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CTR PROGRESS REPORT GRAICI" NUMBER 2770 Na=e of Investigator: D2borah Title of Original Grant: Period Cove.red: fro~- 1/01/92 Hoshizaki to,. 12/31/92 Isolation and Expression of a Drosophila Lipid Gene Abstract of the specific aims as stated in the original application: Little i~ known about the mechanisms involved in regulating lipid eukaryotes. We are the first to initiate a molecular analysis of d,.---' how the~e gene~ are initially "turned on" during fat c regulation of lipid metabolism in a genetically tractor,I- research effort we are interested in the coordinated cloning lipid genes and making lipid gene mutants as regulation of lipid synthesis and to obtain target gene mechanisms regulating lipid synthesis and fat cell spec stated in the original application were l) the determint developmental expression of a putative lipid binding pr, cytogenetie region of this gene and isolation of mutants. List any publications (author, title and journal) resuitin contain a nrinted acknowledgment of CTR support. For press" means yon have a preprint; otherwise use "accepte ~.~m'e~tion by ...... ", "submitted for publication" or qn preparation'. Do not in~ude publications that do not acknowledge CTR. Hoshizaki, D.K., Lunz, R., Johnson, W., and Ghosh, M. (1992) Identification of fat cell enhancer activity using P-element LacZ enhancer traps. (in preparation) Hoshizaki, D.K., Tornari, J., and Johnson, W. (1992} Identification of cwr, a gene expressed during the establishment of fat cell identity. (in prep-~'~ation) Report of Progress (no more than 4 pages, please): 5O717054