNAPTIC VESICLES Nici~tlnic agents a~illitnt|y cndinI causing i~ relea~ nicolinc aFnis do ~1. Evi~ Io this c~*¢~=t coxtcx vesicl~ a~ n~inic a~ ~-nic~in~ din@ wcrc i~,- bated at 5" C ~or five minul~ Io lily I~ ~¢1¢~ ~ A~ b~ I~ drup. Nicolin~ a~nls ~nslr~l~d by I~ fict thil TEC his ~n i~wn io bl~i i~ nlc~inic ~lou. C. Y., lxmK. ~. P., Polr~p~i, R. ~ ~iil, ~. L. Atchlvex Internationatei de P~m~ynamle ¢t de 7"h/tat,ie 187( I): 88-96. 1970. Frl~ Ihc I~plilnlrlil Mcdicil~. Io~a ('ily 63
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03 0 0 C) STUDIF.S OF |)MAE.INDUCED POTENTIATION OF 1lIE PRESSOR AND t'ONTRACrlLE RESP~NSF.S 30 NOREPINEPIlRINE IN NORMAL AND RESF.RPINI-.'.TREA'~I~D ANIMA|.~ While it has been relxwled Ihlt DMAE. a hem{cholinlum derivaliv¢. enhances lhc ~c~ a~ ~lr~lile ~ to exogenously admini~lc~cd ~nd e~o~l7 ~c~e~d h~l not ~cn ck~ly dc6~. ~i~ ~r ~ml ev~e~e Ihal DMAI~- ~rv~ z~ direcbzclin~ zmi~ pi~-Irc~cd c~ts, bl~k~ ~ ~ ~re~r~ ~ur~ll uplakc ~ch~ism ~ the c~t nictitatin~ ~m~m to C~V administered a~ cndc~n- nu~ly rtle~d ~pi~hr~ pinc~i~, l)MAE-ind~ ~cn~i*t~ ~ t~ ~s Io nerve slin,ula- I)~AE rclci~s ~r~phri~ Ar~hivel I~trr~oti~,nale~ Jr Phar~nom~c rt de Th/rul6r I ql (~): 365-375. 1971. EFFECT~ OF NICOTINE ON SELF-STIMULATION IN RATS bert, tall w£.rc llai~ to p~ a ~vcr [o ~i~ inlrlc~nill cl£clric Ilimulmti~ ~rou~ I slc~tmz~ally implanted ~)lar c~cclr~ ,n two diffc~nl areas ~ the hy~halam~. Ni~{i~ was levels. The effects of n~i~ wc~ f~ to ~ ~in{ for ~ff.slimulati~ was ~cd It ]7.5 #~k¢ I~ h,~cf d~l ~ nko6nc in rm{I wilh h)w f¢~n~ riles. t#tcs, ni~i~ h~ vc~ little cff~l o~ even c~u~ ~pre~i~. Nicotine hid no ~lbl~ cff~t ~ un~inf~ rcs~s a tc~i.~ fan~l~ ~LinI .~t. ~ c~ ~ ~ pr~cd in animals treated with ~rpi~ 24 ~ cJ~l~r. It ~ pr~d that n~nti~, by acting ~ ~ ¢cnl¢al nko[]nlc<~li~fg~ r~. may indirrcHy cau~ rclca~ of m~rcpi~phrinc wh~h. in turn. Wt~uco 1he (m ~lr.~limulllum Pradhan. $. N. and Bowling. C. The Journal ol Phartnacohr/¢y a~d E,pc/iraentol Th~rapeuticJ 176( I ) 229- 243, 1971. ' O¢~er .up~rl: U. S. Public Hc~ ~ce. Fr~ [~ ~paetmcn[ ~ Pharmacolo~. llowatd Univc.ily College ~ Medlc~n¢, Washington. D.C. EFFECT OF COLD STORAGE ON TIlE RESPONSE OF GUINEA-PIG TAENIK C'OLI TO CERTAIN CATECIIOI.AMINF.S AND ()TII[:.R AGENTS (:old Itora[I.,c al~ccls imoolh muscle rcspo~i¢l [o lympalhomlntcl~c amin¢l and olhcr aclive IK, cMI in ~vc~al compkl ways. In I~ c~pcr|mcnt.~. ~elaaation plr,.)Juccd by I:~cnykp~rm¢. epinephrine, n,mcpinc. cold Ilorag¢ o1' up Io st- day~. The reslx)~les o1' Ih¢ cold aimed iI~p Io the tim three o( tbe'.e dvup w©te p~'~nt~ ~ pr=Irellmenl with alpha.bk~:k- in~ i~'¢nll b~l no~ by IteltmclR ,ilh beta.blocki~ ~enla; lee oppcrJile wal o~:~*.~tved Io~ Ihe responu. In isopr04erenol. O~ Ihe o4hcr hand, lhe con- Ir-cl~ produced by moth,choline, physosli~mi~e. KCI. and Ba decreased oiler Ihrcc I~ sia ~ayll enid IIo~a~e. Simillrly, Ih¢ ~elaaali~m produced by ATP and 3',5"-cyclic AMP waa olin decreased afle~ culd ato~a~e. I~cubafion in ~ CI medium had no ¢ffc¢1 o~ tl~ inhibilo~ action c~ ealccholami~e used in tom linked ttrip~ but aupprccscd the sponge to ATP and Y.5"-AMP. II cin be seen Ihll in Ihil expcrlmcnl the cold sqoced strip still rcspo~cd well to c,,techollmi~,~ but m-4 to ATP and T.~'-AMP; moreover, slphl- sod bct~-Id~ncrgic rccepIo~ Mocking a~.cnts d~d not mod~[y Ih¢ I¢~po~1¢ Io cloSe,ore ATP snd Y.?'-AMP while iuch blocking sgcfll~ prevenled ¢slccho~smJ~e ¢¢lpon~. Th¢~ dill lu~st thai th~ rcla~atio¢l mechanisml o4' cat~:holaminca may he dil~¢rcn! from Ihat o{ cxc~cnoul high energy $hib~ta, $.. Ilallori0 K. and Timmennan, D. Europeon ]ourn#l o] P~moco~o£y I I :321 "33 I. 1970. Oilier supporl: U. S, Pub~ Ilealth ,~:rvicc and Hawaii lleart ,ion. From Ihe Dcpartmen! c~ PharmacologT, Univer~ily of Ilawaii. Ilnnolulu ADRENERGIC INNERVATION AND CI:X:AINE-INDUCED POTENTIATION OF ADRENER(HC RESPONSES OF AORTIC STRIPS FROM YOUNG AND OLD RABBITS Th~ us~ O~ the rabbit lortlc llrip II I ~Jrmlc~ I~I hu very ~ullr in .Smlying md~t~ ~h,nbmm. In th~ h~lolnEicml :t~dy. i cslcc~laminc-s~;~ fl~c~ was ~d in the lunica Ihc ~)r~ac ~ y~n~ rabbis ~1 m)l ~ old rabt)ill. Aflcr five ,lays ~1 c,,hl 65
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O~ 0 0 O0 melr~ ~h~. ~he ~ ~ ~n~ r~bbils weec f~nd ~o conl~in I~e ~s aorlae to n~;~ a~ tyrami~ w~ ~i~antly greater Ihan Ihal ~ ~d ~tenliJl~ by ~,~ ~ st~ ~ ~ ~. ~ainc-induccd ~enlialion 20 minuta in n CI* *~ ~m IM t~at~nl with MN* * ~ C~* *. ~i~ ~lcnli*l~ I~ C~ ~ *-i~ ~lr~ in a C~ ~ *-free ~dium wilh t h*~ ~a,lum ~t~(. ~ multi su~t Ihnt mS~tne~K~ ~rve ]our~l o~ P~~ o~ E ~i~ntal Thrra~utic~ I ~ 7 ( 5 ) : G21 - 1971. lnd A~t~n ~,1 A~i~t~ Ed~Jli~ Jnd R~arch Foundal~. TIlE EF'~ECT OF COCAINE ON CATECllOI~O- METHYLTRANSFF.RASE AND ON TtlE RESPONSE TO NOREI'INEPIIRINE OF RABBIT AORTIC STRIPS Although Ih¢ cootcntr~6on~ o~ lO'S M ~d lO'* M cocaim: cau~'d the po~cnl;-5on o~s the oc~r~-imluc~ contraction II~p4, such conom~mtkm* did flol inhibit c~,t~:hol-O-mclhyltrimfert~ (COMT) f~m r~ li~. "!~ ~ntrsUom o( I0 • M ~Ikd which po4c~dsted the nc~inc~hrifl~-|nductd contr~clion csntly de~'~u~d COE4T oct~ly. Cocmm~. but no~ pym~alk~, po,entiatcd induc~ eontr~clion e~ 4 d~ys cokl ~ Uril~. TI~ data indk:,tc no p~iti~ c'~d~flc¢ to mpp0~ the theft tha! cocaine-induced potenl~tkm ts medi.tc'd b)' the ied~to~' actloe o( cocaine (m th~ C~MT enzyme system. J'apa~ese ]ourr,~| of phm~aca4o~ 21:5S9-56Z, 1971. From the Department ¢~ Phlumm:c4(,13,. Uni~it), Medicine. I looolulu, 66 TIlE RELATION$1tlP BETWEEN EXTERNAL CAI.CIUM CONCENTRATION AND TIlE RECOVERY RATI:. OF AORTIC STRIPS FROM NICOTINE TACI|YPIIYLAXIS The depletion o{ cnd~cnous caltcho~aminc st~'cs by s~:nts whkh Ihmugh c~tcchol.mine-r~eas¢ mcch~n;sm~ i~ co~i~e~d to bc O.: m©chan- n~lurc ~ n~ofi~-i~ I~hy~yls~ ~ ~ dear. In stvi~, u ~Fated ex~u~ to ~ ~ ~nlr~l~ ~ nkoli~ I~hy~ylax;s. C~p~le ~ve~ ~u~ 5~ rain f~lowin~ ~ ~ ~ fi~st u~ul~ ~ ~c~. I~1~ in ~dium c~luinin ~cp~phvi~ (tO t M) ~ ~ (~0 ~ M) d~ ~t ~ar (o ~ ~e to cat~am[~ ~l~ ~t lll~t tO t~ md~c~r~ ~rv¢ ¢ff~l~ ~tc b7 ~m,iut~n whkh ~¢venls [uro~anJou~o~ ~o~ 16:1~-1 12. 19~1. CNS EFFECTS OF TIlE ALDEliYDE PRODUCTS OF BRAIN MONOAMINES The prcScn! mri~J o( experimcnl~ uho~ that 5-hydro~yindole-c~l*k~:- h)~e (3-IITA) s~ ~m~hy~ (t~hy~) ere s~ ~hsv~al eff~b ~ cs~nt~ nfl~uls. ~r ~lnt~ compel ~-HTA E~ ended ~ I~ ~ ~ ~w ~pti~ii7 ~ tn. ~l~ Jbw mpli~ty. In ~tmt to h~mlyi~u. ~lll. I!. C. end ~le~ln~ W. J. B~o~ P~?chloer~ 2: t tg-t39, 1970. 67
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O~ 0 O~ 0 O~E,r ,upporl'. II. S Publk: Ilcahh Service. |:tom the 13¢p=Hmcnt of Phutm=colog7, (.'hic=~ ~Vlcdical School. C1'~iczl~o TII~ INFt.UF.NCE OE INIIIBITORS OF AMINE ON TIlE EEFI~('IS ()F SEROTONIN AND ITS METABOLIIES ON PIIOTIC t~V()KE[) ~TENTIAL IN RABBITS ~n~l~ ~ ~rol~;n (~), ~-h~x~t~ (~ltTOL), and ~¢~tiats ~ete ~pt~d ~ 1~ ~ 5-h~y~e~ teslcd at ~HIAA or ~tlT. ~I(T ~d~d t~ ~ m~(ive wsve (~W) sm~t;t~e st all ~t t~cd ~ ~t ~ t~ SNW ~k~n mourned 1~-20 minutes afire in~lkm (~ 0.03 m ~ ~IIT. end tl wll pecccd<d IIIns~nl cnhanccmcnl ~ t~ ~. 1~ ~atmac~k)~kal lee Ihtce hydro~yin~l~ ~ Ih~t 511TOL ~ 5111AA • 1 5lIT. In addol~n, wctreal~nl with IwO different inhlbilo~S of amine mrl~lism. N.~nzyI-N-~lhylwop2"yflylami~ (par~ylinc). ~nd ¢thyllhiur~m disul~ (] ~D). m~krdl~ ahc~cd the effects ol 5111" with- ~j~ie~6027(I) ~-~. 1971, CIIRONICALLY ADMINISTERED NICOTINE AND TIlE BI COD PRF.~URE OF NORMOTENSIVE AND RENAl. IIYPERTEN$1VE RATS Chronic adminislr~tk:~ o~ n~ in ~ dHnkin~ wa~cr ~ rats. in proliX, ~we~r t~ ~ eff~l was rcvc~o and = "~w" o~ lhc **h;~" ~s ~n~l;~ ~wc~ the sysh)lic p¢~su~c ~,lcnl,~l rclcv=~¢ Io I~ ~ ~ I~g In human hy~rtc~hm wa~ the z~kcd ptt~ ~c~u~ and ~hc ~cd ~ri~ ~ recovery affcr w*th- 68 draw=l of the hiKhcst dosc o| nlcolin¢. With such Gkcl7 that the ~av7 s~kcr w~ stttm~s to b~esk his h~bit may undergo a prolonged ~r~ of elevated prc~urc~ W~nCH, 0. Archive~ Intrrn~rio~olr~ de Pharm~yno~ie el de Th/rupie 1~7(2): 367-376. 1970. From (~ ~par(~nl Kan~s ~h~ o( Pharmacy. ~wre~c. A ~UDENT EXERCISE IN CLINICAL PIIARMA~I.(~;Y: RENAL EFFECTS OF I)IURETI~ A ~p ~ 122 ~d~al slants IcM~ I~ ~nsl effort ~ ci~¢ s the ~nmdon ci~ was ~si~d =) a c~paralivc cfl~tivencu t¢lut~ship. ¢) inl~matlon ~ing different sit~ d Kl~n. I~ d) th¢ effigy ~ diffcrc~es with res~ct Io the i~ncc d I~ tfl~t= ~lwecn I~ plsc¢~ I~ I~ various med~lt~ns. lwccn I~ r~n~ ~ I~ ¢~Ee~ vs. ~ns~ker within any dru~ ~t~p. ~ch ~ the mcd~at~na ~a~ ~ttd ~ilh In i~Ra~ in u~in¢ vtdumr. In ~rul t~rc wus a ~ r~ relnl~n~ip wile hyd~hh~olhinzi~ wile I~ 6, 12, and 25 m~ ~. II0wc~r. t~ 50 m~ ~ ~ hyd~hlm~ thia~ did ~ p¢~uct an i~Ra~ in uri~ ~w ~tcat¢~ lean lee 25 m~ ~. No =dvanl=~¢ N t~ ~m~n=lion ~ hydn~h~olhla~idc =~ Iti- =ml¢~ was I~. T.C, Currtnl T~rap~ulic Re.arch 12 ( I I ) : 759-769. 1970 sily ~ Virgin*'* ~h~ ~ Mcd~i~, ~ur~ltesvil~. Tile KININ-FORMING SYSTEM IN PLASMA Since there i,~ c=islin~ evidence o1' va~ullr permeability ind~.l~nd,-ntly of known mcd;alion systems, it h=~ hcc,~me c~mi*l ~ifch f~ Olaf ~ss,blc mechanilms Ihll ind~ v~ular inju,y A,,.m~ I~ humorll m~huni~ms thai musl ~ consi~Fed in I~ mr,halEru el ~u~h injury i~ [1~ kmln (or,**in~ syslcm. In this stu*ly, s numt~r ~,f n~c~t~ wc~c U~d 1o activate the Ei~in ~ySlCl*~ 69
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lhree components of Lhe kinin foaming system have tx'¢n pt.ified in wh~h u~n ~cdv~fi~ cle~s inlo ~u~nils N 30.~ which acli~a~c • r~m~ esterm~ activity m~ ~ ~li~l7 ch~r~d l~ No, 229, ~ 137-145, A~il 19)1. ~t7 m~ ~ I1~ Fr~ t~ ~ol ~ ~X~H~nt~ Pmt~. ~ri~ (~in~ and ~m~h F~t~, ~ J~lm. ~l. METABOLIC FACTORS AFFECTING PROTEIN SYNTIIESIS BY LUNG /IV VITRO The ac~dit;<m ~ ~lu~ Io lung slic~s incubated with Ieucin~- i~a~ ~ pr~cin ~ ~livity ~ t~ K~-i~uble material ~st~ ~ m#¢k~ ~m~. GmI~I~, ~. m~ rt~ ~ not #u~nt mmi~ ~d im~ml~ into ~olcin ~ h~,l~ z# d~s ~. Ncit~ ~lmltatc ~ ~lli~ ~ Io the ~Kt~ mlxtu~e cauls an i~ m I~ amlm K~ ~t~ into pr~e~, even thigh camhi~ ~'~ni~n(ly au~nt t~ ox~at~ ~ palmilk ac~-~*C Io ~. ~ ¢ff~ ~ ml~nk K~ on w~cin tyn~l with and without b ~ intent at H may ~ ~ ~ ~anhm by whkh ¢1~ au~ms ~ein Ipl~l. Mt~k tc~ markedly ~We~s formation ~ t'CO: w~n ~t~C ~ I~ ~le ~t cmu~ only a ~st ~prcss~m ~ *~ ~l~m w~fl gl~-I-"C h t~ so.Irate. This a~vc~al ~lated ~mli~s tu~ ~lt I~ ~ tff~t is ~dialcd through the ~nt~ ~ale pathway rater Ihln I~ lr~a~xyl~ acid cycle, M~o. D.. Si~. M. R. I~ ~e~klmp. H. lo~l of ~pptied PhyJIo~y 30( 1 ) : I ~. 1971. Fr~ I~ Pulmry I)i~l~n. Vclerlnl Adminillral+on + (~orgc Wa~h- in~ University Medial Center, Wahines, 7O STRF.SS AND CIGARE'I-I'E SMOKE EFFECTS ON LUNG MI FO~'IIONDRIAt. PIIOSPIIORYLATION Male guinea pi~:s weft eapo~ed to cigarell¢ Imoke on m 2~ day acute exposure regimen. To insure mo~th bfealhing, the narel d theM: animals were occluded with warm mollcn paraffm of with m qulck-iclling Iklmd ~l;con( rubber. Sham-.cxposcd animals were sub~ectcd to Ihe lame condi- lions of no, so plug~inf., confinement, and machine noh¢ wilhoul ci~arelle smoke. TI~ slrcss o~ forced mo~th brcalhing nmJ Ihe |uperimpo~lion cigarette smoke on this s!rcas cau~.d losses ifl oxidali~e CffK:iency in Ih¢ guinea i~g lung mitocho(~Jrl8 I~ vivO. ll'owe~cr, ef1~ncy was greater in the mO~ilh-brcathin~, air-inhallng animals than in cigarelle Imokerl ul~¢l" Ih~ lame condillolls. TI~ "liahl~,c'u'" o~ ~lx~pho~,lal~m c~mpling at mitoclm~drlal tiles 2 (cylochmm¢ vel) and 3 (cylochrr~¢ oalda~ kvcl) wan mcaauled in mentl, using arlif~'ial ¢kclrolt ~atm o~ I~C~lm. The m,0qlh.blealh. Ink rmnsmoking animal! k~! ¢lT~e~cy al bo~h 8~lcl ? amJ 3. MOulh- brealhing Imokcrl Iosl el~cie.~] oIIly at phospho~latlcm transfer -;tc 3. These strcu and cigarette anode el~ecl| al 141¢1 2 and 3, Icspeclivcly. ~_~,t .th,t !~ .k~, ~. o.;U.,~.~ ~.~/I,,~, ~m~,~y ,re Uu~ ,o nefenl mocnan,sms ac~hng at six'title Iocl wtthin the mltoehondrlon. " Kyle. J. L. and Rieje~. W. ,4rchive~ o[ Environmental Ileal~h 21 (4) :492-497. 1970. From Ihe Life S~ienc~ Research Divi~3~, lit R~arch Inslhulc. IX. Chemistry and Biochembtry GEL PERMEATION ANALYSIS OF MACROMOLECULAR ASSOCIATION BY AN EQUILIBRIUM MI~rllOD Macromolecular auociatk>n by L*cl per~tk>n c~n Ix determined by .~ ~l.uilibrium ..n~l .h~d..in II?.i~ I~prr, • th~l'~od~amic (l¢1cri~l. k)fl o~ the ump~t cam, d.lm~, rlz.al~o~., m ...p~..nted in terms of the equihbrium co~. slant lot |ssoaalmn and c'~mhb~um p~rth~o~i c~f~c;~nt~ fo~ qTe¢~l p.~-"scnt. The t.heor.elk:al an,,lyl~ ykkh an eqtmlion relating the cqulvakfllm e4 ....mo~o~. r in the etlema/pha~e to Io1~1 equi~lenl~, from which Ihc c~u.llllx|um co~slxnl fo~ ~l~ocl~lio~ ruby I~ o~t~Jocd. Those p~ram¢lcr~, crd~cal in experlm~nlal cleslgn, gtl |wtlling time. and Ctnl~ifuRal cnllap~¢ Ix~nl arc determined r(x Seph~de~ ~.b of poemily G-25 to G.200 Appli- calion of the melbod to human bemock)bin ~v¢1 a value of K~ ": 5 X IO '* lo¢ dit~ociation (~ oxyhemoglobin at pll 7.0 in 0.1 M buffer. Cameron. B. F.. Sklar, L., Grctnfield0 V. and Adler, A. D 3.eporaIio~ .;¢tence 6(2):217-22B. 19"/I. 71
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:Z: From the New EngJ~nd ln~titul~. R~dg¢~¢l~, Conn.: D~partmcn! of Imcrnzl f~ llcmalolo~c=l Re.arch. Iloward Ilu~hcs Mcdkal Insliluk'. BIPIIASIC BI.OOD OXYGEN DISSOCIATION CURVES IN IIEM(X;LOBIN S IIEMOGLOBINOPATttlE3. SICKLE CEI.[. IIETEROZY(;OTES The I)Url:)~ o~ thll ll~ly wu Io evllull¢ blood oxygcnalion in hcn~- ~lobin S I~tc~ozy~olcs (A-S -nd S-.C) And. by comp-ri~,~n with curves art bi~=~. S=m~ in wh~h 2.3-D~ is vc~ ~w or a~¢nl ~mc~hl~. lulling that I~r¢ ~ I diffcremi=l biMing or 2,1-1)P(; S and ~n-S ~mo~o~n in cclh N ~tc~. ~c biph=~ curve ~cn conE~d in I ~g~n ~ p=l~nl. U~cr physiologic conditi~ms ira]7", p11=74, ~=.44 mm). Co.eros. B. F. Bi~ hen.col and ~phT~h ol R~s~o~ch Co~muniration~ 4 } (4) R~E-g92. 19~1. From t~ ~p=rt~nt ~ Inlcrn=l Mcd~i~. University ~ Miami ~1 of Mcd~ci~ indlhc ~=torm [or Hcm=iolog~c Re.arch, Itowa~d PIIOTO-OXIDATION OF BOVINE OXYMYO<:;LOBIN IN FROZEN SOLUTIONS. TIlE EFFEC]" OF REDOX ACTIVE INORGANIC ELEMENTS IN MUSCLE EXTRACTS ' The proem o~ oxidation o( myo~lobin in Klueous m~clc effect o~ rc<lo~ ActlV¢ ltl~lln¢~ in muscle o~ the photocataly~d auloxida. tion rcKl~o~, p'im~rllT At Acid pll whcR the conv¢rlk:m is from tl~ red MbO.. to I1~ I~own MMb. In thc~ it~xll~$, I:~olocAlll),~d autoxidallon ~ MbOe .-~ MMb in froccn ¢xtrK~ Wll ~'o~ln<l tO O~y ~rst order kinelics u {ourKI I'o¢ Mb<)~ o( Ipei'm while ind ho¢~. Formalion ol MM~OII in crystallized b¢ef MMb w~l Iludi~d. It| pK c~ ionlz~tlo~ figO is ch,scl,y similar to Ihat o{ llxrm whale And horse -nd differs from that o/ Among the unlx)und clcmcnll e~Amincd ~n bet[ muscle cKIrlcI$, iron m(~l rc,lpo~liblc fro" plK~O-OXi~Illio~I O~ MbO.,z. EDTA F ir~,n .c~u~d further i~:rcAlc in o, iiJAtlon; EDTA Aloee, however, caused prolccl,)n In 72 Ass~'. S. A.. flrztzler. ]., Cameron. B. F. ~nd Yunls, A. A. Comparative Ri,~kemistrTt aM Ph7sMol7 398( 2 ) : 395-407, 197 I. Olher *Mpprl: U. S. Pu~ t1~ ~ ~M ~c M~hi~n AEricullu~c ExF~i~nt Stal~. Eat ~n¢ Fr~ t~ ~pad~nts ~ Mcd~i~ s~ B~mistry. Univcr~ly of Miami I'~a~d Ilu~ Mcd~ I~tilulc. Miami, ~a. INTERFERON: EVIDENCE FOR SUBUNIT STRUCrURE Moul~ int¢~cron wu purillcd over 500-|old by dil~¢rcntial p~¢¢ipilA. lion. cenlri|ug=tion. ~cl chro, mato~'Aphy. =~d B ~ lcchniq~ ~ ¢lccl~ c~ti~nlll p~Kcdu~, wll ~¢iEcd I~t 15~[oM. ~dh inlc~fe~ont, • ll~Eh initially ~1 ~ ~1 ch~llo~, di~pl~cd intercom. F~m B (i~r~ ~nl (pl) 7.3~) h~ ~ ~l~ul~r wci~hl N • ~ 3B.~ ~ F~m A (pI ?.1~) w~h ~ cq~ll~ ~livc, ~ ~lccul~r wci~l ~ 19.~. PuH~ From B ~ ~e inlo Form A. ~1 I~ ~e~ re~l~n ~ur~ Io ~ m~h ~r exlenl. In human F~m B (pl ~.~) h~d • ~1~ ~ei~l ~ l~t 24.~ ~ From A (pl ~.3~ ) ~h~h m~ ~l~in up Io BS~ ~ I~ I~1 ~clivily. ~ ~cul~r ~ci~ht ~ 12.~. ~h ~m~ ~ Io ~ ~117 ~ive. ~e native ~ulc txlt~ ~ • di~t ~ ~imil~ ~ i~nlk~l su~nlts I~t I~m~l~, ~h~h p~ ~cu~ within I~ ~11~ ~ ~l ~cm Io Iced Cm~er. ~. A. P~ee~in~ o/ I~ N~l~l Ac~emy oJ ~ttnce~ 67(2):620-62R. 1970 Univc~ily ~1 of M~. PURIFICATION OF MOUSE AND llUMAN INTERFF.RONS: DETECI'ION OF SUBUNIT STRUC-rURE Mouse and human lnterftto~|, vial-induced, initially bch=~cd wss I:mrlr~d over chromAtogrAphy. And isoclectric Iocu~in~: human InltHelon wA~ purif~d About 1:5(X)-~old. A! one Atop du~nE p~ific~lion (l~(~lc(l~k: |m:u~inl)..1~o. forms ~ each I~n ~1 19,~) and Form A (human) 73
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(mou~) h~s a mol~ul~r wri~ht c~ls I~ • din~r ~ two ~imil~r. of Form B into A i~ pr~t~ by I~ cx~urt In low ~h. In ~hc prc~ncc ~ 0.0~ M Na~, little tv~e for two ~ul,r ~arms cxisls. C~er. W. ~. P~o~[ve Bi~hr~ ~n~ ~ ~n~s ~ SYSTEMATIC :5-¢U[)IES ON TIlE BREAKiX')WN OF IN TO8A~ SMOK~ UO. ~ i+ ~+~I~ +m. M~.bm~ Im I~ lo+m~li+. ~ Ibm ~m~ trt ~ a~ on Ibt ~il p~ictbn b ma~ 0n the f~mat~n ~ DDT ~t~ p~t* I~, ~c~l ch~, ~-(~h~l) ~th~. p~hlorot~nz~ ~n~ ~ lob~, ~m~ in I~ ~minE z~c it.ll w~rc la~c ~n~ ~ hTdeo~ ~ ~+~1~. C~+, N. ~., ~1, ~. ~, ~ ~, N. BeI~ C~ T~l~h~l 5(4) : 167-174, 1970. SY~'I'EMATIC STUDIE~ ON THE BREAKI~)W~ OF p.~D~ IN TOBA~ S~K~: I!. I~TI~ AND IDENTIFICATION OF DEGRADAIlON PRO~ FROM TIlE PYROI.YSIS OF p.~D~ IN A NI~EN A~PIIERE ~hil fl~t I~slellli bv~tl~l~ lnlo Ihc breakdown i,f I'.~ I)I)T in ?4 1967. Two r~uhanl piperl -tready have ~Im~rtcd Ihc lcsulls and n~chmn- isis of ~ b~cak~n ol p.~DDT in • ~n al~p~re, and m p.~-D~T I~ea~d Iobacco ploycd in ~ pyrolysis its pyrolysis pr~ll, p.~DDT It~re ~d the pyroly~s ~ w~ ~l~ in ~nll~ i1 -80" C F~risil ~umnl, ~ ~K~ i~al~ weR: ~,~DDT. p,~DDE. z~. p.~h~ro~nyl. ~h~, ~z~h~lhz~. ch~ ~n~. IctrKhlor~lhyk~, Ir~h~lhyl~, ~l~ tetrKhl~, chk~- CEo~e, N. M. ~ ~, N. B, A ~Ttical Cimi~r# 43 (7) : B19-E53, ! 97 I. ni "ll ~i!¢ Univcisity, G~M~. EXCRETION OF NICKEL COMPOUNDS BY TIlE RAT: BLOOD AND URINE LEVELS Nickel and many comlx~nd/h~ve been Ihown to Ix: earcinot~nic In ~imals. Since ~c route ol ~<lministr~lJo~ do¢~ not ~em to l~ impotlmnl, this iludy was inauluraled to I¢¢ ihctilc[ nickel iolabilh~l in liuucl ind. if il does, *hll C~ililulcl Ihe ioule slid Isle 0~ elcrclion lio~ elipc~mcrllll inimll. For Illll invtllilli~, lilt Fi~ch¢l-311 Iltl *¢ilhlnl ipp~oxlmlitly 260 ! *¢r¢ divkled inlo I~ t~ IhlCe each. The lrtilrd rail *err in~C¢lcd inlrimulculldI in bolh hind leli *hh 30 mI ol nlct¢l- o¢¢n¢, nictcl ic¢1ii¢ 0¢ lllcld powlr, ill luspindcd in 0.l ml OClinoin. Ccmll~ intmlll *eli i~¢~¢d lilh in equal volum¢ vchlcl¢ o~ll#. All IhRt- ,k:id FO*ll, ~le ic¢111¢, ind ni¢l¢locin¢ were i~pktly iolubilLtcd. Wilhin 14 llou~l llktcl k~l ,~I¢ modcrile concfnllili0ll ill Ih¢ urine and silo ill Ih¢ blood ~llliinI Ihil pcikxl ol lime. The ~¢um I~. evil were Icpallled ¢kcllx~pho~¢ticllly a~d oiciel *~ I'ou~! to be bound Io Ih¢ albumin Iracl~on. For drlrcllon and an-I)lia o~ nl¢lc¢l in bi~lo~ll malctill, a ¢x:~o¢imciiic mclhod I~oyed usinl qulrmxillnm-i.3-<liih~ol IS die C'h~n, ). K. M.. Ilaro, R. T. ~ F'll.t, T#i~ Waimann ~ournal rlI lllolol#, 29( I ) : I-15. 197 I. OI/ler llIpporii II. S. Publl¢ Ilcallh .~ivic¢. Ca.ie-Ilium-ll~tlwnhllt 'l'lul! Fund and Ihc i~ Marlins FJtat¢. From the Inllilulc ell C'hem~cal B~,h+p.y. IJniverihy of San I'~lllcl'.l 75
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O3 O3 ¢0 X. Epidemloloey PREDICTING I.ONOEVITY: ME'I"IIODOLOG, y AND CRIIIOUE This b~k ha~ two main purpo~s, first, to advance the state (~4 knowl- edict ol Ih¢ mdhtxloh~£,/ o1' longevity rcscan:h and ~ccond, to increase understanding ~ mull,varial¢ dart analysis mcllx~Js for social rcearch in ~ncrd. A~Jng is t process that interests all o( us, but the Ic~hnolo~ and methodology necessary to =~0qu=tely tludy thi~ sub~-ct have lx~n woefully lacl, ing foe year~. In "this book alx~ut Ion~vity, chapters arc deveted to Review o( the I..iteratur¢; Generating the l~ta; Univariate Procedures; I,ineat D~criminant and Re~rt-~tlon Pre~:edurcs; |:actor Analysis; and No~lloear Procedures. -r~ research rcl'~led ~'rc was undertaken in con. ncction ~,ith the Normative A~jng Sludy of the Veterans in o~dcr to i~lcnt*fy ~¢diClmt ~ |[~i~l~ and kmgt'vity which could |~c buds chan~ in ~*~a~ ~ ~nt va,~ a~ ~ wen~ from Io mullivafi, lc tnalDia, a~ f~ li~a~ Io ~li~ar analysis. ]~e ~¢o~l~s to account f~ sdvm~ ~vily. while t~ conlr=~ is I~c lot R~. C. I.. ~ Br~t. R. Prtdicflnl ~n~vlt7." Mel~f7 oM Cr#/qu¢, Lcx~n~on, Mz~ : [). C. ~r lipprl~ N=li~ll Inslitulc ~ (~ild Ilcllth and ~{umln ~vch~p ~nl IM No{m=li~ Aging SlMy, COMPUTER BASED DATA ANALYSIS IN LONGEVITY RF-~EARCll This paper i~ p~imarily con~rncd with the application of n,uhipIc ~.roccdur¢l for data analD~s to a ~vcn data set in order to maximize the '=catch for m¢anin~.'" The (Lisa atud~cd comisted o( the life h,~t,~ry in- ~hitc mile ~lhl in ~l~ durln~ 196~. A l~ll ~ 70 wriahlcl ~s vlriablcl ~s ~ pr~c~ Ir~ uni~lrill¢ Io mu~iv~ri~lc and ~r~m licit in mccounling for ~Ic~lc 76 Enslcin. K anti R-~c. C. L. (Grantee: B. Bell) ( "omputer~ and I~,,,medicol Re~ea~ch 3 (4) : 289-329. 197 O. Olh*.r support: National Inslilul¢ of ~ild lklllh and Iluman Ikvch~ mcnl. [:~om I~ f;c~cc Computer Cooler. I~., R~Ilcr. N.Y , and A~n£ Sludy. Vclc~ans Adminlslral~ ~ulp~licnl Clinic. I~l{m PET ASSOCIATION WITlt SELECTED ltUMAN CANCERS: A IIOUSEIIOI.D OUE-TrlONNAIRE SURVEY Two quc~tlonnaire sludiet, one ~ in early aM one in I=lc 1969, tuevcycd tl~ dc~cc ~4 l=~l~ cx~mc to ~stk cm~. ~p. mml keels in ~30 ~lcclcd *'i~1' Cl~C¢ ~ds I~ 53() C~It*~I ~dds, ~cau~ lym~u~=, kukcmim, m~ ~m fC~cKnl Ih¢ I~l ¢onCC~ in Inimlll km~wn Io ~ Clued by I~ ('-Iy~ kNA lun.~ "i~x'" c~¢~ c=~s were ~¢d !~ I~ di=~l~ c=l¢~ic=. In ca¢ly su[vcy, failure to m=lch ~ls f~ dut=l~ ~ ¢¢s~c kd In = wh~h ~c~nlcd f~ In I~nl cx~i~ ¢=~u~c Io c~lt in lamaist wilh lym~ma. This ~m~inI ~al w~ ~ in I~ ~c~d ~u~vcy. Overall, ~ d,fler¢~ in eXCUSe IO Call. ~, ~ parJk~l~ was ~lwcen I~ in~l ~l~nt ~ l~ mllc~ ¢onlrig ~K~ddl. No Ihc~ ~ls. I~ ivcrl~ num~ ~ ~ll ~ over the p~! ~l~. Ih¢ avtrl~ humor N ~cils Ihll ~11 h~ ~¢n ~, I~ ~r¢¢ of h=ndlinI in I~ INl~in~ ~il~ ~ ells: I~s, lever, fur bill=, lump. ~m~. mali~aE7. w~m~ I~ ~. AI~. m) different= in ~imi~=r coM~l~s wcr¢ f~M ~ ~, ~ I~ family n~m~ wilh cl~c~. 7~()% did ~t ~n till. II ~ I~rc{or¢ unlikely I~l till ~lc i '=ci~ in I~ ~c~lity ~ human From the ~parl~nl ~ P=lho~, ~nivc~ily o~ ~ulhc~n C1JRRENT INFORMATION ON FELINE AND CANINE CANCERS AND RELATIONSIIIP OF LACK OF RI:.I.ATIONSIIIP TO IIUMAN CANCER It is rn(~t unlikely that canctr in call caut¢l co~lccr in man While we k~w thai the &t~sl~ cat hll I hiRh nllufll prcvmlc~ i~ ly.,p~tml 77
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0'~ 0 0 "xl C~ C.D suppor! spread r~ Ihc~ fclln~ C-type' lu~ vi~ Io do~ or man. Wh¢lh~r t~ ~iru~s spread ¢v~n f~ c~ ~o c~l u~ nalu~al cond~fion~ csl~is~d. II ap~rs that. un~, n~tur~l c~dlt~ns, fcli~ C.ly~ a~ in.riled ~ indi~ I~t~nt ~ wh~h may ~ctivatc lalcr in IK~. ~c ~u~i~lit7 ~ ~elain human ~lls Io in vi~eo inlccl~m I~ ~1~7 ~ ~ c~l# ~ ¢~m~ i~l~n¢ I~ in I~ cnviron~m. ~e ~wly f~fld R~~I ~NA ~ra~ may m~ tn vitr~ ~ pr~ts ~ t~ fcl~ C-I~ v~t ~me acliv~ti~ and its ~vcmmE ~d~ular ~h~ntsmt. ~ordn~r. ~. B. From ~ l~n~nt ~ P~t~, Unevenly ~ ~u~hern California ~h~l ~ ~i~. !~ An~. RELATION OF r~VERTY AND RACE TO ANTENATAL INFECT'ION MoR child,¢n ~ ~ f,milics dlc during the few weeks ~ than ~ children ~ t~ ~-~. While u~mutril~n is ~ de~m- 8lrst~ c~nt (~ th~ cx~uivc ~tinalsl m~allty, 1~ p~cnt st~y a~wa that antcnatsl inf~t~ ~ 8 f~ al~. Analysis ~ I.(~4 O~ lUt~ ~ stiil~ ~ ~ i~ in New Y~k Cit~ ~owcd thor 27% ~ t~ ~ ~ ~ni~l ~u~ia or ~is (~ ~h), ~mfit7 ~l~ tO t~ ~t~ ~ i~f~cd am~ ~u~. Infs~ts ~ia, a~ ~nlt~, ~t5 ~h l~nt ~ ~m~ status tS~ ~ inflmmmml~ ~, RII~ ~ Jnflmm~t~ ~ hi~t in bl~ks In whhcs, l~an~ ~;th #~t~ m~ ~flu~ e~ ~ inf~t~ hsd 32 ~EL ~ inf~t~ infs~ wc~ ~ ~ ~ ~0~, ~t th~ ~lh in t~ ~rma~nt ~ ~ t~ T~ N~ E~ 1~ of M¢~ 2B3 { t I ) : 355-3 ~. t 970. F~ t~ l~,l~nt d PI~, ~mTIvmet# Stltc Unlvc,sh~ ~ M~im. I{r~. ~ ~ ~nt ~ P~t~k~. Cotumbi~ ~nity Colk~ ~ Phys~a~ and Sur~, N~ Ymk City. Active Projects Following is a list d the ptlncipal in~stigaton o¢ instituti,ns d p~o~cls u~* ~ay o~ tctivat~ du~ag t~ ~caf ¢~d /uric 30. 1971. togethe~ wilh Ihc rcs~tlve pro~ fil~. Completed pto~cts are hstcd in SIF.PFIF~N g. AYRF.~. C~dmpulmona~ t.~wo~7. S~. ¢¢m't I|o~pit,I. New Yc~k ~'rol~'JJo~ ol ~ed*ci~. U~i~y ~ FREDF.EIK B. BANO, M.D~ C. L. ~.) I~OJ E(.'T TITLE ~ ~ ~i~s i~ ~ lu~l ~l ffftfl~ Io ~l~mly ¢m~y- D,~IM effete ~ ¢llm,ell¢ ~mk~ im ~l~y ¢m~yxmm ~y t~*~ ~ man ~ d t~ ~lnl ~ ~mumk/ 79
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0 0 7U 0 0 I!10. R F.SF ARCII ('(1NStlt 1ANT $. INC.. CImb,~Jt¢, M,ll BIO.RESFARCN tNSll'It) I F. INC. RARBARA ll ~R(IWN, I~lD.. C'A~'I. ~0 651(:~ 6368 PRINCIPAL IN¥1rl;I"IGATOR tin I N.%TITiJ'rlON JACK CHALON. M II. Alibl,,l Prelim. ')Olin E. CRAIOXEAD. M.D, I",ole~oe el Pe~Aolof~. U~,er~l M Veym~l Medical 5(bo~ Bmli~l~oo. T. TIMOTHY CRO~KER. M.D.. CARROI.L E. CRCI~. )OLIN P. DELANEY. M ~ble reol¢~ ol 5~lm, U~v~y EDWARD F. ~MINO. M r¢c1~. In.irate ol 81 ml ciiculili~l Ill ille kllt~i limb thl iillill nt~ol~i Illlim M¢libotlc llliillllilo~litll 5iilrl* I.lllilllllollblpi blllll~l Iohlll#
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O~ 0 0 C~ 0 0 PROJECT TITI.E See I ~¢l~sn. A. ~ An rl~l~mLc~cll r~'mlch ~'o|ram on II~C t~l¢dOly Of bumln cm~¢¢ round.Ileal I,~l m¢iJholic fur~l~ ol sl.cc~l,r 82 PRINCIPAl. I N ¥ Ir.%-l'l CAI~R (IR INSTITIITI()N lit RF.~EARCH INSTIIU'I"F~ C1~1o" AARON I. LADMAN, end CA~lrm~m. Scko04 oi Med<~¢. AIt~lo~q~¢. (l~- llaltd u~ Tl~odm¢ N. Fifty. M.D.) RICIIARD A. I.ERNFR, M D., 3~1/5.~ Jolll. C8,1. mma&lq to life IIV:NIO~rI~ S¢c OuarncH. I. I.
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0 0 PIIINCIPAI. I NYF_qTI C A T~R OR IN.~TITI fl'l ON MASON RP.SI~.ARCH lt4STITUTE. Wo~(~4a, Msm. I~)NAI..D I MA_~LARO. M.D. Inl~ Unl.,~-r~r Scbcx~ o~ Wm~binl~o~. D. C. tiANS MEIEIL D.V M. $~ Me MICI<(tui~JLO~IICAL AS$OC| ATES. I1~++ D~llt~, Md. 84 PRINCIPAl. ! NVP.qTIC ATOR OR INN'TITIJTION ALBERT If. NIDFN. Id D. rrol+~ ol IOHH W. PARKER. M.D. r~of.~ ol r~k~. Uniw~y ~ MARY ~ARN5 PARSIII.EY. ~. AJ~l~l#m rrnlr..w oI A~ ~ O~- ~trr~j ~d (;P~T. ~ ~ S. N. P~A~IIAN. M ~. ~ O. reel~l- D.C. ~RA~ON. Br~ ULRICH l|. SCHAEPM. M ~lrcb II~llulc, Mecbs~Jm o~ ml~,r~#~o~ or ~llulmr muf~y by ¢alc,m0~n~"
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0 a) (D ~) ERIK SKINIIOI, MD. CASh LOU~$ A. SOt.OFF. lU D. rrol,~ el Chm~ad Med~i~ ~ C~ef. Div~ o~ Cud;o/o~. Tcmid, tJni~..,~ty thr,ld, SII~L~N C, SOMMF.IL~ M.D. CII~. ca/ Pvofr~ o/ r~4o~?. C~ ~ Uul-e~,~V. ~-w Y~k Cky. $OUTIlW£ST RE~FARCIf INSTI- DAVID M. Sr, dl . ~D, £~'~t0~. D~. ~1 C¢~. ~'ooEIT~. N. Y. r~ojEcT TITLE. c~'~r~.,a blood ~ i~ ~moE¢. and 36 PRINCiPAl. IN¥ F-~;TICATOR OR I N.~TITUTI IIN UNIVERSITY OF SAN FRANCIS(~O. Sin ELLIOT $. VF,SEtL, M.D~ Peele.ca=" .~I Ct~lr~, ROMEO A. Vl~ M O. A~tt rrol¢~ ol r~y. Y~ Univ~r. Mi, e~loty. Um~y ~ W~. SIMON II. WFNDE~ ~O., ol ~I~L Nmm~. ~OM~ C. WP~[. ~. A~ 87
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0 0 o 0 plUlmon~ly (~y1|u~cl~n rollo,~- childhood 'Completed Projects Following is • liar o( the I~im:ipal invmllgator~ or inzlilu6~z listed a~ 89
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O~ r,o[¢x.~m, of 5~(QOI~. t/n,vr,~*~y of Cb~. ~lo. ALBERT DAMON, ~.D. M.D.. ~¢- L F. DA~N. ANDREW S, DIBNER. KAL~ L ~MAN, ~.D. DlrecI~ IlCHA~D H. JoHN W. ~K~IN. M.D. ~eole~ Ol I~ler~l Med~,~. Stale Um~ly of Iowa C~)c~ of Mcd~,~, l~s Chy. IIYMAN ENOF£BERO, M.D, AHesd. HENRY L ~BER, ~D+ R~ch I~- Umlverllty of ~ulbern Cmlilorni~ DANA L. yARN~OR~. M ~ O~ Umi~l~ Health ~¢r~icel, ~~b~ay Medial (~lclc of U~r~I7. Atb~n7. H Y. WII.I.IAM I FISIIBI-'.IN. M.D~ CAId ol I.p,dem,~totR. ('b~C.lO Board ~ Health. ChkllO. RU~FLI. S. FISIIER, M.D. U~y ~ Me,yla~ ~ ol Med~i~, B~h- B. L. FREE~ANDER. M.D. °~l~l m~ MedK~I ~m~, ~n FImn- GILBERT II, FIIED~ M.D. Ck~l ARTHUR FUR~. ~.D. ~me ol Chem~ B~, Finny.Howell ~d}. r,olr~ J~y Cily, rro/e~ el rerl~. H~d I~A ~ M,D., V~am A~Lni~t~t~ goa~. A~t~ rrol¢~ U~¢~Y o~ ]~ Mc~ C~:~. ARTHUR L. GROSS. M S.. Srn,o~ Bio- A~e Clim~ rrole~ ~. Uoi~y ~ Cmh/~nas M~I CARL. C. FMANK ~y. U~Iy ~ Okl,~s Mcd~*I I~EPH H. HAFKEN~IIIEI. M.D, Med~ r~le~ HERBERT I. HA~IIORNF~ M,D. ~K W. HEA~ M D., ~ot.~ of 91
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JO~FPI! N. KIRSNER. M D. Yrof.,o,. o! ~ER H. KNAPP. M D, Re:ter<k rr~ [t~ W P~ck~try. ~ Univcruty KEHN~ P. KNUD~N. M.D. ~y. ~ Y~k CHy+ Cir. MAR~N Kt~IlNFR, M l) ,~* Ymk ~M~ C. LAIP~Y. M D, of r~y. N~b~uecn R~E~ K. ~I~N, M.D. CA/el ol M*~. F~ C~T H~. R~ERT H. U~EL~ ~.O, HERBERT L. LOMSA~O. M,O.. m P.H,, A~h~tc. C~r R~*rcb Imc,lult. 92 IOI.{N P. MANOr. M CHRI~OPH~R M ~AR~N. MD. AJ. New Jetty ler.cy City. CHA~L~ C. McA~THUR. ~e~. tiltyard Untvcro,y. CHARI.F5 I. M~A~ ~.. AJ+ IIENRY C. ¢1~, New ~klm. HENRY D. MCI~, M.D.. ProJ¢~ oI MeJki~ EDWARD McKE~ M D. HERBERT McKEN~ ~ o~ P~. ~ C~ V~ R~ L, McLEAN. M ~eJ~ Of Medi¢~, ~y U~Iy ~ of McdK;~. AtlanlL ~LLIAM F. NE~I. t.. McNIVEN. Itlimi C~ of t~ntimry. ('bKIIO- BERNARD I. M|LI.ER. M D. ol Amtm7, )cRouton Mcdmal C~k~, Dirtcl~, Mcnl~ Ile.t~h Re~cfl I~. A~. HUGH MO~MF.~Y. M.D.. T~ I~1~ ~ M~ N.Y. KENN~ M. M~ER, M D, rro~r~ o~ Me4~J~. (;em~lown t~ EDMONO ~NY MURkilY, Bar ~. Me. ~NA~ M, PA~ ~,D, ALBERT B. PALMER. ~ D. rtol#~, Dr~lmtnt of P~ck~olY. R~E MAIIE PANO~RN. 93
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94 F.RNF~ ~NDIlP.IMER, I'~,D. Ym~, T. M, ~N~EBORH. SAM ~R~. ~.D~ ~e~. ALEXANDER S~ I'REDRICK I. ~AR~ M JACK r. ~ONO, M.D. A~e r~ U~y ~ ~ ~ N~ MARION B, SUI~EROE~ M.D. P,~ ~. New Y~k C~y, H~d U~7, of ~ E~, U~ ~ll Umve~y Ym~ LIE S~ ~AI, ~,D. Rr~h A~ E. D. WARNER. M r/IN~'o~7, S~aIC Unlvc~Ull, d lows C'~. SHI~ WARREN, M.D. DI~ o }OHN S. WA~ R~ARD L ~I~LE~ M.D., CIl~ DUANB O. WEN~ PR~RICK E. WH~N, R~ER I. ~UAM~ k~ U~y ~ ~ M~I~. lO~ r. ~A~. M D. r~/,~ ol 9~

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